f"'ellulose Ethers
`
`Mylan v. Qualicaps, IPR2017-00203
`QUALICAPS EX. 2017 - 1/86
`
`

`

`Mylan v. Qualicaps, IPR2017-00203
`QUALICAPS EX. 2017 - 2/86
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`

`

`Mylan v. Qualicaps, |PR2017—OO203
`QUALICAPS EX. 2017 — 3/86
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`Mylan v. Qualicaps, IPR2017-00203
`QUALICAPS EX. 2017 - 3/86
`
`

`

`3
`LHandbook
`METHOCE * L
`Cellulose E her ~ . -- ,.-,.-.-. .o'x.
`I
`Products
`-------_______ ..
`!
`
`•,:•r
`
`.
`
`I~...;..::.~, :, ,;_: J ~(-
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`- - - 1
`I
`
`fS0/4 7 01
`
`Because you need quality, reliability and
`performance predictability in a thickener,
`protective colloid, film-former, emulsi(cid:173)
`fier ... that's why Dow designs, man(cid:173)
`ufactures, and continues to improve
`METHOCEL water-soluble cellulose
`ether products.
`
`"11~~~~;!~~~}~£~~~~,~~~0~3
`
`LOAN ITEM DUE BACK BY:16/02/2017
`The British Library, On Demand, Boston Spa,
`Wetherby,United Kingdom, LS23 7BQ
`OnDemand.bl.uk
`
`lc
`
`NOTICE - The Information m this bulletin is presented 1n good faith, but no warranty, express or implied, is given nor is freedom from
`any patent owned by The Dow Chemical Company or by others to be inferred. Inasmuch as any assistance furnished by Dow with
`reference to the proper use and disposal of its products is provided without charge, Dow assumes no obligation or liabil ity therefor.
`
`I
`
`TH~ DOW CHEMICAL COMPANY l DESIGNED PRODUCTS DEPARTMENT • MIDLAND, MICHIGAN 48640
`i
`
`-
`
`Printed in U.S.A.
`
`"Trademark of The Dow Chemical Company
`
`Mylan v. Qualicaps, IPR2017-00203
`QUALICAPS EX. 2017 - 4/86
`
`

`

`Handbook on
`METHOCEL*
`Cellulose Ether
`Products
`
`Because you need quality, reliability and
`performance predictability in a thickener,
`protective colloid, film-former, emulsi(cid:173)
`fier ... that's why Dow designs, man(cid:173)
`ufactures, and continues to improve
`METHOCEL water-soluble cellulose
`ether products.
`
`NOTICE - The information in th1s bulletm IS presented m good faith, but no warranty, express or implied, is g1ven naris freedom from
`any patent owned by The Dow Chemical Company or by others to be inferred Inasmuch as any assistance furnished by Dow with
`reference to the proper use and disposal of 1ts products IS provided without charge, Dow assumes no obligation or liability therefor.
`
`THE DOW CHEMICAL COMPANY • DESIGNED PRODUCTS DEPARTMENT • MIDLAND, MICHIGAN 48640
`
`Printed in U.S.A.
`
`~
`
`*Trademark of The Dow Chemical Company
`
`Mylan v. Qualicaps, IPR2017-00203
`QUALICAPS EX. 2017 - 5/86
`
`

`

`HANDBOOK ON
`M ETH 0 C E L'' CELLULOSE ETHER PRODUCTS
`
`SECTION 1
`
`SECTION 2
`
`SECTION 3
`
`SECTION4
`
`SECTION 5
`
`SECTION 6
`
`PRODUCT BASICS
`TYPES .................................................................. 1•1
`GRADES ................................................................ 1•1
`VISCOSITIES ............................................................ 1•1
`PHYSICAL FORMS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1•1
`PRODUCTS/FORMS/VISCOSITIES/GRADES ........... .. ................ . 1•2
`
`PROPERTIES I APPLICATIONS I BY PRODUCTS
`PROPERTIES ..... .. ......................... . ........................... 2•1
`APPLICATION LITERATURE ............................................... 2•2
`APPLICATIONS ............ . .................. .. ............. ... ......... 2•3
`APPLICATIONS BY PRODUCTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2•5
`
`STRUCTURES I D.S.
`METHYLCELLULOSE ................. ............. .... . ...... . ........... 3•1
`HYDROXYPROPYL METHYLCELLULOSE .. ........ .. ........ . .............. 3•1
`HYDROXYBUTYL METHYLCELLULOSE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3•2
`D.S.-DEGREE OF SUBSTITUTION ........ .. ....... . . .... ............... . 3•2
`D.S. AND WT.% FOR VARIOUS PRODUCTS .. ................. . ...... . .. ... 3•3
`
`SOLUTION PREPARATION
`PREPARATION ....................... . . ... .......................... ..... 4•1
`TREATED POWDERS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4•1
`UNTREATED POWDERS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . 4•3
`
`PROPERTIES: POWDER
`MISCELLANEOUS PROPERTIES
`Resistance to Microorganisms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5•1
`Moisture Sorption ................ . . ......... . ..... .................. 5•1
`Equilibrium Moisture Content, 25°C . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5•2
`SOLUBILITY IN NON-AQUEOUS SOLVENTS
`Solvent Solubility at Ambient Temp. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5•3
`Solvent Solubility at Elevated Temp. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5•3
`Representative Solvents at Elev. Temp. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5•4
`
`PROPERTIES: SOLUTION
`FUNDAMENTAL PROPERTIES OF SOLUTIONS
`General Aqueous Solution Properties . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6•1
`Viscosity, MW /Viscosity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6•3
`Effect of Concentration on Viscosity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6•5
`Effect of pH on Viscosity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6•7
`Effect of Additives on Viscosity
`
`-continued
`
`' Trademark ofThe Dow Chemical Company
`
`Form No. 192-703-78
`
`Mylan v. Qualicaps, IPR2017-00203
`QUALICAPS EX. 2017 - 6/86
`
`

