wo 2005/020121
`
`PCT/KR2003/001921
`
`FIG.5
`
`5/5
`
`game between groups
`
`perform login operation...-- 20i0
`
`configure groups
`
`select opposite group
`
`make agreement for
`game progress rule
`
`------2040
`
`progress game while
`monitoring hea I th state_.__ 2050
`
`give notification
`indicating game progress
`state to group members_.__ 2060
`
`2070
`
`provide incentive
`
`2080
`
`end
`
`2090
`
`Apple Inc.
`APL1002 Part 2 of 2
`U.S. Patent No. 8,989,830
`
`0261
`
`

`
`INTERNATIONAL SEARCH REPORT
`
`~nternational application No.
`PCT/KR2003/001921
`
`A.
`
`CLASSIFICATION OF SUBJECT MATTER
`
`IPC7 G06F 19/00
`According to International Patent Classification (IPC) or to both national classification and IPC
`
`FIELDS SEARCHED
`B.
`Minimum documentation searched (classification system followed by classification symbols)
`IPC7 G06F 19/00, 1PC7 G06F 17/60
`
`Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched
`KR : IPC as above
`
`Electronic data base consulted during the intertnational search (name of data base and, where practicable, search terms used)
`USPAT, FPD, PAJ, KJPASS
`
`c. DOCUMENTS CONSIDERED TO BE RELEVANT
`
`Category*
`
`Citation of document, with indication, where appropriate, of the relevant passages
`
`Relevant to claim No.
`
`A
`
`A
`
`A
`
`A
`
`A
`
`KR 2002-0009119 A (UZ DREAM Co., LTD.) 01 FEBUARY 2002 (Family one)
`* Whole Documents.
`
`KR 2002-0069697 A (ELECTRONICS AND TELECOMMUNICATIONS RESEARCH
`INSTITUTE) 05 SEPTEMBER 2002 (Family None)
`* Whole Documents.
`
`KR 2002-0091343 A (KIM DAE JOONG) 06 DECE?vlBER 2002 (Family None)
`* Whole Documents.
`
`KR 2002-0091344 A (KIM DAE JOONG) 06 DECENIBER 2002 (Family None)
`* Whole Documents.
`
`US 2002/0007286 AI (NEC CORP.) 17 JANUARY 2002 (Family None)
`* Whole Documents.
`
`1- 17
`
`1- 17
`
`1- 17
`
`1- 17
`
`1- 17
`
`D Further documents are listed in the continuation of Box C.
`
`D See patent family annex.
`
`uE''
`
`*
`Special categories of cited documents:
`"A" document defining the general state of the art which is not considered
`to be of particular relevance
`earlier application or patent but published on or after the international
`filing date
`''LI' document which may throw doubts on priority claim(s) or which is
`cited to establish the publication date of citation or other
`special reason (as specified)
`t!QH document referring to an oral disclosure, use, exhibition or other
`means
`document published prior to the international filing date but later
`than the priority date claimed
`
`npn
`
`ltTn
`
`later document published after the international filing date or priority
`date and not in conflict with the application but cited to understand
`the principle or theory underlying the invention
`uxn document of particular relevance; the claimed invention cannot be
`considered novel or cannot be considered to involve an inventive
`step when the document is taken alone
`"Yq document of particular relevance; the claimed invention cannot be
`considered to involve an inventive step when the document is
`combined with one or more other such docum~nts,such combination
`being obvious to a person skilled in the art
`"&" document member of the same patent family
