Office Address:
`
`Education:
`
`Curriculum Vitae
`
`Maureen D. Donovan, Ph.D.
`
`University of Iowa
`College of Pharmacy
`115 S. Grand Ave
`Iowa City, IA 52242
`maureen-donovan@uiowa.edu
`319-335-9697
`
`University of Minnesota College of Pharmacy
`Minneapolis, Minnesota
`Bachelor of Science in Pharmacy, 1983
`
`University of Michigan College of Pharmacy
`Horace H. Rackham School of Graduate Studies
`Ann Arbor, Michigan
`Ph.D. (Pharmaceutics), 1989
`
`PROFESSIONAL EXPERIENCE
`
`2013-present
`
`2008-2013
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`
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`2008-present
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`1996-2008
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`
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`1989-1996
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`
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`1991
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`
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`1986-88
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`Associate Dean for Undergraduate Programs
`College of Pharmacy
`University of Iowa
`Iowa City, IA
`
`Division Head
`Division of Pharmaceutics and Translational Therapeutics
`University of Iowa College of Pharmacy
`Iowa City, IA
`
`Professor
`Division of Pharmaceutics and Translational Therapeutics
`University of Iowa College of Pharmacy
` owa City, IA
`
`Associate Professor
`University of Iowa College of Pharmacy
`Division of Pharmaceutics
`Iowa City, IA
`
`Assistant Professor
`University of Iowa College of Pharmacy
`Division of Pharmaceutics
`Iowa City, IA
`
`Visiting Scholar
`SmithKline Beecham Pharmaceuticals
`King of Prussia, PA
`
`Staff Pharmacist
`Clark Professional Pharmacy
`Ypsilanti, MI
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`Exhibit 1052
`IPR2017-00807
`ARGENTUM
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`ADDITIONAL POSITIONS AND MEMBERSHIPS
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`2011-present
`
`Visiting Professor, Tongji School of Pharmacy, Tongji Medical University,
`Wuhan, China
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`Member, Environmental Health Sciences Research Center, University of Iowa
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`Member, Nanoscience and Nanotechnology Institute at the University of Iowa.
`
`2010-present
`
`2009-10
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`PUBLICATIONS
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`Thesis
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`Donovan, Maureen D. The Molecular Weight Permeability Dependence of the Absorption of
`Polyethylene Glycols in the Nasal and Gastrointestinal Mucosa and Its Correlation to Size
`Dependent Diffusion. Ph.D. Thesis, The University of Michigan, 1989.
`
`Publications
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`1. Miller SC and Donovan MD. Effect of Poloxamer Gels on the Miotic Activity of Pilocarpine
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`Nitrate in Rabbits. Int. J. Pharm. 12, 147-152, 1982.
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`2. Donovan MD, Flynn GL, Amidon GL. The Molecular Weight Dependence of Nasal
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`Absorption: The Effect of Absorption Enhancers. Pharm. Res. 7, 808-815, 1990.
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`3. Donovan MD, Flynn GL, Amidon GL. Absorption of Polyethylene Glycols 600 through 2000:
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`The Molecular Weight Dependence of Gastrointestinal and Nasal Absorption. Pharm. Res.
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`7, 863-868, 1990.
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`4. Donovan MD and Zhou M. Drug Effects on In Vivo Nasal Clearance in Rats. Int. J. Pharm.
`116, 77-86, 1995.
`
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`5. Chung FY and Donovan MD. Pre-systemic Bradykinin Metabolism in Rat and Sheep Nasal
`Homogenates. J. Pharm. Sci. 84, 794-798, 1995.
`
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`6. Chung FY and Donovan MD. Bradykinin Metabolism in Rat and Sheep Nasal Secretions.
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`J. Pharm. Sci. 84, 829-834, 1995.
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`7. Bhat PG, Flanagan DR, Donovan MD. The Limiting Role of Mucus in Drug Absorption:
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`Drug Permeation through Mucus Solution. Int. J. Pharm. 126, 179-187, 1995.
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`8. Huang Y and Donovan MD. Microsphere Transport Pathways in the Rabbit Nasal Mucosa.
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`Int. J. Pharm. Adv. 1, 298-309, 1996.
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`9. Chung FY and Donovan MD. Nasal Pre-systemic Metabolism of Peptide Drugs:
`Substance P Metabolism in the Sheep Nasal Cavity. Int. J. Pharm. 128, 229-237, 1996.
`
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`10. Zhou M and Donovan MD. Recovery of the Nasal Epithelium following Laureth-9 Induced
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`Damage. Int. J. Pharm. 130, 93-102, 1996.
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`11. Bhat PG, Flanagan DR, Donovan MD. Drug Diffusion through Cystic Fibrotic Mucus:
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`Steady-State Permeation, Rheologic Properties, and Glycoprotein Morphology. J. Pharm.
`Sci. 85, 624-630, 1996.
`
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`12. Bhat PG, Flanagan DR, Donovan MD. Drug Binding to Gastric Mucus Glycoproteins. Int. J.
`Pharm. 134, 15-25, 1996.
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`13. Zhou M and Donovan MD. Intranasal Mucociliary Clearance of Bioadhesive Polymer Gels.
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`Int. J. Pharm. 135, 115-125, 1996.