`

`Rheology of Solutions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6•9
`Thermal Gelation, Aqueous Media .................................... 6•11
`Gel Strength, Texture ................................................. 6•12
`Effect of Additives on Thermal Gel .................................... 6•13
`Gel Point Raising Additives ........................................... 6•14
`FACTORS AFFECTING USE OF SOLUTIONS
`Recommended Concentrations for Coatings ........................... 6•15
`Surface Activity, Aqueous Solutions ................................... 6•17
`Defoamers, Aqueous Solutions ....................................... 6•17
`Effect of Freezing, Solutions .......................................... 6•19
`Preservatives, Aqueous Solutions ..................................... 6•21
`Compatibility, Aqueous Solutions ..................................... 6•21
`
`PROPERTIES: FILM
`GENERAL FILM PROPERTIES
`EFFECT OF ADDITIVES ................................................... 7•2
`RESISTANCE TO SOLVENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7•2
`THERMOPLASTIC FORMING .............................................. 7•2
`
`REGULATED USES
`FOODS .................................................................. 8•1
`"A" Brand Products .................................................. 8•1
`"E", "F", "K", Brand Products ........................................ 8•1
`PESTICIDE USE .......................................................... 8•1
`PHARMACEUTICALS, PARENTERAL INJECTIONS . . . . . . . . . . . . . . . . . . . . . . . . . . 8•2
`COSMETICS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8•2
`
`ANALYSIS
`9•1
`MEASUREMENT OF VISCOSITY
`Ubbelohde Tube Measurement ....................................... 9•2
`SUMMARY, OTHER METHODS ............................................ 9•3
`References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9•3
`
`HANDLING CONSIDERATIONS
`HEALTH ................................................................. 10•1
`STORAGE ............................................................... 10•1
`SPILLS, HOUSEKEEPING ................................................ . 10•1
`DISPOSAL .............................................................. . 10•1
`FACSIMILE MATERIAL SAFETY DATA SHEETS
`Methylcellulose ...................................................... 10•3
`Hydroxypropyl Methylcellulose ....................................... 10•5
`Hydroxybutyl Methylcellulose ........................................ 10•7
`
`SECTION 7
`
`SECTION 8
`
`SECTION 9
`
`SECTION 10
`
`Mylan v. Qualicaps, IPR2017-00203
`QUALICAPS EX. 2017 - 7/86
`
`

`

`SECTION 1
`PRODUCT BASICS
`
`Because you need quality, reliability and
`performance predictability in a thickener,
`protective colloid. film-former, emulsi(cid:173)
`fier ... that's why Dow designs, man(cid:173)
`ufactures, and continues to improve
`METHOCEL water-soluble cellulose
`ether products.
`
`TYPES
`
`. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1•1
`
`GRADES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1•1
`
`VISCOSITIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1•1
`
`PHYSICAL FORMS . . . . . . . . . . . . . . . . . . . . . . . . . 1•1
`
`PRODUCTS/FORMS/VISCOSITIES/GRADES . . 1•2
`
`-
`
`NOTICE-The information in this bulletin is presented in good fa ith, but no warranty, express or implied, is given nor is freedom from
`any patent owned by The Dow Chemical Company or by others to be inferred. Inasmuch as any assistance furnished by Dow with
`reference to the proper use and disposal of its products is provided without charge, Dow assumes no obligation or liability therefor.
`
`THE DOW CHEMICAL COMPANY • DESIGNED PRODUCTS DEPARTMENT • MIDLAND, MICHIGAN 48640
`
`Printed in U.S.A.
`
`' Trademark of The Dow Chem ical Company
`
`1
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`Mylan v. Qualicaps, IPR2017-00203
`QUALICAPS EX. 2017 - 8/86
`
`

