`
`American Society of Hematology
`Thirty-Seventh Annual Meeting
`December 1-5, 1995
`Seattle, WA
`
`* b
`
`s * % a F
`
`a
`
`io
`
`Fr
`
`Cs
`
`Cellirion, Inc. 1101
`Celltrion v. Genentech
`
`‘VOL 86, NO 10, Supplement
`
`1
`
`to
`
`NOVEMBER 15,1995
`
`
`
`
`
`HEALTHSCIENCESLIBRARY
`
`UniversityofWisconsin
`
`NOV201995
`
`
`1805
`
`LindenBriveMadison,Wi53706
`
`1 of 11
`
`
`
`BLOOD
`
`HEALTH SCIENCES LIBRARY
`University of Wisconsin
`
`NOV 20 1995
`
`TheJournal of
`The American Society ofHematology
`
`1305 Linden Drive
`Madison, Wi 53706
`
`
`Blood: The Journal of The American Society of Hematol-
`Saunders Company and sent to Blood: The Journal of The
`ogy (ISSN 0006-4971) is published 25 times, in two volumes
`American Society of Hematology, W.B. Saunders Company,
`per year, by W.B. Saunders Company. Dates of issue are
`Periodicals Dept., 6277 Sea Harbor Dr, Orlando, FL 32887-
`4800.
`the first and the 15th of each month except Novemberin
`which three issues will be published. W.B. Saunders Com-
`Agents for the United Kingdom,Ireland, and Europe: Har-
`pany Corporate and Editorial Offices: The Curtis Center,
`court Brace & Company Ltd, 24-28 Oval Rd, London NW1
`Independence Square West, Philadelphia, PA 19106-3399.
`7DX, England. Agents for Australia and New Zealand:
`Accounting and Circulation Offices: W.B. Saunders Com-
`Harcourt Brace & Company Australia, 30-52 Smidmore St
`pany, Periodicals Dept., 6277 Sea Harbor Dr, Orlando, FL
`(Locked Bag 16), Marrickville, NSW 2204, Australia.
`32887-4800. Second class postage paid at Orlando, FL
`Agents for Japan and Korea: Harcourt Brace Japan, Inc,
`32862, and at additional mailing offices.
`Ichibancho Central Bldg., 22-1 Ichibancho, Chiyoda-Ku,
`POSTMASTER:Send change of address to Blood: The
`Tokyo 102, Japan.
`Journal of The American Society of Hematology, clo WB.
`Copyright © 1995, The American Society of Hematology.
`Saunders Company, Periodicals Dept., 6277 Sea Harbor Dr,
`All rights reserved. No part of this publication may be repro-
`Orlando, FL 32887-4800,
`ducedortransmitted in any form or by any means,electronic
`Editorial correspondence should be addressed to:
`or mechanical, including photocopy, recording, or any infor-
`James D. Griffin, MD, Editor-in-Chief
`mation storage and retrieval system, without permission in
`BLOOD
`writing from the publisher. Printed in the United States of
`The Journal of The American Society
`America.
`of Hematology
`Correspondence regarding permission to reprintall or
`1018 Beacon Street
`part of any article published in this journal should be ad-
`Brookline, MA 02146
`dressed to Journal Permissions Dept., W.B. Saunders Co.,
`Correspondence regarding subscriptions or change of
`Orlando, FL 32887. Telephone number 1-407-345-2500.
`address should be addressed to W.B. Saunders Company,
`Other correspondence (copyediting, production) should
`Periodicals Dept., 6277 Sea Harbor Dr, Orlando, FL 32887-
`be addressed to:
`4800.
`BLOOD
`CustomerService: 1-800-654-2452.
`W.B. Saunders Company
`Change of address notices, including both the old and
`The Curtis Center
`new addresses of the subscriber, should be sent at least one
`Independence Square West
`month in advance.
`Philadelphia, PA 19106-3399
`Yearly subscription rates: United States and posses-
`The appearanceof the code at the bottom ofthe first page
`sions: individual, $306.00; institution, $430.00; single is-
`of an article in this journal indicates the copyright owner's
`sues, $21.00. All other countries: individual, $445.00:insti-
`consent that copies of the article may be made for personal
`tution, $497.00; single issues, $21.00. Forall areas outside
`orinternal use, or for the personal or internal use of specific
`the United States and possessions,
`there is no additional
`clients. This consentis given on the condition, however, that
`charge for surface delivery. For air mail delivery, add
`the copier pay the stated per-copy fee through the Copyright
`$144.00. Student and resident: United States and posses-
`Clearance Center, Inc. (222 Rosewood Dr, Danvers, MA
`sions: $157.00; all other countries: $428.00. To receive
`01923) for copying beyond that permitted by Sections 107
`student/resident rate, orders must be accompanied by name
`or 108 of the US Copyright Law. This consent does not
`of affiliated institution, date of term, and the signature of
`extend to other kinds of copying, such as copying for general
`program/residency coordinator on institution letterhead.
`distribution, for advertising or promotional purposes,for cre-
`Orderswill be billed at individual rate until proof of status
`ating new collective works, or for resale. Absence of the
`is received. Back issue and back volumeprices are those
`code indicates that the material may not be processed through
`in current effect. Single issues, both current and back, exist
`the Copyright Clearance Center, Inc.
`in limited quantities and are offered for sale subject
`to
`Advertising Representative: Cunningham Associates,
`availability, Back issues sold in conjunction with a sub-
`PO Box 308, Park Ridge, NJ 07656,
`telephone (201)
`767-4170.
