`
`Cancer of the Breast - SEER Stat Fact Sheets
`
`(https://web.archive.org/web/20150907161940/http://www.cancer.gov/)
`
`Surveillance, Epidemiology, and End Results Program
`Turning Cancer Data Into Discovery
`
` Home
` Statistical Summaries
` Cancer Stat Fact Sheets
`SEER Stat Fact Sheets: Breast Cancer
`
` Cancer of the Breast
`
`Statistics at a Glance
`At a Glance
`
`Estimated New
`Cases in 2015
`% of All New Cancer
`Cases
`
`231,840
`
`14.0%
`
`Estimated Deaths
`in 2015
`% of All
`Cancer Deaths
`
`40,290
`
`6.8%
`
`2005-2011
`
` The number of new cases of breast cancer was 124.8 per 100,000 women
`per year. The number of deaths was 21.9 per 100,000 women per year. These rates are age-adjusted and based on 2008-
`2012 cases and deaths.
`
`: Approximately 12.3 percent of women will be diagnosed with breast cancer at some
`point during their lifetime, based on 2010-2012 data.
`
`States.
`
`: In 2012, there were an estimated 2,975,314 women living with breast cancer in the United
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`Percent Surviving
`5 Years
`89.4%
`Number of New Cases and Deaths per 100,000:
`Lifetime Risk of Developing Cancer
`Prevalence of This Cancer
`
`
`12/28/2017
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`Cancer of the Breast - SEER Stat Fact Sheets
`
`Survival Statistics
`How Many People Survive 5 Years Or More after Being Diagnosed with Breast Cancer?
`Relative survival
`(http://seer.cancer.govhttps://web.archive.org/web/20150907161940/http://surveillance.cancer.gov/survival/measures.html) statistics
`compare the survival of patients diagnosed with cancer with the survival of people in the general population who are the
`same age, race, and sex and who have not been diagnosed with cancer. Because survival statistics are based on large groups
`of people, they cannot be used to predict exactly what will happen to an individual patient. No two patients are entirely alike,
`and treatment and responses to treatment can vary greatly.
`
`Based on data from SEER 18 2005-2011. Gray figures represent those who have died from breast cancer. Green figures
`represent those who have survived 5 years or more.
`
`More about 5-year survival rates
`(http://seer.cancer.govhttps://web.archive.org/web/20150907161940/http://seer.cancer.gov/statistics/types/survival.html)
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`Percent Surviving
`5 Years
`89.4%
`Additional Information
`
`
`12/28/2017
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`Cancer of the Breast - SEER Stat Fact Sheets
`
`Survival by Stage
`Cancer stage at diagnosis, which refers to extent of a cancer in the body, determines treatment options and has a strong
`influence on the length of survival. In general, if the cancer is found only in the part of the body where it started it is
`.
` (sometimes referred to as stage 1). If it has spread to a different part of the body, the stage is
` or
`The earlier breast cancer is caught, the better chance a person has of surviving five years after being diagnosed. For breast
`cancer, 61.1% are diagnosed at the local stage. The 5-year survival for localized breast cancer is 98.6%.
`
`
`
`Confined to
`Primary Site
`
`
`Spread to Regional
`Lymph Nodes
`
`Cancer Has
`Metastasized
`
`Unstaged
`
`
`
`SEER 18 2005-2011, All Races, Females by SEER Summary Stage 2000
`
`More about breast cancer staging
`(http://seer.cancer.govhttps://web.archive.org/web/20150907161940/http://www.cancer.gov/cancertopics/pdq/treatment/breas
`t/Patient/page2)
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`Percent of Cases by Stage
`5-Year Relative Survival
`localized
`regional
`distant
`Additional Information
`Percent of Cases & 5-Year Relative Survival by Stage at Diagnosis: Breast Cancer
`Loca l ized (61%)
`Reg iona l (32%)
`D istant (6%)
`Unknown (2%)
`
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`Number of New Cases and Deaths
`How Common Is This Cancer?
`Compared to other cancers, breast cancer is fairly common.
`
`Cancer of the Breast - SEER Stat Fact Sheets
`
`Breast cancer represents 14.0%
`of all new cancer cases in the
`U.S.