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`14. Nardviriyakul N, Wurster DE, Donovan MD. Determination of Diffusion Coefficients of
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`Sodium p-Aminosalicylate in Sheep Nasal Membranes and Dialysis Membranes by Fourier
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`Transform Infrared Horizontal Attenuated Total Reflectance Spectroscopy. J. Pharm. Sci.
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`86, 19-25, 1997.
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`15. Chou K-J and Donovan MD. Distribution of Antihistamines into the CSF following Intranasal
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`Delivery. Biopharm. Drug Disp. 18, 335-346, 1997.
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`16. Donovan MD and Huang Y. Large Molecule and Particulate Uptake in the Nasal Cavity:
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`The Effect of Size on Nasal Absorption. Adv. Drug Deliver. Rev. 29, 147-155, 1998.
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`17. Chou K-J and Donovan MD. Distribution of Local Anesthetics into the CNS following
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`Intranasal Administration. Int. J. Pharm. 168, 137-145, 1998.
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`18. Chou K-J and Donovan MD. Lidocaine Distribution into the CNS following Nasal and
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`Arterial Delivery: A Comparison of Local Sampling and Microdialysis Techniques. Int. J.
`Pharm. 171, 53-61, 1998.
`
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`19. Khanvilkar K, Donovan MD, Flanagan DR. Drug Transfer through Mucus. Adv. Drug
`Deliv. Rev 48, 173-193, 2001.
`
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`20. Donovan MD Sex and Racial Differences in Pharmacologic Response: Effect of Route of
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`Administration and Drug Delivery System on Pharmacokinetics. J. Womens Health 14(1),
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`30-37, 2005.
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`21. Kandimalla K. and Donovan M.D. Carrier Mediated Transport of Chlorpheniramine and
`Chlorcyclizine across Bovine Olfactory Mucosa: Implications on Nose-to-Brain Transport.
`J. Pharm. Sci. 94, 613-624, 2005.
`
`
`22. Sinn PL, McCray PB, Donovan MD, Shah AJ. Viscoelastic Gel Formulations Enhance
`Airway Epithelial Gene tTransfer with Viral Vectors. Am. J. Resp. Cell. Mol. Biol. 32, 404-
`410, 2005.
`
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`23. Chemuturi NV, Hayden P, Klausner M, and Donovan MD. Comparison of Human
`Tracheal/bronchial Epithelial Cell Cultures (EpiAirway) and Bovine Nasal Respiratory
`Explants for Nasal Drug Transport Studies. J. Pharm. Sci. 94, 1976-1985, 2005.
`
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`24. Kandimalla K. and Donovan M.D. Localization and Differential Activity of P-glycoprotein in
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`the Bovine Olfactory and Nasal Respiratory Mucosae. Pharm. Res. 22, 1121-1128, 2005.
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`25. Kandimalla K. and Donovan M.D. Transport of Hydroxyzine and Triprolidine Across Bovine
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`Olfactory Mucosa: Role of Passive Diffusion in the Direct Nose-to-Brain Uptake of Small
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`Molecules. Int .J. Pharm. 302, 133-144, 2005.
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`26. Chemuturi NV and Donovan MD. Metabolism of Dopamine Hydrochloride by the Nasal
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`Mucosa. J. Pharm. Sci. 95, 2507-2515, 2006 (doi:10.1002/jps.20724).
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`27. Chemuturi NV, Haraldsson JE, Prisinzano TP, and Donovan MD. Role of Dopamine
`Transporter (DAT) in Dopamine Transport Across the Nasal Mucosa. Life Sci. 79, 1391-
`1398, 2006.
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`28. Donovan MD. Nose to Brain Drug Delivery: An Optimistic Pessimist’s Analysis. In
`Respiratory Drug Delivery 2006. Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ (Eds).
`Davis Healthcare International Publishers, River Grove IL. 2006, p. 239-248.
`
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`29. Shah AJ and Donovan MD. Rheological Characterization of Bioadhesive Polysaccharide
`Polymers with Reduced Mucociliary Clearance for Intranasal Delivery. AAPS
`PharmSciTech, 8(2):Article 32, 2007. (http://www. aapspharmscitech.org) doi:
`10.1208/pt0802032
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`30. Shah AJ and Donovan MD. Formulating Gels for Decreased Mucociliary Transport Using
`Rheologic Properties: Polyacrylic Acids. AAPS PharmSciTech, Article 33, 2007. (http://www.
`aapspharmscitech.org) doi: 10.1208/pt0802033
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`31. Foo M-Y, Cheng Y-S, Su W-C, and Donovan MD. The Influence of Spray Geometry on
`Intranasal Deposition and Distribution. J. Aerosol Med. 20 (4), 495-508, 2007 [doi:
`10.1089/jam.2007.0638]
`
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`32. Chemuturi NV and Donovan MD. The Role of Organic Cation Transporters in Dopamine
`Transport Across Olfactory and Nasal Respiratory Tissues. Mol. Pharmaceutics, 4(6), 936–
`942, 2007. [doi:10.1021/mp070032u]
`
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`33. Abbas AO, Donovan MD, Salem A. Technical Aspects of Formulating Poly (lactide-co-
`glycolide). J. Pharm. Sci. , 97, 2448-2467, 2008. [doi: 10.1002/jps21215]
`
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`34. Zhang H, Schmidt M, Murry DJ, Donovan MD. Permeation and Systemic Absorption of R-
`and S- Baclofen across the Nasal Mucosa. J. Pharm. Sci.,100. 2717-2723, 2011.