`scription are on a proratedbasis. Subscriptions are accepted
`on a calendar year basis. 1994 bound volume price:
`Publication of an advertisement in Blood does not imply
`$105.00; outside US, please add $40.00 for postage. To
`endorsementofits claims by The American Society of He-
`purchase a 1994 bound volume, customer must be a sub-
`matology or by the Editors or Publisher of the journal.
`scriber for 1994. Cumulative Index (1980-1989) price:
`Every effort has been made to check generic and trade
`$125.00; outside US, please add $2.25 for surface delivery,
`names,and to verify drug doses. The ultimate responsibility,
`or $8.00 for air mail delivery. Prices are subject to change
`however, lies with the prescribing physician. Please convey
`without notice. Checks should be made payable to W.B.
`any errors to the Editors.
`
`The American Society of Hematology certifies that the continuing medical education offering provided by
`BLOOD, The Journal of The American Society of Hematology, meets the criteria for up to 22 hours of credit
`in Category 5(a) for the Physician’s Recognition Award of the American Medical Association.
`
`© 1995. The American Society ofHematology. Ne
`
`Philadelphia, PA
`
`A Division of Harcourt Brace & Company
`
`2 of 11
`
`Celltrion, Inc. 1101
`Celltrion v. Genentech
`IPR2017-01122
`
`Celltrion, Inc. 1101
`Celltrion v. Genentech
`IPR2017-01122
`
`2 of 11
`
`
`
`\?
`7 Ho)
`- Cb 7
`
`ro
`
`* |
`
`BLOOD
`The Journal of The American Society ofHematology
`Editor-in-Chief: James D. Griffin, Boston, MA
`
`Associate Editors
`
`Frederick R. Appelbaum, Seattle, WA
`Laurence A. Boxer, Ann Arbor, MI
`H. Franklin Bunn, Boston, MA
`Michael L. Cleary, Stanford, CA
`Connie J. Eaves, Vancouver, BC
`
`Tucker W. LeBien, Minneapolis, MN
`J. Evan Sadler, St. Louis, MO
`Sanford J. Shattil, La Jolla, CA
`Neal S. Young, Bethesda, MD
`
`Managing Editor: Ken G. Kornfield, Brookline, MA
`
`EDITORIAL BOARD
`
`Nader G. Abraham, New York, NY
`Neil Abramson, Jacksonville, FL
`Peter Agre, Baltimore, MD
`Kenneth C. Anderson, Boston, MA
`Joseph H. Antin, Boston, MA
`James O. Armitage, Omaha, NE
`Jane E. Barker, Bar Harbor, ME
`Joel S. Bennett, Philadelphia, PA
`Nancy Berliner, New Haven, CT
`Alan Bernstein, Toronto, ON
`Bruce R. Blazar, Minneapolis, MN
`David M. Bodine, Bethesda, MD
`Dario Campana, Memphis, TN
`Jaime Caro, Philadelphia, PA
`Peter A. Cassileth, Miami, FL
`William M.Crist, Memphis, TN
`Alan D’Andrea, Boston, MA
`Albert B. Deisseroth, Houston, TX
`David N. Fass, Rochester, MN
`Stephen J. Forman, Duarte, CA
`Barbara Furie, Boston, MA
`Janice L. Gabrilove, New York, NY
`Tomas Ganz, Los Angeles, CA
`Mark Ginsberg, La Jolla, CA
`David Ginsburg, Ann Arbor, MI
`Mark A. Goldberg, Boston, MA
`John M. Goldman, London, UK
`Peter L. Greenberg, Stanford, CA
`John M. Harlan, Seattle, WA
`David E. Harrison, Bar Harbor, ME
`Ronald Hoffman, /ndianapolis, IN
`Thomas H. Howard, Birmingham, AL
`James Ihle, Memphis, TN
`Russel Kaufman, Durham, NC
`
`Kenneth Kaushansky, Seattle, WA
`John H. Kehrl, Bethesda, MD
`Thomas J. Kipps, La Jolla, CA
`Tadamitsu Kishimoto, Osaka, Japan
`Daniel M. Knowles, New York, NY
`Richard A. Larson, Chicago, IL
`Timothy J. Ley, St. Louis, MO
`Jack Levin, San Francisco, CA
`Dan L. Longo, Frederick, MD
`Bob Léwenberg, Rotierdam, The Netherlands
`Paul J. Martin, Seattle, WA
`Rodger P. McEver, Oklahoma City, OK
`Phillip McGlave, Minneapolis, MN
`Robert McMillan, La Jolla, CA
`Jay E. Menitove, Cincinnati, OH
`Donald Metcalf, Melbourne, Australia
`Joseph P. Miletich, St. Louis, MO
`Ronald L. Nagel, Bronx, NY
`Peter J. Newman, Milwaukee, WI
`Robertson Parkman, Los Angeles, CA
`GordonL, Phillips, Lexingion, KY
`Mortimer Poncz, Philadelphia, PA
`Ching-Hon Pui, Memphis, TN
`Jerome Ritz, Boston, MA
`Paul N. Sondel, Madison, WI
`Robert F. Todd III, Ann Arbor, MI
`Douglas M. Tollefsen, St. Louis, MO
`Paula B. Tracy, Burlington, VT
`Fatih M. Uckun, Minneapolis, MN
`Catherine M. Verfaillie, Minneapolis, MN
`Stephen J. Weiss, Ann Arbor, MI
`David A. Williams, /ndianapolis, IN
`Cheryl L. Willman, Albuquerque, NM
`
`PAST EDITORS
`
`William Dameshek (1946-1969)
`Frederick Stohlman, Jr (1970-1974)
`Ernst R. Jaffé (1975-1977)
`Paul A. Marks (1978-1982)
`John W. Adamson (1983-1987)
`Arthur W. Nienhuis (1988-1992)
`
`3 of 11
`
`Celltrion, Inc. 1101
`Celltrion v. Genentech
`IPR2017-01122
`
`Celltrion, Inc. 1101
`Celltrion v. Genentech
`IPR2017-01122
`
`3 of 11
`
`
`
`CONTENTS
`
`Vv
`
`
`
`The Journal of The American Society of Hematology
`
`CONTENTSVOL 86, NO 10, Suppl 1 NOVEMBER15, 1995
`
`
`
`COVER FIGURE
`
`Cover figure is Sun Mask by James Bender, courtesy of Bailey Nelson Gallery, Seattle, WA.