`
`Date ofthe actual completion of the international search
`
`Date of mailing of the international search report
`
`26 APRIL 2004 (26.04.2004)
`
`27 APRIL 2004 (27.04.2004)
`
`Name and mailing address of the ISAlKR
`
`G Korean Intellectual Property Office
`
`920 Dunsan-dong, Seo-gu, Daejeon 302-701,
`Republic ofKorea
`Facsimile No. 82-42-472-7140
`Form PCT/lSA/210 (second sheet) (January 2004)
`
`Authorized officer
`
`YANG, Tae Hwan
`
`Telephone No. 82-42-481-5782
`
`(Up
`
`0262
`
`

`
`PCT
`
`(51) International Patent Classification 7 :
`A61B 5/00
`
`Al
`
`WORLD INTELLECTUAL PROPERTY ORGANIZATION
`International Bureau
`INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT)
`wo 00/47108
`
`(11) International Publication Number:
`
`(43) International Publication Date:
`
`17 August 2000 (17.08.00)
`
`(21) International Application Number:
`
`PCT/IL00/0007 4
`
`(22) International Filing Date:
`
`3 February 2000 (03.02.00)
`
`(30) Priority Data:
`128427
`
`8 February 1999 (08.02.99)
`
`IL
`
`(63) Related by Continuation (CON) or Continuation-in-Part
`(CIP) to Earlier Application
`us
`Piled on
`
`60/121,290 (CON)
`22 February 1999 (22.02.99)
`
`(81) Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG,
`BR, BY, CA,CH, CN, CR,CU,CZ, DE, DK, DM, EE,
`ES, Fl, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP,
`KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA,
`MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU,
`SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG,
`US, UZ, VN, YU, ZA, ZW, ARIPO patent (GH, GM, KE,
`LS, MW, SD, SL, SZ, TZ, UG, ZW), Eurasian patent (AM,
`AZ, BY, KG, KZ, MD, RU, TJ, TM), European patent (AT,
`BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU,
`MC, NL, PT, SE), OAPI patent (BF, BJ, CF, CG, CI, CM,
`GA, GN, GW, ML, MR, NE, SN, TD, TG).
`
`Published
`With international search report.
`Before the expiration of the time limit for amending the
`claims and to be republished in the event of the receipt of
`amendments.
`
`(71) Applicant (for all designated States except US): MEDOC LTD.
`llLIIL]; P.O. Box 423, 30095 Ramat Yishai (IL).
`
`(72) Inventors; and
`(75) Inventors/Applicants (for US only): GAFNI, Ehud [IL/IL];
`Ha'Oren Street 45, 30095 Ramat Yishai (IL). GAFNI,
`Edna [ILIIL]; Ha'Oren Street 45, 30095 Ramat Yishai (IL).
`TREYSTMAN, Alexander [ILIIL]; Ha'Oren Street 56A,
`30095 Ramat Yishai (IL).
`
`(74) Agents: FENSTER, Paul et al.; Fenster & Company Patent
`Attorneys, Ltd., P.O. Box 10256, 49002 Petach Tikva (IL).
`
`(54) Title: AMBULATORY MONITOR
`
`MEMORY
`
`34
`
`20
`
`/
`
`24
`
`21
`
`30
`
`COMMUNICATION
`PORT
`
`36
`
`PC
`
`(57) Abstract
`
`An ambulatory monitor (20) is used to increase patient compliancein medicine taking, reporting side effects, disease progress,
`symptoms, and/or the effect of treatment. The preferred embodiment includes the monitor (20), an alert generator (24), a controller (22), a
`display (26), a sensor/accelerometer (32), and a communication port (30) for the patient (21 ).
`
`0263
`
`

`
`Codes used to identify States party to the PCT on the front pages of pamphlets publishing international applications under the PCT.