`[doi:10.1002/jps.22499; PMCID 21283988]
`
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`35. Zhang H, Prisinzano T, and Donovan MD. Permeation and Metabolism of Cocaine in the
`Nasal Mucosa. Eur J Drug Metab Pharmacokinetics 37(4), 255-262, 2012.
`[doi:10.1007/s13318-012-0085-x]
`
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`36
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` Zhang H, Lin C-W, Donovan MD. Correlation between Nasal Membrane Permeability and
`Nasal Absorption Rate. AAPS PharmSciTech 14(1), 60-63, 2013.
`[doi:10.1208/s12249-012-9884-2]
`
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`37. Lack WD, Fredricks D, Petersen E, Donovan MD, George M, Nepola J, Smucker J, Fermino
`JE. The Effect of Low Dose Aspirin on Bone Healing in a Rabbit Ulna Osteotomy Model. J
`Bone Joint Surg, 95(6), 488-96, 2013. [doi: 10.2106/JBJS.L.00462]
`
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`38. Al-Ghabeish M, Scheetz T, Assem M, Donovan MD. Microarray Determination of Expression
`of Drug Transporters in Humans and Animal Species Used in the Investigation of Nasal
`Absorption. Mol. Pharm. 12(8), 2742-2754, 2015.
`
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`39. Dhamankar V, Assem M, Donovan MD. Expression and Localization of Major Cytochrome
`P450 Metabolizing Isoforms in Bovine Nasal Olfactory and Respiratory Mucosa. Inhal. Tox.
`16, 1-11, 2015. [doi: 10.3109/08959378.2015.1066903]
`
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`40. Xu J, Li G, Wang Z, Si L, Huang J, Donovan MD. The Role of L-type Amino Acid
`Transporters in the Uptake of Glyphosate across Mammalian Epithelial Tissues.
`Chemosphere. in press [http://dx.doi.org/10.1016/j.chemosphere.2015.11.062]
`
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`41. Dhamankar V and Donovan MD. Metabolic Loss of Melatonin during Nasal Permeation
`Demonstrates CYP1A2-like Activity in the Nasal Mucosa. In review
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`42. Awasthi R, An Guohua, Donovan MD, Ponto LB. Relating Observed Psychoactive Effects to
`the Plasma Concentration of ∆9-tetrahydrocannibinol (THC) and Active Metabolite: An
`Effect-Compartment Modeling Approach. in revision
`
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`42. Reiland J and Donovan MD. Expression of Drug Transporters in Cultured Human Mammary
`Epithelial Cells. in preparation
`
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`43. Reiland J and Donovan MD. Analysis of Peptide Transport in MCF10A Cells by Flow
`Cytometry. in preparation
`
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`44. Foo M-Y and Donovan MD. Viscosity and Surface Tension Effects on Nasal Spray
`Characteristics. in preparation
`
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`45. Foo M-Y and Donovan MD. A Geometric Model to Predict Nasal Deposition Efficiency.
`in preparation.
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`Other Publications
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`1. Donovan MD. Rifampin Stability Monograph in Chemical Stability of Pharmaceuticals. A
`Handbook for Pharmacists 2nd Edition. Connors KA, Amidon GL, and Stella VJ, John
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` Wiley & Sons, New York, NY 1986.
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`2. Amidon GL, Sinko PJ, Donovan MD. "Oral Absorption of Peptide and Peptide-Type Drugs:
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`Problems and Prospects." in Peptides, Theoretical and Practical Approaches to Their
`Delivery. Capsugel Symposia Series, Greenwood, SC Capsugel Library, 1992.
`
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`3. Donovan MD. Gender Equity in Faculty Hiring and Retention in The Dean's Compass:
`Practical Advice for Achieving Excellence, P. Chase, B. Hayes, V. Yanchik (Eds). AACP
`2007.
`
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`4. Donovan MD. Graduate Education in Colleges of Pharmacy in The Dean's Compass:
`Practical Advice for Achieving Excellence, P. Chase, B. Hayes, V. Yanchik (Eds). AACP
`2007.
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`BOOK CHAPTERS
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`Donovan MD and Flanagan DR. “Bioavailability of Disperse Dosage Forms” in Pharmaceutical
`Dosage Forms: Disperse Systems Lieberman HA, Rieger MM, and Banker GS (Eds). Marcel
`Dekker, New York, 1995.
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`Donovan MD “The Effect of Route of Administration and Distribution on Drug Action” in Modern
`Pharmaceutics (5th Ed). A.T. Florence and J. Siepmann (Eds), CRC Press, Boca Raton, FL, 2009
`
`Donovan MD. “”The Feminine World of Drug Delivery. On Female Needs and Delivery of Drugs
`Vaginally” in Physical and Biophysical Foundations of Pharmacy Practice. Issues in Drug
`Delivery. GL Flynn and MS Roberts. Michigan Publishing, Ann Arbor, MI 2015.
