`(cid:36)(cid:86)(cid:86)(cid:68)(cid:92)(cid:3)(cid:86)(cid:87)(cid:85)(cid:68)(cid:76)(cid:81)(cid:29)(cid:3)(cid:55)(cid:17)(cid:3)(cid:80)(cid:72)(cid:81)(cid:87)(cid:68)(cid:74)(cid:85)(cid:82)(cid:83)(cid:75)(cid:92)(cid:87)(cid:72)(cid:86)(cid:3)(cid:54)(cid:48) (cid:16)(cid:20)(cid:20)(cid:19)(cid:31)(cid:31)(cid:31)(cid:31)
`Infection: 10^7
`fungi were
`inoculated to
`create an
`injection for 60
`days (bandaged
`for two weeks)
`(cid:20)(cid:20)(cid:19)(cid:31)(cid:31)(cid:31)(cid:31)(cid:31)(cid:31)(cid:31)(cid:34)(cid:34)(cid:31)(cid:31)(cid:31)
`Animals: 4-week old male guinea pig dialysis 14 days 2
`Infection control group ° C 7 days
`Identification:
`control
`H-R
`H-L
`Ne-R
`Ne-L
`B-R
`B-L
`T-R
`T-L
`N-R
`N-L
`
`x1
`120
`Unmeasurable CFU
`191
`Unmeasurable CFU
`132
`620
`585
`758
`161
`580
`
`Dilution group ° C 7 days
`x10
`x100
`8
`209
`27
`252
`14
`75
`71
`58
`24
`116
`
`M ean
`SD
`
`x1
`
`1% Base control group/foot
`Identification: Base
`H-R
`H-L
`Ne-R
`Ne-L
`B-R
`B-L
`T-R
`T-L
`
`858
`95
`38
`181
`811
`285
`34
`119
`
`x10
`
`117
`13
`0
`27
`90
`49
`3
`6
`
`x100
`
`11
`1
`0
`3
`12
`5
`0
`2
`
`(cid:55)(cid:85)(cid:72)(cid:68)(cid:87)(cid:80)(cid:72)(cid:81)(cid:87)(cid:29)(cid:3)(cid:19)(cid:17)(cid:20)(cid:3)(cid:80)(cid:79)(cid:3)(cid:90)(cid:68)(cid:86)(cid:3)(cid:68)(cid:83)(cid:83)(cid:79)(cid:76)(cid:72)(cid:71)(cid:3)(cid:71)(cid:68)(cid:76)(cid:79)(cid:92)(cid:3)(cid:73)(cid:82)(cid:85)(cid:3)(cid:20)(cid:24)(cid:3)(cid:71)(cid:68)(cid:92)(cid:86)(cid:3)(cid:86)(cid:3)(cid:54)(cid:48) (cid:16)(cid:20)(cid:20)(cid:19)(cid:31)(cid:31)(cid:31)
`
`(cid:40)(cid:73)(cid:73)(cid:72)(cid:70)(cid:87)(cid:29)(cid:3)(cid:54)(cid:68)(cid:70)(cid:85)(cid:76)(cid:73)(cid:76)(cid:70)(cid:72)(cid:71)(cid:87)(cid:90)(cid:82)(cid:3)(cid:71)(cid:68)(cid:92)(cid:86)(cid:3)(cid:68)(cid:73)(cid:87)(cid:72)(cid:85)(cid:3)(cid:87)(cid:75)(cid:72)(cid:3)(cid:73)(cid:76)(cid:81)(cid:68)(cid:79)(cid:3)(cid:87)(cid:85)(cid:72)(cid:68)(cid:87)(cid:80)(cid:72)(cid:81)(cid:87)(cid:15)(cid:3)(cid:71)(cid:76)(cid:68)(cid:79)(cid:92)(cid:86)(cid:76)(cid:86)(cid:3)(cid:20)(cid:23)(cid:3)(cid:71)(cid:68)(cid:92)(cid:86)(cid:3)(cid:21)(cid:3)(cid:90)(cid:72)(cid:72)(cid:78)(cid:86)(cid:3)(cid:69)(cid:68)(cid:81)(cid:71)(cid:68)(cid:74)(cid:72)(cid:71)(cid:3)(cid:20)(cid:20)(cid:19)(cid:31)(cid:31)(cid:31)(cid:31)(cid:31)(cid:31)(cid:31)
`Culture: 7 days at 30° C, guinea pig dialysis 1
`
`0
`30
`3
`33
`2 T-L
`5
`6
`15
`0
`21
`
`No. of fungi in skin ° C
`7 days
`(CFU/foot)
`600
`12725
`955
`14550
`3750
`3550
`2900
`805
`5800
`4563.5
`4858.063941
`Fungi in skin control
`group/f
`(CFU/foot)
`
`5070
`475
`190
`905
`4500
`1937.5
`170
`595
`
`No. of fungi in skin ° C
`7 days
`(Log CFU/foot)
`2.778
`4.105
`2.980
`4.163
`3.574
`3.550
`3.462
`2.906
`3.763
`
`#NUM !