`

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`SECTION 1
`PRODUCT BASICS
`
`Because you need quality, reliability and
`performance predictability in a thickener,
`protective colloid, film-former, emulsi(cid:173)
`fier ... that's why Dow designs, man(cid:173)
`ufactures, and continues to improve
`METHOCEL water-soluble cellulose
`ether products.
`
`TYPES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1•1
`
`GRADES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1•1
`
`VISCOSITIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1•1
`
`PHYSICAL FORMS . . . . . . . . . . . . . . . . . . . . . . . . . 1•1
`
`PRODUCTS/FORMS/VISCOSITIES/GRADES . . 1• 2
`
`NOTICE - The information in this bulletm is presented in good faith. but no warranty, express or implied, is given nor is freedom from
`any patent owned by The Dow Chemical Company or by others to be inferred. Inasmuch as any assistance furnished by Dow with
`reference to the proper use and disposal of its products is provided without charge, Dow assumes no obligation or liability therefor.
`
`•
`
`THE DOW CHEMICAL COMPANY • DESIGNED PRODUCTS DEPARTMENT • MIDLAND, MICHIGAN 48640
`
`Printed in U.S.A.
`
`~
`
`Trademark of The Dow Chemical Company
`
`Mylan v. Qualicaps, IPR2017-00203
`QUALICAPS EX. 2017 - 9/86
`
`

`

`PRODUCT BASICS
`
`TYPES
`METHOCEL cellulose ether products are made by react(cid:173)
`ing cellulose with appropriate chemical reagents in the
`presence of caustic soda. The products are manufac(cid:173)
`tured in essentially three different chemical types:
`
`• Methylcellulose ... made using methyl chlo(cid:173)
`ride ... these are the METHOCEL A brand products.
`
`• Hydroxypropyl methylcellulose ... made using pro(cid:173)
`pylene oxide and methyl chloride ... these are the
`METHOCEL E, F, J, and K brand products.
`• Hydroxybutyl methylcellulose ... made using
`butylene oxide and methyl chloride ... these are the
`METHOCEL HB brand products.
`
`Brands
`
`METHOCELA
`METHOCEL E,
`F, J, K
`METHOCEL HB
`
`Chemical Types
`
`Methylcellulose
`
`Hydroxypropyl methylcellulose
`Hydroxybutyl methylcellulose
`
`GRADES
`METHOCEL cellulose ether products are supplied in two
`grades: premium and standard.
`ALL premium-grade METHOCEL methylcellulose and
`hydroxypropyl methylcellulose products:
`
`• are accepted as additives for a variety of food and
`drug uses
`
`• meet the requirements ofthe Food Chemicals Codex
`and the international Codex Alimentarius
`
`METHOCEL A brands of premium-grade cellulose ether
`products:
`
`• meet U.S. Pharmacopeia (U.S.P.) requirements for
`methylcellulose
`
`METHOCEL E, METHOCEL F, and METHOCEL K brands
`of premium-grade cellulose ether products:
`
`• meet U.S. Pharmacopeia (U.S.P.) requirements for
`hydroxypropyl methylcellulose
`
`© 1974, 1878, The Dow Chemical Company
`
`VISCOSITIES
`METHOCEL cellulose ether products are available in
`various viscosity types, ranging from 5 cps to 75,000 cps.
`All solution viscosities are measured with Ubbelohde
`capillary tubes at a 2 percent concentration at 20°C
`(68°F). Viscosities available for each product designation
`are summarized below: Labelling will use the abbrevia(cid:173)
`tion "C" for 100 and "M" for 1000 units.
`
`Products
`
`METHOCEL A
`METHOCEL E
`METHOCEL F
`METHOCELJ
`METHOCEL K
`METHOCEL HB
`METHOCEL 228
`METHOCEL 240
`METHOCEL 856
`
`Viscosities Available
`
`15; 400; 1,500; 4,000
`5; 15; 50; 4,000
`50; 4,000; 40,000
`5,000; 12,000; 20,000; 40,000; 75,000
`35; 100; 4,000; 15,000
`12,000
`4,000
`40,000
`75,000
`
`PHYSICAL FORMS
`METHOCEL cellulose ether products are available in two
`physical forms: Powder (and Surface-Treated Powder)
`and Granular. Solutions of untreated powder must be
`prepared by the hot-cold technique or alternate methods
`(described in Section 4 of the handbook). Surface(cid:173)
`treated powder forms are dispersible in cold water. The
`dissolution of surface-treated powder products can be
`controlled by a shift in pH. The following table shows the
`individual products available in each physical form.
`Surface treatment is designated by the letter "S".
`
`Physical Form
`
`Product Availability
`
`Powder
`
`Surface-Treated
`Powder
`
`Granular
`
`Most types, grades, and
`viscosities are avail-
`able in powder form.
`METHOCEL 228,
`METHOCEL 2408
`METHOCEL J5M8,
`METHOCEL J12M8,
`METHOCEL J20M8
`METHOCEL J40M8
`METHOCEL J75M8,
`METHOCEL 8568
`METHOCEL K15M8
`METHOCEL K4MDG8
`METHOCEL K15MDG8
`
`Product information on Types, Grades, Viscosities, and
`Forms of METHOCEL cellulose ether product is sum(cid:173)
`marized on p 1•2.
`
`NOTICE- This information is presented in good faith, but no warranty, express or implied, is given nor is freedom from any patent
`owned by The Dow Chemical Company or by others to be inferred. Inasmuch as any assistance furnished by Dow with reference
`to the proper use and disposal of its products is provided without charge, Dow assumes no obligation or liability therefor.
`
`THE DOW CHEMICAL COMPANY • DESIGNED PRODUCTS DEPARTMENT • MIDLAND MICHIGAN 48640
`
`Printed in U.S.A.
`
`~
`
`Form No. 192-674-78
`
`Mylan v. Qualicaps, IPR2017-00203
`QUALICAPS EX. 2017 - 10/86
`
`

