r-----
`!
`
`LEU(99)
`
`SER( 96)
`GL Y(.99}
`Gl Y(99}
`
`PR0(.96)
`GLY
`
`SERt 95l
`lEU( 98)
`A~G\ 961
`
`SEA( 97)
`
`f PHE( 97)
`
`••P
`ala GUJ GLU GLU GLU Gl
`GLU GLU GLU GLU GLU GLU GLU GLU GLU GL.U GLU GLU GLU GLU GLU
`VAL
`VAL
`VA<-
`VAl.
`VAl.
`VAl.
`VA.l
`VA.l
`VA.l
`VAL
`VAL W\L
`VAL
`VAL
`VA<-
`VAL
`VAl.
`VA'-
`VA'-
`VAL
`VAL
`VI
`GLN GLN GLN GLN GLN GLN GLN GLN GLN GLN GLN GLN GLN GLN GLN GlN GLN GLN GLN GLN GLN Gl
`LEU u
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LE:U
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`VAL
`VAL
`VAL
`VAL
`VAL
`leu
`leu
`leu
`VAL
`lou
`VAL
`VAL
`VAL
`VAL
`VAL
`VAL
`leu
`VAL VI
`VAL
`VAL
`VAL
`GLU GLU GLU GLU
`asp GLU GLU GLU GLU GLU GLU GLU GLU GLU GLU GLU GLU GLX GLU GLU GLX Gl
`SEA
`SEA
`SEA
`SEA SEA SEA
`SEA
`SEA SEA SEA
`SEA SEA SEA
`SEA
`SEA
`SEA SEA SEA
`SEA
`SE
`thr
`SEA
`GLY GLY GLY GLY GLY GLY GLY
`tRY GLY GLY GLY GLY GLY GLY GLY GLY GLY GLY GLY GLY GLY Gl
`GLY GLY GLY GLY GLY GLY GLY GLY GLY GLY GLY GLY GLY GLY GLY GLY GLY GLY GLY GLY GLY Gl
`GLY GLY GLY GLY GLY GLY GLY GLY GLY GLY
`GLY
`ala
`GLY GLY GLY GLY GLY GLY
`LEU
`LEU
`LE
`VAL
`ile
`VAL
`VAL
`VI
`lys
`GLN GLX Gl
`lys
`PRO PRO PF
`PAD PRO
`LY GLY GLY GLY GLY Gl
`LY GLY GLY GLY GLY
`ER SER
`SE
`SEA
`SEA
`SER
`LEU
`LEU
`LEU
`LEU
`LEU
`LE
`AAG ARG
`ARG ARG AF
`LEU
`LEU
`LEU
`LEU
`LEU
`LE
`SER SEA
`SEA
`gly
`SE
`SEA
`CYS CYS
`CYS
`CYS CYS C\
`ALA
`LA
`ALA
`ALA
`ALA Al
`ALA
`ALA
`LA
`ALA
`ALA
`ALA
`ALA Al
`SEA SEA SEA SEA
`SEA
`SEA SER
`SE
`
`L
`S'ER
`LEU
`
`GLN
`
`GLY
`
`SER
`LEU
`
`L
`
`L
`LY
`SEFI
`LEU
`
`~
`L
`R
`l
`l
`ER
`LEU
`
`U
`A
`S
`
`EU
`ER
`YS
`LA
`A
`LA
`SEA SEA SEA
`
`R
`LEU
`
`U
`
`AL
`AL
`SEA
`
`LEU
`
`LEU
`
`LEU
`
`U
`Ja
`S
`
`A
`SER
`
`SEA
`
`A
`
`LN
`
`SER
`oly
`
`SEA
`LEU
`
`EU
`
`..
`
`~
`GLN
`PRO
`GLY
`GL Y
`SEA
`LEU
`
`LN
`
`LY
`
`GL
`PR
`
`GL
`
`GL
`
`S
`LEU
`
`SER
`LEU
`
`SEA
`LEU
`
`R
`LEU
`
`SE
`LEU
`
`LEU
`LEU
`SEA
`SEA
`CYS CYS
`ALA
`ALA
`ALA
`ALA
`SEA
`SEA
`
`SER
`
`SEA
`
`SEA SEA
`
`SEA
`
`TYR
`
`S
`PHE
`
`G
`VAL
`
`:ER
`SEA
`
`"-
`H~
`TYR GLY ASN
`
`~~-~
`ASP
`
`x ·
`TYR
`THR
`
`P
`
`T
`P
`
`HFI
`H
`
`H
`H
`1-J
`E
`
`E
`R
`R
`E PH·
`
`E
`
`E
`e
`E
`
`-
`r
`THA ALA
`
`TYR
`
`.,
`PHE Pf
`
`Pf
`
`""SBDWif
`llf'" LEU
`ARG ARG RRO! ElMS f l fAAG
`i CYS
`I ALA( 95)
`GLY(95} JMMUN" UlSIDAl"' GLY GLY Gl
`l
`THA I EU
`::EREST: TAP
`
`L
`T
`R
`TYR
`SEA
`ASX
`ALA
`TVA
`ASN
`VAL MET MET MET
`TYR ASN
`VAL
`
`A
`
`VAL
`VAL
`VAL
`ARG ARG ARG AAG ARG
`GLN GLN GLN GLN GLN
`ALA
`ALA
`ALA
`ALA ALA
`PRO PRO
`PRO
`PRO PAD
`GLY GLY GLY GLY GLY
`
`VAL
`
`VAL
`ARG
`
`TAP
`TAP
`TAP
`VAL
`VAL
`VAL
`PRO
`ARG ARG
`GLN GLN GLY
`ALA
`ALA
`VAL
`PRO
`THR
`PRO
`GLY GLY GLY
`LYS
`LYS
`ARG
`GLY GLY GLY
`LEU
`LEU
`LEU
`GLU GLU
`TAP
`TAP
`VAL
`GLY
`
`A
`SEA
`ALA
`MET MET
`LYS
`SEA
`
`VAL
`
`TAP
`VAL
`
`TAP
`VAL
`
`PHE
`PHE
`THA
`THA
`PHE
`val
`pne
`SEA
`Tr.R
`ASX
`HIS
`TYR
`SEA
`VAL
`MET MET
`ASX
`
`SEA
`TAP
`VAL
`ARG
`GLN
`ALA
`PRO
`GLY
`LYS
`ALA
`LEU
`GLX
`TAP
`VAL
`SEA
`ALA
`ILE
`TYR
`
`Gl
`n
`A~
`Ml
`H
`
`TF
`LE
`AF
`Gl
`Gl
`PF
`Gl
`L\
`Gl
`PF
`Gl
`TF
`VI
`SE
`Tt
`ll
`n
`Tl
`
`I
`
`fTRP
`
`AAG{.95)
`iGLN~ 95)
`
`~~i$( 95)
`
`I LYS(.95)
`i LEU( 951
`
`ITP.P
`VAL( 95)
`l
`
`I
`I
`
`I
`iAAG
`lpHE
`tLE
`ISER
`
`At=IG
`
`'T'r"R
`
`1/ET( 951
`
`96)
`
`Fy
`
`LY
`
`VAt.
`
`"""
`
`1s0.
`
`120·
`
`AAG
`GLY
`
`'"'"'·
`
`sli!.
`
`"
`/>.
`~
`:t
`/>.
`e
`:t
`,.
`\..
`1.
`
`'i
`
`SEA
`ARG
`ASN
`ASP
`SEA
`LYS
`ASN
`THR
`LEU
`t•YR
`LEU
`GLN
`MET
`LEU
`SEA
`LEU
`lEU
`ARG
`GLU
`PRO ALA
`GLU GLU
`ASP
`ASP
`THA
`THR
`ALA
`ALA
`VAL
`VAL
`TYR
`TYR
`TYR
`TYR
`CYS CYS
`ALA ALA
`AAG ARG
`sEA
`VAL
`THR
`f?RO
`PRO
`VAL
`ALA SEA
`ALA
`LEU
`ALA
`VAL
`SEA
`ASP
`LEU GLY
`THA
`TAP
`LEU
`TYR
`TYR
`
`•
`
`PHE
`SI'R GLY
`ALA
`SEA
`VAL
`VAL
`TAP
`TAP
`GLY GLY
`GLN GLN
`liLY GLY
`m" THR
`LEW
`LEU
`VAl
`THR
`
`z0.
`
`\0·
`
`0.