`The American Society of Hematology: Officers of the Society Since [ts Founding ..........:ccsssssessssecsssessesssesesseseseeeeeee
`
`SeisdocsaSeeSeeuiissahany sack eaamsageesennenees
`The American Society of Hematology, 1995 .....c.cccccsccssesssssesesesestssecsescscscecsnees
`daa
`
`
`Standing Committees, 1995 oo... ecececcesuesessesessesesnestssnenessesssassssesesesacsssacsusensssesessueassuesessusessnvssssacstseuenesasansansnseavaueeneanens
`
`SCEPC SABCOMMELEES, 1995 sccsacesossecsccuisezesascswel sitesiOsc be NERSENcatssc 5
`Recipients Of Awards ........cccccssesesssessesesesesssesssusrssnesssneessusnssneaesssesssasscsasasensateassessusssecessansasassecnasacaetecaesasseseusnicavaceens
`
`2
`3
`
`+
`
`6
`
`REVIGWERS OBADSURACES:.usnvssanezonosnceansonsnescinszauiesizasasenaserssesiaslivecanessictAt tteochseure Staiheadpaacesoeaietsansssnen
`
`Acknowledgment.......sssessssssssssesssessesssecsssssesenscsnsesssssscsossesssssascsnsssesancessssuseesssenesueeuesanecsnsenssssuccencssussueseuserasssuseneasaseaneee
`
`FICUTe. MCEONE: SIHOS ccsneceornnnscenevoesinsoininicorensastrenvanavawsvap'cicasiawneyiaieultatyeotssuese sce eltcitslo aia abaou saa secbuele bts
`
`INSHONRT OMICE:
`
`sascos cece ces cs coerce neaa USAGES EAS ENGAGER Gs SR TISTE on SHAT ASTOR D OSA kes eton preonporenenssnonnseennmnsnserecvereeaeroespecers
`
`COTPOrAteTOSCANOAL SVTORID,
`
`scxseeesessyny coesnscestexsesmanpiaensnexe cases bon iesaccressass supa aconcsiaeasecesynectuanapseenubNanEeaeamneRe
`
`7
`
`8
`
`9
`
`9
`
`10
`
`Master SCHECNG sass sscanissiascaazocvaaiacessscestsistiwinsacieit Bin asclinsipeigsaaiee i nce Rnesoc 12
`
`General TSOrMAMON® cp ssisesscaazewsasnnesvansonccenesasvesennuaroxanscinssuaescepuasgieectetatsabCusbatiizc sas dSDUGS USCRUSW CREDBESOeae
`Mapsof Washington State Convention & Trade Center
`
`Levels 1, 2, and 3 v.cecesscesescssesssessssecsssneessesssesesssvevsvssesssescsssasasevavsuesassssssseasasevacsasssavasassvessisavstavavaressseavseseseseeseevececeee
`
`LLGVBEA cisnassessssvseusasssccanssaaicase sects cailhd NASR UBEN BIBSNANSOINE SETS assis seenmonsnnentmaenenenmaneneueerevennaeenwerusarrene
`
`Level 6 oocccescecsesessesesssesesenessessessacsesenssmesscsassssansnuessesevesessussusavssasavssassussuessesersenssseanesnesstsarsaueensstsesessusaiesacssesseeaseasesesseve
`
`18
`
`22
`
`23
`
`24
`
`Program of the Education Committee ............0..ccccccesessssssssvsessvsvsseseosesesesessssesveevevesvavereavaveeeteseieesseeeeeeees
`
`Scientific Subcommitiee: Program ‘at-aGlance)
`
`25
`
`26
`
`33
`
`34
`
`37
`38
`39
`
`Ecucation. Program at Glance wssccssiscccsssssecssstcsctusces vas asseaians Sheenagees bibakeste BhoSiS aeaaenssntgennsvenntsnes
`
`ssscssscuseausssssnasacsscssccussssascatwssveeccecacuckissaictateiosuiauislssiesias conse ucae
`
`Scientific Subcommittee Program ........scessssesssessssssessseessseeesssessssvessssssssavsssaecesssvessassessueessueesssuessasesesavasssesssseeseesevecesaees
`
`Special, LECwiTped enerecsisnsssvnsanensancensasnesncnansssnsnsscanaacnuavunesescpastissaevebedae sical tsi ecoeubeaaaarunpanne cescsi
`
`so Safes edb sbsuavieSnepevnnannnneenneneennenerewnesenneeerram»ennevapneoesamseanadinaensteoneess
`MEEEIRE-PLOLESSOF scscascsscuieusctesraasaaagesisiteeSeSsesset
`
`Meet-the-Investigator 2.0.0.0...