`
`#NUM !
`#NUM !
`Fungi in skin control
`group/f
`(Log CFU/foot)
`3.705
`2.677
`2.279
`2.957
`3.653
`3.287
`2.230
`2.775
`
`
`
`N-R
`N-L
`
`x1
`
`1% KP-103 treatment group
`Identification: K
`H-R
`H-L
`Ne-R
`Ne-L
`B-R
`B-L
`T-R
`T-L
`N-R
`N-L
`
`x1
`
`1% LCZ Treatment group
`Identification: L
`H-R
`H-L
`Ne-R
`Ne-L
`B-R
`B-L
`T-R
`T-L
`N-R
`N-L
`
`942
`105
`
`259
`88
`156
`7
`51
`37
`781
`597
`708
`87
`
`89
`35
`22
`36
`4
`54
`27
`83
`65
`25
`
`x10
`
`x10
`
`130
`10
`
`35
`25
`16
`1
`4
`0
`109
`85
`97
`13
`
`14
`6
`0
`1
`1
`4
`1
`10
`8
`3
`
`19
`1
`
`3
`3
`3
`0
`1
`0
`10
`4
`1
`2
`
`4
`0
`1
`0
`0
`0
`0
`1
`0
`0
`
`M ean
`SD
`
`x100
`
`M ean
`SD
`
`x100
`
`M ean
`SD
`
`6500
`525
`2086.75
`2239.483213
`
`3.813
`2.720
`3.009559652
`0.549009096
`
`Fungi in skin-103
`treatment
`(CFU/foot)
`
`1295
`440
`780
`35
`255
`185
`5450
`4250
`4850
`435
`1797.5
`2043.187767
`Fungi in skin Z
`treatment group
`(CFU/foot)
`445
`175
`110
`180
`35
`270
`135
`415
`325
`125
`221.5
`129.7507225
`
`Fungi in skin-103
`treatment
`(Log CFU/foot)
`3.112
`2.643
`2.892
`1.544
`2.407
`2.267
`3.736
`3.628
`3.686
`2.638
`2.855461343
`0.670038337
`Fungi in skin Z treatment
`group
`(Log CFU/foot)
`2.648
`2.243
`2.041
`2.255
`1.544
`2.431
`2.130
`2.618
`2.512
`2.097
`2.25206703
`0.312293586
`
`
`
`x1
`
`1% TBF treatment group
`Identification: T
`H-R
`H-L
`Ne-R
`Ne-L
`B-R
`B-L
`T-R
`T-L
`N-R
`N-L
`
`100
`12
`1
`25
`216
`7
`362
`379
`32
`9
`
`x10
`
`10
`0
`0
`1
`28
`1
`53
`44
`1
`2
`
`x100
`
`M ean
`SD
`
`2
`0
`0
`1
`1
`0
`4
`3
`1
`0
`
`Fungi in skin F
`treatment group
`(CFU/foot)
`500
`60
`5
`125
`1080
`35
`2650
`2200
`160
`45
`686
`928.4955573
`
`Fungi in skin F treatment
`group
`(Log CFU/foot)
`2.699
`1.778
`0.699
`2.097
`3.033
`1.544
`3.423
`3.342
`2.204
`1.653
`2.247349412
`0.830272354
`
`
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