`

`I
`
`st
`SP
`st
`p
`
`st
`SP
`st
`p
`
`st
`p
`
`st
`SP
`pr
`st
`p
`pr
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`
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`SP
`
`st
`SP
`
`st
`SP
`
`st
`SP
`
`st
`SP
`
`50,000
`30,000-
`
`18,000
`12,000-
`
`st
`SP
`
`pr
`st
`p
`st
`SG
`
`pr
`st
`p
`pr
`p
`
`pr
`st
`p
`
`5600
`3500-
`
`75M
`
`40M
`
`20M
`
`15M
`
`12M
`
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`
`4M
`
`~ • N
`
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`premium
`st-standard
`
`Forms
`
`..
`
`*in percent aqueous solutions at 20°C, viscosity in centipoise
`
`SG-Granular, surface-treated
`SP-Powder, surface-treated
`P-Powder, untreated
`
`Grades
`
`st
`p
`
`1800
`1200-
`
`15C
`
`pr
`st
`p
`
`st
`p
`
`pr
`st
`p
`
`pr
`p
`
`pr
`st
`p
`
`pr
`p
`
`pr
`st
`p
`
`p
`p
`
`350-550
`
`80-120
`
`40-60
`
`13-19
`
`4-'
`
`METHOCEL 856
`
`METHOCEL 240
`
`METHOCEL 228
`
`Methylcellulose
`Hydroxybutyl
`METHOCEL HB
`
`Methylcellulose
`Hydroxypropyl
`METHOCELK
`
`Methylcellulose
`Hydroxypropyl
`METHOCELJ
`
`Methylcellulose
`Hydroxypropyl
`METHOCEL F
`
`Methylcellulose
`Hydroxypropyl
`METHOCEL E
`
`Methylcellulose
`METHOCELA
`
`RANGE
`
`'
`
`4C
`
`100
`
`50
`
`35
`
`15
`
`5
`
`VISCOSITY*
`
`Products, Forms, Viscosities, Grades for METHOCEL Cellulose Ether Products
`
`Mylan v. Qualicaps, IPR2017-00203
`QUALICAPS EX. 2017 - 11/86
`
`

`

`SECTION 2
`PROPERTIES/
`APPLICATIONS/
`BY PRODUCTS
`
`Because you need quality, reliability and
`performance predictability in a thickener,
`protective colloid, film-former, emulsi(cid:173)
`fier ... that's why Dow designs, man(cid:173)
`ufactures, and continues to improve
`METHOCEL water-soluble cellulose
`ether products.
`
`PROPERTIES
`
`. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2•1
`
`APPLICATION LITERATURE
`
`APPLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2•3
`
`APPLICATIONS BY PRODUCTS
`
`. . . . . . . . . . . . . 2•5
`
`2
`
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`
`-
`
`NOTICE- The information in this bulletin is presented in good faith, but no warranty, express or implied, is given nor is freedom from
`any patent owned by The Dow Chemical Company or by others to be inferred. Inasmuch as any assistance furnished by Dow with
`reference to the proper use and disposal of its products is provided without charge, Dow assumes no obligation or liability therefor.
`
`THE DOW CHEMICAL COMPANY • DESIGNED PRODUCTS DEPARTMENT • MIDLAND, MICHIGAN 48640
`
`Printed in U.S.A.
`
`~
`
`*Trademark of The Dow Chemical Company
`
`Mylan v. Qualicaps, IPR2017-00203
`QUALICAPS EX. 2017 - 12/86
`
`

