4/4/2017
`
`TAVR by Edwards
`
`MENU
`
`(https://www.tavrbyedwards.com/)
`
`TAVR with the Edwards SAPIEN 3 valve
`
`Better Than Surgery
`
`for Intermediate-Risk Patients*
`*The PARTNER II trial intermediate-risk cohort, VI population (n=2,005); the di韚erence in the primary endpoint (composite of all-cause mortality, all stroke,
`and ≥ moderate aortic regurgitation at one year) event rate between TAVR with the SAPIEN 3 valve and surgery appeared to be clinically signiퟌcant.
`
`Ask your doctor about transcatheter aortic valve replacement (TAVR) with the
`SAPIEN 3 valve today.
`
`IMPORTANT RISK INFORMATION FOR PATIENTS
`
`O U R L A T E S T V A L V E
`
`MENU
`
`(https://www.tavrbyedwards.com/)
`
`OUTER SEALING SKIRT
`Virtually eliminates moderate to severe leakage
`around the valve*
`*PARTNER II trial high-risk TF SAPIEN 3 valve cohort 30-day results
`
`APPROVED FOR INTERMEDIATE-RISK PATIENTS
`The SAPIEN 3 valve builds upon research and development we have
`conducted over several decades.
`https://tavrbyedwards.com/ourlatestheartvalvesapien3
`
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`TAVR by Edwards
`
`MENU
`
`(https://www.tavrbyedwards.com/)
`
`TAVR with the Edwards SAPIEN 3 valve
`
`Better Than Surgery
`
`for Intermediate-Risk Patients*
`*The PARTNER II trial intermediate-risk cohort, VI population (n=2,005); the di韚erence in the primary endpoint (composite of all-cause mortality, all stroke,
`and ≥ moderate aortic regurgitation at one year) event rate between TAVR with the SAPIEN 3 valve and surgery appeared to be clinically signiퟌcant.
`
`Ask your doctor about transcatheter aortic valve replacement (TAVR) with the
`SAPIEN 3 valve today.
`
`IMPORTANT RISK INFORMATION FOR PATIENTS
`
`O U R L A T E S T V A L V E
`
`MENU
`
`(https://www.tavrbyedwards.com/)
`
`OUTER SEALING SKIRT
`Virtually eliminates moderate to severe leakage
`around the valve*
`*PARTNER II trial high-risk TF SAPIEN 3 valve cohort 30-day results
`
`APPROVED FOR INTERMEDIATE-RISK PATIENTS
`The SAPIEN 3 valve builds upon research and development we have
`conducted over several decades.
`https://tavrbyedwards.com/ourlatestheartvalvesapien3
`
`1/11
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`TAVR by Edwards
`conducted over several decades.
`
`As the leader in heart valve science and innovation, we have purposefully designed our transcatheter heart valves with the same proven materials and features as
`our leading surgical valves.
`To request a free information kit, click here (/requests).
`
`(https://edwardspatientconnect.com/Answers/TBE_Tout_LatestValve)
`
`IMPORTANT RISK INFORMATION FOR PATIENTS
`
`(https://www.tavrbyedwards.com/)
`
`MENU
`
`https://tavrbyedwards.com/ourlatestheartvalvesapien3
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`TAVR by Edwards
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`IMPORTANT RISK INFORMATION FOR PATIENTS
`
`MENU
`
`(https://www.tavrbyedwards.com/)
`T H E C L I N I C A L D I F F E R E N C E
`
` (assets/downloads/SAPIEN_3_Patient_Brochure.pdf)
`
`(assets/downloads/PARTNER_II_Trial_Clinical_Events_Summary.pdf)
`Transcatheter aortic valve replacement
`(TAVR) with the Edwards SAPIEN 3 valve
`demonstrated 75% lower rates of 30-
`day all-cause mortality and disabling
`stroke compared to surgery in
`intermediate-risk patients.
`†
`
`
`
`†The PARTNER II trial intermediate-risk cohort 30-day unadjusted clinical event rates for TAVR with the SAPIEN 3 valve, as treated population (n=1,077).
`‡The PARTNER II trial intermediate-risk cohort unadjusted clinical event rates, AT population.
`
`https://tavrbyedwards.com/ourlatestheartvalvesapien3
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`TAVR by Edwards
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`IMPORTANT RISK INFORMATION FOR PATIENTS
`
`Y O U R P R O C E D U R E
`
`MENU
`
`At this moment, thousands of our heart valves are
`(https://www.tavrbyedwards.com/)
`HELPING PEOPLE LIVE THEIR LIVES
`Around the world, TAVR has helped people su韚ering from severe aortic stenosis. If you are researching treatment
`options for severe aortic stenosis or will be having the TAVR procedure, we are here to help you.