`
`THA
`THF\
`THA
`ALA
`ALA
`ALA
`LEU
`VAL
`LEU
`TYR
`TYA
`TYR
`TYR
`TYR
`TYA
`CYS CYS CYS CYS,
`ALA
`ALA
`ALA
`ALA
`ARG ARG
`ARG
`LYS
`ASP GLY
`LEU
`SEA
`ALA
`LYS
`VAL GLY
`VAL
`PRO SfR
`THR
`TYA
`ALA
`ALA
`VAL
`VAL
`TYR
`ALA
`SEA
`TYA
`P«E
`PHE
`PRO
`THR
`PHE
`
`LEU
`GLU
`ALA
`ALA
`GLU GLU
`ASP
`ASP
`
`19&$ THR
`
`ALA
`VAL
`VAL
`TYR
`TYA
`TYR
`TYR
`CYS CYS
`ALA
`ALA
`AAG AAG
`PHE
`AAG
`GLN
`PRO
`PHE
`~AL
`GLN
`
`m TYA
`
`LEU
`GLN
`MET MET
`ASN ASN
`GLY
`ASN
`LEU
`LEU
`VAL
`GLY
`THA GLN ARG
`GLU
`VAL
`ALA PRO
`ALA
`GLU GLU GLU GLX
`ASP
`VAL
`ASX
`ASP
`THA
`THR SEA
`THR
`ALA
`ALA
`ALA
`ALA
`VAL
`VAL
`ILE
`VAL
`TYR
`TYR
`TYR
`TYR
`TYR
`CYS CYS CYS CYS
`ALA
`ALA ALA
`ALA
`ARG AAG ARG ARG
`THA
`ASP
`VAL
`ASX
`ALA ARG
`ARG
`VAL
`PRO
`VAL GLY
`LEU
`GLY
`SEA PRO GLY
`TYR
`PRO
`GLY
`THA
`SEA VAL
`TYR
`THR
`SEA ALA
`PHE
`SEA
`PRO CYS
`THR SEA
`VAL
`PHE
`
`PHE
`AJJ.!:t:J)Ef~RTMENT ~HEALTH
`'WII.II'IYLIIIIUIAII.I C!CD\III"'CC!
`VAL
`~~---- -~~V"1'1'1r"'W;I,- ........ ~,_,.._"
`TRP
`GLY g~~P~ic Health lijt(vice
`GLN
`GLY tQlioNJinstitutes~ Health
`THR
`LEW
`LYS
`LEU
`LEU
`V-'l. VAL
`VAL
`VAL
`THR
`SER
`THR
`THR
`VAL
`
`.....
`
`IAET PHE
`AU.
`ASP
`ASP
`VAL
`HIS
`VAL
`TRP
`TAP
`TAP
`GLY G'-Y GLY
`GLN GLN GLN
`Gt.Y CiLY GLY
`Tl<l~ T,.R
`TWA
`PRQ
`uEC
`LEU
`VAL
`VAIL
`VAL
`THR
`THR
`SEA
`
`At
`Gl
`G<
`Sl
`y,
`ll
`T'
`AI
`AI
`Sf v,
`L'
`Gl
`Af
`PI
`AI
`ll
`Sl
`A!
`
`"
`
`A!
`AI
`G1
`L'
`Tl
`u
`r
`Ll
`G
`Ll
`AI
`
`LEU
`GLN
`MET MET
`ASN
`ASX
`
`SER GLY "
`
`Ll
`LEU
`LEU
`ARG AAG A!
`ALA
`ALA
`PI
`GLU GLX G
`ASP ASX
`A:
`THR GLY Tl
`A,
`ALA GLY
`PI
`VAL VAL
`T'
`TYR
`TYR
`TYA
`TYF\
`T'
`CYS CYS G
`ALA
`VAL
`A:
`ARG
`SEA
`L'
`ASP
`ASX G
`r
`VAL
`LEU
`ll
`ALA
`ALA
`Tl
`ALA
`ARG
`LEU
`
`.,
`
`G
`Al
`Tl
`PI
`
`PHE
`
`r:
`G
`G
`G
`Tl
`Li
`v
`Tl
`v
`s
`Sanofi/Regeneron Ex. 1029, pg 902
`
`GLY
`LYS
`GLV
`
`,,. ...
`
`TI<R
`VAl
`THR
`VAL
`SE"R
`
`Merck Ex. 1029, pg 928
`
`

`
`SEQUENCES OF PROTEINS OF
`IMMUNOLOGICAL Ill!EREST
`
`Elvin A. Kabat, Tai Te Wu, Howard Bilof'aky,
`Mar-garet fleid-~liller, and Harold Perry
`
`( 1983)
`
`Page;
`
`6;
`
`20 Position -1 of' 145'CL (pr-ecur-sor heavy chaina) should be Phe.
`
`15;
`
`31 Pau and Paul ars the same protein.
`35
`
`10K26-12A1
`and
`54; 204 The antibody speCificities for 10K-44-7A1
`205
`light chains) should by anti-p-azobenzene arsenate.
`
`(mouse kappa
`
`65;
`
`65 j
`
`65;
`
`65;
`
`66;
`
`67:;
`
`13 SAPC178 and SAPC176 (mouae lambda light chains) ahould be named as S178
`16
`and S176.
`
`fief'er>ences f'or HOPC 1, J6 9B, H2061, S176, and H2020 (mouse
`lambda
`4
`light
`should be Weigert, M., Cesar!, LM., l'onkovich. s.J. & Cohn, H.
`5 chains)
`6
`(1970) !lature, 228, 1045-1047.
`16
`17
`
`should be
`(mouse lambda light chains)
`7 Ret'eroences f'or W3159 a.nd MOPC511
`I.H. & Weigert, M.
`12 Cesari,.
`(1973) Pt"oc. Nat!. Acad. ScL U.S.A., 70,
`2112-2116.
`
`2
`3
`13
`
`26
`27
`
`sequenced
`light chains) were
`(lllouse 12Jllhda
`and S17B
`J558, XS104,
`completely, while HOPC1,
`J6 98 t H2061, S176, H2020 • W3159, and MOPC511
`(mouse lambda
`light chains) were analyzed by amino acid sequence
`compos! tions.
`
`and MAB-13
`'l'here ia an additional ref'erence to 'l'EPC952
`light chaina) Le., Elliott, B .. W., Jr., Steiner, L.A~
`(1981) Fed. Proc., 40, 1098.
`
`lambda
`(mouse
`& E:isen, H.N.
`
`The statement in the notes of lOOQ.se lambda light chains, "The order of'
`the genes has been determined as V1-J3-C3-J1-C1-V2-J2-C2-J4-C4," should
`be
`replaced by
`11 'l'hera are
`two
`linkage groups:
`J3-C3-J1-C1
`and
`J2-C2-J.II-CJ.j.. •
`
`111;
`
`23 Po.sitions 13 and 14 of' CAM (human hea.vy chain subgroup III) should be
`Gln and Ly:;, respectively.
`
`168;
`
`30 Position 171 of' Sll.3'CL (light constant chain) .should be Asn.
`
`168;
`
`should be Ser
`35 Position:;, 1112 and 143 o!' MOPC315 (light con~tant chain)
`and Gly respectively. based on the translation ft'om nucleotide sequences
`(Bothwell, A,.L.M., Paskind, H., Roth, M., Imanishf .. Kari. T. 1 Rajewskyf
`K. & Baltimore, D ..
`(1982) Nature, 298, 380-38.2'; Wu, G.E., Govindi. N.,
`Hozumi, N, & Mu"ialdo, H.
`(1982) llucl. Acids Res., 10, 3831-3843).
`
`185; 52 Positions 258 and 263 or MOPC173
`(heavy constant chain) have been
`revised by the authors to Pro and Val respectively.
`
`2!J6;
`
`The position numbering !"or ths codons of
`light chain variable
`should r-ead as 95, 95A, 95B, 95C, 95Dt 95E, 95F, 96, and 97.
`
`region
`
`l l
`
`~
`
`..!.!1.
`
`,IS.
`
`t
`
`1
`t
`
`The human kappa J-segment.:s (Hieter, P.A., Maize!, J.V., Jr. & Leder, P.