`

`SECTION 2
`PROPERTIES/
`APPLICATIONS/
`BY PRODUCTS
`
`Because you need quality, reliability and
`performance predictability in a thickener,
`protective colloid, film-former, emulsi(cid:173)
`fier ... that's why Dow designs, man(cid:173)
`ufactures, and continues to improve
`METHOCEL water-soluble cellulose
`ether products.
`
`PROPERTIES
`
`. . . . . . . . . . .. .. .. . . . .. .. . .. . . .. 2•1
`
`APPLICATION LITERATURE
`
`APPLICATIONS .. .. .. .. .. .. .. .. .. .. .. .. .. .. 2•3
`
`APPLICATIONS BY PRODUCTS
`
`. . . . . . . . . . . . . 2•5
`
`2
`
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`
`NOTICE- The information in this bu llet in is presented in good faith, but no warranty, express or implied, is given nor is freedom from
`any patent owned by The Dow Chemical Company or by others to be inferred. Inasmuch as any assistance furnished by Dow with
`reference to the proper use and disposal of its products is provided without charge, Dow assumes no obligation or liability therefor.
`
`THE DOW CHEMICAL COMPANY • DESIGNED PRODUCTS DEPARTMENT • MIDLAND, MICHIGAN 48640
`
`Printed in U.S.A.
`
`~
`
`Trademark of The Dow Chemical Company
`
`-
`
`Mylan v. Qualicaps, IPR2017-00203
`QUALICAPS EX. 2017 - 13/86
`
`

`

`PROPERTIES AND APPLICATIONS
`PROPERTIES
`METHOCEL cellulose ether products have an excep(cid:173)
`tional and valuable combination of physical and
`chemical properties. These include:
`
`Water Solubility
`They dissolve in water in all proportions; the
`maximum concentration is limited only by vis(cid:173)
`cosity.
`
`Organic Solubility
`Certain types and grades are soluble in a number
`of binary organic and organic-water solvent sys(cid:173)
`tems; these provide a unique combination of
`organic and water solubility.
`No Ionic Charge
`They have no ionic charge (are not poly(cid:173)
`electrolytes); therefore, they will not complex with
`metallic salts and ionic organics to form insoluble
`precipitates.
`Thermal Gelation
`Their aqueous solutions gel when heated beyond a
`definite temperature, providing controllable quick(cid:173)
`set properties. The gels formed go back into
`solution upon cooling, unlike gels formed by pro(cid:173)
`tein thickeners.
`Surface Activity
`They provide surfactancy in solutions where emul(cid:173)
`sification, protective colloid action, and phase
`stabilization are required. Their surface tensions
`range from 42 to 56 dynes per em (water is 72
`dynes per em); a typical surfactant has a surface
`tension of 30 dynes per em.
`Metabolic Inertness
`Used as food and drug additives, they are not
`metabolized and therefore do not add calories in
`the diet.
`Enzyme Resistance
`They are comparatively enzyme-resistant, provid(cid:173)
`ing excellent viscosity stability during long-term
`storage.
`
`Low Ash
`The non-ionic structures leave low residual ash, a
`benefit in refractory uses.
`
`@1974, 1978, The Dow Chemical Company
`
`Low Taste and Odor
`They are therefore excellent in use in food and
`pharmaceutical applications.
`
`pH Stability
`They have a useful and wide pH range of 3.0-11.0.
`
`Water Retention
`They retain water in the presence of water-ab(cid:173)
`sorbing porous surfaces such as wallboard, ce(cid:173)
`ment blocks, bricks, etc.
`
`METHOCEL cellulose ether products also have a number
`of noteworthy performance properties making them
`useful as:
`
`Thickeners
`They thicken both aqueous and non-aqueous sys(cid:173)
`tems. The degree of thickening is related to spe(cid:173)
`cific product viscosity and chemical type.
`
`Film Formers
`They form clear, tough, flexible films that are
`excellent barriers to oils and greases.
`
`Binders
`They have excellent functionality as binders for
`pigments, tobacco products, paper. . .
`in both
`coating and adhesive end-uses.
`
`Lubricants
`They reduce friction in rubber, asbestos cement,
`and ceramic extrusions and improve pumpability
`of concrete slurries.
`
`Suspending Aids
`They prevent solid particles from settling and thus
`inhibit the formation of sediments.
`
`Protective Colloids
`They prevent droplets and particles from coalesc(cid:173)
`ing or agglomerating.
`
`Emulsifiers
`They stabilize emulsions both by reducing surface
`and interfacial tension, and by thickening the
`water phase.
`
`-Continued
`
`NOTICE- This information is presented in good faith, but no warranty, express or implied, is given nor is freedom from any patent
`owned by The Dow Chemical Company or by others to be inferred. Inasmuch as any assistance furnished by Dow with reference
`to the proper use and disposal of its products is provided without charge, Dow assumes no obligation or liability therefor.
`
`THE DOW CHEMICAL COMPANY • DESIGNED PRODUCTS DEPARTMENT • MIDLAND MICHIGAN 48640
`
`Printed in U.S.A.
`
`~
`
`-L..--:--1 1""-----··
`
`•
`
`"T"' - ~ --- I
`
`-.1. "T"I...- - -
`
`Mylan v. Qualicaps, IPR2017-00203
`QUALICAPS EX. 2017 - 14/86
`
`