`
`FOR THE PURPOSES OF INFORMATION ONLY
`
`AL
`AM
`AT
`AU
`AZ
`BA
`BB
`BE
`BF
`BG
`BJ
`BR
`BY
`CA
`CF
`CG
`CH
`CI
`CM
`CN
`cu
`cz
`DE
`DK
`EE
`
`Albania
`Annenia
`Austria
`Australia
`Azerbaijan
`Bosnia and Herzegovina
`Barbados
`Belgium
`Burkina Faso
`Bulgaria
`Benin
`Brazil
`Belarus
`Canada
`Central African Republic
`Congo
`Switzerland
`C<lte d 'Ivoire
`Cameroon
`China
`Cuba
`Czech Republic
`Germany
`Denmark
`Estonia
`
`ES
`FI
`FR
`GA
`GB
`GE
`GH
`GN
`GR
`HU
`IE
`IL
`IS
`IT
`JP
`KE
`KG
`KP
`
`KR
`KZ
`LC
`Ll
`LK
`LR
`
`Spain
`Finland
`Prance
`Gabon
`United Kingdom
`Georgia
`Ghana
`Guinea
`Greece
`Hungary
`Ireland
`Israel
`Iceland
`Italy
`Japan
`Kenya
`Kyrgyzstan
`Democratic People's
`Republic of Korea
`Republic of Korea
`Kazakstan
`Saint Lucia
`Liechtenstein
`Sri Lanka
`Liberia
`
`LS
`LT
`LU
`LV
`MC
`MD
`MG
`MK
`
`ML
`MN
`MR
`MW
`MX
`NE
`NL
`NO
`NZ
`PL
`PT
`RO
`RU
`SD
`SE
`SG
`
`Lesotho
`Lithuania
`Luxembourg
`Latvia
`Monaco
`Republic of Moldova
`Madagascar
`The fanner Yugoslav
`Republic of Macedonia
`Mali
`Mongolia
`Mauritania
`Malawi
`Mexico
`Niger
`Netherlands
`Norway
`New Zealand
`Poland
`Portugal
`Romania
`Russian Federation
`Sudan
`Sweden
`Singapore
`
`SI
`SK
`SN
`sz
`TO
`TG
`TJ
`TM
`TR
`TT
`UA
`UG
`us
`uz
`VN
`YU
`zw
`
`Slovenia
`Slovakia
`Senegal
`Swaziland
`Chad
`Togo
`Tajikistan
`Turkmenistan
`Turkey
`Trinidad and Tobago
`Ukraine
`Uganda
`United States of America
`Uzbekistan
`VietNam
`Yugoslavia
`Zimbabwe
`
`0264
`
`

`
`wo 00/47108
`
`PCT /IL00/0007 4
`
`AMBULATORY MONITOR
`
`RELATED APPLICATIONS
`
`This application claims the benefit under 119( e) of US provisional application
`
`60/121,290, with like title and filed on February 22, 1999, the disclosure of which is
`
`5
`
`incorporated herein by reference.
`
`FIELD OF THE INVENTION
`
`The present invention relates to ambulatory monitors, especially for tracking the
`
`progress of diseases and the effectiveness of medical treatments.
`
`BACKGROUND OF THE INVENTION
`
`10
`
`Ambulatory patient monitors, also of types that automatically measure signals, are
`
`known. For example, one such device is described in U.S. Patent 4,354,375, the disclosure of
`
`which is incorporated herein by reference. U.S. Patent 5,293,879 and an article "Ambulatory
`
`Monitoring of Tremor and Other Movements Before and After Thalamotomy: A New
`
`Quantitative Technique", by EJW van Someren, WA van Gool, BFM Vonk, M Mirmiran, JD
`
`15
`
`Speelman, DA Bosch and DF Swaab, in Journal ofNeurological Sciences, 117 (1993) pp. 16-
`
`23, the disclosures of which are incorporated herein by reference, suggest using an ambulatory
`
`for monitoring Parkinson's disease. In the latter patent, it is suggested that the monitor
`
`automatically administer a pharmaceutical to a patient.
`
`U.S. Patent 5,642,731, the disclosure of which is incorporated herein by reference,
`
`20
`
`describes a portable device for reminding a patient to take medicine and for querying a patient
`
`(to some extent) regarding side effects. This patent describes a device that is large enough to
`
`hold one or more types of pills. A non-portable device for reminding a patient to take a blood
`
`test is described in U.S. Patent 5,442,728, the disclosure of which is incorporated herein by
`
`reference.
