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`/ November13, 1996
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`Press Release
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`Antifungal Agent "Mentax"(Butenafine HCl) Approved by FDA
`
`November13, 1996
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`PenedermInc. ( head office: California, U.S.), the licensee of antifungal agent Mentax ( generic name: butenafine HCl) in the US, informed KAKEN
`PHARMACEUTICALon October18 that the drug has obtained FDA approval asan ethical drug.
`
`KAKEN concluded a license agreement with Penederm in 1992. The drug was approved as a cream for treating athlete's foot.
`
`Penederm and Schering-Plough Healthcare Products ( head office: New Jersey, U.S. ) will co-market the productin the U.S. under the current
`trademark Mentax starting in January 1997,
`:
`
`KAKEN hasalready licensed Mentax in almost all countries. KAKEN expects that the FDA's approval will give momentum to licensing,
`development and governmental approval of Mentaxin Asian countries.
`
`1.
`
`Information on Mentax
`
`Mentax ( generic name: butenafine hydrochloride ) is a new antifungal agent with a benzylamine structure. Unlike imidazole, Mentaxinterferes
`with the synthesis of ergosterole in cell membrane components. Becauseit absorbs through both the epidermis and hair follicles it penetrates the
`stratum corneum and the deepparts of the skin, thus exhibiting a very powerful anti-fungal activity against Trichophyton and other superficial
`fungi. Another advantageto this medicationis that it only needs to be applied once a day. Mentax has been sold in Japanin liquid and cream forms
`since April 1992.
`
`Brand name:
`Generic name :
`Indication :
`
`Mentax
`butenafine hydrachloride
`tinea pedis ( athlete's foot )
`
`2.
`
`Information on Penederm
`
`Penederm, established in 1987, is specialized in the development and manufacturing of topical preparations. It has unique proprietary ( drug
`delivery system ) technology and specializes in the area of dermatology.
`
`Company name :
`Headoffice :
`President and CEO :
`
`Penederm Inc.
`Foster.City, California, USA
`Lloyd H. Malchow
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`3.
`
`Information on Schering-Plough Healthcare Products,Inc.
`This company is Schering-Plough's OTC and personal care productsdivision. Schering-Plough is engaged in the development, manufacture and
`marketing of drugs and healthcare products ona global basis.
`
`Company Name :
`Head office :
`President:
`
`Schering-Plough Healthcare Products,Inc.
`Liberty Corner, New Jersey, USA
`Donald Conklin
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`Back to list
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`
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`http://www.kaken.co.jp/english/en_release/en_nr19961113.html
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`12/5/2017
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`Page 1 of 1
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`Kaken Exhibit 2200
`Acrux v. Kaken
`
`IPR2017-00190
`
`
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