ID
`
`Pharmacology
`
`Interactions
`
`References
`
`Trials
`
`Economics
`
`Properties
`
`Spectra
`
`Taxonomy
`
`Comments
`
`Targets (5) Enzymes (18) Transporters (2) Biointeractions (25)
`
`Show Drugs with Similar Structures
`
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`
`Identification
`Identification
`
`Name
`
`Acetaminophen
`
`Accession Number DB00316 (APRD00252)
`
`Type
`
`Groups
`
`Description
`
`Structure
`
`Synonyms
`
`Small Molecule
`
`Approved
`
`Acetaminophen, also known as paracetamol, is commonly used for its analgesic and antipyretic effects. Its therapeutic
`effects are similar to salicylates, but it lacks anti-inflammatory, antiplatelet, and gastric ulcerative effects.
`
`CH 3
`
`HN
`
`O
`
`OH
`
` MOL
`
`SDF
`
`PDB
`
`SMILES
`
`InChI
`
`4-(Acetylamino)phenol
`
`4-acetamidophenol
`
`4'-hydroxyacetanilide
`
`Acenol
`
`acetaminofén
`
`Acetaminophen
`
`acétaminophène
`
`APAP
`
`N-acetyl-p-aminophenol
`
`p-acetamidophenol
`
`p-acetaminophenol
`
`p-Acetylaminophenol
`
`p-hydroxy-acetanilid
`
`p-hydroxyacetanilide
`
`p-hydroxyphenolacetamide
`
`Paracétamol
`
`Paracetamol
`
`Paracetamolum
`
`External IDs
`
`
`
`NSC-109028 / NSC-3991
`
`Product
`
`Ingredients
`
`Approved
`Prescription
`Products
`
`Not Available
`
`Show 10
`
` entries
`
`Search:
`
`Par Pharm., Inc.
`Exhibit 1051
`Page 001
`
`

`

`Name
`
`Dosage
`
`Strength
`
`Route
`
`Labeller
`
`Childrens Silapap
`
`Liquid
`
`160
`mg/5mL
`
`Oral
`
`bryant ranch prepack
`
`Marketing
`Start
`
`Marketing
`End
`
`1994-09-05 Not
`applicable
`
`Ofirmev
`
`Solution
`
`10 mg
`
`Intravenous Cadence
`Pharmaceuticals, Inc.
`
`Not
`applicable
`
`Not
`applicable
`
`Ofirmev
`
`Ofirmev
`
`Injection,
`solution
`
`Injection,
`solution
`
`10 mg/mL
`
`Intravenous Mallinckrodt Hospital
`Products Inc.
`
`2010-11-08 Not
`applicable
`
`10 mg/mL
`
`Intravenous Cardinal Health
`
`Regular Strength Qpap
`
`Tablet
`
`325 mg/1
`
`Oral
`
`bryant ranch prepack
`
`2010-11-08 Not
`applicable
`
`1996-02-01 Not
`applicable
`
`Marketing
`Start
`
`Marketing
`End
`
`2015-03-09
`
`2017-03-10
`
`2011-03-09
`
`2015-12-29
`
`Approved Generic
`Prescription
`Products
`
`Show 10
`
` entries
`
`Name
`
`Acephen
`
`Acetaminophen
`
`Showing 1 to 5 of 5 entries
`
`Previous
`
`1
`
`Next
`
`Search:
`
`Dosage
`
`Strength
`
`Route
`
`Labeller
`
`Suppository
`
`325 mg/1
`
`Rectal
`
`325 mg/1
`
`Oral
`
`Remedy
`Repack
`
`Remedy
`Repack
`
`Tablet
`
`Tablet
`
`300 mg/1
`
`Oral
`
`2013-04-04
`
`2017-01-20
`
`Acetaminophen and Codeine
`Phosphate
`
`Good Neighbor Pharmacy Pain
`Relief
`
`Tablet, film coated,
`extended release
`
`650 mg/1
`
`Oral
`
`Remedy
`Repack
`
`bryant
`ranch
`prepack
`
`2008-11-03 Not
`applicable
`
`Approved Over the
`Counter Products
`
`Show 10
`
` entries
`
`Showing 1 to 4 of 4 entries
`
`Previous
`
`1
`
`Next
`
`Search:
`
`Name
`
`Dosage
`
`Strength
`
`Route
`
`Labeller
`
`222 AF Extra Strength Caplet
`(500mg)
`
`Tablet
`
`500 mg
`
`Oral
`
`222 AF Regular Strength
`Caplet (325mg)
`
`Tablet
`
`325 mg
`
`Oral
`
`222af Extra Strength 500mg
`
`Tablet
`
`500 mg
`
`Oral
`
`222af Regular Strength
`325mg
`
`Tablet
`
`325 mg
`
`Oral
`
`Merck Frosst
`Canada & Cie,
`Merck Frosst
`Canada & Co.
`
`Merck Frosst
`Canada & Cie,
`Merck Frosst
`Canada & Co.
`
`Merck Frosst
`Canada & Cie,
`Merck Frosst
`Canada & Co.
`
`Merck Frosst
`Canada & Cie,
`Merck Frosst
`Canada & Co.
`
`7 Select Acetaminophen
`
`Tablet
`
`500 mg/1
`
`Oral
`
`7 Eleven
`
`7 Select Childrens Pain Relief Suspension
`
`8 Hour Pain Relief
`
`Tablet, film
`coated,
`
`160
`mg/5mL
`
`Oral
`
`7 Eleven
`
`650 mg/1
`
`Oral
`
`Hyvee
`
`Marketing
`Start
`
`Marketing
`End
`
`1992-12-31
`
`1997-08-14
`
`1992-12-31
`
`1997-08-14
`
`1978-12-31
`
`1997-08-14
`
`1977-12-31
`
`1997-08-14
`
`2014-05-14 Not
`applicable
`
`2014-08-13 Not
`applicable
`
`2005-09-23 Not
`applicable
`
`Par Pharm., Inc.
`Exhibit 1051
`Page 002
`
`