`
`25
`
`A disadvantage the pill-box device is that it must be carried around, as it is apparently
`
`too large to be worn. Consequently, patient compliance may be compromised, for example if
`
`the patient has no pockets in his apparel or if the patient is embarrassed or inconvenienced by
`
`carrying the pill-box around. If a patient does not carry the pill-box, he will not get any
`
`reminders, answer questions and/or otherwise be monitored.
`
`30
`
`SUMMARY OF THE INVENTION
`
`An object of some preferred embodiments of the invention IS to mcrease patient
`
`compliance in medicine taking and/or in reporting side effects, disease progress, symptoms
`
`and/or the effect of treatment. In a preferred embodiment of the invention, this increase in
`
`1
`
`0265
`
`

`
`wo 00/47108
`
`PCT/IL00/00074
`
`compliance is achieved by providing the patient with a device that is worn, preferably- a
`
`wristwatch-like device.
`
`An object of some preferred embodiments of the invention is to increase a confidence
`
`level of a patient's subjective reports by providing objective data which can be compared with
`
`5
`
`the subjective record of the patient.
`
`An object of some preferred embodiments of the invention is to shorten pharmaceutical
`
`clinical trials and/or improve their credibility by enhancing the acquisition of patient data,
`
`especially with regard to side effects and treatment efficacy. In a preferred embodiment of the
`
`invention, data acquisition is enhanced by questioning the patient using focused queries.
`
`10
`
`Preferably, the queries are structured and/or dependent on previous responses. Additionally or
`
`alternatively, the queries take into account data which is logged by an ambulatory monitor,
`
`either automatically or manually.
`
`One aspect of some preferred embodiments of the invention relates to a patient
`
`querying device which is worn by the patient. In a preferred embodiment of the invention, the
`
`15
`
`device is worn on a wrist, preferably having an exterior similar to a wrist-watch, possibly
`
`incorporating the functionality of a wristwatch. Alternatively, the device may be worn as a
`
`necklace and/or on a chain or cord around the neck. In a preferred embodiment of the
`
`invention, the device includes a display, which displays various information, including one or
`
`more of a query, a reminder, a time, processed and/or sensed data and/or an indication of a
`
`20
`
`response by the patient. Alternatively or additionally, the queries, the patient responses and/or
`
`other information display use an auditory channel (for output and/or input).
`
`An aspect of some preferred embodiments of the invention relates to a worn device
`
`which provides reminders to a patient, as well as querying the patient. In a preferred
`
`embodiment of the invention, the reminders include one or more of a reminder to take
`
`25 medicine, to eat, to drink, to be tested, to visit a doctor and/or fill out a form.
`
`In some preferred embodiments of the invention, the device also monitors one or more
`
`physiological parameters of the patient, for example, movements, body position/posture, pulse
`
`rate, blood pressure, ECG, temperature and/or oxygenation level. Alternatively or additionally,
`
`environmental variables are monitored by the device, for example, ambient sounds, ambient
`
`30
`
`temperature, ambient light levels and/or ambient air-pressure. Alternatively or additionally, to
`
`automatic monitoring, physiological parameters, ambient environmental conditions and/or
`
`patient activities may be logged manually, by a person entering them into the device. In some
`
`cases, the logging of data is initiated by a patient, in others, the device requests the data.
`
`2
`
`0266
`
`

`
`wo 00/47108
`
`PCT /IL00/0007 4
`
`In a preferred embodiment of the invention, when the device queries the patient, the
`
`queries are responsive to the manually and/or automatically logged data, for example, to
`
`determine a relationship between a meal time and the effectiveness of a medicine or a side
`
`effect of the medicine. In a preferred embodiment of the invention, such querying is used
`
`5
`
`during a clinical study of a medicine, to better classify, investigate and collect data about side(cid:173)
`
`effects and/or medicine efficacy.
