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`T~filJATf.lnJ 8/J.c t1r-ee
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`PAGE ----"'-N_,_,0"'--'-:--"'8'-'"'-1 __
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`NO: 11781
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`TITLE Fffed of I H {Jfl pi,h·c k ~rtM..6t!n
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`I . Add the calculated amount of 2000 ppm stock of 12-hydroxysteanc acid in propylene glycol.
`2. Add the calculated amount of propylene glycol.
`3. Add the indicated amount of Travatan-Z 0.004%, no zinc or propylene glycol (FID 111169).
`4. Mix and Adjust pH .
`
`5. Add the calculated amount of Zinc Chloride stock solution. Mix. *'· ·r,/ /;r t:. f,.;u/ !J'h()w·~.
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`• • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •
`
`CONFIDENTIAL – PROTECTIVE ORDER MATERIAL
`
`Entered By:
`
`(cont. on page
`
`[2
`
`Date
`~-)-) .-fJt
`
`ALCON 2016
`Argentum Pharm. LLC v. Alcon Research, Ltd.
`Case IPR2017-01053
`
`
`
`BOOK
`NO: 11781
`TITLE £~cf of 1J// (}"
`
`~
`
`PAGE
`lttt/.rc/-e fOrme~~" 1~ fRAlll?Tll/I/ ~k !i~t!' PROJECT#
`
`)
`
`NO: 82
`?JIJ!f
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`REF
`
`(cont. on page <t 5 - )
`
`Date
`~-))--Ob
`
`CONFIDENTIAL – PROTECTIVE ORDER MATIERAL
`
`
`
`BOOK
`
`NO: 11781
`TITLE" FjfeJ- rl ~ H o" &,h'c[.; ·tvrw.t.lttr ,~ TRAfJATf1tJ tJk Free
`SJ
`
`(cont. from page .
`
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`·- _,_,,_.,~,__., _ _,, "
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`PAGE
`PROJECT#
`
`NO: 83
`J)S7f7
`
`. -·
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`
`Sample
`ID
`
`12-HSA
`Concentration
`added to
`sample
`
`Total 12-HSA
`Concentration
`(amount added
`plus amount found
`in formulation)
`
`I
`2
`3
`4
`5
`
`6
`
`7
`
`8
`9
`10
`35
`
`36
`
`37
`
`38
`
`0
`0
`0
`3
`3
`
`3
`
`3
`
`3
`3
`3
`4.5
`
`4.5
`
`45
`
`4.5
`
`2
`2
`2
`5
`5
`
`5
`
`5
`
`5
`5
`5
`6.5
`
`6.5
`
`6.5
`
`65
`
`pH
`
`5 59
`6.00
`6.51
`5.53
`5 75
`
`5.90
`
`6.00
`
`6.1 I
`6.25
`6.50
`5.50
`
`5.75
`
`5.90
`
`6.00
`
`Turbidity
`(NTU)
`
`Visual
`Observation
`of Particles
`
`26
`2.3
`2.8
`2.5
`28
`
`2.7
`
`3.0
`
`93
`6.8
`90
`3.0
`
`2.8
`
`5.9
`
`5.6
`
`No
`No
`No
`No
`No
`
`No
`
`No
`
`Yes
`No
`Yes
`No
`
`No
`
`No
`
`No
`
`Mk~ooP< -~I/ ' .
`
`g.- ,_');.o
`
`·
`
`Observation
`
`---~ -
`
`,~Y•' vv·-0-••-•...,,V•.,,,,._...Y.,..,...,.~v.,.N~
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`
`• •
`•
`•
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`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`•
`
`Not Evaluated
`Not Evaluated
`Not Evaluated
`Not Evaluated
`Not Evaluated
`White Crystalline
`Particles Not Observed
`White Crystalline
`Particles Not Observed
`Not Evaluated
`Not Evaluated
`Not Evaluated
`Not Evaluated
`White Crystalline
`Particles Not Observed
`White Crystalline
`Particles Observed
`White Crystalline
`Particles Observed
`Not Evaluated
`Not Evaluated
`Not Evaluated
`White Crystalline
`Particles Not Observed
`White Crystallme
`Particles Observed
`White Crystalline
`Particles Observed
`White Crystallme
`Particles Observed
`Not Evaluated
`Not Evaluated
`Not Evaluated
`Not Evaluated
`Not Evaluated
`Not Evaluated
`Not Evaluated
`Not Evaluated
`Not Evaluated
`Not Evaluated
`Not Evaluated
`Not Evaluated
`Not Evaluated
`Not Evaluated
`Not Evaluated
`Not Evaluated
`Not Evaluated
`Not Evaluated
`Not Evaluated
`Not Evaluated
`
`, ...................... -
`
`. . . . . . , . . . . . f r ... -
`
`-~~··~·----,__.,_
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`
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`
`....
`
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`
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`
`6.10
`6.25
`6.50
`
`5.58
`
`5.75
`
`5 90
`
`6.00
`
`610
`6.25
`6.50
`5.57
`5.80
`5 90
`6.00
`6.17
`6.25
`6.52
`5.57
`5.75
`5.90
`6.00
`610
`625
`6.50
`5.54
`6.00
`6.50
`
`13
`17
`18
`
`2.6
`
`6.2
`
`5.l
`
`9.3
`
`16
`8.3
`92
`25
`15
`21
`20
`18
`20
`12
`28
`20
`30
`26
`38
`30
`26
`32
`38
`3.3
`
`Yes
`Yes
`Yes
`
`No
`
`No
`
`No
`
`Yes
`
`Yes
`No
`Yes
`Yes
`Yes
`Yes
`Yes
`No
`Yes
`Yes
`Yes
`Yes
`Yes
`Yes
`Yes
`No
`No
`No
`No
`No
`
`Entered By : - ; ; µ
`
`(cont. on page
`
`t'N_f)"
`
`)
`
`--A•~AAA~'~,,~=Ah">~-~-AA--
`
`Date
`~-J-J.-Ob
`
`39
`40
`41
`
`II
`
`12
`
`13
`
`14
`
`15
`16
`17
`18
`19
`20
`21
`22
`23
`24
`25
`26
`27
`28
`29
`30
`31
`32
`33
`3i
`
`................
`
`........ , ........ ,."
`
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`
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`
`....
`
`45
`4.5
`4.5
`
`6
`
`6
`
`6
`
`6
`
`6
`6
`6
`9
`9
`9
`9
`9
`9
`9
`15
`15
`15
`15
`15
`15
`15
`15
`15
`15
`
`65
`65
`65
`
`8
`
`8
`
`8
`
`8
`
`8
`8
`8
`II
`ll
`II
`II
`II
`II
`II
`17
`17
`17
`17
`17
`17
`17
`17
`17
`17
`. . .
`
`''"
`
`Verified By fl,,,,,...n,. v1? yv-)}.
`/ / - -
`L/
`CONFIDENTIAL – PROTECTIVE ORDER MATIERAL
`
`Date
`7~>-<''
`
`