Lawrence Steinman, MD
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`CURRICULUM VITAE
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`LAWRENCE STEINMAN, M.D.
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`Born:
`Child:
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`Education
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`B.A.
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`M.D.
`NIH Fellow
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`Post-graduate Training
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`Internship:
`Resident:
`Resident:
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`Fellow:
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`Academic Posts
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`Assistant Professor:
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`Associate Professor:
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`Professor
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`Professor
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`Chairs
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` November 14, 1947, Los Angeles, California
` Jonathan Baruch Steinman
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` Dartmouth College, 1964-1968
` Major: Physics; Minor: Russian, Phi Beta Kappa, Magna Cum Laude
` Harvard University, 1968-1973
` Chemical Neurobiology at Harvard Medical School with Torsten Wiesel, 1970-71
`
`Stanford University Hospital, Surgery
`1973
`Stanford University Hospital, Pediatrics
`1974
`1977-1980 Stanford University Hospital, Pediatric and Adult Neurology
`
`1975-1977 Weizmann Institute of Science, Chemical Immunology
`1975-1976 Aharon Katzir Katchalsky Fellow
`1976-1977 National Institutes of Health Visiting Fellow
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`1980-1985 Stanford University, Departments of Neurology
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`and Pediatrics
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`1985-1991
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`Stanford University, Departments of Neurology,
`Pediatrics and Genetics
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`1994-1997 Weizmann Institute of Science
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`1991-present Stanford University, Departments of Neurology
`
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`and Neurological Sciences, Pediatrics and Genetics
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`Chairman, Stanford University Program in Immunology
`2002-2011
`2008-present Incumbent of GA Zimmermann Chair as Professor of
`Neurological Sciences, Neurology, and Pediatrics
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`Apotex v. Novartis
`IPR2017-00854
`NOVARTIS 2023
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`Professional Awards and Prizes
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`1979
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`1981-1986
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`1988-2002
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` Lawrence Steinman, MD
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`S. Weir Mitchell Award, American Academy of Neurology
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`Teacher-Investigator Award, National Institutes of Health
`
`Senator Jacob Javits Neuroscience Investigator Award from Congress of the
`United States and National Institutes of Health
`
`Dr. Friedrich Sasse Award for Outstanding Contributions in Immunology
` from the Free University of Berlin
`
` John M. Dystel Prize for Outstanding Contributions in Multiple Sclerosis
`Research, National MS Society & the American Academy of Neurology
`
`Outstanding Inventor Stanford University
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`Honorary Doctorate Hasselt University
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`Elected to Institute of Medicine, renamed National Academy of Medicine (2015)
`
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`1994
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`2004
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`2004
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`2008
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`2009
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`2011
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`Charcot Prize for Lifetime Achievement in MS Research- International
`Federation of MS Societies
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`Elected to the National Academy of Sciences
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`Anthony Cerami Award in Translational Medicine
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`Fellow of the American Academy of Neurology
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`Fellow American Association for Advancement of Science
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`2015
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`2015
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`2015
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`2016
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`Professional Organizations
`American Academy of Neurology
`Fellow American Academy of Neurology
`American Neurological Association
`American Association of Immunologists
`Clinical Immunology Society
`
`Board Certification
`American Board of Psychiatry and Neurology (Neurology), 1984
`
`Patents [partial list]
`1.Immunotherapy of Autoimmune Disease, US Patent Number 4,695,459
`2. Polypeptide Pertussis Toxin Vaccine, US Patent Number 5,000,952
`3. Anti-T-Cell Receptor Determinants as Autoimmune Disease Treatment, Patent EP 0340109B1.
`4. T cell receptor variable transcripts as disease related markers. US patent 5667967 9/16/97.
