~-·
`
`· ;.u
`u.
`tu
`
`GLU """ GLN
`
`...,
`
`al<l
`GLU
`GLU
`GLU
`GLU
`GLU
`GLU
`GLU GLU
`GLU
`GLU
`VAL
`V"I.
`VM.
`VIW.
`VAi.
`VAL
`VAL
`VAL VAi.
`V A(.
`VAi.
`V"I.
`GLN
`GLN
`GLN
`GLN
`GLN
`GLN
`GLN
`GLN
`GLN GUI
`GLN
`GLN
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`t.u
`VAL
`VAL VAL VAl VAL VAL
`.. u
`VAl VAl
`Al
`leu
`feu
`lfu
`3 1822 01003 0666
`sp GLU GLU GLU GLU GLU GLU GLU GLU GLU GLU GLU GLU GLX
`6
`~GPt"v~G~L~v~·-·G~l~Y~vGcPLv~~ooe~~ ~t~ ~t~ ~~~ ~I~ ~t~ ~t~ ~t~ ~t~ ~t~ ~t~ ~t~ ~t~ ~I~
`7 ~
`GL YI 991
`8
`".lLV GLV GLY GLY GLY CLY CLY GLV GLY GLY GLV GLV GLV GLY GLY
`GL YC.99)
`9
`GLV OLY QlY
`10
`11
`•2
`13
`1•
`
`PAOI 961
`GLV
`
`SER(.961
`LEUC.98)
`ARGI 961
`
`CVS
`
`ALAC.95>
`SER( 971
`GLVC 95)
`PHEC 971
`
`Gl Y
`t Y
`Gl Y
`SER s
`
`(
`
`t.
`
`f ,, StH
`
`•
`
`,
`H ~H< :,Uc
`
`,
`
`t
`
`_ •
`
`:O,LH
`
`')t 11
`
`~l.H
`
`•
`
`....
`
`:,EH
`
`•
`
`•
`)
`:=tt::ft ht "
`
`LY GLY
`l V GLY
`:.ht sen ~EH SER
`
`CVS C VS
`ALA ALA
`ALA ALA
`
`•
`
`•
`
`A
`
`•
`
`S
`1'
`lA
`
`VS
`LA
`tA
`
`S
`
`A
`
`AL:
`ALA'. A
`
`~1
`..
`
`CVS CVS
`lA ALA ALA
`Al.A ALA
`l ,4
`
`SER
`
`P
`
`H
`
`X
`
`H
`E
`
`f
`
`P•
`
`~
`
`E
`
`T
`
`AL
`
`GLU
`VAL
`GLN
`LEU
`VAL
`GLU
`SER
`GLY
`GLY
`GLY
`LEU
`VAL
`lys
`PRO
`GLY
`GLY
`SER
`LEU
`AAG
`LEU
`SER
`CVS
`ALA
`ALA
`
`&>'s
`
`ALA
`ALA
`SER
`GLY
`PHE
`
`THA ••I
`
`SEA
`ASX
`HIS
`SEA
`MET
`
`GLU. GLU
`VllL VAi.
`GLN GU<
`LEU
`LEU
`I
`VAL
`\
`VAL
`GLX G
`GLU
`SER S.
`thr
`GLY 0t
`GLY
`GLV QL
`GLV
`GLY
`GLY
`LEU
`LEU
`•le
`VAL
`GLX
`GLN
`PRO
`PRO
`GLY
`GLY
`GLY
`GLY
`SER
`SER
`LEU
`LEU
`ARG
`AAG
`LEU
`LEU
`SER
`CVS
`ALA
`Al.A
`SER
`GLY
`PHE
`
`...
`~
`
`GU -OI.' :a
`
`LEU ""°
`
`~-~ tli1~Ifii-ift111 :;II
`r~st ·rou111~ N~; 't¢.t1i rg Qt !~
`;:~ ~t~ p' L~"Ft '." o: • ; ; E Lll lllcri•~ s O"" '" fil ~ ~~
`IMMU
`IU~, b&1fll4lSE~ (.~~
`~i ~~~ ~t~ f~~ ,.HE~ ~Re.., rr1 !rs1!~ ALA SEA TVA
`
`ALA
`TAP
`MET MET
`I YS SER
`
`TAP
`VAL
`
`VAL
`ARG
`
`TAP
`VAL
`ARG
`Glll
`
`PHE
`•
`it;;<l
`TVA
`VAL
`MET
`ASX
`
`SER
`TRP
`VAL
`ARG
`GlH
`ALA
`PRO
`GLY
`LYS
`ALA
`LEU
`GLX
`TAP
`VAL
`SER
`ALA
`ILE .