`ccssssssssssessesessessvesneesneesnesssesncesucssussuesssssasesuesuessesssssstsencssasssuesaversvsstussusssucstessuseavevaaveraveseees
` asasiccsnpaunscwuatci ns ceseReGARTOIS 40
`
`LO9S WOVE SPEARCE TMGENK
`
`SATURDAY, DECEMBER 2, 1995
`
`Day-at-a-Glance ......csccsescssesessseesssuneesuiscsnisessuscssussessssecsssusessscesssvenraueasauesssusentsvcasansessuvsnsausassusssessssessvasssussssuesiviavesavessaee
`
`43
`
`
`
`FMUCGHOM PROSIANT sissesnsscncinssccanicwssswonsncstiusssescvweicstcasitt SES NDEEARNS EAU SGRSR OSES ito CCasom aenenonensnenosesjpeene 45
`
`Ham-Wasserman Lecture ..........ssscssssssseessnseeessnsessesseiesssuavessssuessssstiessnsavensnsuserssnuinssuvanesarsauesessasavsnsssveassasesessavesssenvuaee
`46
`
`(Continued on following page)
`
`4 of 11
`
`Celltrion, Inc. 1101
`Celltrion v. Genentech
`IPR2017-01122
`
`Celltrion, Inc. 1101
`Celltrion v. Genentech
`IPR2017-01122
`
`4 of 11
`
`
`
`vi
`
`(Contents continued)
`
`CONTENTS
`
`Education Program .....sscscssssesssessssesssesssssscssnescsvsnssseenesnensssnensssenssassnsaesnsensoasosssssneniensauenseunansanensaneanssasuacnenannanaracnsransassesss
`
`
`Subcommittees ........c..esescescesessescessesssecessescscsssssisnsersessseseneseessncasssseneseaenssnasanensessenerseeasenees
`
`Council on Thrombosis ......:c.ssscessssscsssscsesccsnscecseceesescsssscsssssssesssnreresssesssaceneasnnsssassnnssseasssnscanssnerscsarseserenseasenes
`Welcome Reception .......sesssessessesssessessesssesecssnssessnssusanesseensesessnensssassnsaneasesnssnssnssasssnennssasenesuseunanscsnenuiansniaaussnsanaesnsannesianses
`Poster Session I
`
`46
`46
`48
`48
`
`49
`Hemoglobinopathies and ThalassemiasI ...........sssssesseseseseseseesrssnesnsssssnessessnessscneansensennnneansneenscnnsassansaeanssnenessensanseses
`50
`Hematopoietic Cell Proliferation and Differentiation I ...........:.ssssssessesesnesneesesnenessnseeenssnssessnenessneaneenssaeneenneaienees
`52
`Hematopoietic Growth Factors I .......sssssseessesssssenesenessesessesssseessnesessesnssasesesenesnsassaneneensasaseniansaneasausenssnsnssnsansnssassesess
`53
`Granulocytes and Monocytes I ......sssssesseccsesssssssnssessnesseesessnesessnssneenssaesneesesnnesnsesnsniennssnsenatesssesssssnenssaneasennennsnneeanenneases
`55
`Molecular Oncology I
`.......1s-scsssssssessosescssscesesssneeessnsnsesscsesssesesnsnsssassensssasneasassncesucnsecaeneuecsecencnsnsnsesnsnssnenasenscaneceorseess
`56
`Acute Leukemia I .........c.sccsscecsssecssnscsecessecsssescscnescssessssesscsessssnenestenesssesssencesusssseasasssecssnassnecsssensusaesnssensisnassaeaucennaneasaas
`58
`Myelodysplasia and Myeloproliferative Disorders [
`.........+s:s:ssssesesseeesssessssessensseesnsnsenssisessneensanenssnsensinenesasnuannanennanas
`60
`LymphomaI ......sesssessesssesessesesssneesnencssessesnenensacaceensusnsssanssseasscseessnesenssenssenensensuensneusenessasususasscncnsanensasacgsisanssneasanennessents
`61
`Myeloma and CLL I .....sesssesssssesssesesssessecnesnesnecsnesneenssaesnsenseanenseensanecussiesscsenssanensonscsssensavenscanecscenscanensquacnesaneasesusanncecs
`62
`Immunohematology I
`..........-:sssssessscesssssesssssssesseesesssesessscssesessnensanensssssssssesesscseeasneesssnsensnreneavesesuensansseeresnssaeseaneneseaease
`63
`Coagulation 1 .....cccesssessessesssesescsessnescsssssnsssssuncnesenssnecassssenssanenseanennssussassssncssacanesessuesasssesassansaseanensanacnequiensssananatacaananses
`66
`Platelets and Megakaryocytes I o......c.cssscsessssessesssesesecssreeseseseesnenseennsneesaeisassceseesnansnensssanazsnenanssesseansenennerenenenenanenenes
`66
`Thrombosis I ......ccccccsccesescesseccessseeseseseseasesenacsecsccecevsssecarsecersesesseaassceaenaeenesaseseesssnacssessessseeareuseraesssesaesenaaessauaneeneaseneneeses
`68
`Transplantation—Clinical Results [
`.......ss:sssssesssesesssesmenesnenssneeseesnssnesssnasseisecssassssnnsaneensesnenssanenueanennsensennsanesaceananeenneay
`
`
`Transplantation—Clinical CareI........ 70
`Transplantation—Experimental1 .........ss:cesessesessesesnenesnesentensnsensnsarsnsnssssecseisessisesssseseasenscsnnneicaneueanaueeneneagaasanaasasansnansss
`72
`Transplantation—Cell Processing I
`.........sssscsssessssesessssssesessrecsesenessneesssesessecsesenessnsesesacsienssseasnsnanssanscansensseneeseenseensees
`74
`
`SUNDAY, DECEMBER3, 1995
`Day-at-a-G]annce ....s.sesessesessesessescssesessensssessseenenesaesesacnesneassnensniensnssnsssanasssacsnsesasessisacnsensneensncensnereansucasaueneaasasnasnansiacacigsess
`Education Program .......s.sscssssssssssesessssssnssessnensssesesasssensssesesueenssienssesnsnenssnenssnacassacesssssnssaseneassssaneavensqseeneanensanensaneaneonsnees