`

`8 Hour Pain Relief
`
`extended
`release
`Tablet, film
`coated,
`extended
`release
`
`650 mg/1
`
`Oral
`
`Cvs Health
`
`2008-08-27 Not
`applicable
`
`A.F. Anacin Tablets 325mg
`
`Tablet
`
`325 mg
`
`Oral
`
`A.F.anacin Extra Strength
`Tablets
`
`Tablet
`
`500 mg
`
`Oral
`
`Whitehall Robins
`Inc.
`
`Whitehall Robins
`Inc.
`
`1994-12-31
`
`1997-08-07
`
`1994-12-31
`
`1998-07-29
`
`Showing 1 to 10 of 1,721 entries
`
`Previous
`
`1
`
`2
`
`3
`
`4
`
`5
`
`…
`
`173
`
`Next
`
`Unapproved/Other
`
`Products
`
`Show 10
`
` entries
`
`Search:
`
`Name
`
`Dosage
`
`Strength
`
`Route
`
`Labeller
`
`Marketing
`Start
`
`Marketing
`End
`
`Acetaminophen
`
`Tablet
`
`325 mg/1
`
`Oral
`
`Cardinal Health
`
`2011-06-02
`
`Acetaminophen
`
`Tablet
`
`500 mg/1
`
`Oral
`
`Cardinal Health
`
`2011-06-02
`
`Acetaminophen
`
`Tablet
`
`500 mg/1
`
`Oral
`
`Cardinal Health
`
`2011-06-02
`
`Not
`applicable
`
`Not
`applicable
`
`Not
`applicable
`
`Oral
`
`Cardinal Health
`
`2011-06-02
`
`Acetaminophen
`
`Tablet
`
`325 mg/1
`
`Extra Strength Mapap
`
`Tablet
`
`500 mg/1
`
`Oral
`
`Mapap
`
`Tablet
`
`325 mg/1
`
`Oral
`
`Mc Kesson Contract
`Packaging
`
`Mc Kesson Contract
`Packaging
`
`2011-12-20
`
`2011-08-29
`
`Not
`applicable
`
`Not
`applicable
`
`Not
`applicable
`
`International
`Brands
`
`Show 10
`
` entries
`
`Showing 1 to 6 of 6 entries
`
`Previous
`
`1
`
`Next
`
`Search:
`
`Name
`
`Acamol
`
`Aceta Elixir
`
`Aceta Tablets
`
`Acetalgin
`
`Actamin
`
`Actimol
`
`Algotropyl
`
`Alvedon
`
`Aminofen
`
`Anacin-3
`
`Company
`
`Teva
`
`Not Available
`
`Not Available
`
`Not Available
`
`Not Available
`
`Not Available
`
`Not Available
`
`Not Available
`
`Not Available
`
`Not Available
`
`Brand mixtures
`
`Show 10
`
` entries
`
`Showing 1 to 10 of 44 entries
`
`Previous
`
`1
`
`2
`
`3
`
`4
`
`5
`
`Next
`
`Search:
`
`Name
`
`Labeller
`
`Ingredients
`
`(extra Strength) Acetaminophen, Caffeine & 8mg Codeine Phosphate Caplets Stanley
`Pharmaceuticals, A
`
`Acetaminophen
`/ Caffeine / Codeine
`
`Par Pharm., Inc.
`Exhibit 1051
`Page 003
`
`

