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`POSTGRADUATE MEDICINE is pleased to publish 111-
`nouocerricats of courses. meetings, special events, etc.
`Ail such notices should be received no later than the
`rwerity-fifth of the second month preceding the month
`of Issue; ie., for the January issue, information should
`be received by November 25. Send notices to: Edi-
`torial Department, POSTGRADUATE MEDICINE. 4015
`West 65th Street, Minneapolis, Minnesota 55435.
`
`ARTHarns FOUNDATION: Enterirn scientific sessions
`in. 1969:
`Allied Health Professions, December 4, Pioneer
`Hotel, Tucson, Ariz. Conta.cr: Mrs. Judy
`Shugar, AHPS Executive Secretary-, Arthritis
`
`Foundation.
`American Rheumatism Association, December 5-6,
`Pioneer Hotel, Tucson, At _ COOMV t bliss
`MargarerWalsh, ARA Executive Secretary, Arth.
`rids Foundation, 1212 Avenue of the Anseri.
`cis, New York 10036.
`
`STATE UNIVERS/TV or NEw YORK DOWNSTATE
`MEDICAL CENTBR. BROOKLYN: Biochemistry lec-
`ture series, 1969 and 1970;
`Functional interrelations of adipose tissue and
`liver, November 12
`The role of cyclic AMP in the control of adipose
`time me )ism. December 10
`Possible actions of insulin on the structure arid
`Function of fat cell membraneo, January 14
`Srudies of adipose tissue in obese and rionobo.e
`humans. February 11
`influence of periodicity of eating on adipose fissag
`Eattabalisra, Much 11
`forma: Dr. 'William R. Sarisione, Assisi:mit Profes-
`sor of Biochemistry, State University cif New York
`Downstate Medical Center, 450 Clarkson Ave.,
`Brooklyn 11203_
`
`UNIVERSITY OF CALIFORNIA EXTENSION. LOS AN-
`GELES'. Two week training program in mental re-
`tardation for physicians and allied professionals, Feb-
`ruary 9.20 and jure 8-19, 1970, ar UCLA Neuropsy-
`chiatric institute. Contact: Continuing Education in
`Medicine. Room 15-39 Rehabilitation Center, Wen
`Medical Campus, University of California, Los An-
`geles 90024.
`
`Additional announstroema ire en pages 54, 209 and. 242,
`
`(sodium levothyroxine)
`
`tadlcalions; SYNTH ROI (sod RPM levothyroxine) Is specific replace-
`ment therapy for diminished or absent thyroid function resulting
`from primary or secondary atrophy of the gland, COrigenikal defect.
`surgery, excessive radiation, or antithyrOid drugs, IndiCatiOnS f
`SYNTHROID (sodium fevothyroxine) Tablets include moedema,
`hypothyroidism without myxederna. hypothyroidism Fri pregnancy,
`pediatric and. geriatric hypothyroidism, hypopiluilary hypothyroil•
`ism, simple (non •toxic} poster, and reproductive disorderS associa.led
`wi1h hypothyroidism. SYNTHROID (radium evol ITyrox ne) InjrCtiOn.
`is indicated in rnyxedematous coma and other thyroid dysfunctions
`where rapid replacement of the hormone is required. When a pa.
`tient does not respond to oral therapy, SYNTHROID (sodium levo.4
`thyroxine} Injection may be administered intravenously to avoid anyd
`oueStiOn of poor absorption by either the Oral Or the intramuscular
`roue.
`
`ProtaLkti121114: As with other thyrOid Oreparati-OnS, van overdosage
`may cause diarrhea or cramps. nervousness. tremors, tachycardia,
`vomiting and continued weight loss. These affects may begin after
`four or five days or rnay not become apparent for one to three weeks..
`Patients receiving the drug should be observed closely for signs
`If indications of riveridosage appear, disconlinuO
`thyrotootovs.
`medication for 2,6 days,. than resume al a lower dosage level. In
`patients with diabetes mellitus, careful observations should be made
`for changes in insulin or other anlidiabetio drug dosage require-
`ments. If hypothyroidism is accompanied by adrenal insufkiency. as
`nodison's Disease (chronic subcortical insufficiency), Sirnmonds's
`Disease (panhyoopituitarisrn) or CuShing's syndrome (hyperactren-
`alism), these dyslunctions must be corrected prior to and during
`SYNTHRO10.(sodiurn levothyroxine) administration. The drug
`should be administered with caution 10 patients with C.ardiOvaSCular
`disease: development of chest pains or other aggravations of car-
`diovaseular disease requires a reduction in dosage.
`
`Contraindications: ThyrotoxiO0Sis, acute myocardial inlarction.
`
`Side effects: The effects of SYNTHROID (sodium levothyroxine)
`therapy are slow in being manifested. Side effects, when hey do
`occur. are secondary to increased rates of body metabolism: sweat-
`kg, heart palpitations with or without pain, leg tramps, arid weight
`loss. Diarrhea, mini I ing, a nd nervousness have a Iso been observeiji
`Myriedematous patients with heart disease have died from abrupt
`increases in dosage of thyroid drugs. Careful observation of the
`patient during the beginning of any thyroid therapy will alert the
`physician to any untoward effects.
`In most cases with side effects, a reillAtIOn i nOOSal)e followed by
`a more gradual adjustment upward will result in, a more accurate
`indication of the patient's dosage reoui rernents without the appear-
`ance olsid e effects.
`
`Dosage and Ad mini/wallow The activity of a 0.1 mg. S (cid:9)
`hIROID
`(sodium levethyroxi40 TABLET is equivalent to approxinnetely one
`grain thyroid, U.S.P. Administer SYNTHROID tablets as a single
`daily dose, preferably after breakfast, In hypothyroidism without
`impel:Wm, the usual initial adult dose i$ 0,1 mg, daily, and may be
`increased by 0.1 mg. every 30 days until proper metabolic balance is
`attained. Clinical evaluation should be made monthly and PB1
`measurements about every eo days. Final maintenance dosage
`usually range from 0.2.0.4 mg. daily. In adult rnyxederna, starting
`ease should be 0.0e5 mg. daily. The dose may be increased to 0.05
`mg. alter two weekS and I00.1 mg- at the end of a SeCOnel two yotek.S.
`The daily dose may be further increased at two-month intervals by
`0.1 mg_ until the Optimum maintenance dose is reached (01-1„0 mg,
`
`0.05 mg.. 0.1 mg., 0,15 mg,, 0-2 mg., 0.3
`Su ppl I act: Ta Wets.: 0.06 (cid:9)
`mg., 0,5 Mg., scored arid COW-coded, in bottles of 100 and 500.1nje‘
`tion: 500 mg. lyophilized active ingredient and 10 mg. of klanniW,
`N.F., in .* nil. single-dose vial, with 5 (cid:9)
`vial Of Sodium Chloride
`Injection, U-S,P., as a diluent.
`
`SYNTIlROlD (sodium levothyroxin0 INJECTION may be adrninis-
`tered intravenously utilizing 200-100 meg. of a solution Containing
`100 mcg, per ml, It significant intV0VerrcOnt is AIM $ 1104YA The follow-
`ing day, a repeat injection of 100-2133, mcg, may be given.
`
`1EC afinsioir or lawniier miorivoriris. iiiic
`
`FL! NT LABORATORIES
`Morton Greve. Illinois WOW
`
`1.8 (cid:9)
`
`POSTGRADUATE MEDICINE