`( 1982) J. Biol. Chem., 257, 1516-1522) are as t'ollows:
`..u
`TTC PHE
`ACT THR
`TTC PRE
`GGC GLY
`PRO
`CCT
`GGG GLY
`ACC
`THR
`AAA
`LYS
`GTG VAL
`GAT ASP
`ILE
`ATC
`AAA
`LYS
`CGT AJlG
`
`TRP
`TGG
`96
`THR
`97 ACG
`98 TTC PHE
`99 GGC GLJ
`100 GAA GLN
`101 GGG GLY
`102 ACe THR
`103 AAG
`LYS
`1oq GTG VAL
`105 GAA GLU
`106 ATC
`ILE
`107 AAA
`LYS
`108 CGT ARG
`
`TJR
`TAC
`ACT THR
`TTT PHE
`GGC GLJ
`CAG GL!l
`GGG GLY
`THR
`ACC
`AAG
`LYS
`LEU
`CTG
`GAG GLU
`ATC
`ILE
`AAA LY.S
`cGT ARG
`
`CTC LllU
`ACT THR
`TTC PHE
`GGC GLY
`GGA GLY
`GGG GLY
`ACC
`THR
`AAG
`LYS
`GTG VAL
`GAG GLU
`ATC
`!LE
`AAA
`LYS
`CGT ARG
`
`ILE
`ATC
`ACC
`THR
`TTC PHE
`GGC GLY
`CAA GLN
`GGG GLY
`ACA THR
`CGA
`ARG
`CTG
`LEU
`GAG GLU
`ILE
`ATT
`AAA
`LYS
`CGT ARG
`
`Sanofi/Regeneron Ex. 1029, pg 903
`
`Merck Ex. 1029, pg 929
`
`

`
`SEQUENCES OF
`PROTEINS OF
`IMMUNOLOGICAL
`INTEREST
`
`Tabulation and Analysis of
`Amino Acid and Nucleic Acid Sequences of
`Precursors, V-Regions, C-Regions, J-Chain,
`f3z-Microglobulins, Major Histocompatibility Antigens,
`Thy-1, Complement, C-Reactive Protein, Thymopoietin,
`Post-gamma Globulin, and a;rMacroglobulin
`
`1983
`
`Elvin A. Kabat*, Tai Te Wu t, Howard Bilofs~ +,
`Margaret Reid-Miller+, and Harold Perry+
`
`*Depts. of Microbiology, Human Genetics and Development, and Neurology, Cancer Center/
`Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New
`York, NY 10032 and the National Institute of Allergy and Infectious Diseases, Bethesda, MD
`20205
`t Depts. of Biochemistry, Molecular Biology, and Cell Biology, and Engineering Sciences and
`Applied Mathematics, Northwestern University, Evanston, IL 60201 and the cancer Center,
`Northwestern University Medical School, Chicago, IL 60611
`::1: Bolt Beranek and Newman Inc., Cambridge, MA 02238
`
`The collection and maintenance of this data base is sponsored through Contract N01-RR-8·2118
`by the following components of the National Institutes of Health, Bethesda, MD 20205:
`Division of Research Resources
`National Cancer Institute
`National Institute of Allergy and Infectious Diseases
`National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases
`National Institute of General Medical Sciences
`
`U.S. DEPARTMENT OF HEALTH
`AND HUMAN SERVICES
`Public Health Service
`National Institutes of Health
`(1983)
`
`XH£ HEALTH SCIENCES LIBRARY
`n4VTS
`,. __ .,. ... .......,..,.,rTmv nl:i' "i\T.TVn'Ql\IT .d
`
`Sanofi/Regeneron Ex. 1 029, pg 904
`
`Merck Ex. 1029, pg 930
`
`

`
`Our listing of sequences will be kept up to date. Investigators are invited to send additional
`sequence data when accepted for publication. Send two copies of the manuscript together with
`a letter of acceptance from a journal to:
`Dr. EA Kabat
`National Institutes of Health
`Building 4, Room 337
`9000 RockvUie Pike
`Bethesda, Maryland 20205
`If a computer tape is available, please send it to facilitate entering sequences.
`When published, three reprints should be provided.
`If any published sequences have been overlooked or if any errors are found, please bring them to
`our attention.
`-
`
`Sanofi/Regeneron Ex_ 1 029, pg 905
`
`Merck Ex. 1029, pg 931
`
`

`
`CODON& OF VARIABLE REGIO~ UGHT CHAINS
`a
`e
`a
`s
`4
`10
`g
`7
`2
`1
`HK101 HK102 MOPC MOPC MOPC MOPC KZA MPC MOPC 5107
`41
`21
`167
`149
`11
`B
`1138
`(K2i
`
`11
`T1
`
`12
`L&
`
`13
`T2
`
`15
`14
`Li' PKAPPA
`(11)24
`
`18
`17
`"16
`IG.303
`IG1 3
`IG99
`LAMBDA LAMBDA LAMBDA
`
`21
`20
`19
`S43 MOPC Pl.AI
`315
`~13
`
`240
`
`10
`11
`12
`13
`14
`15
`16
`17
`1S
`19
`
`20 ,
`
`22
`23
`24
`Z5
`Z6
`27
`27A
`278
`27C
`270
`27E
`27F
`2.B
`29
`.30
`31
`3.2
`33
`34
`35
`36
`37
`3a
`39
`40
`41
`4.2
`43
`44
`
`45 .. 47 ..
`
`49
`50
`&1
`
`52 sa
`
`54
`55
`56
`57
`58
`59
`60
`
`61 •• 63
`
`64
`85
`66
`
`87 •• 69
`
`70
`71
`72
`73
`74
`75
`76
`77
`78
`79
`so
`81
`82
`
`83 •• 85 .. 87 ••
`
`"" 90
`""
`
`91
`92
`
`94
`95
`96
`97
`97A
`978
`97C
`970
`97E
`97F
`98
`99
`100
`101
`102
`103
`104
`105
`106
`106A
`107
`10S
`
`c
`D
`R
`1
`
`F
`
`R •
`
`c
`D
`R
`2
`
`F
`R
`3
`
`c
`D
`A
`3
`
`F
`R
`•
`
`GAG
`ATC
`CAG
`ATG
`ACC
`CAG
`TCT
`CCA
`TCC
`TCA
`CTG
`TCT
`GCA
`rcr
`GTA
`GGA
`GAC
`AGA
`GTC
`ACC
`ATC
`ACT
`TGT
`CGG
`GCG
`AGG
`GAG
`
`GGT
`ATT
`AGC
`AGC
`TGG
`TTA
`GCC
`TGG
`TAT
`eAG
`eAG
`AAA
`CeA
`GAG
`AAA
`GCC
`CCT
`AAG
`TCC
`CTG
`ATC
`TAT
`GCT
`GCA
`TCC
`AGT
`TTG
`CAA
`AGT
`GGG
`GTC
`CCA
`TCA
`AGG
`TTC
`AGC
`GGC
`AGT
`GOA
`TCT
`GGG
`ACA
`GAT
`TTC
`ACT
`CTC
`ACC
`ATC
`AGC
`AGC
`CTG
`GAG
`CCT
`GAA
`GAT
`TTT
`GCA
`ACT
`TAT
`TAG
`TGC
`CAA
`CAG
`TAT
`AAT
`AGT
`TAG
`CCT
`
`QAT
`AAC
`GAC
`GAG
`ATT
`ATT
`ATC
`ATC
`GTG
`GTA
`CAG
`GAG
`ATG
`ATA
`ATG
`ATG