`

`~ • 2
`
`Application and formulation information is available in
`the following reports. Please request from your Dow
`salesman those in which you are interested.
`
`Application Literature
`
`Title or Description
`Form No.
`192-347
`METHOCEL In Bakery Goods .............................................. .
`192-348
`METHOCEL In Food Dressings ............................................. .
`192-349
`METHOCEL In Breaded Foods ............................................. .
`192-350
`METHOCEL In Low Cal Salad Dressing ..................................... .
`Why I How To Specify METHOCEL ............... ... ... .. .. .. ............... .
`192-400
`192-405
`METHOCEL In Fried Foods ................................................. .
`192-406
`METHOCEL Thickeners in Latex Paint ...................................... .
`METHOCEL In Paint Removers ............................................. .
`192-407
`192-408
`METHOCEL In PVC Processing ............................................. .
`192-409
`METHOCEL In Dietetic Foods .............................................. .
`METHOCEL, Aqueous Systems for Tablet Coating ............................ 192-622-77
`METHOCEL In Ceramic Mixes ............................................... 192-626-78
`METHOCEL In Detergent Additives .......................................... 192-639-78
`METHOCEL In Food Products ............................................... 192-642-78
`METHOCEL In Cosmetics and Toiletries ...................................... 192-671-78
`METHOCEL In Drywall ..................................................... 192-672-78
`
`Application literature is regularly updated and new pieces are regularly produced. Please have your Dow
`salesman keep your literature on METHOCEL current.
`
`Mylan v. Qualicaps, IPR2017-00203
`QUALICAPS EX. 2017 - 15/86
`
`