`
`A differentiation should be noted between querying which is delayed and/or initiated
`
`responsive to a medicine taking time, expected blood level and/or other parameters which are a
`
`function of medicine metabolism and querying which delayed responsive to physiological
`
`1 o
`
`processes, such as the circadian cycle, the menstrual cycle or the birth process.
`
`In a preferred embodiment of the invention, an ambulatory monitor is used for one or
`
`more of disease progress monitoring, data collection for diagnosis, drug studies, drug schedule
`
`planning and/or treatment effectiveness detennination. In a preferred embodiment of the
`
`invention, the data that is collected by the monitor is downloaded to a computer, on which the
`
`15
`
`data may be analyzed by a technician and/or a physician.
`
`One aspect of the invention relates to an ambulatory monitor being adapted for a
`
`particular disease. In one example, Parkinson's disease, the device may be provided with
`
`buttons having a size, shape and/or pressure response which is especially adapted for the use of
`
`Patients with Parkinson's disease. Alternatively or additionally, the logic of operation of the
`
`20
`
`device is adapted to the disease, for example requiring confirmation for every input or
`
`requiring a longer press duration, to take into account a higher probability of a patient
`
`inadvertently pressing a wrong button. In another example, the monitor is adapted for pain
`
`monitoring, for example by including dedicated sensors; software for analyzing sensor results
`
`and displaying different queries and/or reminders; and/or faceplate marking.
`
`25
`
`An aspect of some preferred embodiments of the invention relates to usmg an
`
`ambulatory monitor for long term monitoring. In one preferred embodiment of the invention,
`
`the device monitors changes over a long period. In another example, the device provides
`
`reminders for infrequently occurring events, for example, a yearly checkup or a reminder to
`
`replace an implanted battery. In one example, suspected Alzheimer's disease is diagnosed, by
`
`30
`
`periodically presenting questions to a patient, over a long period, so that degradation of mental
`
`and/or memory skills can be assessed.
`An aspect of some preferred embodiments of the invention relates to coordination of an
`
`ambulatory monitor with other medical care. In one example, a reminder device which is worn
`
`by a health-care provider is synchronized with the ambulatory monitor, so that that health care
`
`3
`
`0267
`
`

`
`wo 00/47108
`
`PCT /IL00/0007 4
`
`provider (for example a personal nurse) is reminded whenever the patient receives a medicine
`
`taking reminder. Thus, the patient can feel independent, while patient compliance is increased.
`
`Alternatively or additionally, one or more queries may be directed at the health-care provider,
`
`for example, to report on the patient's movements, activity state, mental alertness and/or mood.
`
`5
`
`Such two coordinated monitors may also be useful where the patient does not answer queries
`
`at all, for example senile persons or babies. The two devices may be coordinated using
`
`wireless communication, for example, IR, Ultrasound or RF radiation. Alternatively or
`
`additionally, the devices are coordinated using a synchronized clock and suitable logic, so that
`
`one device is aware of the expected operation of the other device.
`
`10
`
`One aspect of some preferred embodiments of the invention relates to a method of data
`
`entry by a patient. In a preferred embodiment of the invention, the patent entered at least some
`
`of the data using an analog scale, for example, entering a pain level on a scale between 0 and
`
`10. In a preferred embodiment of the invention, the data is entered by pressing a button to
`
`move a marker along a scale and releasing the button when the desired data value is displayed.
`
`15
`
`This data entry method has the advantage of clear feedback to the patient regarding his input.
`
`In addition, if the patient has difficulty entering data, the absolute error may be expected to be
`
`small. Further, correcting such a data entry does not require erasing the data entry and
`
`reentering it, only correcting it, for example by moving the marker some more. In one
`
`embodiment of the invention, the analog scale is displayed with a varying resolution, so that
`
`20
`
`there is a maximal resolution at about the marker. Alternatively or additionally, the speed of
`
`motion of the marker is a function of the duration of the button pressing. In some cases,
`
`information regarding the patient state and/or various physiological problems thereof may be
`
`determined by analyzing the act of data entry itself. Analog data entry, often provides more
`
`such data to be analyzed.