`
`Donovan MD, Foo A, Sawant N. Aerosol Delivery to the Nasal Cavity – A Tortuous Pathway to
`Efficacy. In: Dhand, R, editor. Textbook of Aerosol Medicine. Knoxville(TN): International Society
`of Aerosols in Medicine; 2015. p.e1-40. Available from: www.isam.org.
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`
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`PATENTS
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`“Formulation and method for treating neoplasms by inhalation” M.E. Placke, A.R. Imondi, M.J.
`Brooker, J.E. Frye, P.K. Shah, D.R. Flanagan, M.D. Donovan US 6,348,209.
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`“RNA interference in respiratory epithelial cells” PB McCray, BL Davidson, A Fischer, HP Jia,
`MD Donovan. US 7,297,786 (11/20/07).
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`ABSTRACTS
`
`"Poloxamer Gels for Ophthalmic Drug Delivery" Maureen D. Donovan and Susan C. Miller
`University of Minnesota/3M Research Poster Session St. Paul, MN December 15, 1982.
`
`"Evaluation of a Pilocarpine Nitrate Ophthalmic Gel" Maureen D. Donovan and Susan C. Miller
`Rho Chi Vistas in Pharmacy Program Kansas City, MO March 4-5, 1983.
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`"Molecular Weight Permeability Dependence in the Nasal and Gastrointestinal Mucosa"
`Maureen D. Donovan, Gordon L. Flynn and Gordon L. Amidon American Association of
`Pharmaceutical Scientists 2nd National Meeting Boston, MA June 5-12, 1987. Pharm. Res.
`4, S38, 1987
`
`"The Effect of Absorption Adjuvants on the Molecular Weight Permeability Profile of Polyethylene
`Glycols in the Nasal Mucosa" Maureen D. Donovan, Gordon L. Flynn and Gordon L. Amidon
`American Association of Pharmaceutical Scientists 3rd National Meeting Orlando, FL October
`30-November 3, 1988. Pharm. Res. 5, S97, 1988
`
`"Diffusion of Polyethylene Glycols 600-2000 through HEMA-MA Hydrogels" Maureen D.
`Donovan, Gordon L. Flynn and Gordon L. Amidon 16th International Symposium on Controlled
`Release of Bioactive Materials Chicago, IL August 6-9, 1989. Proceed. Int. Symp. Control. Rel.
`Bioactiv. Mater. 16, 213-214, 1989.
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`"The Molecular Weight Permeability Dependence of Polyethylene Glycols through Mucin"
`Maureen D. Donovan, Gordon L. Flynn and Gordon L. Amidon American Association of
`Pharmaceutical Scientists 4th National Meeting Atlanta, GA October 22-26, 1989. Pharm. Res.
`6, S120, 1989.
`
`"Osmotic Effects on the Molecular Weight Permeability Profile of PEG in the Nasal Mucosa"
`Maureen D. Donovan, Michael Arndorfer and Kristen K. Swantz American Association of
`Pharmaceutical Scientists 6th National Meeting Washington D.C., November, 1991. Pharm.
`Res. 8, S129, 1991
`
`"Assessment of Mucosal Damage following Intranasal Drug Administration" Maureen D.
`Donovan and Mengping Zhou American Association of Pharmaceutical Scientists 7th National
`Meeting San Antonio, TX November, 1992. Pharm. Res. 9, S207, 1992.
`
`"Drug Binding Studies to BSA and Reconstituted Mucin by Diafiltration" Pavan G. Bhat, Douglas
`R. Flanagan and Maureen D. Donovan. American Association of Pharmaceutical Scientists
`Midwest Regional Meeting Chicago, IL May 17, 1993.
`
`"Proteolytic Activity in Nasal Secretions" Francis Y. Chung and Maureen D. Donovan. 20th
`International Symposium on Controlled Release of Bioactive Materials Washington D.C. July,
`1993. Proc. Int. Symp. Control. Rel. Bioactiv. Mater. 20, 1993.
`
`"The Effects of Drugs on Intranasal Clearance In Vivo" Mengping Zhou and Maureen D.
`Donovan. American Association of Pharmaceutical Scientists 8th Annual Meeting Orlando, FL,
`November 1993. Pharm. Res. 10, S196, 1993.
`
`"Distribution of Antihistamines into the CSF following Intranasal Delivery" Kang-Jye Chou and
`Maureen D. Donovan. American Association of Pharmaceutical Scientists 8th Annual Meeting
`Orlando, FL November, 1993. Pharm. Res. 10, S196, 1993.
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`"Drug Interaction with and Permeation through Mucus" Pavan G. Bhat, Douglas R. Flanagan,
`Maureen D. Donovan. American Association of Pharmaceutical Scientists 8th Annual Meeting
`Orlando, FL November, 1993. Pharm. Res. 10, S259, 1993.
`
`"Bradykinin Degradation in Rat Nasal Secretions and Plasma" Francis Y. Chung and Maureen
`D. Donovan. American Association of Pharmaceutical Scientists Midwest Regional Meeting
`Chicago, IL May, 1994.
`
`"Comparison of Drug Permeation Rates through the Nasal Mucosa of Three Animal Species"
`Hsiao-Hui Wu, Peichung Kuo, and Maureen D. Donovan. American Association of
`Pharmaceutical Scientists Midwest Regional Meeting Chicago, IL May, 1994.