`
`
`Subcommittees ...........ceccccccssssccscrsssrsocessessccenccerssensaveseceecsccseecncssececrsoscnnsressesacsieassuassacsessauacnacsstenscsedseusbnacoseseseesavensorsnaae
`
`saaeabasdaspuneasemeenaeneeaheeeeipaanenanenenite seennvecoomegennTeenenesse
`Plenary Session sssvissssisscsccssscsscssssesciissassnscssnveveacssiasvsnstnnsves
`Forum on the Practice of Hematology ......:..cccscescsssssessesssessesssesssesesensesneeeseesssenseseaseenseneensssnscssiensssnsassasanensenensesaeenes
`Poster Session II
`
`Aemias J ..........ccssscssssescsssccsssceccseoccsescssesseanscncecsacscescossacsenssscsescssusseseaseasnaesnsesseasansauessesesssesoossrosssnecsasesessarnaeresensars
`
`Aemiias IT ..ccccsscscsscsscsssecssccccssseccsssceessncssencessenssscnscssenecescnsesssssesessecouseesesensesenseneceosecessererenssensecsetenssieneasanansneesasanseransars
`
`Hemoglobinopathies and Thalassemias ID ........scsssssssssesessesseeeeseenesnssnesrsesesssessrseensessssnssssenssusensanecnecnscneenscaneensegsaens
`Hematopoietic Cell Proliferation and Differentiation TD
`..........sssessssssessesecsesscsesssnecsenecsnnesecneienneesnnesanesssnssassesnseesses
`Hematopoietic Growth Factors IL .......ccscssessessssesesesesenessensssessseessseessssnssseessseasseenenesnensunananiansnsacserecessesasinensasensarsnsass
`Lymphocytes and Immunology [
`...........sesessesessesesenessessneeneneenessneeesuenssienanassssasnsnsensessssusreassseasaeeneasenensrasuaunsusarsaniansans
`
`76
`71
`71
`
`80
`80
`
`81
`
`81
`
`83
`84
`86
`87
`
`5 of 11
`
`(Continued on following page)
`
`Celltrion, Inc. 1101
`Celltrion v. Genentech
`IPR2017-01122
`
`Celltrion, Inc. 1101
`Celltrion v. Genentech
`IPR2017-01122
`
`5 of 11
`
`
`
`CONTENTS
`
`(Contents continued)
`
`MOcular Oncoley) II.
`
`.2sncrasessonencassgseseoensnsoagsgunavaeesnoreraaaynesermnassoursdaatonnnensvennsomeveownaniuyaGdavvsasalyaS USN ElusDnettnsetabneect
`
`AGUS Leukemia TM saxsscsassesnccisswausasaccsocscnatwa cas sesciau ssa sew castu iis aa say ee¥osdseska ese Saarasapealbes Soto cedoctanas NT siaseaisees
`
`vii
`
`89
`
`90
`
`PCatTeerDN asccsocnwsicti casas senses ingcsc Son aS aaa STERN eG AEGEAN WOK (uN IEROM 91
`
`Eaymnnponnna TE ses scnecususssacasssskacpeisesasiccseascnateases tia spd eesepevewcene ceaeaveiia eesnaaveeteattaaweitevcestaeeiusitosaccgin mSSees
`
`Myeloma and CLL [ID
`
`......cccccsesessessssesesessesessesssnenssnesssensasencscenesssseseseseseaenecacsecessssacacsnsacsasnssesssarensscsesssssusseseaceseaueacsecs
`
`COACUIGTORML sass cs ccswsccsconcenssvarasinucssnanusvasswuasasvessepusivaeaswasuaneve nes cANUsaiuitceDA ills eanSETS ARERR ei NaSTeN
`
`92
`
`94
`
`95
`
`AHTOMbOSISHL ss ccascctacce ae ssceteeescciare us acesSereae 97
`
`Transplantation—Clinical Results [0 ...........scssssssssesesesssseseseesesesaeassnesssesecsencssessessassesesesseessscessececsesecerssecseaeaneasane
`
`TranSplantetiGi—“Cinieats Cape NT
`
`zeay escass a xcaresssearses Ses ceeetme yd casas spew ee onges capone somos oes eacas rcaencnscn npsan none sees SAS
`
`TRANSPIANIANON—EAPSHMEMtAl UI
`
`ssscsciessnvnssnnssrsssssnewirassvirevacsssesstesvatsnstecsieentsiteceicsvessuiccawesavataniseyassubsiaceeiWaweicsssceids
`
`Transplantation—Cell Processing U0
`
`scscacisswssassvssasgyccaicasssieussesstelenassanbaeea sbaiisicvascousstesesbeteseetennensoacesessenecossveceomecreneresre
`
`Gene Therapy/Transfer I
`
`..........ssssesesesnesesesesessesseseesensesnenssieeassessseensessensueacsesussasessscseacssenasacessnecsusecesseararensesneacuneeasee
`
`98
`
`100
`
`103
`
`104
`
`106
`
`MONDAY, DECEMBER 4, 1995
`
`
`
`DayeitAMONGiscescesss oc staves asvanaaevennisnrszenuzecapeaeutenreaerisssoo ae Si zushyeta eee haeadiak yeaa Reeanol atestpees Tan beeen 108
`
`Simultaneous Sessions
`
`AMUSED Ts wisstiacosicaciasssinsssnctiscet sweats uci satSeANS aN DEAL TE SEALS EaGS EASA ENON TS Sa VCE BCA SSS CCL SRN ISB USEE ia Hs
`
`Hemoglobinopathies and Thalassemias | ..............csesssessssssesssesniesseseneeseseessnensaceneesneseneessssaccensessecsessssssacssuueseseeneessceese
`
`HRMOMIODIODates Nil AtASSONMR I acerctirn vate Rea ST ues Clay reece eat w ore ease Es Rena ned coaegaee based lence
`
`Hematopoietic Cell Proliferation and Differentiation I ...........sscssscssssscssssscsessesseecesosessessesesenessssevesbusneeseessecneessseneseees
`
`Hematopoietic Cell Proliferation and Differentiation [1 .......2.......:.ccec:cecsssssesesesesececseseeveescssescursesesaceanearseeavaneacereanee
`
`110
`
`110
`
`111
`
`111
`
`112
`
`FleMalOpoletic: Growth: Factors I.