`
`2. Lung and Bronchus Cancer
`3. Prostate Cancer
`4. Colon and Rectum Cancer
`5. Bladder Cancer
`6. Melanoma of the Skin
`7. Non-Hodgkin Lymphoma
`8. Thyroid Cancer
`9. Kidney and Renal Pelvis Cancer
`10. Endometrial Cancer
`
`221,200
`220,800
`132,700
`74,000
`73,870
`71,850
`62,450
`61,560
`54,870
`
`158,040
`27,540
`49,700
`16,000
`9,940
`19,790
`1,950
`14,080
`10,170
`
`In 2015, it is estimated that there will be 231,840 new cases of breast cancer and an estimated 40,290 people will die of this
`disease.
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`Common Types of Cancer
`Estimated New
`Cases 2015
`Estimated
`Deaths 2015
`1. Breast Cancer (Female)
`231,840
`40,290
`14.0%
`
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`12/28/2017
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`Who Gets This Cancer?
`Female breast cancer is most common in middle-aged and older women. Although rare, men can develop breast cancer as
`well. The number of new cases of breast cancer was 124.8 per 100,000 women per year based on 2008-2012 cases.
`
`Cancer of the Breast - SEER Stat Fact Sheets
`
`Breast cancer is most
`frequently diagnosed
`among women aged 55-
`64.
`
`SEER 18 2008-2012, All Races, Females
`
`All Races
`
`White
`
`Black
`
`Asian /
`Pacific Islander
`American Indian /
`Alaska Native
`
`Hispanic
`
`Non-Hispanic
`
`SEER 18 2008-2012, Age-Adjusted
`
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`Median Age
`At Diagnosis
`61
`Sex-Specific Cancer
`Percent of New Cases by Age Group: Breast Cancer
`Number of New Cases per 100,000 Persons by Race/Ethnicity: Breast Cancer
`
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`12/28/2017
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`Who Dies From This Cancer?
`Overall, female breast cancer survival is good. However, women who are diagnosed at an advanced age may be more likely
`than younger women to die of the disease. Breast cancer is the fourth leading cause of cancer death in the United States. The
`number of deaths was 21.9 per 100,000 women per year based on 2008-2012.
`
`Cancer of the Breast - SEER Stat Fact Sheets
`
`The percent of breast
`cancer deaths is highest
`among women aged 55-
`64.
`
`U.S. 2008-2012, All Races, Females
`
`All Races
`
`White
`
`Black
`
`Asian /
`Pacific Islander
`American Indian /
`Alaska Native
`
`Hispanic
`
`Non-Hispanic
`
`U.S. 2008-2012, Age-Adjusted
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`Median Age
`At Death
`68
`Sex-Specific Cancer
`Percent of Deaths by Age Group: Breast Cancer
`Number of Deaths per 100,000 Persons by Race/Ethnicity: Breast Cancer
`
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`12/28/2017
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`Cancer of the Breast - SEER Stat Fact Sheets
`
`Trends in Rates
`Changes Over Time
`Keeping track of the number of new cases, deaths, and survival over time (trends) can help scientists understand whether
`progress is being made and where additional research is needed to address challenges, such as improving screening or
`finding better treatments.
`
`Using statistical models for analysis, rates for new breast cancer cases have been stable over the last 10 years. Death rates
`have not changed significantly over 2002-2012. 5-year survival trends are shown below the figure.
`
` (http://seer.cancer.govld/breast.html)
`
`5-Year Relative
`Survival
`SEER 9 Incidence & U.S. Mortality 1975-2012, All Races, Females. Rates are Age-Adjusted.
`
`75.2%
`
`74.8%
`
`78.4%
`
`84.6%
`
`86.8%
`
`89.6%
`
`89.7%
`
`91.0%
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`Celltrion, Inc., Exhibit 1135
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`Year
`1975
`1980
`1985
`1990
`1995
`1999
`2003
`2007
`New Cases, Deaths and 5-Year Relative Survival
`View Data Table
`
`
`12/28/2017
`
`More About This Cancer
`Cancer and the Female Breast
`
`Cancer of the Breast - SEER Stat Fact Sheets
`
` (http://seer.cancer.gov/web/20150907161940/http://seer.cancer.gov/i/factsheets/breast-lg.jpg)
`
`Inside a woman's breast are 15 to 20 sections, or lobes. Each lobe is made of many smaller sections called lobules. Fibrous
`tissue and fat fill the spaces between the lobules and ducts (thin tubes that connect the lobes and nipples). Breast cancer
`occurs when cells in the breast grow out of control and form a growth or tumor. Tumors may be cancerous (malignant) or
`not cancerous (benign).