`5. Treatment of central nervous system inflammatory disease with matrix metalloprotease
`inhibitors. US Patent 5532265
`6. DNA Vaccination for induction of suppressive T cell response. US patent 5,939,400
`7.Treatment of Demyelinating Disease with Ordered Peptide, US patent 6531130,
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` Lawrence Steinman, MD
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`8. Methods for treatment of multiple sclerosis using peptide analogues at position 91 of human
`myelin basic protein U.S.6,329,499
`9. Methods for treatment of multiple sclerosis using peptide analogues at position 91 of human
`myelin basic protein U.S.6,369,033
`10. Methods for treatment of multiple sclerosis using peptide analogues at position 91 of human
`myelin basic protein U.S.6,489,299
`11. US 6740638 Methods for treatment of multiple sclerosis using peptide analogues of human
`myelin basic protein
`12. EP0792286 Methods for treatment of multiple sclerosis using peptide analogues at position
`91 of human myelin basic protein
`13. US 7030098 DNA Vaccination to Treat Autoimmune Disease
`14. US 7070780 Treatment of Demyelinating Disease with Ordered Peptide
`15. US 6794414 Methods and Compositions for Treating Diseases Mediated by
`Transglutaminase Activity
`16. Osteopontin Related Methods and Compositions, US Patent 10/495,893 allowed 6/11/2007
`17. DNA Vaccination for Treatment of Autoimmune Disease (Treating Type 1 Diabetes Mellitus)
`notice of allowance on appication 11/289,266
`18. Polynucleotide Therapy (Treating IDDM), Notice of Allowance US Patent Application
`10/302,098, Expiration March 16, 2024. See related patents:
`19. US 7811813 Methods and Immune Modulatory Nucleic Acid
`DNA Vaccination for Treatment of Autoimmune Disease (Treating Type 1 Diabetes Mellitus)
`see related patents including
`20. US7,579,328;
`21. US7,544,669;
`22. AU2002362019;
`23.CN02827318.4;
`24. NZ533294;
`25. EP 1,931,390;
`26. AU 20329440;
`27. EP 1,569,696;
`28. NZ 540,276;
`29.IL168715;
`30. JP 4750419
`31. Therapeutic and Diagnostic Uses of Antibody Specificity Profiles, 10/120,578, Expiration April
`10, 2022
`32. US Patent No. 7,875,589, "Alpha B-Crystallin as a Therapy for Rheumatoid Arthritis”, issued
`January 25, 2011
`33. US Patent No. 7,867,976 NOGO Epitopic Fragments for Modulating Immune Response,
`Issued Jan 11, 2011
`34. US Patent No. 8148084 Diagnosis of Autoimmune Disease, Issued April 3, 2012
`35. US 8,257,700, "Proteomic Analysis of Active Multiple Sclerosis Lesions”
`36. US 8,252,775, "Method of Treating MS With Phosphocholine Containing Lipids."
`37. US 8,771,689 Alpha B-Crystallin as a Therapy for Ischemia or Inflammation
`38. U.S. Patent No. 8,835,391, “Alpha B-Crystallin as a Therapy for Multiple Sclerosis
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`Administrative & Advisory Posts
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`Advisory Committee on Pertussis Immunization, Institute of Medicine,
`Fellowship Advisory Committee, National Multiple Sclerosis Society
`Grant Review Committee, National Multiple Sclerosis Society
`
`1987-1990
`1988-1991
` 2006-2011
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` Lawrence Steinman, MD
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`Medical Advisory Committee, Muscular Dystrophy Association 1990-2002
`Medical Advisory Committee, National Multiple Sclerosis Society
`1990-1995
`Member Immunological Sciences Study Section, NIH
`
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`1991-1995
`Advisory Committee, Institute of Medicine, on “Multiple Sclerosis & Other
`
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` Neurologic Disorders in Veterans of the Persian Gulf & Post-9/11 Wars”
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` 2015-present
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`Editorial Posts
` 1988-2006
`International Immunology, Transmitting Editor
`Journal of Immunology, Associate Editor 1991-1995
`Neurobiology of Disease, Associate Editor 1998-2015
`Proceedings of the National Academy of Sciences
` 2015-present
`
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`Business Positions
`Centocor, Board of Directors 1991-1999, when sold to Johnson and Johnson
`Neurocrine Biosciences, Founder Advisor 1992-2005, Board of Directors 2001-2005
`Roche Biosciences, Scientific Advisory Board 1998-2002
`Bayhill Therapeutics, Founder 2001-2011, Head of SAB, and member of Board of Directors
`Atreca, Founder 2011 and member of Board of Directors
`Cardinal Therapeutics Founder 2008, Board of Directors
`Transparency Life Sciences Founder 2011, Head Scientific Advisory Board
`Tolerion, Founder 2013, Board of Directors
`Receptos SAB 2012-present
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` Lawrence Steinman, MD
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`BIBLIOGRAPHY
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`Journals
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`Budin J and Steinman L. Theory of transfinite numbers. In: Research Papers in Mathematics
`1.
`(R.E. Gaskill, ed.), National Science Foundation and Oregon State University, 1963, pp 9-31.
`
`Lam DMK and Steinman L. Uptake of gamma-aminobutyric acid in the goldfish retina.
`2.
`Proceedings of the National Academy of Sciences USA, 68:2777, 1971.
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`Steinman L and Ames A. The sites of synthesis and the subsequent migration of newly
`3.
`synthesized protein in retina. Tissue and Cell, 6:137, 1971.
`
`Steinman L. Maldistribution of physicians in Yugoslavia. Journal of Medical Education,
`4.
`49:182, 1974.
