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`(JP). ~’~ IE (ARIKA, Tadashi) [JP/JP]; ~565-0802
`~ffff~ [] i~i~[Ji~8-T201 Osaka (JP).
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`(21) I~ [~ hq. J~-:
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`;gg =--~ ~t-t- (KAKEN PHARMACEUTICAL CO., LTD.)
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`(54) Title: METHOD FOR DETECTING PATHOGENIC MICROORGANISM AND ANTIMICROBIAL AGENT, METHOD
`FOR EVALUATING THE DRUG EFFECT OF ANTIMICROBIAL AGENT, AND ANTIMICROBIAL AGENTS
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`(57) Abstract: A novel method for evaluating the drug effect of an antimicrobial agent which comprises eliminating the antimicro-
`bial agent remaining in a biological sample, etc. to thereby accurately evaluate the drug effect of the antimierobiai agent without
`being affected by the remaining antimicrobial agent. Remedies for nail mycosis which can be obtained by the drug effect evaluation
`-- method as described above.
`
`(57) ~,~J:
`
`ACRUX DDS PTY LTD. et al.
`EXHIBIT 1010
`IPR Petition for
`U.S. Patent No. 7,214,506
`
`1 of 42
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`7+ [] 7 / ~ X (Trichophyton mentagrophytes) i ~, ~ !
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`;~3 ;~t ~- I~ ~ (Antimicrobial Agents and Chemotherapy,
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`36:2523--2525, 1992, 39:2353--2355, 1995)o ~_J, ~ ,
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`Conference on Antimicrobia] Agents and Chemotherapy,
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`New Or|eans, Louisiana, 1996, Abstr. F80)o
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`4 of 42
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`Onychomycoses, Drugs, 58’ 283-296 1999)
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