`

`10 Person Ansi
`
`Division Of Vita
`Health Products
`Inc.
`
`Genuine First Aid
`
`25 Person Ansi
`
`Genuine First Aid
`
`50 Person Ansi
`
`Genuine First Aid
`
`7 Select Day Time Relief
`
`7 Select Migraine Formula
`
`7 Select Night Time Relief
`
`7 Select Night Time Severe Cold Cough and Flu
`
`7 Select Night Time Severe Cold, Cough and Flu
`
`7 Select Pain Relief PM
`
`7 Eleven
`
`7 Eleven
`
`7 Eleven
`
`7 Eleven
`
`7 Eleven
`
`7 Eleven
`
`Showing 1 to 10 of 2,605 entries
`
`Previous
`
`1
`
`2
`
`3
`
`4
`
`5
`
`…
`
`261
`
`Next
`
`Categories
`
`Acetanilides
`Acetates
`Acids, Acyclic
`Amides
`Analgesics
`Analgesics, Non-Narcotic
`Anilides
`Antipyretics
`Central Nervous System Agents
`Combined Inhibitors of CYP3A4 and P-glycoprotein
`Cytochrome P-450 CYP1A2 Substrates
`
`Acetaminophen
`/ Acetylsalicylic acid
`/ Bacitracin
`/ Benzalkonium
`/ Benzocaine
`/ Ethanol / Ibuprofen
`/ Lidocaine
`/ Neomycin
`/ Polymyxin B Sulfate
`/ Water
`
`Acetaminophen
`/ Acetylsalicylic acid
`/ Bacitracin
`/ Benzalkonium
`/ Benzocaine
`/ Ethanol / Ibuprofen
`/ Isopropyl Alcohol
`/ Lidocaine
`/ Neomycin
`/ Polymyxin B Sulfate
`/ Water
`
`Acetaminophen
`/ Acetylsalicylic acid
`/ Bacitracin
`/ Benzalkonium
`/ Benzocaine
`/ Ethanol / Ibuprofen
`/ Isopropyl Alcohol
`/ Lidocaine
`/ Neomycin
`/ Polymyxin B Sulfate
`/ Water
`
`Acetaminophen
`/ Dextromethorphan
`/ Phenylephrine
`
`Acetaminophen
`/ Acetylsalicylic acid
`/ Caffeine
`
`Acetaminophen
`/ Dextromethorphan
`/ Doxylamine
`
`Acetaminophen
`/ Diphenhydramine
`/ Phenylephrine
`
`Acetaminophen
`/ Diphenhydramine
`/ Phenylephrine
`
`Acetaminophen
`/ Diphenhydramine
`
`Par Pharm., Inc.
`Exhibit 1051
`Page 004
`
`

`

`Cytochrome P-450 CYP2A6 Substrates
`Cytochrome P-450 CYP2C8 Substrates
`Cytochrome P-450 CYP2C9 Substrates
`Cytochrome P-450 CYP2D6 Substrates
`Cytochrome P-450 CYP2E1 Substrates
`Cytochrome P-450 CYP3A Inducers
`Cytochrome P-450 CYP3A Inhibitors
`Cytochrome P-450 CYP3A4 Substrates
`Fatty Acids
`Fatty Acids, Volatile
`Lipids
`Methemoglobinemia Associated Agents
`Nervous System
`P-glycoprotein/ABCB1 Inhibitors
`P-glycoprotein/ABCB1 Substrates
`Peripheral Nervous System Agents
`Sensory System Agents
`
`UNII
`
`362O9ITL9D
`
`
`
`CAS number
`
`103-90-2
`
`Weight
`
`Average: 151.1626
`Monoisotopic: 151.063328537
`
`Chemical Formula
`
`C H NO
`8 9
`
`2
`
`InChI Key
`
`RZVAJINKPMORJF-UHFFFAOYSA-N
`
`InChI
`
`InChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)
`
`IUPAC Name
`
`N-(4-hydroxyphenyl)acetamide
`
`SMILES
`
`CC(=O)NC1=CC=C(O)C=C1
`
`Pharmacology
`Pharmacology
`
`Indication
`
`For temporary relief of fever, minor aches, and pains.
`
`Structured
`Indications
`
`
`
`Fevers
`Pain
`
`Pharmacodynamics Acetaminophen (USAN) or Paracetamol (INN) is a widely used analgesic and antipyretic drug that is used for the relief of
`fever, headaches, and other minor aches and pains. It is a major ingredient in numerous cold and flu medications and
`many prescription analgesics. It is extremely safe in standard doses, but because of its wide availability, deliberate or
`accidental overdoses are not uncommon. Acetaminophen, unlike other common analgesics such as aspirin and
`ibuprofen, has no anti-inflammatory properties or effects on platelet function, and it is not a member of the class of
`drugs known as non-steroidal anti-inflammatory drugs or NSAIDs. At therapeutic doses acetaminophen does not irritate
`the lining of the stomach nor affect blood coagulation, kidney function, or the fetal ductus arteriosus (as NSAIDs can).
`Like NSAIDs and unlike opioid analgesics, acetaminophen does not cause euphoria or alter mood in any way.
`Acetaminophen and NSAIDs have the benefit of being completely free of problems with addiction, dependence,
`tolerance and withdrawal. Acetaminophen is used on its own or in combination with pseudoephedrine,
`dextromethorphan, chlorpheniramine, diphenhydramine, doxylamine, codeine, hydrocodone, or oxycodone.
`
`Acetaminophen is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of
`cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis. Unlike NSAIDs,
`acetaminophen does not inhibit cyclooxygenase in peripheral tissues and, thus, has no peripheral anti-inflammatory
`affects. While aspirin acts as an irreversible inhibitor of COX and directly blocks the enzyme's active site, studies have
`found that acetaminophen indirectly blocks COX, and that this blockade is ineffective in the presence of peroxides. This
`might explain why acetaminophen is effective in the central nervous system and in endothelial cells but not in platelets
`and immune cells which have high levels of peroxides. Studies also report data suggesting that acetaminophen
`selectively blocks a variant of the COX enzyme that is different from the known variants COX-1 and COX-2. This enzyme
`is now referred to as COX-3. Its exact mechanism of action is still poorly understood, but future research may provide
`further insight into how it works. The antipyretic properties of acetaminophen are likely due to direct effects on the
`heat-regulating centres of the hypothalamus resulting in peripheral vasodilation, sweating and hence heat dissipation.
`
`details
`
`details
`
`details
`
`Actions
`
`Organism UniProt ID
`
` 
`
`inhibitor
`
`Human
`
`P23219
`
`inhibitor
`
`Human
`
`P35354
`
`Pharmacological
`action
`
`Kind
`
`Protein
`
`yes
`
`Protein
`
`yes
`
`Target
`
`Prostaglandin G/H synthase 1
`
`Prostaglandin G/H synthase 2
`
`Prostaglandin G/H synthase 3
`
`Protein
`
`unknown
`
`inhibitor
`
`Mouse
`
`not
`applicable
`
`Mechanism of
`action
`
`Par Pharm., Inc.
`Exhibit 1051
`Page 005
`
`