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`Steinman L, Cohen I, Teitelbaum D, and Arnon R. Regulation of autosensitization to
`5.
`encephalitogenic myelin basic protein by macrophage-associated and soluble antigen. Nature,
`265:173, 1977.
`
`Teitelbaum D, Steinman L and Sela M. Unprimed spleen cell populations recognize
`6.
`macrophage-bound antigen with opposite net electrical charge. Proceedings of the National
`Academy of Sciences USA, 74:1693, 1977.
`
`Lonai P and Steinman L. Physiological regulation of antigen binding to T cells: Role of a
`7.
`soluble macrophage factor and of interferon. Proceedings of the National Academy of Sciences
`USA, 74:5662, 1977.
`
`Steinman L, Cohen I, Teitelbaum D, Glickman E and Arnon R. Regulation of autoimmunity by
`8.
`the mode of presentation of autoantigen to lymphocytes. In: Regulatory Mechanisms in
`Lymphocyte Activation. DO Lucas (ed), New York Academic Press, p. 728, 1977.
`
`Lonai P, Steinman L, Zeicher M and Puri I. Physiological regulation of the H-2 complex.
`9.
`Cellular Immunology, 27:341, 1977.
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`10. Steinman L, Tzehoval E, Cohen I, Segal S, and Glickman E. Sequential interactions of
`macrophages, initiator T lymphocytes and recruited T lymphocytes in cell-mediated responses to
`soluble antigen. European Journal of Immunology, 8:29, 1978.
`
`Lonai P, Ben-Neriah Y, Steinman L, and Givol D. Selective participation of immunoglobulin V
`11.
`region and major histocompatibility complex products in antigen binding T cells. European Journal of
`Immunology, 8:827, 1978.
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`12. Sogg R, Steinman L, Rathjen B, Tharp B and O'Brien J. Cherry red spot myoclonus
`syndrome. Ophthalmology, 86:1861, 1979.
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`13. Steinman L, Cohen I and Teitelbaum D. Natural occurrence of thymocytes with receptors for
`myelin basic protein. Neurology (Minneapolis), 30:755, 1980.
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`14. Steinman L, Dorfman L, Tharp B, Forno L, Kelts K, O'Brien J and Sogg R. Peripheral
`neuropathy in the cherry red spot-myoclonus syndrome (Sialidosis Type 1). Annals of Neurology,
`7:450-456, 1980.
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` Lawrence Steinman, MD
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`15.
`Lonai P, Puri I, Zeicher M and Steinman L. Regulation of antigen binding to T cells: The role of
`products of adherent cells, and the H-2 restrictions of the antigen bound. In: Advances in
`Experimental Medicine and Biology. MR Escobar and H Friedman (eds), New York, Plenum Press,
`pp. 451-458, 1980
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`16. Chan CC, Sogg RL and Steinman L. Isolated oculomotor palsy after measles immunization.
`American Journal of Ophthalmology, 89:446, 1980.
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`17. Steinman L, Smith ME and Forno LS. Genetic control of susceptibility to experimental allergic
`neuritis and the immune response to P2 protein. Neurology (Minneapolis), 31:950-954, 1981.
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`18.
`Lonai P, Steinman L, Friedman V, Drizlikh G and Puri J. Specificity of antigen binding by T
`cells: Competition between soluble and Ia associated antigen. European Journal of Immunology,
`11:382-387, 1981.
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`19. Steinman L, Rosenbaum JT, Sriram S and McDevitt HO. In vivo effects of antibodies to
`immune response gene products: Prevention of experimental allergic encephalitis. Proceedings of
`the National Academy of Sciences USA, 78:7111-7114, 1981.
`
`20. Steinman L. Neurologic complications of routine immunization. Western Journal of Medicine,
`137:315, 1982
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`21. Steinman L, Sriram S, Adelman NE, Zamvil S, McDevitt HO and Urich H. Murine model for
`pertussis vaccine encephalopathy: Linkage to H-2. Nature, 299:738-740, 1982.
`
`22. Sriram S, Solomon D, Rouse RV and Steinman L. Identification of T cell subsets and B
`lymphocytes in mouse brain EAE lesions. Journal of Immunology, 129:1649, 1982.
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`23. Steinman L, Clancy RR, Cann H and Urich H. Neuropathology of propionic acidemia.
`Developmental Medicine and Child Neurology, 25:87-94, 1983.
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`24. Waldor M, Sriram S, McDevitt HO and Steinman L. In vivo therapy with monoclonal anti I-A
`antibody suppresses immune response to acetylcholine receptor. Proceedings of the National
`Academy of Sciences USA, 80:2713-2717, 1983.
