`
`This table gives approximate factors for converting doses expressed in terms of mg/kg
`
`from one species to an equivalent surface area dose expressed as mg/kg in the other
`
`species tabulated. The assumptions and constants of the paper by Freireich EJ, et al,
`1966 are used.
`
`
`
`Mouse
`
`1
`
`1/2
`
`1/4
`
`1/6
`
`1/12
`
`0E:MI-I.
`
`Monkey
`
`4
`
`Man
`
`12
`
`2
`
`7
`
`1
`
`3
`
`3/5
`
`1/3
`
`2
`
`1
`
`Ex: Given a dose of 50 mg/kg in the mouse, what is the appropriate dose in the monkey
`assuming equivalency on the basis of mg/m2? 50 mg/kg x 1/4 = 13 mg/kg.
`
`Representative Surface Area to Weight Ratios [km] for Various
`Speciesl
`
`
`
`Mouse
`
`0.02
`
`0.0066
`
`Monkey
`
`Human, Child
`
`3.0
`
`20
`
`0.24
`
`0.80
`
`3.0
`
`12
`
`25
`
`1 Freireich, EJ, et al. Quantitative comparison of toxicity of anticancer agents in mouse,
`rat, dog, monkey and man. Cancer Chemother Rep.1966;50(4):219—244.
`
`Ex: To express a mg/kg dose in any given species as the equivalent mg/sq.m. dose,
`
`multiply the dose by the appropriate km factor. In adult humans, 100 mg/kg is
`
`equivalent to 100 mg/kg x 37 kg/sq.m. = 3700 mg/sq.m.
`
`Guidance Posted August 2007
`
`Revised February 2014
`
`Last ACUC Review: April 2015
`
`|nnoPharma Exhibit 1063.0001
`
`