`
`(/requests)
`
`(https://edwardspatientconnect.com/Answers/TBE_Tout_HelpingPeople)
`
`IMPORTANT RISK INFORMATION FOR PATIENTS
`
`(https://www.tavrbyedwards.com/)
`
`MENU
`
`https://tavrbyedwards.com/ourlatestheartvalvesapien3
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`TAVR by Edwards
`
`Beneퟌts of TAVR:
`
`Relief of symptoms, in some cases immediately
`Reduction in pain and anxiety
`Improved heart function
`May shorten recovery time to resume everyday activities
`
`Quality of Life Improvement:
`
`TAVR has shown improvement in a patient's health as early as 30 days after their procedure. Patients
`reported improvements in quality of life, including:
`Ability to take care of themselves
`Ability to participate in everyday activities
`The most serious RISKS of the TAVR procedure are:
`death, major stroke, major vascular
`complications, and life threatening bleeding
`event.*
`
`It is important to talk with your doctor about the exact procedure you will have, the product you will receive, and the
`literature on clinical studies using that product.
`
`*See the Edwards SAPIEN 3 valve patient brochure (assets/downloads/SAPIEN_3_Patient_Brochure.pdf) for more
`detailed information on these and other risks.
`
`(https://edwardspatientconnect.com/Answers/TBE_Tout_TAVR_Beneퟌts)
`
`IMPORTANT RISK INFORMATION FOR PATIENTS
`
`(https://www.tavrbyedwards.com/)
`
`MENU
`
`Transfemoral Approach
`
`The most common way to perform TAVR is through the transfemoral approach. An incision will be made in
`your leg, where your doctor will insert a short, hollow tube called a sheath.
`
`The Edwards SAPIEN 3 transcatheter heart valve will be placed on the delivery system and compressed on a
`balloon. The delivery system carrying the valve will be placed through the sheath and delivered to your aortic
`valve. The balloon of the delivery system will be in埌ated, expanding the new valve within your diseased valve.
`
`The valve will push the lea埌ets of your diseased valve aside, securing itself into place. The new valve should
`begin working immediately.
`https://tavrbyedwards.com/ourlatestheartvalvesapien3
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`begin working immediately.
`
`TAVR by Edwards
`
`TAVR is a less invasive procedure available
`for people who need their aortic valve
`replaced and are at intermediate or greater
`risk for open heart surgery.
`
`To ퟌnd out if TAVR is right for you, please talk with your doctor and locate a TAVR Center near you.
`
`(https://edwardspatientconnect.com/Answers/TBE_Tout_TF_Approach)
`
`IMPORTANT RISK INFORMATION FOR PATIENTS
`
`MENU
`This guide will help you ask the right questions during your next
`doctor's visit.
`(https://www.tavrbyedwards.com/)
`
`(assets/downloads/Doctor_Discussion_Guide.pdf)
`
`(https://edwardspatientconnect.com/Answers/TBE_Tout_YourGuide)
`
`https://tavrbyedwards.com/ourlatestheartvalvesapien3
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`TAVR by Edwards
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`IMPORTANT RISK INFORMATION FOR PATIENTS
`
`MENU
`These educational materials will help you learn more about
`severe aortic stenosis and TAVR.
`(https://www.tavrbyedwards.com/)
`
`(/requests)
`
`IMPORTANT RISK INFORMATION FOR PATIENTS
`
`https://tavrbyedwards.com/ourlatestheartvalvesapien3
`
`7/11
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`TAVR by Edwards
`
`
`
`(https://www.tavrbyedwards.com/)
`
`IMPORTANT RISK INFORMATION FOR PATIENTS
`
`(https://www.tavrbyedwards.com/)
`
`MENU
`
`https://tavrbyedwards.com/ourlatestheartvalvesapien3
`
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`TAVR by Edwards
`
`IMPORTANT RISK INFORMATION FOR PATIENTS
`
`(https://www.tavrbyedwards.com/)
`
`MENU
`
`MORE THAN
`
`150,000
`
`PATIENTS
`treated with Edwards SAPIEN
`transcatheter heart valves
`WORLDWIDE*
`
`*Includes all valves from the Edwards SAPIEN transcatheter
`heart valve platform.
`
`https://tavrbyedwards.com/ourlatestheartvalvesapien3
`
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`TAVR by Edwards
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`IMPORTANT RISK INFORMATION FOR PATIENTS
`
`(https://www.tavrbyedwards.com/)
`
`MENU
`
`https://tavrbyedwards.com/ourlatestheartvalvesapien3
`
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`TAVR by Edwards
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`IMPORTANT RISK INFORMATION FOR PATIENTS
`
`(https://www.tavrbyedwards.com/)
`
`MENU
`
`IMPORTANT RISK INFORMATION FOR PATIENTS
`
`https://tavrbyedwards.com/ourlatestheartvalvesapien3
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`
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