`

`PROPERTIES AND APPLICATIONS
`APPLICATIONS
`Increasing numbers of manufacturers use the favora(cid:173)
`ble properties of METHOCEL cellulose ether products
`to improve many commercial products. Special bul(cid:173)
`letins on many of these uses are available.
`
`METHOCEL cellulose ether products are used in:
`
`Adhesives
`For their innate adhesive properties and to provide
`thickening to adhesive formulations.
`
`Agricultural Chemicals
`As spray adherents, fungicide stickers, protective
`films, and dispersing agents for wettable
`powders.
`
`Ceramics
`To provide green strength, water retention, and
`lubricity in refractory mortars and cements, and in
`glaze slips. They leave minimal ash when fired.
`
`Chemical Specialties
`As thickeners, suspending agents, binders, film
`formers, and emulsion stabilizers in chemical(cid:173)
`manufacturing and processing operations.
`
`Construction Products
`To provide water retention and to add workability
`to cement and gypsum formulations such as dry(cid:173)
`wall joint cements, cement plasters and stucco,
`tile mortars and grouts, and portland cement
`mortars.
`
`Cosmetics
`To provide viscosity control, emulsification and
`stabilization, lubricity and feel. clarity, foam sta(cid:173)
`bility, and surfactant compatibility in lotions, hand
`and face creams, hair dressings, deodorants, de(cid:173)
`pilatory creams, shampoos. and toothpastes.
`
`Foods
`As thickeners, binders, emulsifiers, stabilizers, and
`colloidal suspending agents in a variety of prod(cid:173)
`ucts, including salad dressings, fruit pie fillings,
`baked goods, dietetic foods, breading batters,
`
`@1974, The Dow Chemical Company
`
`fried foods, milk shake drinks, and convenience
`snacks. The thermal gelation property can be used
`to advantage in many of these applications.
`Leather
`The thermal gelation property is utilized in pasting
`adhesives during the drying operation, and the
`thickening property is an advantage in leather
`finishing.
`
`Paint
`As protective colloids, thickeners, and pigment(cid:173)
`suspension aids for latex paints. The products
`offer viscosity stability, wet-edge retention, ease
`and flexibility of incorporation, and also contribute
`to paint film integrity.
`
`Paint Removers
`Where the unique combination of organic and
`water solubility allows use as a thickener for
`scrape-off and flush-off paint removers.
`
`Paper Products
`As film formers useful for greaseproof coatings,
`adhesives, surface sizings, and release coatings.
`
`Pharmaceuticals
`As binders, granulating agents, and film coatings
`for tablets; as bulk laxatives; as film formers for
`burn therapy; as stabilizers for ointments and
`creams; as thickeners for lotions and jellies; and
`as troche bases.
`
`Polyvinyl Chloride
`As protective colloids in suspension polymeriza(cid:173)
`tions to provide improved resin porosity, higher
`plasticizer absorption rates, and control of resin
`particle-size distribution.
`
`Plywood
`To control viscosity in glues used for lamination.
`
`Printing Inks
`As thickeners and suspending agents for water(cid:173)
`base inks.
`
`Resins
`As mold-release agents for fiber-reinforced plas(cid:173)
`tics and as thickeners and stabilizers for water(cid:173)
`based coating emulsions.
`
`-Continued
`
`NOTICE- This information is presented in good faith , but no warranty, express or implied, is given nor Is freedom from any patent
`owned by The Dow Chemical Company or by others to be inferred. Inasmuch as any assistance furnished by Dow wtth reference
`to the proper use and disposal of its products is provided without charge, Dow assumes no obligation or liability therefor.
`
`THE DOW CHEMICAL COMPANY • DESIGNED PRODUCTS DEPARTMENT • MIDLAND MICHIGAN 48640
`
`Printed in U.S.A.
`
`~
`
`l=nrm Nn 1Q?-fl7fl-78
`
`Mylan v. Qualicaps, IPR2017-00203
`QUALICAPS EX. 2017 - 16/86
`
`

`

`2 • 4
`
`PROPERTIES AND APPLICATIONS
`
`Rubber
`As mold-release agents and as stabilizers and
`thickeners in rubber latexes.
`
`Textiles
`As binders in textile printing pastes, in latex coat(cid:173)
`ings, and as sizing agents. As thickeners for carpet
`backsizing formulations, and for providing faster
`drying speeds, wider effective coating viscosity
`range, more uniform coating, higher holdout, and
`quick grab.
`
`Tobacco
`As binders and film formers for reconstituted
`tobacco sheets, and as adhesives in cigar and
`cigarette fabrication.
`
`Choice of the specific METHOCEL cellulose ether
`product will vary in each industry according to the
`application. The range of METHOCEL cellulose ether
`products is deliberately designed to accommodate the
`widest possible range of formulating and processing
`equipment, and of application environments.
`
`Mylan v. Qualicaps, IPR2017-00203
`QUALICAPS EX. 2017 - 17/86
`
`

`

`PROPERTIES AND APPLICATIONS
`APPLICATIONS BY PRODUCTS
`
`The types of METHOCEL cellulose ether products used
`commercially in different applications are listed in the
`following table. For specific formulation assistance or
`for further information on making a choice of product
`best suited for your specific need, contact the De(cid:173)
`signed Products group in your local DOW Sales Office.
`
`The designations for METHOCEL cellulose ether prod-
`
`ucts are intended to simplify customers' understanding
`of their purchases. The prefix letter designates chemi(cid:173)
`cal type. The numeral denotes the centipoise viscosity,
`with a C and an M indicating the viscosity in hundreds
`and thousands, respectively. Suffix designation of S
`denotes surface-treated powder. If a product has no
`such suffix designation, it is available only in non
`surface-treated powder form.
`
`APPLICATION
`
`METHOCEL
`A
`
`METHOCEL
`E
`
`METHOCEL
`F
`
`METHOCEL
`J
`
`METHOCEL
`K
`
`ADHESIVES
`Leather Pasting
`Temporary Binding Agent
`for Glass Fibers
`Thickener in Phenol-
`Formaldehyde Adhesives
`
`Stationery Adhesives
`
`Wallpaper
`
`General Adhesives
`
`AGRICULTURE
`Dispersing Agent For
`Wetting Powders
`Dust Stickers
`Seed Stickers
`Spray Drift Control
`Spray Stickers
`Weed Killers
`Suspending Aids
`
`A4M
`
`A15
`
`A4M
`
`A4C
`
`A4M
`
`A4M
`
`A15
`
`A15
`A15
`
`A15C
`
`F4M
`228
`
`F4M
`
`F50
`F4M
`
`F4M
`
`E50
`
`@1974, 1978, The Dow Chemical Company
`
`K15M
`
`K4M
`K4MDGS
`
`J75MS
`
`J5MS-J75M
`
`K15M
`
`-Continued
`
`NOTICE- This information is presented in good faith . but no warranty, express or implied. is given nor is freedom from any patent
`owned by The Dow Chemical Company or by others to be inferred. Inasmuch as any assistance furnished by Dow with reference
`to the proper use and disposal of its products is provided without charge, Dow assumes no obligation or liability therefor.
`
`THE DOW CHEMICAL COMPANY • DESIGNED PRODUCTS DEPARTMENT • MIDLAND MICHIGAN 48640
`
`Printed in U.S.A.
`
`~
`
`• Trademark of The Dow Chemical Comoanv
`
`Form No. 192-677-78
`
`Mylan v. Qualicaps, IPR2017-00203
`QUALICAPS EX. 2017 - 18/86
`
`