`
`25. Steinman L, Solomon D, Zamvil S, Lim M and Sriram S. Prevention of EAE with anti I-A
`antibody: Decreased accumulation of radiolabeled lymphocytes in the central nervous system.
`Journal of Neuroimmunology, 5:91-97, 1983.
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`26. Sriram S and Steinman L. Anti I-A antibody suppresses active encephalomyelitis: Treatment
`model for IR gene linked diseases. Journal of Experimental Medicine, 158: 1362-1367, 1983.
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`27. Sriram S, Schwartz G and Steinman L. Myelin basic protein coupled spleen cells prevent
`EAE. Cellular Immunology, 75:378-382, 1983.
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`28. Dave P, Curless RG and Steinman L. Cerebellar hemorrhage complicating methylmalonic and
`proprionic acidemia. Archives of Neurology, 41:1293-1296, 1984.
`
`Trotter JL and Steinman L. Homing of Lyt 2+ and Lyt 2- T cell subsets and B lymphocytes to
`29.
`the central nervous system of mice with acute experimental allergic encephalomyelitis. Journal of
`Immunology, 132:2919-2923, 1984.
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`30. Waldor MK, Hardy RR, Hayakawa K, Steinman L, Herzenberg LA and Herzenberg LA.
`Disappearance and reappearance of B cells following in vivo treatment with monoclonal anti I-A
`antibodies. Proceedings of the National Academy of Science USA, 81: 2855-2858, 1984.
`
`Trotter J and Steinman L. Homing of lymphoid populations in EAE. In: EAE: A Good Model
`31.
`for MS. M Kies and E Alvord (eds), Alan Liss, New York, pp. 105-110, 1984.
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`32. McDevitt HO, Adelman N, Watling D, Sriram S and Steinman L. The use of monoclonal anti I-
`A antibodies for haplotype specific immunosuppression in animal models of autoimmune disease.
`In: Immunogenetics. T Sasazuki and T Tada (eds). San Diego, Academic Press, pp. 85-94, 1984.
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`33. Sriram S and Steinman L. Postinfectious and postvaccinial encephalomyelitis.. In: Neurology
`Clinics. Saunders, Philadelphia, 2:341-353, 1984.
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`34. Steinman L, Sriram S and Waldor MK. Therapy of autoimmune diseases with antibodies to
`immune response gene products. Clinical Immunology Newsletter, Vol. 5, 3:43-45, 1984.
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`35. Steinman L, Trotter J, Waldor MK and Sriram S. New approaches to therapy of autoimmune
`disease. In: Concepts in Immunopathology. J. Cruse (ed). Karger, Basel, Vol. 1, pp. 85-95, 1985.
`
`36. Shalev R and Steinman L. Whooping cough immunization: The experiments and the
`lessons. Harefuah (Journal of the Israel Medical Association), 109:47-49, 1985.
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`37. Steinman L, Weiss A, Adelman N, Lim M, Oehlert J, Zuniga R, Hewlett E and Falkow S.
`Murine model for pertussis vaccine encephalopathy: Role of the major histocompatibility complex;
`antibody to albumen and to B. pertussis; and pertussis toxin. In: Proceedings of the Fourth
`International Symposium on Pertussis. C. Manclark (ed). Karger, Basel, pp. 439-446, 1985.
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`38. Steinman L. Introduction to Immunotherapy. Annual Course, Neuroimmunology-Virology.
`American Academy of Neurology, pp 15-30, 1985.
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`39. Waldor MK, Hardy R, Herzenberg LA, Herzenberg LA, Lanier L, Sriram S, Lim M and
`Steinman L. Reversal of EAE with monoclonal antibody to a T cell subset marker (L3T4). Science,
`227:415-417, 1985.
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`Trotter J, Sriram S, Rassenti L, Jen Chou C-H, Fritz RB and Steinman L. Characterization of T
`40.
`cell lines and clones from SJL/J and (BALB/c x SJL/J)F1 mice specific for myelin basic protein.
`Journal of Immunology, 134:2322-2327, 1985.
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`Zamvil S, Nelson P, Trotter J, Mitchell D, Knobler R, Fritz R and Steinman L. T cell clones
`41.
`specific for myelin basic protein induce chronic relapsing EAE and demyelination. Nature, 317:355-
`358, 1985.
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`42. Steinman L, Weiss A, Adelman NE, Lim M, Zuniga R, Oehlert J, Hewlett E and Falkow S.
`Pertussis toxin is required for pertussis vaccine encephalopathy. Proceedings of the National
`Academy of Science USA, 82:8733-8736, 1985.
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`Zamvil S, Nelson P, Mitchell D, Knobler R, Fritz R and Steinman L. Encephalitogenic T cell
`43.