`
`25
`
`In a preferred embodiment of the invention, a patient may enter several types of data
`
`usmg an "analog" data input. Alternatively or additionally, some of the data entry may
`
`comprise selection from a list of discrete entries. Optionally, the physician sets the values of
`
`the ends of the analog scale and/or of the discrete choices. It is noted that using an Analog
`
`input device is known for patient studies. However, such a device is typically large (~lOcm)
`
`30
`
`and inconvenient to carry around. In addition, it is not practical to provide a patient with two
`
`or more such devices to entry multiple data types. Thus, comparison of changes in two such
`
`entered data types in an ambulatory patient was not a viable option.
`
`An aspect of some preferred embodiments of the invention relates to data analysis of
`
`data acquired by the ambulatory monitor. One advantage of some monitors of the present
`
`4
`
`0268
`
`

`
`wo 00/47108
`
`PCT /IL00/0007 4
`
`invention is synchronization between the patient query responses, medicine taking and other
`
`activities of the patient. In one example, a data analysis can be used to determine an average
`
`"time-to-ON" of a Parkinson's patient (i.e., the time period from the time the medication was
`
`taken until the patient switches from OFF to ON and feels an improvement in his motor
`
`5
`
`abilities).
`
`An aspect of some preferred embodiments of the invention relates to intercom1ecting an
`
`ambulatory monitor and external communication networks. In a preferred embodiment of the
`
`invention, the monitor can connect to a doctor's web site or to a pharmaceutical companies
`
`web site to upload patient data and/or responses to queries, and/or to download new
`
`10
`
`programming, for example for detecting and/or avoiding newly discovered side effects or
`
`inter-drug interactions.
`
`An aspect of some preferred embodiments of the invention relates to the determination
`
`of pain level from an analysis of automatically sensed movement and/or posture data. In a
`
`preferred embodiment of the invention, sudden onset of pain and/or high pain levels are
`
`15
`
`identified when there is a sudden reduction in the amount of movement of an accelerometer. In
`
`another example, pain levels may be correlated with the patient's manner of walking:
`
`accelerations, gait profile, regularity of rhythm, step size, speed, way of starting and/or
`
`favoring oflimbs (especially in lower back pain and limb injuries). In a preferred embodiment
`
`of the invention, the monitor learns to associate particular characteristics of features of the
`
`20 walk and/or movement profile with varying levels of pain. Alternatively or additionally, pain
`
`level may be determined by analyzing the temporal profile of the patient's posture and/or
`
`position, for example, walking straight, walking hunched, laying down, standing up or
`
`sleeping. Alternatively or additionally, such changes in motion are correlated with changes in a
`
`measured heart rate (which is expected to increase with pain).
`
`25
`
`There is therefore provided in accordance with a preferred embodiment of the
`
`invention, an ambulatory monitor, comprising:
`
`a fastener for attaching said monitor to an ambulatory person to be monitored;
`
`a display;
`
`an input interface; and
`
`30
`
`a query generator which generates queries to said display and which receives answers
`
`to said queries using said input interface.
`
`Preferably, the monitor comprises:
`
`at least one sensor which generates a signal responsive to a sensed value; and
`
`5
`
`0269
`
`

`
`wo 00/47108
`
`PCT/IL00/00074
`
`an automatic logger, which logs data responsive to said signal. Preferably, data
`
`comprises raw signal data from said sensor. Alternatively or additionally, said data comprises
`
`process signal data from said sensor. Alternatively or additionally, said at least one sensor
`
`comprises a physiologic sensor that senses a physiologic variable of said person. Alternatively
`
`5
`
`or additionally, said at least one sensor comprises an environmental sensor that senses a
`
`parameter of an environment of said person. Alternatively or additionally, said at least one
`
`sensor comprises a motion sensor that senses a motion of at least of a portion of said person.