`TVA
`
`ARG
`GLY
`
`·~ 16
`17
`16
`t9
`20
`21
`22
`23
`2•
`25
`2e
`21
`28
`29
`30
`3i
`32
`33
`34
`35
`36A
`368
`ii
`37
`31 ,.
`AO .. •2
`43 .. 45
`48 ;-
`
`46
`47
`
`I '54
`
`TAP
`
`AAGj 95)
`GLN< 951
`
`0 ROC 95!
`GLY
`LVS( 951
`
`LEIJC.95>
`
`TRP
`VAL( 95)
`
`TAP
`TAP TRP
`VAL VAL
`VAL
`AAG ARG PRO
`GLN GLN GL Y
`ALA VAL ALA
`PAO THA PAO
`GLY GLY GLV
`LYS ARO
`LVS
`GLY GLY GLY
`lEU
`LEU
`LEU
`GLU GLU
`TAP TRP
`
`'"
`
`l "TP· ·
`\/AL
`VA-
`• -...
`./A..
`AAG ARG ARG
`AAG
`GLN GLN Cl;LN
`GLN
`ALA ALA A.LA
`ALA
`PRO PRO P RO
`PRO
`GLY GLY ~LY
`GLY
`LYS
`GLV
`LEU
`r.•
`
`~ ee
`.w;-
`PHE
`67
`ee
`M
`70
`71
`
`•LE
`SEA
`•RG
`
`TYP
`
`MEI ( 951
`
`72 t ~
`15
`76 n
`Te
`t
`79
`i ao
`8 1
`e?
`' ~:
`·.:.
`
`SEA
`ARG
`ASN
`ASP
`se'll
`LYS
`ASN
`THR
`LEU
`TVA
`LEU
`GLN
`MET
`LEU
`SEA
`LEU
`LEU
`GlU • AllG
`PRO ALA
`n1 •1 GLU
`ASP
`THA
`ALA
`VAL
`TYR
`TVA
`CVS
`AlA
`AAG
`SER
`!'AO
`VAL
`MR
`I.EU
`VAL
`
`....,.
`
`_
`
`ALA
`
`ft~~ ·1~
`
`THR
`AlA
`VAL
`VAL
`TYA
`TVA
`TVA
`TYR
`CVS
`CVS
`ALA
`AlA
`_ ARQ AAG
`·,;He- - - - - -
`AAG
`GLN
`PRO
`PHE
`VAL
`GlN
`
`THA THA
`THA
`ALA ALA
`ALA
`LEU
`LEU
`VAL
`TYR
`TYR
`TVR
`TYR
`TYR
`TVA
`CVS CVS
`CVS
`ALA AlA
`ALA
`AAG ARG ARG
`~ASP
`SER Al.A
`VAL GLY
`THR PAO
`TVR
`ALA
`VAi. VAL
`Al.A SER
`PtiE PflO
`THA
`PtfE
`
`THA
`ALA
`VAL
`TVA
`TYR
`CVS
`ALA
`LYS
`GLY
`LYS
`VAL
`SER
`ALA
`TVA
`
`TYR -
`
`\
`\
`
`PHE
`-'SV-~1>EP~RT:TMENT °'HEALTH
`-·-- r~~ -~~ftU'JMAN SEftYIGES
`~~ ~~P~lc ~Health *ice
`~ lfillof:Mll l~nstltute~ Health
`.....
`LEU
`LEU
`1..EU
`LYS
`VAi. V.... VAt.
`SER THR THll
`
`THA
`
`GLY
`T1W'
`I.EU
`TWI
`
`TYR -GlY
`
`KR
`VAL
`TllP
`GLY
`OLN
`QLY
`Tlill
`LEU
`
`MET
`ASN
`GLV
`LEU
`AAG
`ALA
`GLX
`ASX
`GLY
`GLY
`VAL
`TVA
`TYR
`CVS
`VAL
`
`SER AsX
`
`VAL
`
`. }~~ ~~~
`
`MET
`ASN
`ASN
`LEU
`LEU
`~~ ~~~·
`GLU GLX
`VAL ASX
`SER THR
`ALA ALA
`
`VAL
`THll
`PRO
`GLU
`ASP
`THA THA
`ALA ALA
`VAL VAL
`TVA
`TVA
`TYR TYR
`TVA
`TYR
`CVS CYS
`CYS C'fS
`ALA AlA
`ALA ALA
`AAG ARG
`ARG ARG
`ASP --;;sx-
`THR - V AL
`ALA ARG
`ARG VAL
`PRO VAL GLY LEU
`OLY SER PRO GLY
`OLY THR TYR PRO
`TVA SER VAL THR
`SER Al.A
`PHE
`POO CYS
`SER
`THR SER ·
`PtiE VAL
`
`MET PHE
`ASP Al.A
`VAL HIS
`TAP. TRP .