`clones specific for myelin basic protein: An unusual bias in antigen presentation. Journal of
`Experimental Medicine, 162:2107-2124, 1985.
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`44. Novotny E, Singh G, Wallace D, Dorfman LJ, Louis A, Sogg R and Steinman L. Leber's
`disease and dystonia: A mitochondrial disease. Neurology, 36(8):1053-1060, 1986.
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`45. Sakai K, Tabira T, Endoh M and Steinman L. Ia expression in chronic relapsing ex-
`perimental allergic encephalomyelitis induced by long-term cultured T cell lines in mice. Laboratory
`Investigation, 54,3:345-352, 1986.
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`Zamvil SS, Mitchell DJ, Moore AC, Kitamura K, Steinman L and Rothbard J. T cell epitope
`46.
`of the autoantigen myelin basic protein that induces encephalomyelitis. Nature, 324:258-260, 1986.
`
`47. Bell JI, Rassenti L, Smoot S, Smith K, Newby C, Hohlfield R, Toyka K, McDevitt HO and
`Steinman L. HLA-DQ polymorphism linked to myasthenia gravis. Lancet, Vol. 1 May 10, pp. 1058-
`1060, 1986.
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`48. Steinman L, Waldor MK, Lim M, Herzenberg L, Herzenberg L, McDevitt HO, Zamvil S,
`Mitchell D and Sriram S. Therapy of autoimmune diseases with antibody to IR gene products or to T
`cell surface markers. Annals of New York Academy of Sciences, Vol 475, pp. 274-284, 1986.
`
`49. Steinman L, Zamvil S, O'Hearn M, Schwartz G, Sriram S, Mitchell D and Waldor MK.
`Experiences with anti- Ia therapy in the mouse and in the monkey and the applications to human
`protocols in anti-Ia antibodies in the treatment of autoimmunity. In: Anti-Ia Antibodies In Therapy. J
`Clot and J Sany (eds). London, Academic Press, pp. 109-128, 1986.
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`50. Steinman L, Weiss A, Adelman N, Lim M, Zuniga R, Oehlert J, Hewlett E, Falkow S and
`Zamvil S. Molecular analysis of pertussis vaccine encephalopathy. In: Vaccines 86, Modern
`Approaches to Immunization. R Lerner, R Channock and F Brown (eds). Cold Spring Harbor, pp.
`187-190, 1986.
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`51. Steinman L. Neuroimmunology Update, Scientific Basis of Neurology. American Academy of
`Neurology, 1986 Course, pp. 43-50.
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`52. Black WJ, Steinman L, Lim M, Kent AR and Falkow S. Non-toxigenic mutants of Bordetalla
`pertussis. In: Bacterial Vaccines and Local Immunity. Ann Sclaro (ed). 1-2, pp. 175-182, 1986.
`
`53. Steinman L. Treatment of autoimmune disease with monoclonal antibodies. In: New
`Horizons in Animal Models for Autoimmune Disease. M Kyogoku and H. Wigzell (eds). Academic
`Press, pp 277-288, 1987.
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`54. Waldor MK, O'Hearn M, Sriram S and Steinman L. Treatment of experimental autoimmune
`myasthenia gravis with monoclonal antibodies to immune response gene products. In: Annals of
`the New York Academy of Science, 505:655-668, 1987.
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`55. Steinman L. Monoclonal antibodies and therapy of multiple sclerosis. In: Multiple Sclerosis.
`FC Rose (ed). John Libbey, London, pp 57-61, 1987.
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`56. Steinman L. Molecular approaches toward a therapy for multiple sclerosis. In: Revista di
`Neurologia. 57:173-174, 1987.
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`57. McDevitt HO, Perry R and Steinman L. Monoclonal anti-Ia antibody therapy in animal models
`of disease. In: Autoimmunity and Autoimmune Disease (Ciba Foundation Symposium 129). Wiley,
`Chichester, pp 184-193, 1987.
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`58. Bell JI, Steinman L, Toyka K and McDevitt HO. HLA-DQ restriction fragment length
`polymorphisms in myasthenia gravis. Annals of the New York Academy of Science, 505:655-668,
`1987.
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`59. Steinman L, Kitamura K, Zuniga R, Lim M and Peroutka S. Experimental murine pertussis
`vaccine encephalopathy. In: Clinical Neuroimmunology. J Aarli, W Behan & PO Behan (eds).
`Blackwells, Oxford, pp. 156-161, 1987
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`60. Peroutka SJ, Kitamura K, Lim M and Steinman L. Treatment of lethal pertussis vaccine
`reaction with histamine H1 antagonists. Neurology, 37:1068-1072, 1987.
`
`61. Gaiser CN, Johnson MJ, deLange G, Rassenti L, Cavalli-Sforza LL and Steinman L.
