`Cumulative Wholesale Dollar Sales
`
`Wholesale Dollar Sales
`(in milfions)
`
`EXHIBIT 2049
`
`$2,500
`
`$2,000
`
`$1,500
`
`$1,000
`
`$500
`
`$0
`
`Year 1
`
`Year 2
`
`Year 7
`Year 6
`Year 5
`Year 4
`Year 3
`==_<_TRAVATAN Z® ==TRAVATAN® =—-LUMIGAN®
`
`Year 8
`
`Year 9
`
`Year 10
`
`[QV/A; Federal Reserve Economic Data
`Source:
`Note: Yearly values are calculated as cumulative wholesale dollar sales, with years defined as twelve-month periods from the time of launch. Data for 2005 do not
`include sales in the mail order channel. TRAVATAN Z® was launched in October 2006. TRAVATAN® and LUMIGAN® 0.03% were both launched in March 2001.
`LUMIGAN® 0.01% was launched during the fourth quarter of 2010. Data for year 10 include combined sales of LUMIGAN® 0.03% and LUMIGAN® 0.01%.
`Cumulative wholesale dollar sales are adjusted for inflation and presented in January 2001 dollars.
`
`CONFIDENTIAL-PROTECTIVE ORDER MATERIAL
`
`ALCON 2049
`Argentum Pharm. LLC v. Alcon Research, Ltd.
`Case IPR2017-01053
`
`