`
`"Pre-Systemic Metabolism of Bradykinin and Substance P in the Nasal Mucosa" Francis Y.
`Chung and Maureen D. Donovan. American Association of Pharmaceutical Scientists 9th Annual
`Meeting San Diego, CA November, 1994. Pharm. Res. 11, S205, 1994.
`
`"The Influence of Formulation Viscosity on Intranasal Clearance" Mengping Zhou and Maureen
`D. Donovan. American Association of Pharmaceutical Scientists 9th Annual Meeting San Diego,
`CA November, 1994. Pharm. Res. 11, S205, 1994.
`
`"Selecting Nonabsorbable Markers to Study Water Flux During In Situ Nasal Perfusions" Pei-Fen
`Chou and Maureen D. Donovan. American Association of Pharmaceutical Scientists 9th Annual
`Meeting San Diego, CA November, 1994. Pharm. Res. 11, S206, 1994.
`
`"In Vitro and In Vivo Correlations of Drug Permeability through the Nasal Mucosa" Benjamin P.
`Kuo, Hsiao-Hui Wu, and Maureen D. Donovan American Association of Pharmaceutical
`Scientists 9th Annual Meeting San Diego, CA November, 1994. Pharm. Res. 11, S206, 1994.
`
`“Rheological Characteristics and Intestinal Bioadhesion of Polymer Gels” Mengping Zhou, Diane
`Venice, Douglas R. Flanagan, and Maureen D. Donovan 22nd International Symposium on
`Controlled Release of Bioactive Materials. Seattle, WA July, 1995. Proc. Int. Symp. Control.
`Rel. Bioactiv. Mat. 22, 310-11, 1995.
`
`“Microsphere Transport Pathways in the Rabbit Nasal Mucosa” Ye Huang and Maureen D.
`Donovan 22nd International Symposium on Controlled Release of Bioactive Materials. Seattle,
`WA July, 1995. Proc. Int. Symp. Control. Rel. Bioactiv. Mat. 22, 622-3, 1995,
`
`“Effects of Bioadhesive Polymer Gels on Nasal Mucociliary Clearance” Mengping Zhou and
`Maureen D. Donovan American Association of Pharmaceutical Scientists 10th Annual Meeting
`Miami, FL November, 1995. Pharm. Res. 12, S290, 1995.
`
`“Characterization of Lipid-DNA Complexes Formed between Lipofectin and Calf Thymus DNA”
`Alan M. Goldberg, Douglas R. Flanagan, and Maureen D. Donovan American Association of
`Pharmaceutical Scientists 10th Annual Meeting Miami, FL November, 1995. Pharm. Res. 12,
`S267, 1995.
`
`“Effect of Osmolarity on Plasma Secretion into the Nasal Cavity” Pei-Fen Chou and Maureen D.
`Donovan American Assocaition of Pharmaceutical Scientists 10th Annual Meeting Miami, FL
`November, 1995. Pharm. Res. 12, S316, 1995.
`
`“Drug Permeation through Cystic Fibrosis Mucus Solution” Pavan G. Bhat, Douglas R. Flanagan,
`and Maureen D. Donovan American Association of Pharmaceutical Scientists 10th Annual
`Meeting Miami, FL November, 1995. Pharm. Res. 12, S244, 1995.
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`“Correlation between Drug Diffusion through Cystic Fibrotic Mucus and Rheological Properties
`and Glycoprotein Morphology” Pavan G. Bhat, Douglas R. Flanagan, and Maureen D. Donovan
`American Association of Pharmaceutical Scientists Annual Meeting Seattle, WA October, 1996.
`Pharm. Res. 13, S170, 1996.
`
`“Determination of Diffusion Coefficients of Sodium p-Aminosalicylate in Sheep Nasal Mucosae
`and Dialysis Membranes Using FT-IR-H-ATR Spectroscopy” Nahathai Nardviryakul, Dale Eric
`Wurster, and Maureen D. Donovan American Association of Pharmaceutical Scientists Annual
`Meeting Seattle, WA October, 1996. Pharm. Res. 13, S170, 1996.
`
`“Modification of the Sol-Gel Transition Temperature and Gelling Time of Pluronic F127 Using
`Ionic and Non-Ionic Additives” Ye Huang and Maureen D. Donovan American Association of
`Pharmaceutical Scientists Annual Meeting Seattle, WA October, 1996. Pharm. Res. 13, S212,
`1996.
`
`“Intranasal Delivery of Local Anesthetics into the Central Nervous System” Kang Jye Chou and
`Maureen D. Donovan American Association of Pharmaceutical Scientists Annual Meeting
`Seattle, WA October, 1996.
`
`“The Role of Water Flux in Altering Nasal Bioavailability” Pei-Fen Chou and Maureen D.
`Donovan American Association of Pharmaceutical Scientists Annual Meeting San Francisco,
`CA November, 1998. PharmSci 1, S388, 1998
`
`“An In Vitro Testing System for Assessing Performance of Vaginal Suppositories” V. Mark
`Kothapali, Nahathai Nardviriyakul, Eric R. Butikofer, Michelle L. Maynard, Dale Eric Wurster, and
`Maureen D. Donovan American Association of Pharmaceutical Scientists Annual Meeting San
`Francisco, CA November, 1998. PharmSci 1, S494, 1998.