`Susceptibility to multiple sclerosis associated with an Ig gamma 3 restriction fragment length
`polymorphism. Journal of Clinical Investigation, 79:309-313, 1987.
`
`62. Szafer F, Brautbar C, Tzfoni E, Frankel G, Sherman L, Cohen I, Zadeh S, Aberer W,
`Tappeiner G, Halubar K, Steinman L and Friedmann A. Detection of disease specific restriction
`fragment length polymorphisms in pemphigus vulgaris linked to the DQw1 and DQw3 alleles of the
`HLA-D region. Proceedings of the National Academy of Science USA, 84:6542-6545, 1987.
`
`Friedmann A, Frankel G, Lorch Y and Steinman L. Monoclonal anti I-A reverses chronic
`63.
`paralysis and demyelination in Theiler's virus infected mice: Critical importance of timing of
`treatment. Journal of Virology, 61:898-903, 1987.
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`64. Vollmer T, Waldor MK, Steinman L and Conley F. Depletion of T4-+ lymphocytes reactivates
`toxoplasmosis in the central nervous system. Journal of Immunology, 138: 3737-3741, 1987.
`
`65. Vladutiu A and Steinman L. Inhibition of experimental autoimmune thyroiditis in mice by anti-
`I-A antibodies. Cellular Immunology, 109:169-180, 1987.
`
`Zamvil S, Mitchell D, Moore A, Schwarz A, Stiefel W, Rothbard J and Steinman L. T cell
`66.
`specificity for class II (I-A) and the encephalitogenic N-terminal epitope of the autoantigen myelin
`basic protein. Journal of Immunology, 139:1075-1079, 1987.
`
`Trotter J, Zamvil S and Steinman L. Comparison of antigen specificity, class II MHC
`67.
`restriction, and in vivo behavior of myelin basic protein T cell lines and clones derived from (BALB/c
`x SJL/J)F1 mice. Journal of Immunology, 139:1834-1839, 1987.
`
`68. Waldor M, Mitchell D, Kipps J, Herzenberg LA and Steinman L. Importance of
`immunoglobulin isotype in therapy of EAE with monoclonal anti-CD4 antibody. Journal of
`Immunology, 139:3660-3664. 1987.
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`69. Steinman L. Immunologic basis for functional recovery in neurologic diseases. In: Advances
`in Neurology, Vol 47, Functional Recovery in Neurologic Disease. SG Waxman (ed). Raven Press,
`pp 255-264, 1988.
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`70. Steinman L. Therapy of autoimmune disease with monoclonal antibodies to class II gene
`products of the major histocompatibility complex. In: Progress in Allergy, Monoclonal Antibody
`Therapy. H Waldmann (ed). pp 161-167, 1988.
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`71. Rothbard J, Zamvil S, Steinman L and McMichael A. Restricted nature of the T cell response.
`In: HLA-B27 and Reactive Arthritis. Elsevier, 1988.
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`72. Brautbar C, Holubar K, Szafer F, Tzfoni E, Aberer W, Steinman L and Friedmann A. Specific
`RFLP linked to HLA-DQw1 and DQw3 genes in Austrian non-Jewish pemphigus vulgaris patients.
`In: Dermatology in Five Continents. CE Orfanas, R Stadler and H Gollnick (eds). Springer-Verlag,
`Berlin, pp 377-380, 1988.
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`73. Steinman L. Autoimmunity and the nervous system. In: Neuroimmune Disorders,
`Immunology and Allergy Clinics of North America. Saunders, 8:213-225, 1988
`
`74. Wilner A, Steinman L, Lavie P, Peled R, Friedmann A and Brautbar C. Narcolepsy in Israeli
`Jews is associated exclusively with the HLA-DR2,Dw2 haplotype. Human Immunology, 21:15-22,
`1988.
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`75. Sinha AA, Brautbar C, Szafer F, Friedmann A, Tzfoni E, Todd JA, Steinman L and McDevitt
`HO. A newly characterized HLA-DQ allele associated with pemphigus vulgaris. Science, 239:1026-
`1029, 1988.
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`76. Scharf S, Friedmann A, Brautbar C, Szafer F, Steinman L, Horn G, Gyllenstein U and Erlich
`H. HLA class II allelic variation and susceptibility in pemphigus vulgaris. Proceedings of the National
`Academy of Science USA, 85:3504-3508, 1988.
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`77. Sakai K, Zamvil SS, Mitchell DJ, Lim M, Rothbard JB and Steinman L. Characterization of a
`major encephalitogenic T cell epitope in SJL/J mice with synthetic oligopeptides of myelin basic
`protein. Journal of Neuroimmunology, 19:21-32, 1988.