`ACC
`ACC
`ACC
`ACC
`GAG
`CAG
`CAG
`CAA
`TCT
`GAT
`TCT
`TCT
`CCT
`CCC
`GAA
`CCA
`TCC
`CTC
`AAA
`TCC
`ACC
`TCC
`TCC
`TCC
`AAT
`ATG
`TTA
`CTG
`TCT
`CCT
`TOC
`TCT
`GCA
`ATG GTC
`GCC
`TCA
`ACT
`TCT
`TCT
`GTA
`GT A
`TCT
`CTG
`GGA
`GGA GGA GGA
`GAC
`GAA
`GAG
`GAA
`AGA
`AGG
`TAG
`AGA
`GTC
`GTC GTC GTT
`ACC
`AGT
`ACC
`TCC
`ATC
`CTC
`TTG
`ATC
`ACT
`ACT
`ACC
`TCG
`TGC
`TGT
`TGC
`TGC
`CGG
`GGG
`AAG
`GCG GCA GCC
`AGT
`AGT
`AGT
`GAG
`GAG
`GAG
`
`AAT
`GAG
`AGT
`GTG
`ATT
`ATT
`GGT GlT
`AGT
`AGT
`ACT
`AGC
`AGC
`TAT
`TGG
`TT A GTT
`TTG
`AAC
`TC
`GCC
`TGG
`TGG
`TGG
`TAT GTT
`TAT
`GAG GAG CAA
`GAG
`GAG
`GAG
`AAA
`GAA
`AAA
`CeA CCA GCA
`GGG GAT
`GAG
`AAA
`GGA
`eAA
`GCC
`ACT
`TCT
`CCT
`ATT
`CCT
`AAG
`AAA
`AAA
`CTC
`CGC CTC
`CTG
`CTG
`TTA
`ATC
`ATC
`ATT
`tAG
`TAG
`'fAT
`GAT Gee GGG
`GCC
`ACA GCC
`TCC
`TCC
`TCC
`AGT
`AGT
`AAC
`TTG
`TTA
`CGG
`GAA GAT
`TAG
`AGT
`TCT
`ACT
`GGG
`GGT
`BGG
`GTC GTC GTC
`GCA
`CCC
`CCC
`TCA
`AAA GAT
`AOO
`AGG
`CGC
`TTC
`TTC
`TTC
`AGC
`AGT
`ACA
`GGC
`GGC GGT
`AGT
`AGT
`AGT
`GGA
`AGG GGA
`TCT
`TCT
`TCT
`GGG
`GGG GCA
`ACA
`TCA ACA
`GAA GAT GAT
`TTC
`TAT
`TTC
`ACT
`TCT
`ACT
`CTC
`CTC CTG
`ACC
`Ace
`ACC
`ATC
`ATC
`ATT
`AGG
`AGC
`AGT
`AGC
`AGC
`AGT
`CTG
`CTT
`GTG
`GAG GAG CAA
`CCT
`TCT GCT
`GAT GAA GAA
`GAT GAT
`GAG
`TTT
`TTT
`CTT
`GCA GTA GCA
`ACT
`GAC GAT
`TAT
`TAT
`TAT
`TAG
`TAG CAC
`TGC
`TGT
`TGT
`GAA CTA GGA
`GAG
`CAA CAG
`TAT
`TAT GGT
`AAT
`GCT
`TAG
`AGT
`AGT
`AGC
`TAT
`TCT
`TAT
`TCT
`CCG
`CCG
`TGG
`TAe
`ACG
`ACG
`
`TTC
`TiC
`GGA
`GGT
`GGA GGG
`GGC GGG
`ACC
`ACC
`AAG
`AAG
`CTG CTG
`GAA GAA
`ATC
`ATA
`
`AAA
`CGT
`
`AAA
`
`QGA
`GAC GAG GAC GAC GAA GAC GAC GAG GAC
`GAC
`ATT
`ATC ATC ATT ATC AAT ATC ATC ATC ATC
`GTG
`GAG CAG GTG CAG GTG AAG AAG TTG TTG
`ATG ATG CTI3 ATG CTC ATG ATG CTG CTG
`ATG
`ACT ACT ACC ACC ACC ACC ACC ACT ACT
`ACC
`GAG GAG CAA GAG GAG CAG CAG CAG GAG
`CAG
`TCT TCT TCT TCT TCT TCT TCT TCT TCT
`TCT
`CCA CCA CCG CCA CCA CCA CCA CCA CCA
`CAC
`GCC GCC GCT TCC GCA TCT TCT GCC GCC
`AAA
`TTC
`TCC TCC TCT TCC AlA TCC TCC ATC ATC
`ATG
`CTA CTA TTG TTA ATG ATG ATG CTG CTG
`TCC
`TCT TCT GCT TCT GCT TAT TAT TCT TCT
`ACA
`GCA GCA GTG GCC GCC GCA GCA GTG GTG
`TCA
`TCT TCT TCT TCT TCT TCT TCT AGT AGT
`GTG GTG CT A CTG CTG CT A CT A CCA CCA GT A
`GGT GGT GGG GGA GGG GGA GGA GGA GGA GGA
`GAA GAA GAG GAA CAG GAG GAG GAA GAA GAG
`ACT ACT AGG AGA AAG AGA AGA AGA AGA
`AGG
`GTC GTC GCC GTC GTC GTC GTC GTC GTC GTC
`ACC ACC ACC AGT ACC ACT ACT AGT AGT
`AGC
`ATC ATC ATA CTC ATG ATC ATC TTC TTC
`ATC
`ACA ACA TCC ACT ACC TCT ACT TCC TCC
`ACC
`TGT TGT TGC TGC TGC TGC TGC TGC TGC
`TGC
`CGA CGA AGA CGG
`AGT AAG AAG AGG AGG
`AAG
`GC A GCA GCC GCA GCG GCG GCG GCC GCC GCC
`AGT AGT AGT AGT AGC AGT AGT AGT AGT
`AGT
`GGG GGG GAA GAG TCA GAG GAG GAG GAG GAG
`AGT
`GTT
`GAT
`AGT
`
`AAT AAT TAT GAG AGT GAG GAG AGC AGC GAT
`ATT ATT GGC ATT GTA ATT ATT ATT ATT GTG
`CAC CAC AAT CAT AGT AAT AAT GGC GGC
`AGT
`AAT AAT AGT GGT TCC AGC AGC ACA ACA
`ACT
`TAT TAT TTT TAT AGT TAT TAT AGC AGC
`ACT
`TTA TTA ATG 1TA TAG TTA TTA AlA ATA GTG
`GCA GCA CAC AAC TTG ACC AGC CAC CAC GCC
`TGG TGG TGG TTG CAC TGG TGG TGG TGG
`TGG
`TAT TAT TAG TTT
`TGG TTC TTC TAT TAT
`TAT
`GAG GAG GAG GAG TAG GAG GAG GAG GAG GAG
`GAG GAG CAG GAG GAG GAG GAG CAA CAA GAG
`AAA AAA AAA AAA GAG AAA AAA AGA AGA
`AAA
`GAG GAG CCA GCA AAG CCA CCA ACA ACA CCA
`GGA GGA GGA GGT TCA GGG GGG AAT AAT
`GGG
`AAA AAA GAG GAA GGC AAG AAA GGT GGT CAA
`TCT TCT CCA ACT GCT TCT TCT TCT TCT
`TCT
`CCT CCT CCC ATT TCC CCT CCT CCA CCA CCT
`GAG GAG AAA AAA CCC AAG AAG AGG AGG
`AAA
`CTC CTC CTC CAC AAA ACC ACC CTT CTT CTA
`CTG CTG CTC CTG CCC CTG CTG CTC CTC CTG
`GTC GTC ATC ATC TTG CTC ATC ATA ATA ATT
`TAT TAT TAT TAT ATT TAT TAT AAG AAG
`TAT
`AAT AAT CGT GAA CAT CGT CGT AAT TAT
`TCG
`GCA GCA GCA ACA AGG GCA GCA GCT GCT GCA
`AAA AAA TCe Tee ACA AAe AAC TCT TCT
`TCC
`ACC ACC AAC AAT TCC AGA AGA GAG GAG
`T AC
`TTA TTA CTA TTA AAe TTG TTG Tee TCT
`CGG
`GCA GCA GAA GAT CTG GTA GTA ATC ATC
`TAG
`GAT GAT TCT TCT GCT GAT GAT TCT TCT
`ACT
`GGT GGT GGG GGT TCT GGG GGG GGG GGG GGA
`GTG GTG ATC GTC GGA GTC GTC ATC ATC GTC
`CCA CCA CCT CCA GTC CCA CCA CCT CCT
`CCC
`TCA TCA GCC AAA CCA TCA TCA TeC TCC GAT
`AGG AGG AGG AGG GCT AGG AGG AGG AGG
`CGC
`TTC TTC TTC TTC CGC TTC TTC TTT TTT
`TTC
`AGT AGT AGT AGT TTC AGT AGT AGT AGT
`AC
`GGC GGC GGC GGC AGT GGC GGC GGC GGC GGC
`AGT AGT AGT AGT GGC AGT AGT AGT AGT
`AGT
`GGA GGA GGG AG.G
`AG.T GGA GGA GGA GGA GGA
`TCA TCA TCT TCT GGG TCT TCT TCA TCA
`TCT
`GGA GGA AGG GGG TCT GGG GGG GGG GGG GGG
`ACA ACA ACA TCA GGG CAA CAA ACA ACA
`ACG
`CAA CAA
`GAT ACC GAT GAT GAT GAT GAT
`TAT TAT
`TAT TCT TTT TAT TTT TTl
`TTC
`TCT TCT
`TCT TAG TCT TCT ACT ACT
`ACT