`GLY Gl.Y
`GLN GLH
`GLY GLY
`TMA THll
`
`ASP
`VAL
`TiiP
`(K.Y
`GLN
`Gl.Y
`THA
`LEO
`VM. VM. VM.
`SEii n<A THA
`
`""° L.E<J
`
`LEU
`GLN
`MET
`ASX
`SER
`LEU
`ARG
`ALA
`GLU
`ASP
`THR
`ALA
`VAL
`TYR
`TYR
`CVS
`ALA
`ARG
`ASP
`LEU
`ALA
`Al.A
`ALA
`ARG
`LEU
`
`PHE
`
`-
`
`GLV
`LYS
`GLY
`n<A
`n<R
`
`.., ....
`
`Tiffi
`VAL
`SER
`SEA
`
`LEU
`SEii
`C VS
`ALA
`ALA
`SEA
`GLY
`PHE
`asn
`PHF
`P'llS
`GLlJ
`TYR
`ASN
`Mrt
`HIS
`
`IRP
`LCU
`ARG
`OLN
`GLV
`PRO
`GLV
`LVS
`GLY
`PRO
`GLU
`TRP
`VAi..
`SER
`THR
`ILE
`THR
`TAP
`
`ASN
`GLV
`GLY
`SER
`VAL
`LEU
`TVA
`AV
`ASl(cid:173)
`SEA
`VAi
`LYS
`GlY
`ARG
`PHE
`ALA
`llf
`SER
`ARI ~
`ASP
`ASH
`Al '
`GI"'
`L
`Tl
`LC.
`TYll
`LEU
`GL.N
`LEU
`ASH
`ILE
`LEU
`ARG
`PAO
`GLU
`AS!'
`THll
`ALA
`PHE
`TVA
`TYR
`CVS
`ALA
`LV6
`GLY
`TYll
`ILE
`TRP
`ASH
`GLY
`ASH
`TAP
`PtfE
`
`ASP
`sen
`TAP
`GLY
`GLN
`GlY
`™"
`LEU
`VAl,
`TiiR
`
`VAi ser
`srr
`
`1 of 2
`
`Celltrion, Inc., Exhibit 1079
`
`

`

`11~1UiDiiiiill~Hm11
`3 1822 01003 0666
`SEQUENCES OF
`PROTEINS OF
`IMMUNOLOGICAL
`INTEREST
`
`~
`/f:,
`1/,2.t/'is
`/t;?~
`
`Tabulation and Analysis of
`Amino Acid and Nucleic Acid Sequences of
`Precursors, V-Regions, C-Regions, J-Chain,
`{ji-Microglobulins, Major Histocompatibility Antigens,
`Thy-1, Complement, C-Reactive Protein, Thymopoietin,
`i Post-gamma Globulin, and a 7 Macroglobulin
`
`1983
`
`Elvin A. Kabat*. Tai Te Wu t . Howard Bilofs/fl f .
`Margaret Reid-Miller+. and Harold Perry+
`
`)
`JUi~ 'i 1987
`
`• Depts. of Microbiology, Human Genetics and Development, and Neurology, Cancer Center/
`Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New
`York, NY 10032 and the National Institute of Allergy and Infectious Diseases, Bethesda, MD
`20205
`t Depts. of Biochemistry, Molecular Biology, and Cell Biology, and Engineering Sciences and
`Applied Mathematics, Northwestern University, Evanston, IL 60201 and the Cancer Center,
`Northwestern University Medical School, Chicago, IL 60611
`f Bolt Beranek and Newman Inc., Cambridge, MA 02238
`The collection and maintenance of this data base is sponsored through Contract N01·RR·8·2118
`by the following components of the National Institutes of Health, Bethesda, MD 20205:
`Division of Research Resources
`National Cancer Institute
`National Institute of Allergy and Infectious Diseases
`National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases
`National Institute of General Medical Sciences
`
`U.S. DEPARTMENT OF HEAL TH
`AND HUMAN SERVICES
`Public Health Service
`National Institutes of Health
`(1983)
`
`2 of 2
`
`Celltrion, Inc., Exhibit 1079
`
`