`
`Zamvil SS, Mitchell DJ, Lee NE, Moore AC, Waldor MK, Sakai K, Rothbard JB, McDevitt HO,
`78.
`Steinman L and Acha-Orbea H. Predominant expression of a T cell receptor V gene subfamily in
`autoimmune encephalomyelitis. Journal of Experimental Medicine, 167:1586-1596, 1988.
`
`79. Black WJ, Munoz JJ, Peacock MG, Schad PA, Cowell JL, Burchall JJ, Lim M, Kent A,
`Steinman L and Falkow S. ADP-ribosyltransferase activity of pertussis toxin: Immunomodulation by
`Bordetella Pertussis. Science, 240:656-659, 1988.
`
`80. Oksenberg JR, Gaiser C, Cavalli-Sforza LL and Steinman L. Polymorphic markers of human
`T cell receptor alpha and beta genes. Family studies and comparison of frequencies in healthy
`individuals and patients with multiple sclerosis and myasthenia gravis. Human Immunology,
`22:111-121, 1988.
`
`Todd JA, Acha-Orbea H, Bell JI, Chao N, Fronek Z, Jacob CO, McDermott M, Sinha AA,
`81.
`Timmerman L, Steinman L and McDevitt HO. A molecular basis for MHC class II-associated
`autoimmunity. Science, 240:1003-1009, 1988.
`
`82. Acha-Orbea H, Mitchell DJ, Timmerman L, Wraith DC, Waldor MK, Tausch GS, Zamvil SS,
`McDevitt HO and Steinman L. Limited heterogeneity of T cell receptors from lymphocytes
`mediating autoimmune encephalomyelitis allows specific immune intervention. Cell, 54:263-273,
`1988.
`
`83. Sakai K, Sinha A, Mitchell DJ, Zamvil SS, McDevitt HO, Rothbard JB and Steinman L.
`Involvement of distinct T cell receptors in the autoimmune encephalitogenic response to nested
`epitopes of myelin basic protein. Proceedings of the National Academy of Science USA, 85:8608-
`8612, 1988.
`
`Zamvil S, Mitchell D, Powell M, Sakai K, Rothbard J and Steinman L. Multiple discrete
`84.
`epitopes of the autoantigen myelin basic protein. Journal of Experimental Medicine, 168:1181-
`1186, 1988.
`
`85. Brocke S, Brautbar C, Steinman L, Abramsky O, Rothbard J, Neumann D, Fuchs S and
`Mozes E. In vitro proliferative responses and antibody titres specific to human acetylcholine
`receptor synthetic peptides in patients with myasthenia gravis and relation to HLA class II genes.
`Journal of Clinical Investigation, 82:1894-1900, 1988.
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` Lawrence Steinman, MD
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`
`86. Oksenberg JR, Judd AK, Ko C, Lim M, Fernandez R, Schoolnik GK and Steinman L. MHC
`restricted recognition of immunogenic T cell epitopes of pertussis toxin reveals determinants in man
`distinct from the ADP-ribosylase site. Journal of Experimental Medicine, 168:1855-1864, 1988.
`
`Jonkers M, van Lambalgen R, Mitchell D, Durham SK and Steinman L. Successful treatment
`87.
`of EAE in rhesus monkeys with MHC class II specific monoclonal antibodies. Journal of
`Autoimmunity, 1:399-414, 1988.
`
`88. Oksenberg JR, Sherritt M, Begovich AB, Erlich HA, Bernard CC, Cavalli-Sforza LL and
`Steinman L. T cell receptor V alpha and C alpha alleles associated with multiple sclerosis and
`myasthenia gravis. Proceedings of the National Academy of Sciences USA, 86:988-992, 1989.
`
`89. Alters SE, Steinman L and Oi VT. Comparison of rat and rat-mouse chimeric anti-murine
`CD4 antibodies in vitro: Chimeric antibodies lyse low density CD4+ cells. Journal of Immunology,
`142:2018-2023, 1989.
`
`90. Wraith DC, McDevitt HO, Steinman L and Acha-Orbea H. T cell recognition as the target for
`immune intervention in autoimmune disease. Cell, 57:709-715, 1989.
`
`91. Oksenberg D, Oksenberg JR, Sakai K, Peroutka SJ and Steinman L. Cyclic adenosine 3',5'-
`monophosphate metabolism in activated T cell clones. Immunology, 67(4): 484-488, 1989.
`
`92. Rao NA, Atalla L, Linker-Israeli M, Chen FY, George FW, Martin WJ and Steinman L.
`Suppression of experimental uveitis in rats by anti I-A antibodies. Investigative Ophthalmology and
`Visual Sciences, 30:2348-2355, 1989.