`
`“Effect of Processing Variables on Adenoviral Vector Infectivity” Jeffrey J. Scott and Maureen D.
`Donovan American Association of Pharmaceutical Scientists Annual Meeting Indianapolis, IN
`October, 2000. PharmSci 4, S2285, 2000.
`
`“Drug Permeation through Excised Bovine Olfactory Mucosa” Karunya Kandimalla and Maureen
`D. Donovan American Association of Pharmaceutical Scientists Annual Meeting Indianapolis, IN
`October, 2000. PharmSci 4, S3270, 2000
`
`“Differential Transport Properties of Antihistamines across Olfactory and Respiratory Mucosae”
`Karunya Kandimalla and Maureen D. Donovan American Association of Pharmaceutical
`Scientists Annual Meeting Denver, CO October, 2001. AAPS PharmSci 3(3), 2001
`
`“Influence of Emitted Spray Angle on Nasal Deposition Efficiency” Mow Yee Foo and Maureen
`D. Donovan. American Association of Pharmaceutical Scientists Annual Meeting. Toronto,
`Canada November 11, 2002. AAPS PharmSci 4(4), M1326.
`
`“Dopamine Transport and Metabolism across the Nasal Mucosa” Nagendra Chemuturi and
`Maureen D. Donovan. American Association of Pharmaceutical Scientists Annual Meeting.
`Toronto, Canada November 14, 2002. AAPS PharmSci 4(4), R6127.
`
`“Carrier Mediated Transport of Small Molecules across Bovine Olfactory Mucosa: Implications In
`Nose To Brain Transport” Karunya Kandimalla and Maureen D. Donovan. American Association
`of Pharmaceutical Scientists Annual Meeting, Salt Lake City UT October, 2003. AAPS PharmSci
`5(4), T3140 (2003)
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`“Characterization Of Viscoelastic Properties Of Formulations Resistant To Mucociliary Clearance”
`Ankur J. Shah and Maureen D. Donovan. American Association of Pharmaceutical Scientists
`Annual Meeting, Salt Lake City, UT AAPS PharmSci 5(4), R6144 (2003)
`
`“Drug Permeability Across Bovine Respiratory Tissues Compared To A Human Tracheobronchial
`Cell Culture (Epiairway™)” Nagendra Venkata Chemuturi, Maureen D Donovan, Patrick J
`Hayden, Mitchell Klausner AAPS Annual Meeting, Salt Lake City, UT October, 2003 AAPS
`PharmSci 5(4), T3102 (2003)
`
`“Dopamine Transport And Metabolism across Nasal Mucosa” Nagendra Chemuturi and Maureen
`D. Donovan. AAPS Annual Meeting, Salt Lake City UT October, 2003. AAPS PharmSci, 5(4),
`T3103 (2003)
`
`“Dopamine Transport across Respiratory Epithelium” Nagendra Venkata Chemuturi, Patrick J
`Hayden, Mitchell Klausner, Maureen D. Donovan AAPS Annual Meeting, Salt Lake City UT
`October, 2003. AAPS PharmSci 5(4), T3104 (2003)
`
`“Formulation of Adenoviral Vectors with Inhibitors of Mucociliary Clearance Enhances Gene
`Transfer to Airway Epithelia In Vivo” Patrick L. Sinn, Ankur Shah, Maureen D. Donovan, Paul B.
`McCray, Jr. American Society of Gene Therapy Annual Meeting, Minneapolis MN June, 2004.
`Mol Therapy, 9, Suppl. 1, S191, 2004.
`
`“Reducing mucociliary clearance rates through rheological property optimization” Ankur J Shah
`and Maureen D. Donovan. AAPS Annual Meeting, Baltimore MD November, 2004. AAPS J,
`6(Suppl), 2004
`
`“Nose to brain dopamine delivery: Targeting dopamine transporter and organic cation
`transporter-2 for improved CNS bioavailability and therapeutic effect” Nagendra V. Chemuturi
`and Maureen D. Donovan. AAPS Annual Meeting, Baltimore MD November, 2004. AAPS J,
`6(Suppl),W4290, 2004.
`
`“Localization of p-glycoprotein in human tracheal/bronchial epithelial cell culture (EpiAirway)
`system” Nagendra V. Chemuturi NV and Maureen D. Donovan. AAPS Annual Meeting,
`Baltimore MD November, 2004. AAPS J, 6 (Suppl), W4289, 2004
`
`“Influence of viscosity and surface tension on nasal spray characteristics” Mow Yee Foo and
`Maureen D. Donovan. AAPS Annual Meeting, Baltimore MD November, 2004. AAPS J,
`6 (Suppl), M1137, 2004
`
`“Nose to brain delivery – Characterization of biomolecular processes controlling dopamine
`transport across the nasal mucosa” Nagendra V. Chemuturi and Maureen D. Donovan. AAPS
`Annual Meeting, Nashville, TN. November, 2005
`
`“Rheological characterization of bioadhesive polymer gels with reduced mucociliary transit rates”
`Ankur J. Shah and Maureen D. Donovan. AAPS Annual Meeting, Nashville, TN. November,
`2005
`
`“Optimization of bioadhesive gels for extending intranasal residence time” Ankur J. Shah and
`Maureen D. Donovan. AAPS Annual Meeting, Nashville, TN. November, 2005
`
`“Spray characteristics for optimal deposition beyond the nasal valve” Mow Yee Foo and
`Maureen D. Donovan AAPS Annual Meeting, Nashville, TN November, 2005
`
`“Permeation and metabolism of cocaine in the nasal mucosa” Hefei Zhang and Maureen D.