`
`s-s-.ss-cessscscrccvssaeneosseeapessorepsedeseacnsvorvevsbtennsionesunnspecenanyntensenedrsevennesnytenensesoasaesesneosnsseanie
`112
`113
`
`
`
`Hematopoietic Growth Factors ID ..........scsscscsseessesescsesecseecssscsesesessseceaneesubizaicacaatasbasanicansvantasetisraaun busdaweniadueRseeeaiRS
`
`
`Gramnlocytes and Monocytes siciseasscsascuscsscszavasscasccsssasnsxcutisenviasetae tsleat3aeacicsceabeastabeapiaiisaa aba stevisious sea bieiiasdiooeecs 113
`
`
`Molecular Oncology: sissiesciesssaavasssaeccngeaaesbuaaeigneaniubaslesseiecrensae erssnensbasysssmiaensasnnshoasbensensusssotseepaareationeaieensps 114
`IMGISCILAE ORCONSRG ID ona os ccesgrscanonacossnasensrerecrsventerwcispsaunsnasvasacdveusies NTSNibrT- versa Guan EANRES ut in eS SERRE
`
`
`
`
`
`114
`
`PROVE TICUKCNA seossaicsasscssisaersvecnenietanaiss site oss senasscuasniviedgexgse iiss tc cose bnd Sia Suse San wevaa east Faves aN Cebus
`
`ACNE TCA Ti sic scescaasecess scented tsaAEA S SGI AES g URENGIOSES
`
`Myelodysplasia and Myeloproliferative Disorders I
`
`..........:c.scssssesssesessessseeneseesenssacatsnescsnecssnensarssseseesseeessteesessesessesesee
`
`MESSHUMEMOAN saeazr seca aces STARTS T ox cevsiae sae kof Mecev noon UteaE val das CTE ea woe oan Sena ee coy DES RU oTTa acc apyee Seed
`
`EsYMMPHOMO TL, assiesssscrpecssevesscnasitesartacoasaassissasvsccsscenatessceusteukucaassscaseiewessvaaeeswave aevaunitesiiiers sticker saueias heestcsielaccsiweassizisaezic
`
`DASReomntin ans GUY Tsai cacao esas gba 60S SASS GA SSS BUSTS ASSESSOR Ga ava RSA CTO leaseae aatan en
`
`AmimonGhemiatolony: TD
`
`sisicissiessissescsesicccscmppusesveescansasvanspananncyahsegntasoaeevanpsesrsanseueness onsanssalonsosbaceapeopecoveeearsjooncessearvacoecronsse
`
`CABUTEOR L. nnsireonniensennneacresgensnnsithsicenvaatscrect evenisi ycakensiss okies onersiey scandens ab nou unvennshananeaaus ssc nssnseien Glemenialsnatiscauateiis
`
`Platelets: and: MeQakaryocWes scsi sssssicasccessscascasscsscscswceckaweteksvcsatsesecs tees seieees tetas hone penih yuuinioucomsner re pers
`
`Platelets:and' Megakaryocytesi Il
`
`ssc scsusssiccscisistssasassssis isasscisiies goats sinnsunasvinaneacasspubneis wonnssdbene terscceqsennsosaneneaponcenronstossorees
`
`115
`
`116
`
`117
`
`118
`
`119
`
`120
`
`120
`
`121
`
`121
`
`122
`
`RAONOSSD san acetetnacinceonerests oan epilotunsacaamerrrn teavea ana iTIaRS TINS s oi a TeTERT MINOIETIER 122
`
`(Continued on following page)
`
`6 of 11
`
`Celltrion, Inc. 1101
`Celltrion v. Genentech
`IPR2017-01122
`
`Celltrion, Inc. 1101
`Celltrion v. Genentech
`IPR2017-01122
`
`6 of 11
`
`
`
`viii
`
`(Contents continued)
`
`CONTENTS
`
`REHOVIFAT: DISEASES snscsssconceonsssnsconseocnssenonsonsnonscentevsnenconsenoesanpacssurnenencoucnaszennonysensossennencesenseceaeanensssaenensneceseasireneneanuasease
`
`............-...ccccsssccssssesesnesessensssesescsncsesscnssscussesnsseanensansseassesaessrssassensaisnsassssnsensasenes
`Transplantation—Clinical Results [
`Transplantation—Clinical Care [
`.....essesesssesessesssseeseeeersnenesnenenensnranencensnseneessesssnseseisessssasssensnsssenssenssissssesasseensneensnsinens
`Transplantation—Cell Processing I
`........:.sssssssssssesssssssssccsssssesessescseossssasesnsssssssseresessecesssecsereassresssensesensssnenseseoneroees
`
`Gene Therapy/Transfer 1
`Poster Session [I
`
`.......csssssessscssesssessseseessesessecssseneesnecnessacnsassesenasueesassnasaracuarensssneesssassasseaessnesinasausenssenseasanesienss
`
`Hemoglobinopathies and Thalassemias III ...........-.::ccsscssssssessseseeseeeseeeseesesseesteeseeeecenseecseeseseseesisesesessesneenensseeeteesenes
`
`Hematopoietic Cell Proliferation and Differentiation LL ..........cceeusesseeessneeseesesereensieneseensnrenssreseersesnsesessnenetsennersess
`
`Hematopoietic Growth Factors TID vscccicscssssssssccsssssssesscosssscavesossesnceistescscssuatasesssonstessavesssesanconassbranstvonsesdoasnestasseuebisnes
`
`Hematopoietic Growth Factors TV .....sccsccesseceseesesesseessssenenseesseasessacesnenssesessecssseesreesssnsnesnessanensenseseisagsnsnasanaeeasaaaraaes
`Lymphocytes and ImmunologyI .....