`

`details
`
`details
`
` 
`
`O00519
`Human
`Organism UniProt ID
`Human
`Q8NER1
`
`Fatty-acid amide hydrolase 1
`Target
`Transient receptor potential cation channel
`subfamily V member 1
`
`Protein
`Kind
`Protein
`
`Pharmacological
`unknown
`action
`unknown
`
`inhibitor
`Actions
`Not
`Available
`
`Related Articles
`
`Absorption
`
`Rapid and almost complete
`
`Volume of
`distribution
`
`Not Available
`
`Protein binding
`
`25%
`
`Metabolism
`
`Acetaminophen primarily undergoes glucuronidation (45-55% of the dose) in which this process is facilitated by
`UGT1A1, UGT1A6, UGT1A9, UGT2B15 in the liver or UGT1A10 in the gut. 30-35% of the dose undergoes sulfation.
`This biotransformation is facilitated by SULT1A1, SULT1A3, SULT1A4, SULT1E1 and SULT2A1. A small percentage of
`acetaminophen is oxidized by CYP2E1 to form N-acetyl-p-benzo-quinone imine (NAPQI), a toxic metabolite which is
`then conjugated to glutathione and excreted renally. Studies suggest that CYP3A4 and CYP2E1 are the primary
`cytochrome P450 isozymes responsible for the generation of toxic metabolites. Accumulation of NAPQI may occur if
`primary metabolic pathways are saturated.
`
`Substrate
`
`Enzymes
`
`Acetaminophen
`
`Acetaminophen
`
`Acetaminophen
`
`
`Cytochrome P450 1A2
`Cytochrome P450 2D6
`Cytochrome P450 2E1
`
`
`UDP-glucuronosyltransferase 1-9
`UDP-glucuronosyltransferase 1-6
`UDP-glucuronosyltransferase 1-1
`UDP-glucuronosyltransferase 2B15
`
`
`Sulfotransferase 1A1
`Estrogen sulfotransferase
`Sulfotransferase 1A3/1A4
`Bile salt sulfotransferase
`
`Product
`
`NAPQI
`
`Details
`
`Acetaminophen glucuronide
`
`Details
`
`Acetaminophen sulfate
`
`Details
`
`NAPQI
`
`
`Glutathione S-transferase P
`Glutathione S-transferase theta-1
`
`Acetaminophen cystein
`
`Details
`
`Route of
`elimination
`
`Approximately 80% of acetaminophen is excreted in the urine after conjugation and about 3% is excreted unchanged.
`
`Half life
`
`1 to 4 hours
`
`Clearance
`
`Not Available
`
`Toxicity
`
`Oral, mouse: LD50 = 338 mg/kg; Oral, rat: LD50 = 1944 mg/kg. Acetaminophen is metabolized primarily in the liver,
`where most of it is converted to inactive compounds by conjugation with glucuronic acid and, to a lesser extent, sulfuric
`acid. Conjugates are then excreted by the kidneys. Only a small portion is excreted in unchanged in urine or oxidized via
`the hepatic cytochrome P450 enzyme system (CYP2E1). Metabolism via CYP2E1 produces a toxic metabolite, N-acetyl-
`p-benzoquinoneimine (NAPQI). The toxic effects of acetaminophen are due to NAPQI, not acetaminophen itself nor any
`of the major metabolites. At therapeutic doses, NAPQI reacts with the sulfhydryl group of glutathione to produce a non-
`toxic conjugate that is excreted by the kidneys. High doses of acetaminophen may cause glutathione depletion,
`accumulation of NAPQI and hepatic necrosis. The maximum daily dose of acetaminophen is 4 g. Liver failure has been
`observed at doses as low as 6 g per day. As such, the maximum daily and single dose of acetaminophen is currently being
`reviewed in some countries. N-acetyl-cysteine, a precursor of glutathione, may be administered in the event of
`acetaminophen toxicity.
`
`Affected organisms
`
`Humans and other mammals
`
`Pathways
`
`Pathway
`
`Acetaminophen Metabolism Pathway
`
`Acetaminophen Action Pathway
`
`Category
`
`Drug metabolism
`
`Drug action
`
`SMPDB ID
`
`SMP00640
`
`SMP00710
`
`Par Pharm., Inc.
`Exhibit 1051
`Page 006
`
`