`CTC CTC CTC CTC TCT CTC CTC CCT CTT
`TTC
`AAG AAG ACC ATT CTC ACC ACC AGC AGC
`ACC
`ATe ATC ATT ATC ACA ATC ATC ATe ATC
`ATC
`AAC AAC AAT GGC ATC AGC AGC AAC AAC
`AGe
`AGC AGe CCT AGC AGC AGC AGC AGT AGT
`AGT
`CTG CTG GTG CTT AGC CTG CTG GTG GTG GTG
`GAG eAG GAG GAG GTG GAG GAG GAG GAG GAG
`CCT CCT GCT TCT GAG TAT TAT TCT TCT GCT
`G.AA GAA GAT GAA GCT GAA GAA GAA GAA G.AA
`GAT GAT GAT GAT GAA GAT GAT GAT GAT GAC
`TTT TTT GTT TTT GAT AT13 ATG ATT ATT CTA
`GGG GGG GCA GCA GAT GGA GGA GCA GCA GCA
`AGT AGT ACC GAG GCA ATT ATT GAA GAT GTT
`TAT TAT TAT TAT ACT TAT TAT TAT TAT
`TAT
`TAe TAG TAG TAC TAT TAT TAT TAC TAC
`TAG
`T AC TGT TGT TGT TGT
`TGT TGT TGT TGT
`TGT
`CAA CAA CAG CT A TGC OTT CT A CAA CAA CAG
`CAT CAT CAA CAA CAG GAG GAG CAA CAA CAA
`TTT TTT AGT TAT CAG TAT TAT AGT AGT CAT
`TGG TGG AAT GCT TGG GAT GAT TAT AAT
`TAT
`AGT AGT GAG AGT AGT GAG GAG AGG AGC
`AGT
`ACT ACT GAT TCT GGT TTT TTT TGG TGG
`ACT
`CCT CCT CCG CCT
`T AC CCG CCG CCA CCA CCT
`CCA CTC
`CCC
`ACG
`ACG
`
`CAQ
`GCT
`GTT
`GTG
`ACT
`CAG
`GAA
`TCT
`GCA
`
`CTC
`ACC
`ACA
`TCA
`CCT
`GGT
`GAA
`ACA
`GTC
`ACA
`CTC
`ACT
`TGT
`CGC
`TCA
`AGT
`ACT
`
`GGG
`GCT
`GTT
`ACA
`ACT
`AGT
`AAC
`TAT
`GCC
`AAC
`TGG
`GTC
`CAA
`GAA
`AAA
`CCA
`GAT
`CAT
`TTA
`TTC
`ACT
`GGT
`CTA
`ATA
`GGT
`GGT
`ACC
`AAC
`AAC
`CGA
`GCT
`CCA
`GGT
`GTT
`CCT
`GCC
`AGA
`TTC
`TCA
`GGC
`TCC
`CTG
`ATT
`GGA
`GAC
`AAG
`GCT
`GCC
`CTC
`ACC
`ATC
`ACA
`GGG
`GCA
`CAG
`ACT
`GAG
`GAT
`GAG
`GCA
`ATA
`TAT
`TTC
`TGT
`GCT
`CTA
`TGG
`TAC
`AGC
`AAC
`CAT
`
`CAG
`GCT
`GTT
`GTG
`ACT
`GAG
`GAA
`TCT
`GCA
`
`CTC
`ACC
`ACA
`TCA
`CCT
`GGT
`GGA
`ACA
`GTC
`ATA
`CTC
`ACT
`TGT
`CGC
`TCA
`AGT
`ACT
`
`GGG
`GCT
`GTT
`ACA
`ACT
`AGT
`AAC
`TAT
`GCC
`AAC
`TGG
`GTT
`CAA
`GAA
`AAA
`CCA
`GAT
`CAT
`TTA
`TTC
`ACT
`GGT
`CTA
`ATA
`GGT
`GGT
`ACC
`AGC
`AAC
`CGA
`GCT
`CCA
`GGT
`GTT
`CCT
`GTC
`AGA
`TTC
`TCA
`GGC
`TCC
`CTG
`ATT
`GGA
`GAC
`AAG
`GCT
`GCC
`CTG
`ACC
`ATC
`ACA
`GGG
`GCA
`CAG
`ACT
`GAG
`GAT
`GAT
`GCA
`ATG
`TAT
`TTC
`TGT
`GCT
`CTA
`TGG
`TAC
`AGC
`AAC
`CAT
`
`TTC TTC
`GGC GGT
`TCG GCT
`GGG GGG
`ACA ACC
`AAG.AAG
`TTG CTG
`GAA GAG
`ATA CTG
`
`AAA AAA
`CGT CGT
`
`CAG
`GCT
`GTT
`GTG
`ACT
`GAG
`GAA
`TCT
`GCA
`
`CTC
`ACC
`ACA
`TCA
`CCT
`GGT
`GAA
`ACA
`GTC
`ACA
`CTC
`ACT
`TGT
`CGC
`TCA
`ACT
`ACT
`
`GGG
`GCT
`GTT
`ACA
`ACT
`GGT
`AAC
`TAT
`GCC
`AAC
`TGG
`GTC
`CAA
`GAA
`AAA
`CCA
`GAT
`CAT
`TTA
`TTC
`ACT
`GGT
`CTA
`ATA
`GGT
`OOT
`ACC
`AAC
`AAC
`CGA
`GCT
`.CCA
`GGT
`GTT
`CCT
`GCC
`AGA
`TTC
`TCA
`GGC
`TCC
`CTG
`ATT
`GGA
`GAC
`AAG
`GCT
`GCC
`CTC
`ACC
`ATC
`ACA
`GGG
`GCA
`CAG
`ACT
`GAG
`GAT
`GAG
`GCA
`ATA
`TAT
`TTC
`TGT
`GCT
`CTA
`TGG
`TAC
`AGC
`AAC
`CAT
`TGG
`GTG
`
`GAG GAG
`GCT GCT
`GTT GTT
`GTG GTG
`ACT ACT
`CAG GAG
`GAA GAA
`TCT TCT TCT
`GCA GCA GCA
`
`CTC CTC CTC
`ACC ACC ACC
`ACA ACA ACA
`TCA TCA TCA
`CCT CCT CCT
`GGT GGT GGT
`GAA GI3A GAA
`ACA ACA ACA
`GTC GTC GTC
`ACA AlA ACA
`CTC CTC CTC
`ACT ACT ACT
`TGT TGT TGT
`CGC CGC CGC
`TCA TCA TCA
`AGT AGT AGT
`ACT ACT ACT
`
`GGG GGG
`GCT GCT GCT
`GTT GTT GTT
`ACA ACA ACA
`ACT ACT ACT
`AGT AGT
`AAC AAC
`TAT TAT
`Gee GCC
`AAC AAC
`TGG TGG
`GTC ATC
`CAA CAA
`GAA GAA
`AAA AAA
`eGA eeA
`GAT GAT
`CAT CAT
`TT A TTA
`TTC TTC
`ACT ACT
`GGT GGT
`CIA CTA
`ATA ATC
`GGT GGT
`GGT GGT
`AGe ACC
`AAC AGC
`AAC AAC
`CGA CGA
`GCT GCT
`CCA CCA
`GGT GGT
`GTT GTT
`CCT CCT
`GCC GTe
`AGA AGA
`TTC TTC
`TCA TCA
`GGC GGC
`TCC TCC
`CTG CTG
`ATT ATT
`GGA GGA
`GAC GAG
`AAG AAG
`GCT GCT
`GCC GCC
`ere ere
`ACC ACC
`ATC ATC
`ACA ACA
`GGG GGG
`ACA GCA
`GAG GAG
`ACT ACT
`GAG GAG
`GAT GAT
`GAG GAT
`GCA GCA
`ATG ATG
`TAT TAT
`TTC TTC
`TGT TGT
`GCT GOT
`CTA CTA
`TGG TGG
`TAC TTe
`AGC AGA
`AAC AAC
`CAT CAT
`TGG TTT
`GTG GTT
`
`TTG
`GGT
`GGA
`GGA
`ACC
`AAA
`CTG
`ACT
`GTC
`CTA
`GGT
`
`TTC
`GGC
`GGT
`GGA
`ACC
`AAA AAG
`CTG GTC
`ACT ACT
`GTC GTC
`CTA CTA
`GGC GGT
`
`Sanofi/Regeneron Ex. 1029 1 pg 906
`
`Merck Ex. 1029, pg 932
`
`

`
`247
`
`SOURCE: CODONS OF VARIABLE REGION LIGHT CHAINS
`
`1) HK1D1; HUMAN FOETAL UVEA
`2) HK102~ HUMAN FOETAL UVEA
`3) JIOPC41: MOUSE ADULT
`4) MOPC21: MOUSE MANA FROM MOPC21
`5) MOPC18'7; MOUSE ADULT
`6) MOPC149(K2): MOUSE EMBRYO & PLASMOCYTOMA
`7) K2A: MOUSE EMBRYO
`8) MPC11: MOUSE PLASMACYTOMA
`'9) IIOPC173B: MOUSE PLASMACYTOMA
`10} S107B: MOUSE EMBRYO
`11) T1: MOUSE ADULT
`12) LB: MOUSE ADULT UVEA
`13) T2: MOUSE ADULT, ABNORMAL J OMITTED
`14) l7: MOUSE ADULT UVER
`15) PKAPPA(11)24; MOUSE MRNA FROM MPC11
`16) IGS9LA.IIBDA: MOUSE EMBRYO
`17) IG13LAIIBD•: MOUSE EMBRYO
`18) IGSD3LAMBDA: MOUSE ADULT
`19) 843: MOUSE ADULT
`20) MOPC315! MOUSE ADULT
`21) PLAI~13: MOUSE ADULT
`
`REFERENCE: CODON5 OF VARIABLE REGION LIGHT CHAINS
`
`1) HK101: BENTLEY,D.L & AABBITTS,T.H. (1980) NATURE,2B8,730.733.