`Donovan. AAPS Annual Meeting, San Antonio, TX, October, 2006
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`

`
`“Deposition of nasal sprays in an MRI-derived human nasal airway cast” Mow Yee Foo, YS
`Cheng, WC Su, and Maureen D. Donovan. AAPS Annual Meeting, San Antonio, TX, October,
`2006.
`
`“Nanoparticulate movement through viscoelastic barriers” Chen Ming Lee and Maureen D.
`Donovan. AAPS Annual Meeting, San Antonio, TX, October, 2006.
`
`“Permeation of L-Phenylalanine across the Nasal Mucosa” Hefei Zhang and Maureen D.
`Donovan. AAPS Annual Meeting, San Diego, CA. AAPS Journal, Vol. 9, No. S2, Abstract T2023
`(2007).
`
`“A Geometric Approach to Simulating Nasal Spray Deposition Efficiency” Mow Yee Foo, YS
`Cheng, WC Su, and Maureen D. Donovan. AAPS Annual Meeting, San Diego, CA, November,
`2007, AAPS Journal Vol. 9, No. S2, Abstract W5254 (2007).
`
`“Nanoparticulate Movement in Concentrated Polymer Solutions” Chen Ming Lee and Maureen D.
`Donovan. AAPS Annual Meeting, San Diego, CA. AAPS Journal, Vol 9, No. S2, Abstract W4198
`(2007).
`
`“Measurement of Drug Transport in the Mammary Epithelium Using Cytometric Methods”.
`Joanne E. Reiland and Maureen D. Donovan. AAPS Annual Meeting, San Diego, CA. AAPS
`Journal Vol. 9, No. S2, Abstract T2021 (2007).
`
`“A Novel Biotinylated Chitosan Polymer for Applications in Tissue Engineering and Gene
`Delivery” Aiman Abbas, Maureen Donovan,Aliasger Salem. AAPS Annual Meeting, San Diego,
`CA. AAPS Journal, Vol 9, No. S2, Abstract T3044 (2007)
`
`“Analysis of Mitoxantrone Uptake and Efflux in Mammary Epithelial Cells Using Flow Cytometry”.
`JE Reiland and MD Donovan, AAPS Annual Meeting, Atlanta, GA, AAPS Journal 10(S2), 2524,
`(2008)
`
`“Development of a Predictive Relationship between Nasal Membrane Permeability and Nasal
`Absorption Rate Constant”. H Zhang and MD Donovan, AAPS Annual Meeting, Atlanta, GA.
`AAPS Journal 10(S2), 2916, (2008).
`
`“Chitosan-Dextran Sulfate as Vaccine Delivery Systems “AO Abbas, MD Donovan, AK Salem.
`AAPS Annual Meeting, Los Angeles, CA. AAPS Journal 11(S2), 3849, 2009.
`www.aapsj.org/abstracts/AM_2009/AAPS2009-003849.pdf.
`
`“Biotinylated Chitosan Applications in Enzyme Immobilization.” AO Abbas , MD Donovan, AK
`Salem, AAPS Annual Meeting, Los Angeles, CA. AAPS Journal 11(S2), 3727, 2009.
`www.aapsj.org/abstracts/AM_2009/AAPS2009-003727.pdf.
`
`“Expression of Drug Transporters in the Mammary Epithelium”. JE Reiland and MD Donovan, ,
`AAPS Annual Meeting, Los Angeles, CA. AAPS Journal 11(S2), 3760, 2009.
`www.aapsj.org/abstracts/AM_2009/AAPS2009-003760.pdf.
`
`“PEPT1 and PEPT2 Activity in Human Mammary Epithelial Cells.” JE Reiland, MD Donovan, ,
`AAPS Annual Meeting, Los Angeles, CA. AAPS Journal 11(S2), 3553, 2009.
`www.aapsj.org/abstracts/AM_2009/AAPS2009-003553.pdf.
`
`
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`

`“Localization of Cytochrome P450 (CYP450) Enzymes in Bovine Olfactory and Respiratory
`Mucosa.” VS Dhamankar , KS Walters, MD Donovan, , AAPS Annual Meeting, Los Angeles, CA.
`AAPS Journal 11(S2), 1421, 2009, www.aapsj.org/abstracts/AM_2009/AAPS2009-001421.pdf.
`
`“Size and Surface Properties Determining Nanoparticle Uptake in the Nasal Mucosa”. N Chen,
`DE Wurster, MD Donovan, , AAPS Annual Meeting, Los Angeles, CA. AAPS Journal 11(S2),
`2528, 2009. www.aapsj.org/abstracts/AM_2009/AAPS2009-002528.pdf.
`
`“The Presence of Multiple Nucleoside Transporters in the Nasal Mucosa”. Manar Al-Ghabeish, K.
`Walters, M. Donovan AAPS Annual Meeting, New Orleans, LA AAPS Journal 12(S1), 1180,
`2010.