`

`SNP Mediated
`Effects
`SNP Mediated
`Adverse Drug
`Reactions
`
`Interactions
`Interactions
`
`Drug Interactions
`
`Not Available
`
`Not Available
`
`Drug
`
`Abiraterone
`
`Acebutolol
`
`Interaction
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Abiraterone.
`
`Drug group
`
`Approved
`
`The serum concentration of Acebutolol can be increased when it is combined
`with Acetaminophen.
`
`Approved
`
`Acenocoumarol
`
`Acetaminophen may increase the anticoagulant activities of Acenocoumarol.
`
`Approved
`
`Acetylsalicylic acid
`
`The serum concentration of Acetylsalicylic acid can be increased when it is
`combined with Acetaminophen.
`
`Approved, Vet
`Approved
`
`Afatinib
`
`Albendazole
`
`Aldosterone
`
`Alectinib
`
`Alfentanil
`
`Alitretinoin
`
`Amantadine
`
`Ambrisentan
`
`The serum concentration of Afatinib can be increased when it is combined
`with Acetaminophen.
`
`Approved
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Albendazole.
`
`The serum concentration of Acetaminophen can be decreased when it is
`combined with Aldosterone.
`
`Approved, Vet
`Approved
`
`Experimental
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Alectinib.
`
`Approved
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Alfentanil.
`
`Approved, Illicit
`
`The serum concentration of Alitretinoin can be increased when it is combined
`with Acetaminophen.
`
`Approved,
`Investigational
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Amantadine.
`
`Approved
`
`The serum concentration of Ambrisentan can be increased when it is
`combined with Acetaminophen.
`
`Aminohippuric acid
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Aminohippuric acid.
`
`Approved,
`Investigational
`
`Approved
`
`Approved
`
`Approved
`
`Approved
`
`Approved,
`Investigational
`
`Approved,
`Investigational
`
`Approved,
`Investigational
`
`Approved
`
`Amiodarone
`
`Amitriptyline
`
`Amlodipine
`
`Amobarbital
`
`Amprenavir
`
`Amsacrine
`
`Apixaban
`
`Aprepitant
`
`Aripiprazole
`
`Artemether
`
`Astemizole
`
`The metabolism of Acetaminophen can be decreased when combined with
`Amiodarone.
`
`Approved,
`Investigational
`
`The serum concentration of Amitriptyline can be increased when it is
`combined with Acetaminophen.
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Amlodipine.
`
`Approved
`
`Approved
`
`The metabolism of Acetaminophen can be increased when combined with
`Amobarbital.
`
`Approved, Illicit
`
`The serum concentration of Acetaminophen can be decreased when it is
`combined with Amprenavir.
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Amsacrine.
`
`The serum concentration of Apixaban can be increased when it is combined
`with Acetaminophen.
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Aprepitant.
`
`The serum concentration of Aripiprazole can be decreased when it is
`combined with Acetaminophen.
`
`Arsenic trioxide
`
`The serum concentration of Arsenic trioxide can be increased when it is
`combined with Acetaminophen.
`
`The metabolism of Acetaminophen can be decreased when combined with
`Artemether.
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Astemizole.
`
`Approved,
`Withdrawn
`
`Par Pharm., Inc.
`Exhibit 1051
`Page 007
`
`