`2) HK102: BENTLEY,D.L & RABBITTS,T.H. (1980) NATURE,2BB,730-733.
`3) MOPC4t: SEIOMAN,J.G.,MAX,E.E. & LEOER,f', (1979) NATUAE,1BD,S70-375.
`4) MOPC21: FONG,K,l.ElA. & SALSER,W. (1979) BIOCHEM.BIOPHYS.RES.COMMUN.,9D,832·841; HAMLYN,f'.H.,GAIT,M.J. & MILS-.:EIN,C. (1981) NUCLAClDS
`RES.,9,4485-4494.
`5) MOPC167: JOHO,R..WE:ISSMAN,l.L,EARLY,P.,COLE,J. & HOOD,L (1980) PROC.NAT.ACAO.SCLUSA,n,1106-1110.
`6) MOPCt49(K2): NISHIOKA,Y. & LECER,P. (1980) J~ BIOLCHEM.,255,3691-3694.
`7) K2A! NISHIOKA.,Y. & LEDEA,P. (1980} J.BIOL.CHEM:,255,3691~B94.
`B) MPc1t: SEIOMAN,J.G. & L.EDEA,P. (1980} NATUAE,286,779-7B3.
`9} MOPC173B: MAX.E.E.,SEIDMAN.J.G.,MILLEA,H. & LEDER.P. (1980) CELL,21,793-799.
`10) 51078: KWAN,S.P.,MAX,E.E.,SEIDMAN,J.G.,LEDEA,P. & SCHARFF,M.D. (1981) CE.LL,26,57-66.
`11) Tt: ALTENBUAGEA,W.,STEINMETZ.M. & ZACHAU,H.G. (1980) NATURE,2S7,sti3-60Z.
`12) U: PECH,M.,HOCHTL,J.,SCHNELL,H. & ZACHAU,H.G. (1981) NATURE,291,668-670.
`13) TZ: ALTENBUAGER,W,,STEINMETZ,M. & ZACHAU.H.G. (1980) NATURE,2.B7,603-B07.
`14) L7: PECH,M .. HOCHTL,J.,SCHNELL,H. & ZACHAU,H.G. (1981) NATUAE.~91,668-6?0.
`15) PIU.PPA(11)24: RABBrTTS,T.H.,HAMLYN,P.H. & MATTHYSSENS,G. (1980) CAN.J.BIOCHEM.,5S,176-1B7,
`16) IG91i1LAMBDA: BERNAAD,O.,HOZUMI,N, &. TONEGAWA,S. (1978) CELL,15,1133~1144.
`17) 1Gi13LAIIBDA: TONEGAWA,S.,MAXAt.t,A.M.,TIZARD,R.BEANAAC,O. & GfLBERT,W. (197B) PAOC.NAT.ACAD.SCI.USA,75,1485-1489.
`1B) IG303LAMBDA: BEFINAR.C,O,,HOZUMI,N. & TONEGAWA,S. {1978) CELL, 15,113J.1144.
`19) 843: 80THWELL,A.LM.,PASKINO,M.,AETH,M.,IMAN!SHI~KARI,T.,RAJEWSKY,K.. &. BALTIMOAE,C, (1982) NATURE,29B,380-3B2.
`20) IIOPC315: BOTHWELL.A.LM.,PASKIND,M.,AETH,t.t,.IMAHISHI-KAFII,T.,AAJEWSKV,K. & BALTIMORE,D. (1982) NATUFIE,298,3B0-382.
`2i) PLAI·13: BOTI-IWELL,A.LM.,PA.SKIND,M.,SCHWARTZ,A.C.,SONENSHEIN,G.E.,GEFTERM.L & BALTIMORE,D. (1981) NATURE,290,65-67.
`
`Sanofi/Regeneron Ex. 1029, pg 907
`
`Merck Ex. 1029, pg 933
`
`

`
`CODONS OF VARIABLE REGION HEAIIY CHAINS
`
`5
`4
`3
`2
`1
`LAMBDA LAMBDA LAMBDA HG3 H1 i
`VH26
`VH52
`VHS2
`
`6
`SP1
`-HL
`
`7
`S
`107
`
`a
`12
`11
`10
`9
`MOPC
`MCPC MOPC HPC MOPC
`141
`600
`167
`76
`141
`ADULT EMBRYO
`
`13
`J
`559
`
`18
`17
`Hi
`15
`14
`MPC 81-B S43 MOPC 186
`11
`21
`·1
`
`19
`23
`
`20
`3
`
`21
`102
`
`22
`PCH
`105
`
`, ..
`
`F
`A
`1
`
`c
`D
`A
`1
`
`F
`A
`2
`
`c
`D
`A
`2
`
`F
`A
`3
`
`5
`6
`7
`8
`9
`10
`11
`12
`13
`14
`15
`16
`17
`18
`1Q
`20
`21
`22
`23
`24
`25
`29
`27
`28
`29
`30
`31
`32
`33
`34
`35
`J5A
`35S
`36
`37
`38
`39
`40
`41
`42
`43
`44
`
`45 .. 47
`48 .. 50
`
`51
`52
`52A
`528
`52C
`53
`54
`55
`56
`57
`58
`59
`60
`61
`62
`
`63 •• 65 .. 67 •• 69
`
`70
`71
`72
`73
`74
`75
`76
`77
`78
`79
`80
`81
`62
`62A
`828
`B2C
`63
`64
`
`85 ..
