`W ALLACE/OU=CRANMAIL/CN=RECIPIENTS/CN=EXCHANGE/CN=RSPIVEY>
`Monday, February 06, 2006 1:38:53 PM
`D'Addio Alex <ADAddio@medpointepharma.com>;Fuge Dennis
`<dfuge@medpointepharma.com>
`RE: Pfeiffer Bi Dose Nasal Spray System
`
`Sender:
`
`Sent:
`Recipient:
`
`Subject:
`
`Dennis,
`
`Could you mention this to Paul (or I can)? He is of the impression this is a dual chamber device. Please advise.
`
`Thanks,
`
`Rich
`
`-----Original Message----(cid:173)
`From: D'Addio Alex
`Sent: Saturday, February 04, 2006 3:36 PM
`To: Spivey Richard; Fuge Dennis
`Subject: RE: Pfeiffer Bi Dose Nasal Spray System
`
`Rich,
`
`You are correct. The Valois Bidose is a single-use device intended to deliver two sprays - one for each nostril - of a single
`formulation. It is a specialty device developed for use in applications such as mucosal vaccinations.
`
`Dennis,
`I am available after the Valois meeting to discuss development of a potential combo product.
`
`Alex
`
`-----Original Message----(cid:173)
`From: Spivey Richard
`Sent: Friday, February 03, 2006 8:35AM
`To: Fuge Dennis
`Cc: D'Addio Alex
`Subject: RE: Pfeiffer Bi Dose Nasal Spray System
`
`Good.
`
`Thanks,
`
`Rich
`
`-----Original Message----(cid:173)
`From: Fuge Dennis
`Sent: Fri Feb 03 08:12:48 2006
`To : Spivey Richard
`Cc : D'Addio Alex
`Subject:
`RE: Pfeiffer Bi Dose Nasal Spray System
`
`Rich,
`Valois are coming in on Monday to talk to us about the Bi Dose.
`Dennis
`
`From: Spivey Richard
`Sent: Thursday, February 02, 2006 10:41 PM
`
`HIGHLY CONFIDENTIAL
`-SUBJECT TO STIPULATED PROTECTIVE ORDER
`
`PLAINTIFFS'
`TRIAL EXHIBIT
`PTX0150
`
`MEDA_APTX03470974
`
`PTX0150-00001
`
`1
`
`CIP2121
`Argentum Pharmaceuticals LLC v. Cipla Ltd.
`IPR2017-00807
`
`
`
`To: Fuge Dennis
`Cc: D'Addio Alex
`Subject: RE: Pfeiffer Bi Dose Nasal Spray System
`
`You should discuss with Alex. Everyone is fully c01runitted at this point. We had always wanted to wait until after the proff of
`concept results (April) before spending much resource on this. It may be possible to do some rudimentary testing, but this should be
`discussed with Alex.
`
`Also, as we discussed, I have seen nothing that would indicate that the bi-dose is anything other than two doses, not a dual chamber.
`Can't we quickly find that out?
`
`Rich
`
`From: Fuge Dennis
`Sent: Monday, January 30, 2006 11:58 AM
`To: Spivey Richard
`Subject: RE: Pfeiffer Bi Dose Nasal Spray System
`
`Rich,
`As discussed there are likely to be a number of easier formulation options for the steroid compo product than going the dual
`device/chamber route. Can we tum Gulloose to do work on whether one of the existing steroid suspensions or solutions would accept
`the addition of Azelastine and be stable? I am not looking at a full development effort, just something small to confirm conceptually
`whether we are going to face major formulation issues or whether an existing formulation could be the starting point.
`
`In the meantime, I will explore device options with Valois.
`Best regards,
`Dennis
`
`From: Edick Paul
`Sent: Saturday, January 28, 2006 10:57 AM
`To : Fuge Dennis
`Cc: Fislunan Corey; Spivey Richard; Coniglio Tony
`Subject: RE: Pfeiffer Bi Dose Nasal Spray System
`
`Dennis,
`
`We should put this on the front burner and pursue as exclusive for use in Rhinitis applications ASAP.
`
`Paul
`
`From: Fuge Dennis
`Sent: Friday, January 27, 2006 10:54 AM
`To: sarah.malka@valois.com
`Cc: Spivey Richard; Coniglio Tony; Edick Paul; Fishman Corey
`Subject: Pfeiffer Bi Dose Nasal Spray System
`
`Sarah,
`At our meeting on February 6th could you give your brief perspective on the Pfeiffer's Bi Dose Nasal System and the types of
`products this device is used for, just so that we can assess whether this could be something worth exploring in the future?
`Could you also explain to us how the coordination of activities in the AptarGroup are actually working. Are there separate sales
`representatives? Would a supply agreement cover the total AptarGroup or just the Valois division?
`
`Thanks.
`Best regards,
`Dennis
`
`HIGHLY CONFIDENTIAL
`-SUBJECT TO STIPULATED PROTECTIVE ORDER
`
`MEDA_APTX03470975
`
`PTX0150-00002
`
`2
`
`
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