`

`Atazanavir
`Drug
`
`Atenolol
`
`Atomoxetine
`
`Atorvastatin
`
`Axitinib
`
`Azelastine
`
`Azithromycin
`
`Barbexaclone
`
`Barbital
`
`Benzocaine
`
`Bepridil
`
`The metabolism of Acetaminophen can be decreased when combined with
`Interaction
`Atazanavir.
`The serum concentration of Atenolol can be increased when it is combined
`with Acetaminophen.
`
`Approved,
`Drug group
`Investigational
`Approved
`
`The metabolism of Acetaminophen can be decreased when combined with
`Atomoxetine.
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Atorvastatin.
`
`Approved
`
`Approved
`
`The serum concentration of Axitinib can be increased when it is combined
`with Acetaminophen.
`
`Approved,
`Investigational
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Azelastine.
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Azithromycin.
`
`Approved
`
`Approved
`
`The metabolism of Acetaminophen can be increased when combined with
`Barbexaclone.
`
`Experimental
`
`The metabolism of Acetaminophen can be increased when combined with
`Barbital.
`
`Illicit
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Benzocaine.
`
`Approved
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Bepridil.
`
`Approved,
`Withdrawn
`
`Betamethasone
`
`The serum concentration of Betamethasone can be increased when it is
`combined with Acetaminophen.
`
`Betaxolol
`
`Bexarotene
`
`Biperiden
`
`Boceprevir
`
`Bortezomib
`
`Bosentan
`
`Bosutinib
`
`Approved, Vet
`Approved
`
`Approved
`
`The metabolism of Acetaminophen can be decreased when combined with
`Betaxolol.
`
`The serum concentration of Acetaminophen can be decreased when it is
`combined with Bexarotene.
`
`Approved,
`Investigational
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Biperiden.
`
`The metabolism of Acetaminophen can be decreased when combined with
`Boceprevir.
`
`Approved
`
`Approved
`
`The metabolism of Acetaminophen can be decreased when combined with
`Bortezomib.
`
`Approved,
`Investigational
`
`The serum concentration of Acetaminophen can be decreased when it is
`combined with Bosentan.
`
`Approved,
`Investigational
`
`The serum concentration of Bosutinib can be increased when it is combined
`with Acetaminophen.
`
`Approved
`
`Brentuximab vedotin
`
`The serum concentration of Brentuximab vedotin can be increased when it is
`combined with Acetaminophen.
`
`Approved
`
`Bromocriptine
`
`Buprenorphine
`
`Bupropion
`
`Buspirone
`
`Busulfan
`
`Cabazitaxel
`
`Caffeine
`
`Camptothecin
`
`Canagliflozin
`
`The serum concentration of Bromocriptine can be increased when it is
`combined with Acetaminophen.
`
`Approved,
`Investigational
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Buprenorphine.
`
`Approved, Illicit,
`Investigational, Vet
`Approved
`
`The metabolism of Acetaminophen can be decreased when combined with
`Bupropion.
`
`Approved
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Buspirone.
`
`Approved,
`Investigational
`
`The serum concentration of Busulfan can be increased when it is combined
`with Acetaminophen.
`
`Approved,
`Investigational
`
`The serum concentration of Cabazitaxel can be increased when it is combined
`with Acetaminophen.
`
`Approved
`
`The serum concentration of Caffeine can be increased when it is combined
`with Acetaminophen.
`
`Approved
`
`The serum concentration of Camptothecin can be increased when it is
`combined with Acetaminophen.
`
`The serum concentration of Canagliflozin can be increased when it is
`combined with Acetaminophen.
`
`Experimental
`
`Approved
`
`Par Pharm., Inc.
`Exhibit 1051
`Page 008
`
`

`

`Drug
`Candesartan
`
`Capecitabine
`
`Captopril
`
`Interaction
`The serum concentration of Acetaminophen can be increased when it is
`combined with Candesartan.
`
`Drug group
`Approved
`
`The metabolism of Acetaminophen can be decreased when combined with
`Capecitabine.
`
`Approved,
`Investigational
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Captopril.
`
`Approved
`
`Carbamazepine
`
`The metabolism of Acetaminophen can be increased when combined with
`Carbamazepine.
`
`Approved,
`Investigational
`
`Carfilzomib
`
`Carvedilol
`
`Caspofungin
`
`Celecoxib
`
`Ceritinib
`
`Cerivastatin
`
`Chloroquine
`
`Chlorpromazine
`
`Chlorpropamide
`
`Chlorprothixene
`
`Cholecalciferol
`
`Cholesterol
`
`Cholestyramine
`
`Cholic Acid
`
`Cilazapril
`
`Cimetidine
`
`Cinacalcet
`
`Ciprofloxacin
`
`Cisplatin
`
`Citalopram
`
`The serum concentration of Carfilzomib can be increased when it is combined
`with Acetaminophen.
`
`Approved
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Carvedilol.
`
`Approved,
`Investigational
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Caspofungin.
`
`Approved
`
`The metabolism of Acetaminophen can be decreased when combined with
`Celecoxib.
`
`Approved,
`Investigational
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Ceritinib.
`
`Approved
`
`The serum concentration of Cerivastatin can be increased when it is combined
`with Acetaminophen.
`
`Withdrawn
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Chloroquine.
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Chlorpromazine.
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Chlorpropamide.
`
`Approved, Vet
`Approved
`
`Approved, Vet
`Approved
`
`Approved
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Chlorprothixene.
`
`Approved,
`Withdrawn
`
`The metabolism of Acetaminophen can be decreased when combined with
`Cholecalciferol.
`
`Approved,
`Nutraceutical
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Cholesterol.
`
`Cholestyramine can cause a decrease in the absorption of Acetaminophen
`resulting in a reduced serum concentration and potentially a decrease in
`efficacy.
`
`Experimental
`
`Approved
`
`The serum concentration of Acetaminophen can be decreased when it is
`combined with Cholic Acid.
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Cilazapril.
`
`The serum concentration of Acetaminophen can be decreased when it is
`combined with Cimetidine.
`
`The metabolism of Acetaminophen can be decreased when combined with
`Cinacalcet.
`
`Approved
`
`Approved
`
`Approved
`
`Approved
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Ciprofloxacin.
`
`Approved,
`Investigational
`
`The serum concentration of Cisplatin can be increased when it is combined
`with Acetaminophen.
`
`Approved
`
`The serum concentration of Citalopram can be increased when it is combined
`with Acetaminophen.
`
`Approved
`
`Clarithromycin
`
`The metabolism of Acetaminophen can be decreased when combined with
`Clarithromycin.
`
`Approved
`
`Approved
`
`Clemastine
`
`Clobazam
`
`Clofazimine
`
`The metabolism of Acetaminophen can be decreased when combined with
`Clemastine.
`
`The serum concentration of Clobazam can be increased when it is combined
`with Acetaminophen.
`
`Approved, Illicit
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Clofazimine.
`
`Approved,
`Investigational
`
`Par Pharm., Inc.
`Exhibit 1051
`Page 009
`
`