`
`S7
`
`BB •• 90
`
`91
`92
`93
`94
`95
`96
`97
`96
`99
`100
`100A
`c ~~
`D
`100D
`R
`100E
`3
`100F
`100G
`10<JH
`IO<ll
`
`10<JJ "'""
`
`101
`102
`103
`104
`105
`106
`107
`108
`109
`110
`111
`112
`113
`
`F
`R
`4
`
`GAG
`GTG
`CAG
`CTG
`TTG
`GAG
`TCT
`GGG
`GGA
`O!GC
`TTG
`GTA
`CAG
`CCT
`GGG
`GGG
`TCC
`CTG
`AGA
`CTC
`TCC
`TGT
`GCA
`GCC
`TCT
`GGA
`TTC
`ACC
`TTT
`AGC
`AGC
`TAT
`GCC
`ATG
`AGC
`
`TGG
`GTC
`CGC
`CAG
`GCT
`CGA
`GGG
`AAG
`GGG
`CTG
`GAG
`TGG
`one
`TCA
`GCT
`ATT
`AGT
`GGT
`
`AGT
`GGT
`GGT
`AGC
`ACA
`TAC
`TAC
`GGA
`GAC
`TCC
`GTG
`AAG
`GGC
`CGG
`TTC
`ACC
`ATC
`TCA
`AGA
`GAC
`AAT
`TCC
`AAG
`AAC
`ACG
`CTG
`TAT
`CTG
`CAA
`ATG
`AAC
`AGC
`CTG
`AGA
`GCC
`GAG
`GAC
`ACG
`GCC
`GTA
`TAT
`TAC
`TGT
`OCG
`AAA
`
`AAC
`AGC
`CTG
`AGA
`GCC
`GAG
`GAC
`
`TAT
`CTT
`CAA
`ATG
`AAC
`AGC
`CTG
`AGA
`GCC
`GAG
`GAC
`ATG
`GCT
`GTG
`TAT
`TAC
`TGT
`GCA
`ACA
`
`GAG GAG GAA GAG GAG
`GTG GTG GTG GTG GTG
`GAG GAG ATG AAG AAG
`CTG CTG CTG CTG CTG
`GTG GTG GTG GTG GTG
`GAG GAG GAG GAA GAA
`TCT TCC TCT TCT TCT
`GGG GGG GGG GGA GGA
`GCT GGA GGA GGA GGA
`GAG GGC GGC GGC GGC
`GTG TT A TT A TTG TTG
`AAG GTT GTG GTA GTA
`AAG GAG AAG GAG GAG
`CCT CCT CCT CCT CCT
`GGG GGG GGA GGG GGG
`GCC GGG GGG GGT GGT
`TCA TCC TCC TCT TCT
`GTG CTG CTG CTG CTG
`AAG AGA AAA AGA AGA
`GTT CTC CTC CTC CTC
`TCC TCC TCC TCC TCC
`TGC TGT TGT TGT TGT
`AAG GCA GCA GCA GCA
`GCA GCC GCC ACT ACT
`TCT TCT TCT TCT TCT
`GGA GGA GGA GGG GGG
`T AC TTC TTC TTC TTC
`ACC ACC ACT ACC ACC
`TTC TTC TTC TTC TTC
`AAC AGT AGT AGT AGT
`AGC AGC AGC GAT GAT
`TAG TAG TAT TTC TTC
`TAT TGG GCC TAG TAG
`ATG ATG ATG ATG ATG
`CAC CAC TGT GAG GAG
`
`GAG
`GAG
`GTA
`GTG
`GAG
`AAG
`CTG
`GTG
`AAG
`GTG
`GAA GAG GAG
`TCT TCT TGA
`GGA GGA GGA
`GGA GGA CCT
`GGC GGC GGC
`TTG" TTG CTG
`GTA GTG GTG
`GAG CAA GCG
`CCT CCT CCC
`GGG GGA TCA
`GGT GGA GAG
`TCT TCC AGC
`CTG ATG CTG
`AGA AAA TCC
`CTG CTC ATC
`lCG TCC ACA
`TGT TGT
`TGC
`GCA GTT ACC
`ACT GCC GTC
`TCT TCT TCA
`GGG GGA GGA
`TTC TTC TTC
`ACC ACT TCA
`TTC TTC TTA
`AGT AGT
`ACC
`GAT AAC GGC
`TTC TAG TAT
`lAC TGG GGT
`ATG ATG GTG
`GAG AAC AAC
`
`TGG TGG
`GTG GTG
`CGA CGC
`GAG CAA
`GCC GCT
`CCT CCA
`GGA GGG
`CAA AAG
`GGG GQG
`CTT CTG
`GAG GTG
`TGG TGG
`ATG GTC
`GGA TCA
`ATA CGT
`ATC ATT
`AAC AAT
`CCT AGT
`
`AGT GAT
`GGT GGG
`GGT AGT
`AOC AGC
`ACA ACA
`AGC AGG
`TAG TAC
`GCA GCG
`GAG GAG
`AAG TCC
`TTC GTG
`GAG AAG
`GGC GGC
`AGA CGA
`GTC TTG
`ACC ACC
`ATG ATC
`ACC TCC
`AGG AGA
`GAG GAC
`ACG AAC
`TCC GCC
`AGG AAG
`AGC AAC
`ACA AGG
`GTG CTG
`TAG TAT
`ATG CTG
`GAG GAA
`CTG ATG
`AGC AAC
`AGC AGT
`CTG CTG
`AGA AGA
`TCT GCC
`GAG GAG
`GAG GAC
`
`TGG TGG
`GTT GTC
`CGC CGC CGC
`GAG GAG
`CCT CGT
`CCA CCA
`GGG GGG
`AAG AAG
`AGA AGA
`CTG CTG
`GAG GAG
`TGG TGG
`ATT ATT
`GCT GCT
`GCA GCA
`AGT AGT
`AGA AGA
`AAC AAC
`AAA AAG
`GCT GGT
`AAT AAT
`GAT AAA
`1 AT TAT
`ACA ACA
`ACA ACA
`GAG GAA
`TAG TAO
`AGT AGT
`GCA GCA
`TCT TCT
`GTG GTG
`AAG AAG
`GGT GGT
`CGG CGG
`TTG TTC
`ATC ATC
`GTC GTG
`TCC TCC
`AGA AGA
`GAG GAG
`ACT ACT
`TCC TCC
`CAA CAA
`AGC AGC
`ATG ATG
`GTC CTC
`TAG TAG
`CTT CTt
`GAG GAG
`ATG ATG
`AAT AAT
`GCC GCC
`CTG CTG
`AGA AGA
`GCT GCT
`GAG GAG
`GAG GAG
`ACT ACT
`GCC GCC
`ATT ATT
`TAT TAT
`TAG TAG
`TGT TGT
`GGA GCA
`AGA AGA
`GAT AAT
`
`TAC TAG
`TAG TAG
`GGT GGT
`AGT AGT
`AGC ACC
`
`TGG
`GTC
`CGC CGC
`GAG GAG
`ACT TCT
`CCA CCA
`GGG GAG
`AAG AAG
`AGA GGG
`CTG CTT
`GAG GAG
`TGG TGG
`ATT GTT
`GCT GCT
`GCA GAA
`AGT ATT
`AGA AGA
`AGT TTG
`AAA AAA
`GCT
`CAT TCT
`GAT GGT
`TAT TAT
`AGA GCA
`ACA ACA
`GAA CAT
`TAG TAT
`AGT GCG
`GCA GAG
`TCT TCT
`GTG GTG
`AAG AAA
`OOT GGG
`CGG AGG
`TTG TTC
`ATC ACC
`GTC ATC
`TCC TCA
`AGA AGA
`GAG GAT
`ACA GAT
`TCC TCC
`CAA AAA
`AGT AGT
`GTC AGT
`CTG GCT
`T AC TAG
`GTT CTG
`GAG GAA
`ATG ATG
`AAT AAC
`GCC AAC
`GTG TTA
`AGA AGA
`GCT GCT
`GAG GAA
`GAG GAG
`ACT ACT
`GCC GGC
`ACT Ail
`TAT TAT
`TAG TAG
`TGT TGT
`ACA ACC
`AGA AGG
`GAT CCG
`GCG GGG
`GAG GTC
`TAG CCC
`GGT
`AAT
`AGC
`
`TAG
`
`TGG TGG
`TAG TAG
`TTC TTC
`
`TAG
`TTT
`GGG
`TAG
`TTC
`
`TGG
`GTT
`CGC
`CAG
`CCT
`CCA
`GGA
`AAG
`GGT
`CTG
`GAG
`TGG
`CTG
`GGA
`ACG
`ATA
`TGG
`
`GGT
`AAT
`GGA
`AGC
`ACA
`GAC
`TAT
`AAT
`TCA
`ACT
`CTC
`AAA
`TCC
`AGA
`CTG
`ACC
`ATC
`ACC
`AAG
`GAC
`AAC
`TCC
`AAG
`AGC
`CAA
`GTT
`TTC
`TTA
`AAA
`ATG
`AAC
`AGT
`CTG
`CAA
`ACT
`GAT
`GAC
`ACA
`GCC
`AGG
`TAC
`TAC
`TGT
`GCC
`AGC
`GTC
`TCA
`ATT