`
`Alternatively or additionally, said at least one sensor comprises a motion sensor that senses a
`
`change in posture of said person. Alternatively or additionally, said at least one sensor
`
`10
`
`comprises a motion sensor that senses a change in body position of said person. Alternatively
`
`or additionally, said motion sensor comprises an accelerometer. Alternatively or additionally,
`
`said at least one sensor comprises at least two sensors, of different types. Alternatively or
`
`additionally, said at least one sensor comprises at least two sensors, which measure different
`
`parameters. Alternatively or additionally, said at least one sensor comprises at least two
`
`15
`
`sensors, which are attached to different parts of said person. Alternatively or additionally, said
`
`at least one sensor comprises a sensor which is spatially separate from said monitor.
`
`Preferably, said sensor is a wireless sensor.
`
`In a preferred embodiment of the invention, at least one of said queries is generated
`
`responsive to said logged data. Preferably, said query is generated at a delay responsive to said
`
`20
`
`logged data. Preferably, said delay is responsive to a metabolism of a medication taken by said
`
`person. Alternatively or additionally, said delay is responsive to a physiological process of said
`
`person.
`
`In a preferred embodiment of the invention, said monitor generates a medication
`
`schedule responsive to said logged data. Alternatively or additionally, said fastener comprises
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`a wristband. Alternatively or additionally, said monitor is adapted to be worn around a neck.
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`Alternatively or additionally, said display comprises a visual display. Alternatively or
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`additionally, said display comprises an audio display.
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`In a preferred embodiment of the invention, the monitor compnses a reminder
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`generator which provides said person with at least one reminder using said display. Preferably,
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`said query generator generates at least one query responsive to a response of said person to
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`said at least one reminder. Possibly, said response comprises not complying with said
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`reminder. Alternatively or additionally, said at least one reminder comprises a reminder to eat.
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`Alternatively or additionally, said at least one reminder comprises a reminder to drink.
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`Alternatively or additionally, said at least one reminder comprises a reminder to take a certain
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`medication. Alternatively or additionally, said at least one reminder comprises a reminder for a
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`medical checkup. Alternatively or additionally, said at least one reminder comprises a
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`reminder for a medical test.
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`In a preferred embodiment of the invention, the monitor an alerter which calls attention
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`of said person to said display.
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`In a preferred embodiment of the invention, said input interface is operative to receive
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`unsolicited input from said person. Preferably, said input comprises an indication of a disease
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`state. Alternatively or additionally, said input comprises an indication of a side effect.
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`Alternatively or additionally, said input comprises an indication of an effect of said medicine.
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`Alternatively or additionally, said input comprises an activity of the person. Alternatively or
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`additionally, said query generator generates at least one query responsive to said input.
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`Preferably, said query is generated at a delay responsive to said input. Preferably, said delay is
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`responsive to a metabolism of a medication taken by said person. Alternatively or additionally,
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`said delay is responsive to a physiological process of said person.
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`In a preferred embodiment of the invention, said monitor generates a treatment
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`schedule responsive to said input. Preferably, said treatment schedule comprises a medication
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`schedule.
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`In a preferred embodiment of the invention, said query generator generates at least one
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`secondary query responsive to said person's response to said at least one query. Alternatively
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`or additionally, said query generator comprises a memory and wherein said memory has stored
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`therein an indication of at least one query directed to clinical testing of medical treatment.
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`Alternatively or additionally, said query generator comprises a memory and wherein said
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`memory has stored therein an indication of at least one query directed to selecting between two
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`or more medication schedules.
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`In a preferred embodiment of the invention, said monitor is adapted for monitoring a
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`particular health condition of said person. Preferably, said health condition comprises a
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`chronic disease. Alternatively or additionally, said health condition comprises pain.