`

`Clomifene
`Drug
`
`Clomipramine
`
`Clonidine
`
`Clopidogrel
`
`Clotrimazole
`
`Clozapine
`
`Cobicistat
`
`Cobimetinib
`
`Cocaine
`
`Colchicine
`
`Colforsin
`
`Conivaptan
`
`The serum concentration of Clomifene can be increased when it is combined
`Interaction
`with Acetaminophen.
`The serum concentration of Acetaminophen can be increased when it is
`combined with Clomipramine.
`
`Approved,
`Drug group
`Investigational
`Approved, Vet
`Approved
`
`The serum concentration of Clonidine can be increased when it is combined
`with Acetaminophen.
`
`Approved
`
`The metabolism of Acetaminophen can be decreased when combined with
`Clopidogrel.
`
`Approved,
`Nutraceutical
`
`The metabolism of Acetaminophen can be decreased when combined with
`Clotrimazole.
`
`Approved, Vet
`Approved
`
`The serum concentration of Clozapine can be increased when it is combined
`with Acetaminophen.
`
`Approved
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Cobicistat.
`
`Approved
`
`The serum concentration of Cobimetinib can be increased when it is combined
`with Acetaminophen.
`
`Approved
`
`The metabolism of Acetaminophen can be decreased when combined with
`Cocaine.
`
`Approved, Illicit
`
`The serum concentration of Colchicine can be increased when it is combined
`with Acetaminophen.
`
`Approved
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Colforsin.
`
`Experimental
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Conivaptan.
`
`Approved,
`Investigational
`
`Conjugated Equine
`Estrogens
`
`The serum concentration of Conjugated Equine Estrogens can be increased
`when it is combined with Acetaminophen.
`
`Crizotinib
`
`The metabolism of Acetaminophen can be decreased when combined with
`Crizotinib.
`
`Approved
`
`Approved
`
`Cyclophosphamide
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Cyclophosphamide.
`
`Approved,
`Investigational
`
`Cyclosporine
`
`The metabolism of Acetaminophen can be decreased when combined with
`Cyclosporine.
`
`Approved,
`Investigational, Vet
`Approved
`
`Cyproterone acetate
`
`The serum concentration of Acetaminophen can be decreased when it is
`combined with Cyproterone acetate.
`
`Approved,
`Investigational
`
`Dabigatran etexilate
`
`The serum concentration of the active metabolites of Dabigatran etexilate can
`be increased when Dabigatran etexilate is used in combination with
`Acetaminophen.
`
`Approved
`
`Dabrafenib
`
`Daclatasvir
`
`Dactinomycin
`
`Dapagliflozin
`
`Dapsone
`
`Darifenacin
`
`Darunavir
`
`The serum concentration of Acetaminophen can be decreased when it is
`combined with Dabrafenib.
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Daclatasvir.
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Dactinomycin.
`
`The serum concentration of Dapagliflozin can be increased when it is
`combined with Acetaminophen.
`
`Approved
`
`Approved
`
`Approved
`
`Approved
`
`The risk or severity of adverse effects can be increased when Dapsone is
`combined with Acetaminophen.
`
`Approved,
`Investigational
`
`The metabolism of Acetaminophen can be decreased when combined with
`Darifenacin.
`
`Approved,
`Investigational
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Darunavir.
`
`Approved
`
`Dasatinib
`
`Acetaminophen may increase the hepatotoxic activities of Dasatinib.
`
`Approved,
`Investigational
`
`Approved
`
`Daunorubicin
`
`Debrisoquin
`
`The serum concentration of Acetaminophen can be decreased when it is
`combined with Daunorubicin.
`
`The serum concentration of Debrisoquin can be increased when it is combined
`with Acetaminophen.
`
`Approved
`
`Deferasirox
`
`The serum concentration of Acetaminophen can be decreased when it is
`
`Approved,
`
`Par Pharm., Inc.
`Exhibit 1051
`Page 010
`
`

