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`[Plasma- and tissue concentrations following intramuscular administration of etofenamat.... - Abstract - Europe PMC
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`Search worldwide, life-sciences literature
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`E.g. "breast cancer" HER2 Smith J
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`G) R
`[3 Plasma- and tissue concentrations following intramusguelrgr (.at'dnr}riinist)r‘aOtriton
`etofenamat. Pharmacokinetics of etofenamat and flufenamic acid in plasma,
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`synovium, and tissues of patients with chronic polyarthritis after administration of
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`an oily solution of etofenamat
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`(PM|D:1288513)
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`Kdhler G , Tressel W, Dell HD , Doersing M , Fischer W , Kamp R , Langer M , Richter B , Wirzbach E
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`Zentrum fur orthopadische Rheumatologie, Augsburg.
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`Arzneimittel-Forschung [1992, 42(12):1487-1491]
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`Type: Journal Article, English Abstract (lang: ger)
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`Abstract
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`Studies on Plasma and Tissue Concentrations of Etofenamate following Intramuscular
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`Application/Pharmacokinetics of etofenamate and flutenamic acid in plasma, synovia and tissues of patients
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`with chronic polyarthritis after application of oily etofenamat solution Pharmacokinetics of etofenamate (ETO,
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`CAS 30544-47-9; Rheumon i.m.) and flufenamic acid (FLU, CAS 530-78-9) were investigated in plasma, synovial
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`fluid, and tissues after single intramuscular application of etofenamate to patients with rheumatoid arthritis.
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`62 patients with indicated operative procedure in the knee-joint received a single dose of etofenamate
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`dissolved in oil before operation. At definite times between 1.5 and 48 h post injectionem samples from 6
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`patients of each time group were collected. Samples of plasma, synovial fluid, synovial membrane, muscle,
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`bone, hyaline cartilage, and fat tissue and in some cases meniscus cartilage were taken. Concentrations of ETO
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`and its active metabolite, FLU, were determined by HPTLC. In all tissues investigated, concentration/time
`courses of ETO and FLU were observed. ETO and FLU were measured first in all matrices 1.5 h at the latest 3 h
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`post injectionem. Pharmacokinetics in tissues follows that in plasma. Rate-limiting step is the liberation of drug
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`from the oil depot. For a long period pharmacokinetics of ETO and FLU is mainly determined by the constant
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`liberation from the oil depot (zero order kinetics of liberation). Zero order kinetics is deduced from the linear
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`ascent of the cumulated AUC (in percent) vs. time plot. It is directly related to the liberation of drug from the
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`galenical formu|ation.(ABSTRACT TRUNCATED AT 250 WORDS)
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`http://europepmc.org/abstract/med/1288513
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`|nnoPharma Exhibit 1076.0001
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`1/24/2017
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`[Plasma- and tissue concentrations following intramuscular administration of etofenamat.... - Abstract - Europe PMC
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