`

`2 • 6
`
`PROPERTIES AND APPLICATIONS
`
`APPLICATION
`
`METHOCEL
`A
`
`METHOCEL
`E
`
`METHOCEL
`F
`
`METHOCEL
`J
`
`METHOCEL
`K
`
`ASPHALT
`Asphalt Emulsion
`
`Release Coating
`
`CAULKING COMPOUNDS
`
`CERAMICS
`Refractory Mortars
`Glaze Slips
`Hi-temp Glaze Slips
`
`Porcelain Enamels
`Cements
`Tile Mortars
`Plastic Mixes
`
`CHEMICAL SPECIALTIES
`Aerosols
`Cleaning and Polishing Compounds
`Insecticides
`Sanitizers
`
`CONSTRUCTION PRODUCTS
`Dry Wall Joint Cements
`Masonry Mortars
`Pumpability Aids
`Release Coatings
`Stuccos
`
`Tile Grouts and Adhesives
`
`A15
`
`A4M
`A15
`A4M
`
`A15
`A4M
`A4M
`A4M
`
`A15
`A4M
`A15
`A4M
`
`A15
`
`J12MS
`J75MS
`
`K4M
`
`K35
`
`E50
`
`F4M
`
`J5MS
`J12MS
`
`K4M
`K15M
`
`E50
`
`F4M
`
`F4M
`
`F4M
`F4M
`F4M
`
`F50
`
`F4M
`
`F4M
`F4M
`
`F4M
`
`F4M
`
`J5MS
`
`K4M
`
`J5MS
`
`K4M
`
`•
`
`J5MS
`
`K4M
`
`J5MS-J75MS
`J5MS-J12MS
`J75MS
`
`K4M-K15M
`K4M-K15M
`K15M
`
`J5MS-J12MS
`
`K4M-K15M
`
`J5MS
`J12MS
`856
`
`K4M
`K15M
`
`1e
`
`-Continued
`
`Mylan v. Qualicaps, IPR2017-00203
`QUALICAPS EX. 2017 - 19/86
`
`

`

`PROPERTIES AND APPLICATIONS
`
`APPLICATION
`
`METHOCEL
`A
`
`METHOCEL
`E
`
`METHOCEL
`F
`
`METHOCEL
`J
`
`METHOCEL
`K
`
`COSMETICS
`Creams and Lotions
`
`Deodorants
`
`Hair Dressings
`
`Shampoos
`
`Tooth Pastes
`
`FOODS
`Baked Goods
`Breading Batters
`Dietetic Foods
`Milk Shake Drinks
`Pie Fillings
`
`Salad Dressings
`Snack Foods
`Whipped Toppings
`
`LATEXES
`Creaming of Natural
`Rubbers
`
`Protective Colloids
`
`Thickeners
`
`LEATHER
`Finishings
`
`Pasting Adhesives
`
`E4M
`
`E4M
`
`E50, E4M
`
`1
`E50
`
`1
`E15
`
`E50
`
`F4M
`
`F4M
`F50
`1
`F50
`F4M
`
`1
`F50
`
`F4M
`
`F50
`
`228
`
`F4M
`
`A4M
`A15
`1
`A15
`A4M
`
`A4M
`1
`
`A4M
`
`A15
`
`A4M
`
`A4M
`
`PAINTS
`Acrylics, Polyvinyl Acetate,
`Styrene-Butadiene
`
`1Viscosities dependent on application. Consult Dow.
`
`1
`
`1
`
`1
`
`1
`
`K4M
`K15M
`
`K4M,K15M
`
`K4M
`K100
`1
`
`K4M
`
`K4M
`1
`K100
`
`K4M
`K15M
`K100