`
`Learn more about female breast cancer
`(http://seer.cancer.govhttps://web.archive.org/web/20150907161940/http://www.cancer.gov/cancertopics/types/breast)
`More Information
`Here are some resources for learning more about female breast cancer.
`
`About risk factors for breast cancer
`(http://seer.cancer.govhttps://web.archive.org/web/20150907161940/http://www.cancer.gov/cancertopics/pdq/treatment/breas
`t/Patient#Keypoint2)
`About breast cancer screening
`(http://seer.cancer.govhttps://web.archive.org/web/20150907161940/http://cancer.gov/cancertopics/pdq/screening/breast/Pati
`ent/page1)
`About symptoms and diagnosis of breast cancer
`(http://seer.cancer.govhttps://web.archive.org/web/20150907161940/http://www.cancer.gov/cancertopics/pdq/treatment/breas
`t/Patient#Keypoint4)
`About treatment options for breast cancer
`(http://seer.cancer.govhttps://web.archive.org/web/20150907161940/http://cancer.gov/cancertopics/pdq/treatment/breast/Pati
`ent/page5)
`About clinical trials (http://seer.cancer.govhttps://web.archive.org/web/20150907161940/http://www.cancer.gov/clinicaltrials)
`About breast cancer prevention
`(http://seer.cancer.govhttps://web.archive.org/web/20150907161940/http://cancer.gov/cancertopics/pdq/prevention/breast/Pat
`ient/page3)
`About cancer prevention
`(http://seer.cancer.govhttps://web.archive.org/web/20150907161940/http://www.cancer.gov/cancertopics/pdq/prevention/over
`view/patient)
`
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`Celltrion, Inc., Exhibit 1135
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`Figure: Breast and Adjacent Lymph Nodes
`Additional Information
`
`
`12/28/2017
`
`References
`All statistics in this report are based on statistics from SEER and the Centers for Disease Control and Prevention's National
`Center for Health Statistics. Most can be found within:
`
`Cancer of the Breast - SEER Stat Fact Sheets
`
`Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A,
`Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2012, National Cancer Institute.
`Bethesda, MD, http://seer.cancer.gov/csr/1975_2012/
`(http://seer.cancer.govhttps://web.archive.org/web/20150907161940/http://seer.cancer.gov/csr/), based on November 2014
`SEER data submission, posted to the SEER web site, April 2015.
`Suggested Citation
`All material in this report is in the public domain and may be reproduced or copied without permission; citation as to source,
`however, is appreciated.
`
`SEER Cancer Statistics Factsheets: Breast Cancer. National Cancer Institute. Bethesda, MD,
`http://seer.cancer.gov/statfacts/html/breast.html
`(http://seer.cancer.govhttps://web.archive.org/web/20150907161940/http://seer.cancer.gov/statfacts/html/breast.html)
`
`The SEER Website is a service of the Surveillance Research Program
`(https://web.archive.org/web/20150907161940/http://surveillance.cancer.gov/), in NCI's Division of Cancer Control and
`Population Sciences (https://web.archive.org/web/20150907161940/http://cancercontrol.cancer.gov/)
`
`NIH... Turning Discovery Into Health
`®
`
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`Celltrion, Inc., Exhibit 1135
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`This factsheet focuses on population statistics that are based on the US population. Because these statistics are based on large
`groups of people, they cannot be used to predict exactly what will happen to an individual patient. To see tailored statistics,
`browse the SEER Cancer Statistics Review
`(http://seer.cancer.govhttps://web.archive.org/web/20150907161940/http://seer.cancer.gov/csr/). To see statistics for a specific state,
`go to the State Cancer Profiles
`(http://seer.cancer.govhttps://web.archive.org/web/20150907161940/http://statecancerprofiles.cancer.gov/) .
`The statistics presented in this factsheet are based on the most recent data available, most of which can be found in the SEER
`Cancer Statistics Review (http://seer.cancer.govhttps://web.archive.org/web/20150907161940/http://seer.cancer.gov/csr/). In some
`cases, different year spans may be used. Estimates for the current year are based on past data.
`Cancer is a complex topic. There is a wide range of information available. This factsheet does not address causes, symptoms,
`diagnosis, treatment, follow-up care, or decision making, although it provides links to information in many of these areas.
`