`
`Molecular Oncology Ill .........sssessees
`
`Acute: Leukemia DV *ssscssisiscsssscsssscrmnssosnureninnccsaccnarartriccisusmussnvetanweae
`
`Myelodysplasia and Myeloproliferative Disorders II ............:cscecssesseeeeseesesneeee
`
`
`
`
`Lymphoma IID ........cescessscssscssccsssessesssessscesseenscsssscesscsnseennscesessescesensersccssssensnsscssnsessscsoqeasssnesssssossnsseressensessanseesccenerecae
`Myeloma ‘and CUG UND sasjsaisssccssscccataccsisscciasassicegeegaibecciate iaaaacece aaahhagas pee Neate aORata annaNaS
`"THAMSUSIONS cccoscusssevcassstsnocssnnoesevenuasostsesvsecascsonssouncobonaqsnosesenenisesnopnongronsausegncnnsonseusarsogssenegsnaroesonserehaacereacconsesncaseonzersese
`
`Coagulation TID iswissiscsciscissicsccecsssessesstscsoscctessdopuocscdassonascctetssasccascsbasssaissscsvsasteulvtsscssissasicavssasevseussasevemsssiuasseasestasteessts
`
`Platelets and Megakaryocytes [0 .........c.ccsccesssessesssessssessscescecesescssesestesescesnsescsesssessasseseeceesssneenensesanecseiseaeissasaneesataesaneees
`Thrombosis UD sisisssssscscssscsstisscssaasitassvaascaccestsscaaassescteracisscaustcus tensescantecenstraecbeosuniasssuahsbonasanscenesnstesceniapisaisnvsese
`
`Retroviral Diseases I.
`
`........cssc-snccssscesscossnsssnsussesensensessenvnrenpnsneneoeennoracesnenegsangsonsnsesdsusssesasdubajovasevedeetsoesesascieseaeasesscrancsase
`
`Transplantation—Clinical Results TT .........csssscsssessereccssersesnsesenssessensesenseseaceansesssseacssenssenscssersossesessenereseesesnsesessoseees
`
`Transplantation—Clinical Care IIL .............-ssesssssssssessosssecussesosssoeesesssoossrescsansavassusesescastucnssnsecsssucnsseansavavsbeseeoseesovacsnees
`
`Tinsplantation—Cal PACEseiTID ccsssccnca cacceccennsucetncsuseraceasieaninaardaesspenponaiecssunsnnsecsoasesesssnqienetensveiissecenseapancnennueate
`
`Gene Therapy/Transfer U0 o..cc..ccccccccescscesssccsovsscssssssncnsvasccsucosssdanessucesenbosesenssassassssassntersbastenccavassssssuassassesssessasosessoueess
`Simultaneous Sessions
`
`Red Cell Structure: and Function sccessscisvsstsnsesessacoutecacscescansisaansassvastsussiarccnnaacsarssaswstecuaisaascasaasaaarveawweisaaneeasvedsacetencs
`
`Hemoglobinopathies and Thalassemias TIL ...........cscssssesesseesseseseeessseesersencsnssssensneenscsencacaenssneeseesaneneasnsanassnsnanasacsnae
`
`Hematopoietic Cell Proliferation and Differentiation UD ...............:c:csccsescessessnsesneesssenessenensnseenecssnenseienatinseeneeesaneeee
`
`Hematopoietic Cell Proliferation and Differentiation [V ..........ccccceseeeteeseeseeeseneeeseenetstetseetscanerssnenessseeressesnacssesees
`
`Hematopoietic Growth: Pactors LE sscsscccsisussccsasiscarssssteavianavisstoaevansaessaccvsnws sansa sack sacecsvisuateaveiivonseuesseanesssnaeteeseavensenses
`
`Granulocytes and Monocytes IL ...........rscrssescsersessessssecsrerscssssasscnsssaseseecsessseeeescscescreseaseacnsseneneacessaasieenasssceauscoaseacs
`
`
`
`123
`
`123
`124
`124
`
`125
`
`126
`
`126
`
`128
`
`129
`130
`131
`
`133
`
`133
`
`135
`136
`138
`
`139
`
`140
`142
`
`144
`
`144
`
`146
`
`149
`
`151
`
`153
`
`153
`
`154
`
`154
`
`155
`
`155
`
`
`
`Lymphocytes and Immunology|.. ste ena easiiee aconnonin HORS AeuaNNN ARATE OpReNeNeRNCEE 156
`
`
`
`
`
`
`
`Molecular’ Oncology: ID iesicssissssccsesciscvcisnsuts ssstssasssceucectessansiweassessccsateeasbaneacssesbeusedaveasscsteuspicessoctsaubeetineuinasnNeMes 156
`
`
`
`sssvssecssicerccaccnssnnscenersconsiovensenssnionsnsnsenssnpuaicanonsnnnnsaiieestendsnyssesteannns even gauebsaseannnssennsenpasarecnpenvennes