`
`“The Role of OCT-2 and OCTN-2 in the Transport of Amantadine Across the Nasal Mucosa”.
`Maya George and M Donovan, AAPS Annual Meeting, New Orleans, LA AAPS Journal 12(S1),
`1195, 2010.
`
`“Characterization of CYP450 Drug Metabolizing Activities in the Nasal Mucosa”. Varsha
`Dhamankar and M Donovan, AAPS Annual Meeting, New Orleans, LA AAPS Journal 12(S1),
`4276, 2010.
`
`“Surface Modification and Size Dependence of Nanoparticle Translocation in the Nasal Cavity.”
`Nan Chen, Dale E. Wurster, M. Donovan, AAPS Annual Meeting, New Orleans, LA AAPS
`Journal 12(S1), 6110, 2010.
`
`Role of OCT2 and OCTN2 in Nose to Brain Distribution of Amantadine”. Jiangeng Huang, Maya
`George, Rakesh Awasthi, Maureen Donovan. AAPS Annual Meeting, Washington DC. 2011.
`(http://abstracts.aaps.org/published/ContentInfo.aspx?conID=26805)
`
`“Identification of Multiple Nucleoside Transporters to Facilitate Intranasal Drug Delivery” Manar
`Al-Ghabeish, Maureen Donovan. AAPS Annual Meeting, Washington DC. 2011.
`(http://abstracts.aaps.org/published/ContentInfo.aspx?conID=27021)
`
`“Nose to Brain Delivery of Cimetidine in Rats” Maya George, Maureen Donovan. AAPS Annual
`Meeting, Washington DC. 2011.
`(http://abstracts.aaps.org/published/ContentInfo.aspx?conID=27252)
`
`“CYP1A2 Mediated Metabolism of Melatonin by the Nasal Mucosa” Varsha Dhamankar, Maureen
`Donovan. AAPS Annual Meeting, Washington DC. 2011.
`(http://abstracts.aaps.org/published/ContentInfo.aspx?conID=26519)
`
`“Pharmacoimaging of Drug Disposition after Intranasal Administration” Laura B. Ponto, Susan
`Walsh, Jiangeng Huang, Christine Mundt, John Sunderland, Maureen Donovan. AAPS Annual
`Meeting, Washington DC. 2011.
`(http://abstracts.aaps.org/published/ContentInfo.aspx?conID=26420)
`
`“Surface Modification and Size Dependence of Nanoparticle Translocation in the Nasal Mucosa”
`Nan Chen, Maureen Donovan. AAPS Annual Meeting, Washington DC. 2011.
`(http://abstracts.aaps.org/published/ContentInfo.aspx?conID=26234)
`
`“Permeability Characteristics of Non-Functionalized Cellulose Membranes Prepared From
`Dimethyl Sulfoxide Paraformaldehyde Solvent System- Influence of Degree of Polymerization of
`Cellulose” Bhavik Bhatt, Maureen Donovan, Douglas Flanagan, Vijay Kumar. AAPS Annual
`Meeting, Washington DC. 2011.
`(http://abstracts.aaps.org/published/ContentInfo.aspx?conID=27142)
`
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`

`
`“Expression of Drug Transporters in Animal Models Used for Nasal Absorption Characterization”
`Manar Al-Ghabeish, Todd Scheetz, Mahfoud Assem, Maureen Donovan. AAPS Annual Meeting,
`Chicago, IL 2012. (http://abstracts.aaps.org/published/ContentInfo.aspx?conID=1838)
`
`“A Mass Transport Model for Concurrent Diffusion and Metabolism of Drugs across the Nasal
`Mucosa” Varsha Dhamankar, Stephen Stamatis, Maureen Donovan. AAPS Annual Meeting,
`Chicago IL 2012. (http://abstracts.aaps.org/published/ContentInfo.aspx?conID=893)
`
`“Use of PET Imaging to Measure Nucleoside Transporter-Mediated Distribution from the Nasal
`Mucosa” Laura Ponto, Jiangeng Huang, Susan Walsh, Michael Acevedo, Christine Mundt, John
`Sunderland, Maureen Donovan. AAPS Annual Meeting, Chicago, IL 2012.
`(http://abstracts.aaps.org/published/ContentInfo.aspx?conID=1329)
`
`“Effect of Marijuana Smoking on Global Cerebral Blood Flow in Chronic and Occasional Users.”
`Rakesh Awasthi, Daniel O’Leary, Jonathan Koeppel, R Nguyen, Maureen Donovan, Laura Ponto.
`AAPS Annual Meeting & Exposition, San Antonio TX, November, 2013.
`
`“Expression and Activity of LAT-2: An L-Type Amino-Acid Transporter in the Olfactory and
`Respiratory Nasal Mucosa”. Ana Ferreira, Maureen Donovan. AAPS Annual Meeting &
`Exposition, San Antonio TX, November, 2013.
`
`“Uptake of Quantum Dots Across the Nasal Mucosa”. Bhanu Bejgum, Maureen Donovan. AAPS
`Annual Meeting & Exposition, San Antonio TX, November, 2013.
`
`“Expression of the LAT-2 Transporter in the Nasal Mucosa and Its Role in the Uptak