`TAT
`TAC
`TAC
`GGT
`CGT
`AGC
`GAC
`AAA
`TAC
`TTC
`ACT
`TTG
`
`CAG
`GTA
`CAG
`CTG
`AAG
`GAG
`TCA
`GGA
`CCT
`GGC
`CTG
`GTG
`GCG
`CCC
`TCA
`CAG
`AGC
`CTG
`TCC
`ATC
`ACA
`TGC
`ACC
`GTC
`TCA
`GGG
`TTC
`TCA
`TTA
`ACC
`GGC
`TAT
`GGT
`GTA
`AAC
`
`TGG
`GTT
`CGC
`CAG
`CCT
`CCA
`GGA
`AAG
`GGT
`CTG
`GAG
`TGG
`CTG
`GGA
`ATG
`ATA
`TGG
`
`GGT
`GAT
`GGA
`AGC
`ACA
`GAC
`TAT
`AAT
`TCA
`GCT
`CTC
`AAA
`TCC
`AGA
`CTG
`AGC
`ATG
`AGC
`AAG
`GAC
`AAC
`TCC
`AAG
`AGC
`CAA
`GTT
`TTC
`TTA
`AAA
`ATG
`AAC
`AGT
`CTG
`CAA
`ACT
`GAT
`GAC
`ACA
`GCC
`AGG
`TAC
`TAC
`TGT
`GCC
`AGA
`
`GAG GAG GAG GAT GAG GAG GAG CAT GAG
`GTC GTG GTC GTG GTG GTC GTG GTG GTG
`GAG CAA CAA GAG CAA CAA CAA GAA GAG
`CTG CTG CTA CTG CTG CTG CTG CTG CTG
`GAG GAG CAG GTG GAG GAG GAG GAG GAG
`GAG GAG GAG GAG GAG GAG GAG GAG CAA
`TCT CCT CCT TCT CCT CCT CCT CCT TCT
`GQA GGG GGG GGG GGG GGG GGG GGG GGA
`GCT GCT GCT GGA GCT ACT GCT GCT CCT
`GAG GAG GAG GGC GAG GAA GAG GAG GAG
`CTG CTT TTT TT A CTT CTG CTG GTG CTG
`GT A GTG GTG GTG GTG GTG GTG GTG GTG
`AGA AAG AAG GAG AAG AAG AGG AAG AAG
`CCT CCT CCT CCT CCT CCT CCT CCT CCT
`GGG GGG GGG GGA GGG GGG GGG GGG GGG
`ACT GCT GCT GGG GCT GCT TCT GCT GGT
`TGA TCA TCA TCC TCA TCA TCA TCA TCA
`GTG GTG GTG CGG GTG GTG GTG GTG GTG
`AAG AAG AAG AAA AAG AAG AAG AAG AAG
`ATG CTG CTG CTC CTG CTG CTG GTG ATA
`TCC TCC TCC TCC TCC TCC TCC TCC TCC
`TGC TGC TGC TGT TGC TGC TGC TGC TGC
`AAG AAG AAG GCA AAG AAG AAG AAG AAG
`GGT GCT GCT GCC GCT GCT GGT GCT GCT
`GCT TCT TCT TCT TCT TCT TCT TCT TCT
`GGA GGC GGC GGA GGC GGC GGC GGC GGC
`TAG TAC TAG TTC TAC TAG TAG TAC TAT
`ACC ACC ACC ACT ACC ACC ACC ACC ACG
`TTC TTC TTC TTC TTC TTC TTC TTC TTC
`ACT ACC ACC AGT ACC ACC ACC ACC ACA
`AAC AGC AGC AGC AGC AGC AGC AGC AGC
`TAG TAG TAG TTT TAG TAG TAG TAG TAG
`TGG TGG TTA GGA TGG TCIG TGG TGG TAT
`ATA ATG ATG ATG ATG ATG ATG ATG ATA
`GGT CAC CAC CAC CAC CAC GAT CAC CAC
`
`TGG TGG TGG TGG
`GT A GTG GTG GTT
`AAG AAG AAC CGT
`GAG GAG GAG GAG
`AGG AGG AGG GCT
`CCT CCT CCT CCA
`GGA GGA GGA GAG
`CAT CGA CGA AAG
`GGC GGC GGC GGG
`CTT CTT CTT CTG
`GAG GAG GAG GAG
`TGG TGG TGG TGG
`ATT ATT ATT GTC
`GGA GGA GGA GCA
`GAT AGG AGG TAG
`ATT ATT ATT ATT
`1 AC GAT GAT AGT
`CCT CCT CCT AGT
`
`TGG TGG TGG TGG TGG
`GTG GTG GTG GTG GTG
`AAG AAG AAG AAG AAG
`GAG CAG GAG CAG GAG
`AGG AGG AGG AGG AGG
`CCT CCT CCT CCT CCT
`GGA GGA GGA GGC GGA
`CGA CAA CAA CAA GAG
`GGC GGC GGC GGC GGC
`CTT CTT CTT CTT CTT
`GAG GAG GAA GAG GAG
`TGG TGG TGG TGG TGG
`ATT ATT ATT ATT All
`GGA GGA GGT GGA GGA
`AGG AAT AAC AGG TAT
`ATT ATT ATT ATT ATT
`GAT AAT TAG CAT TAT
`CCT CCT CCT CCT CCT
`
`AAT GGC TCT TCT AGA
`AGT AAT GAT GAT GAT
`GGT GGT AGT AGT GGT
`GGT GGT GAA GAT AGT
`ACT ACT ACT ACT ACT
`AAG AAC CAC AAC AAT
`TAG TAC TAG TAG TAG
`AAT AAT AAT AAT AAT
`GAG GAG CAA CAA GAG
`AAG AAG AAG AAG AAG
`TTC TTC TTC TTC TTC
`AAG AAG AAG AAG AAG
`AGC AGC GAC GGG GGC
`AAG AAG AAG AAG AAG
`GCC GTC GCC GCC GCC
`ACA ACA ACA ACA ACA
`CTG CTG TTG TTG GTG
`ACT ACT ACT ACT ACT
`GTA GTA GTA GTA GCA
`GAG GAG GAG GAG GAG
`ACA AAA AAA AAA ACA
`TCC TCC TCC TCC TCC
`TGC TCC TCC TCC TGC
`AGC AGe AGG AGC AGC
`ACA ACA ACA ACA ACA
`GCC GCC GCG GCC GGC
`TAC TAC TAG TAC TAG
`ATG ACG ATG ATG ATG
`GAG GAG GAG GAG GAG
`CTC CTC CTC CTC CTC
`AGC AGC AGC AGC AGC
`AGC AGC AGC AGC AGC
`CTG CTG CTG CTG CTG
`ACA ACA ACA ACA ACA
`TCT TCT TCT TCT TCT
`GAG GAG GAG GAG GAG
`GAG GAG GAG GAG GAG
`TCC TCT TCT TGT TCT
`GCG GCG GCG GCG GCA
`GTC GTC GTC GTC GTG
`CAT TAT TAT TAT TAT
`TAT TAT TAC TAG TTC
`TGT TGT TGT TGT TGT
`GCA GCA GCA GCA GCA
`AGA AGA AGA ATA AGA
`
`GGA AAT AAT GGC
`GGT AGT AGT AGT
`GGC GGT GGT AGT
`TTT GGT GGT ACC
`ACT ACT ACT CTC
`AAC AAG ACG GAG
`TAG TAG TAC TAT
`AAT AAT AAT GCA
`GAG GAG GAG GAG
`AAT AAG CAC ACA
`TTC TTG TTC GTG
`AAG AAG AGG AAG
`GGC AGC AGC GGC
`AAG AAG AAG CGA
`GCC GCC GCC TTC
`ACA ACA ACA ACC
`CTG CTG CTG ATC
`ACT ACT ACT TCA
`GCA GTA ATA AGA
`GAG GAG GAG GAG
`ACA AAA AAA AAT
`TCC CCC CCC CCC
`TCC TCC TCG AAG
`AGC AGC AGC AAC
`ACA ACA ACA ACC
`GCC GCC GCC CTG
`TAG TAG TAG TAG TTC
`ATG ATG ATG ATG CTG
`GAG GAG GAG GAG GAA
`CTC CTC CTC CTC ATG
`AAC AGC AGC AGC ACC
`AGC AGC AGC AGC AGT
`CTG CTG CTG CTG CT A
`ACA ACA ACA ACA AGG
`TCT TCT TCT TCT TCT
`GAG GAG GAG GAG GAG
`GAG GAG GAG GAG GAG
`TCT TCT TCT TCT ACG
`GCA GCC GCG