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`Alternatively or additionally, said health condition comprises heart disease. Alternatively or
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`additionally, said health condition comprises an anxiety disorder. Alternatively or additionally,
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`said health condition comprises a depression disorder. Alternatively or additionally, said health
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`condition comprises an ADD (Attention deficiency disorder). Alternatively or additionally,
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`said health condition comprises a pulmonary difficulty. Alternatively or additionally, said
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`health condition comprises diabetes. Alternatively or additionally, said health condition
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`compnses a progressive disease. Alternatively or additionally, said disease comprises
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`Parkinson's disease. Alternatively, said health condition comprises a non-disease condition.
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`In a preferred embodiment of the invention, said monitor is adapted for tracking a
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`health condition which is being modified using a medical treatment.
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`In a preferred embodiment of the invention, said monitor is synchronized with a second
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`monitor, adapted to be worn by a second person and wherein said second monitor comprises
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`an alerter which generates an alert to said second person responsive an operation at said
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`monitor. Preferably, said operation comprises a reminder to take medicine. Alternatively or
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`additionally, said monitor and said second monitor are synchronized using wireless
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`communication therebetween. Alternatively or additionally, said monitor and said second
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`monitor are synchronized using a common clock.
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`In a preferred embodiment of the invention, said input interface comprises at least one
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`digital visual analog scale (DVAS) display. Preferably, said at least one DVAS comprises at
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`least two DV ASes.
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`In a preferred embodiment of the invention, said input interface comprises at least one
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`menu selection interface. Alternatively or additionally, said input interface comprises an
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`interface for entering at least two different types of data, each of said types of data having at
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`least three possible values. Preferably, said query generator generates at least one query
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`responsive to a relationship between said two types of entered data.
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`There is also provided in accordance with a preferred embodiment of the invention, a
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`method of detecting a change in pain level, comprising:
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`tracking movements of at least a portion of a person; and
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`analyzing said tracked movements to identify changes in movement caused by a
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`change in pain level. Preferably, said tracked movements comprises changes in posture.
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`Alternatively or additionally, said tracked movements comprises changes in gait. Alternatively
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`or additionally, said tracked movements comprises changes in a time profile of at least one
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`body position.
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`There is also provided in accordance with a preferred embodiment of the invention, a
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`method of data sensing, comprising:
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`automatically logging data of an ambulatory patient;
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`analyzing said data to determine at least one aspect of non-suitability of said logged
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`data;
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`automatically querying said patient to provide data which improves said at least one
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`aspect of non-suitability.
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`There is also provided in accordance with a preferred embodiment of the invention,- a
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`method of entering multi-state information, comprising:
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`displaying, on a worn device, a scale of values, including an indication of a particular
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`value;
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`entering usmg said device a value, which entered value 1s indicated usmg said
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`indication; and
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`storing said entered value, in said device, for later analysis.
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`Preferably, said display emulates a VAS (Visual analog scale). Alternatively or
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`additionally, said entered value indicates a pain value. Alternatively or additionally, the
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`10 method comprises repeating said displaying and said entering a plurality of times for a same
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`type displayed scale. Alternatively or additionally, the method comprises repeating said
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`displaying and said entering a plurality of times for a different type displayed scale.
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`There is also provided in accordance with a preferred embodiment of the invention, a
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`monitor network comprising:
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`a first monitor, worn by a first person, which first monitor generates an alert to said
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`first person; and
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`a second monitor, worn by a second person, synchronized with said first monitor,
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`which generates an alert to said second person responsive to said first monitor. Preferably, said
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`first and second monitors are synchronized using a common clock. Alternatively or
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`additionally, said first and said second monitors are synchronized using at least one wireless
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`transmission between them.
`BRIEF DESCRIPTION OF THE DRAWINGS
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`The present invention will be more clearly understood from the following detailed
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`description of the preferred embodiments of the invention and from the attached drawings, in
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`which:
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`Fig. 1 is a block diagram of an ambulatory monitor, in accordance with a preferred
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`embodiment of the invention;
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`Fig. 2A is a schematic illustration of a faceplate of an ambulatory monitor for
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`Parkinson's disease, in accordance with a preferred embodiment of the invention;
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`Fig. 2B is a schematic illustration of a faceplate of an a