`

`Approved,
`Investigational, Vet
`Approved
`
`Approved
`
`Drug
`
`Delavirdine
`
`Desipramine
`
`Desloratadine
`
`Dexamethasone
`
`combined with Deferasirox.
`Interaction
`
`The metabolism of Acetaminophen can be decreased when combined with
`Delavirdine.
`
`Investigational
`Drug group
`
`Approved
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Desipramine.
`
`Approved
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Desloratadine.
`
`Approved,
`Investigational
`
`The serum concentration of Acetaminophen can be decreased when it is
`combined with Dexamethasone.
`
`Dextromethorphan
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Dextromethorphan.
`
`Diazepam
`
`Diclofenac
`
`The serum concentration of Diazepam can be increased when it is combined
`with Acetaminophen.
`
`Approved, Illicit, Vet
`Approved
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Diclofenac.
`
`Approved, Vet
`Approved
`
`Dicoumarol
`
`Acetaminophen may increase the anticoagulant activities of Dicoumarol.
`
`Approved
`
`Diethylstilbestrol
`
`The serum concentration of Diethylstilbestrol can be increased when it is
`combined with Acetaminophen.
`
`Digitoxin
`
`Digoxin
`
`The serum concentration of Digitoxin can be increased when it is combined
`with Acetaminophen.
`
`The serum concentration of Acetaminophen can be decreased when it is
`combined with Digoxin.
`
`Dihydroergotamine
`
`The metabolism of Acetaminophen can be decreased when combined with
`Dihydroergotamine.
`
`Approved
`
`Approved
`
`Approved
`
`Approved
`
`Dihydrotestosterone
`
`The serum concentration of Dihydrotestosterone can be increased when it is
`combined with Acetaminophen.
`
`Illicit
`
`Diltiazem
`
`The metabolism of Acetaminophen can be decreased when combined with
`Diltiazem.
`
`Diphenhydramine
`
`The metabolism of Acetaminophen can be decreased when combined with
`Diphenhydramine.
`
`Dipyridamole
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Dipyridamole.
`
`The metabolism of Acetaminophen can be decreased when combined with
`Disulfiram.
`
`The serum concentration of Docetaxel can be increased when it is combined
`with Acetaminophen.
`
`Approved,
`Investigational
`
`Domperidone
`
`The serum concentration of Domperidone can be increased when it is
`combined with Acetaminophen.
`
`Approved
`
`Approved
`
`Approved
`
`Approved
`
`Approved,
`Investigational, Vet
`Approved
`
`Approved
`
`Approved
`
`Disulfiram
`
`Docetaxel
`
`Doxazosin
`
`Doxepin
`
`Doxorubicin
`
`Doxorubicin
`
`Doxycycline
`
`Dronabinol
`
`Dronedarone
`
`Duloxetine
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Doxazosin.
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Doxepin.
`
`The serum concentration of Doxorubicin can be increased when it is combined
`with Acetaminophen.
`
`Approved,
`Investigational
`
`The serum concentration of Acetaminophen can be decreased when it is
`combined with Doxorubicin.
`
`Approved,
`Investigational
`
`The metabolism of Acetaminophen can be decreased when combined with
`Doxycycline.
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Dronabinol.
`
`Approved,
`Investigational, Vet
`Approved
`
`Approved, Illicit
`
`The metabolism of Acetaminophen can be decreased when combined with
`Dronedarone.
`
`The metabolism of Acetaminophen can be decreased when combined with
`Duloxetine.
`
`Approved
`
`Approved
`
`Edoxaban
`
`The serum concentration of Edoxaban can be increased when it is combined
`
`Approved
`
`Par Pharm., Inc.
`Exhibit 1051
`Page 011
`
`

`

`Drug
`Efavirenz
`
`Elbasvir
`
`Eletriptan
`
`Eliglustat
`
`Enalapril
`
`with Acetaminophen.
`Interaction
`The serum concentration of Acetaminophen can be decreased when it is
`combined with Efavirenz.
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Elbasvir.
`
`Drug group
`Approved,
`Investigational
`
`Approved
`
`The serum concentration of Eletriptan can be increased when it is combined
`with Acetaminophen.
`
`Approved,
`Investigational
`
`The metabolism of Acetaminophen can be decreased when combined with
`Eliglustat.
`
`Approved
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Enalapril.
`
`Approved, Vet
`Approved
`
`Approved
`
`Enzalutamide
`
`The serum concentration of Acetaminophen can be decreased when it is
`combined with Enzalutamide.
`
`Epinastine
`
`Ergonovine
`
`Ergotamine
`
`Erlotinib
`
`The serum concentration of Epinastine can be increased when it is combined
`with Acetaminophen.
`
`Approved,
`Investigational
`
`The serum concentration of Acetaminophen can be increased when it is
`combined with Ergonovine.
`
`The serum concentration of Acetaminophe