`MOLECAY ONCOOYTV)
`Acute Teukemia KE sasssszccusivssissisaassicsaseceesassecsate seca etait Sas aa kTANTES STIT ESTER
`
`157
`158
`
`7 of 11
`
`(Continued on following page)
`
`Celltrion, Inc. 1101
`Celltrion v. Genentech
`IPR2017-01122
`
`Celltrion, Inc. 1101
`Celltrion v. Genentech
`IPR2017-01122
`
`7 of 11
`
`
`
`CONTENTS
`
`(Contents continued)
`
`Acute: seukemia LV scrssacneess cscs asses ees caresses cen tis sR ato SS oars ionare sis nee peenchnasennnres
`
`Myelodysplasia and Myeloproliferative Disorders IL ........ccsecsssssseesseecessecsesescesneseeeeeescscseseaesesesseensessecseseaseesesaeeeseecee
`
`Eymphomiaely secssiscccssuzesavaciecceceassescsnitenisn zai wise Gegsa eaSRI SOSA NGS De EASIER TEE OSESNRSS
`
`MISCOMAAN CLIT acon ceneyncersnmanranamennranconsnieneeanadoosicae ties ske enantio apensa sien dbesaenesteea DeaninaGesamuabdvsenacenmceneneimensgiOn
`
`WemMAiNeMAGORYT ssaiisssiesscssccswsewweccessicetcecaeecsate tat teeta RCTS Ea NL SRR RAAT ASR Raa EARRINGS
`
`Transfusion I .......cccscsssssssseseseeessesscessenscssessesscsesessuenacsnenseessssassasenasnasssuenasnssacevseuescausesussnesasansesteesesecaceesateracarereeseessaes
`
`COAGUMAHON TL iss cccsssssssanswscsssiessaanensiiactnincuiswans steisiecwccNam chase aceeescis teu tua tiaetsie Tas iia iecaaea saan alain Tate
`
`Coagulation TT oe... ccecccseeseeseeseesseesesnsesceceesesssssessusscsessssaesasecasstsessnesassscscesessessececeacseeesuecstnseesseeseseaeateestaneeetnenseues
`
`Plageleis And MEPaKaryOCytes TED ss. sa siensssccccessnesssvesasenvecensusctensaieancsateussascanstnasnsstbenestarasicauantstanseawalanctshuuaadavoaahseas
`
`Platelets and MegakaryocytesIV ....
`
`TERNOMDOSS: Ths
`csssissnesmnnsagansasceseneosinenwcapsicinswavecvnenesiesasiravacoubisssveseaisecsbtavawasascsuunaviasgubtdpaa raw easibauaphataisitaWiaunuaatNocetahis
`. Transplantation—Clinical Results I sssssczcccssssssesicecassussssccasaszsscgsawwssteasssesacssceassiadaanssissiasietaapoteccesrenscyereesesoeeeeonsrenersee
`Transplantation—Clinical Care [0 .......c.scssesssesesssesseenseseesssesescsseesscsssesesesensssnssseeseacsessseessseseasescarsteesesessnscseseaceresenses
`
`‘Transplantation—Experimecntal I sszisiscdsssisrccascsesncwasescecceay iseascusiecicecasebicaeuscuteawccustassass@esvaceassasasais see cisesssstesgeawiaiowten
`
`Transplantation—Cell Processing [0 ...............cesccsssseessesesseesscesseeseceeeecsessesacsvssssssevsssesssieesvssecvsvecesveseesevseesvisesseveveeceees
`
`Gene: Tictapy/Transler Ul
`Poster Session IV
`
`saissasvcacasaisiasansssasiicanssswsasassasaceusaaiasecisstassw dune scaassdasualiscaa ea laeahgtaauua eeu oie okala Obaseceelnbaua es
`
`Red Cell Steuctire anid Function s.sssssctssceunvscssvsncenaxeasacanseannicncccssasnasasa saat asuaneovaevatnusscameaanhiesatinunwinnen museums
`
`Aremias TID ........ccessescseesssesseesssssuesmessessnesssesnsesnecesesussnesssesuacsuseeuessussussssesaussusarsssacssasaeeeaneesscsusceseseussuesenueenessaceaveceeens
`
`BUCOSS TV “as crnsspnsscoosiiacsepenscnoisisassnensicen sasnsasnaneaysieussatewandivanoudtauie iia na vaasaiysitspb sida tusinesisadettnncoasianssuiieswesiuséassetiawsssheuvatss
`
`Hemoglobinopathies and Thalassemias [V .........s:cscsssssssesessessesneseseseseseeessesesssesessensecsessseacseenassnessecsassescsteecesseneaveeacens
`
`Hematopoietic Cell Proliferation and Differentiation [IV ............c.ccccssssccsessescssessecessecsesecccsseccececcssecsasecesssesseseneeseeseane
`
`Hematopoietic: Growth Factors: V cissscscsasissssessssesssscisectieeceeaeeesseas gas estonslsnas