`
`93. Davis CB, Mitchell DJ, Wraith DC, Todd JA, Zamvil SS, McDevitt HO, Steinman L and Jones
`P. Polymorphic residues on the I-A beta chain modulate the stimulation of T cell clones specific for
`the N-terminal peptides of the autoantigen myelin basic protein. Journal of Immunology, 143:2083-
`2093, 1989.
`
`94. Scharf SJ, Friedmann A, Steinman L, Brautbar C and Erlich HA. Specific HLA-DQ beta and
`HLA-DR beta alleles confer susceptibility to pemphigus vulgaris. Proceedings of the National
`Academy of Sciences USA, 86:6215-6219, 1989.
`
`95. Wraith DC, Smilek DE, Mitchell DJ, Steinman L and McDevitt HO. Antigen recognition in
`autoimmune encephalomyelitis and the potential for peptide mediated immunotherapy. Cell,
`59:247-255, 1989.
`
`96. Sakai K, Mitchell DJ, Hodgkinson SJ, Zamvil SS, Rothbard JB and Steinman L. Prevention of
`experimental encephalomyelitis with peptides that block interaction of T cells with major
`histocompatibility complex proteins. Proceedings of the National Academy of Sciences USA,
`86:9470-9474, 1989.
`
`97. Oksenberg J, Ko C, Judd AK, Lim M, Kent A, Schoolnik G and Steinman L. Multiple T and B
`cell epitopes in the S1 subunit ("A"-Monomer) of the pertussis toxin molecule. Journal of
`Immunology, 143:4227-4231, 1989.
`
`Jonkers M and Steinman L. Treatment of experimental encephalomyelitis by anti-major
`98.
`histocompatibility complex class II specific monoclonal antibodies in Rhesus monkeys. Proceedings
`of the Tenth International Histocompatibility Conference, Immunology of HLA. (Vol.2) B Dupont
`(ed). Springer-Verlag, New York, 1989.
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` Lawrence Steinman, MD
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`99. Mozes E, Brautbar C, Steinman L, Abramsky O, Rothbard J and Brocke S. Immune
`responses of patients with myasthenia gravis to peptides representing different regions of the
`human acetylcholine receptor. Proceedings of the Tenth International Histocompatibility
`Conference, Immunology of HLA. (Vol.2) B Dupont (ed). Springer-Verlag, New York, pp 434-436,
`1989.
`
`100. Scharf S, Friedmann A, Brautbar C, Szafer F, Steinman L, Hom G and Erlich H. HLA class II
`allelic variation and susceptibility to pemphigus vulgaris. Proceedings of the Tenth International
`Histocompatibility Conference, Immunology of HLA, (Vol. 2). B. Dupont (ed). Springer-Verlag, New
`York, 1989.
`
`101. Sinha AA, Brautbar C, Szafer F, Friedmann A, Tzfoni E, Todd J, Steinman L and McDevitt
`HO. Characterization of HLA-DR beta and HLA-DQ beta alleles associated with pemphigus
`vulgaris. In: Immunobiology of HLA, (Vol.2). B Dupont (ed). Springer-Verlag, New York, pp 426-
`428, 1989.
`
`102. Sinha AA, Brautbar C, Szafer F, Friedmann A, Tzfoni E, Steinman L and McDevitt HO. HLA-
`DR and HLA-DQ alleles associated with pemphigus vulgaris. In: Cellular Basis of Immune
`Modulation. JG Kaplan (ed). Alan R. Liss, Inc., New York, pp 465-468, 1989.
`
`103. Acha-Orbea H, Steinman L and McDevitt HO. T cell receptors in murine autoimmune
`diseases. In: Annual Review of Immunology, 7:371-405, 1989.
`
`104. McDevitt HO, Wraith DC, Smilek D, Lundberg W and Steinman L. Evolution, function and
`utilization of MHC polymorphism in autoimmune disease. Cold Spring Harbor Symposium on
`Quantitative Biology, pp 853-857, 1989.
`
`105. Zamvil S and Steinman L. Autoimmune demyelinating disease. Western Journal of
`Medicine, 150:355-356, 1989.
`
`107. Zamvil S, Nelson PA, Steinman L and Mitchell D. Treatment of autoimmune
`encephalomyelitis with an antibody to T cell receptor beta chain. In: Cellular Basis of Immune
`Modulation. JG Kaplan (ed). Alan R. Liss, New York, pp 461-464, 1989.
`
`107. Tang W-L, Fashena S, Powell MB, Steinman L and Ruddle NH. Lymphotoxin: Regulation at
`the molecular and biological levels. In: Molecular and Cellular Mechanisms of Human
`Hypersensitivity and Au