111111111111111111111111111111111111111111111111111111111111111111111111111
`US0063314l5Cl
`(t2l EX PARTE REEXAMINATION CERTIFICATE (6829th)
`United States Patent
`US 6,331,415 C1
`oo) Number:
`Cabilly et al.
`(45) Certificate Issued: May 19, 2009
`
`(54) METHODS 0}' PRODUCING
`TMMUNOGT"OBULINS, VECTORS AND
`TRANSFORMED HOST CELLS FOR USE
`THEREIN
`
`(75)
`
`Inventors: Shmuel Cabilly, Monrovia, CA (US);
`Herbert L. Heyneker, Burlingame, CA
`(US); William E. Holmes, Pacifica, CA
`(US); Arthur D. Riggs, T .a Verne, CA
`(US); Ronald B. \Vetzel, San Francisco,
`CA (US)
`
`(73) Assignees: Genentech, Inc., South San Francisco,
`CA (US); City of Hope, Duarte, CA
`(US)
`
`Reexamination Reque~t:
`No. <J0/007,542, May 13, 2005
`No. 90/007,859, Dec. 23, 2005
`
`Reexamination Certificate for:
`Patent No.:
`6,331,415
`Dec. 18, 2001
`Issued:
`Appl. No.:
`07/205,419
`Filed:
`Jun.1U, 1988
`
`Certificate of Correction issued Jun. 25, 2002.
`
`Related U.S. Application Data
`
`( 63) Continuation of application No. 06/483.457, filed on Apr. 8,
`1983, now Pat. No. 4.816,567.
`
`(51)
`
`Int.Cl.
`C12N 15113
`C12N 15100
`C/2N 15163
`
`(2006.01)
`(200G.Ol)
`(200o.Ol)
`
`(52) U.S. Cl .................. 435/69.6; 435/252.1; 435/252.3;
`435/252.33; 435/254.11; 435/254.2: 435/254.21:
`435/69.7; 435/70.21; 435171.2; 435/71.1;
`435/70.1; 435/320.1; 435/455; 435/483;
`435/485; 435/471: 435/o9.1
`(58) Field of Classification Search ........................ None
`Sec application file for complete search history.
`
`(56)
`
`References Cited
`
`U.S. PATENT DOCUMENTS
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`
`EP
`EP
`El'
`
`FOREIGN PATENT DOCUMENTS
`
`0 036 776
`044722
`0 044 722
`
`3/1981
`1/1982
`1/19H2
`
`(Continued)
`
`OTHER PUBLICATIONS
`
`Harvard Journal of Law & Technology 17(2) (Spring 2004),
`pp. 583-618.*
`Jlm. 5, l<J<J5 preliminary amendment in the Moore U.S.
`Appl. No. 08/461,071. *
`Declaration of Dr. Richard Axel, submitted Oct. 5, 1989 in
`U.S. Appl. No. 08/422,187. *
`
`(Continued)
`
`Primary Examiner Padmashri Ponnaluri
`
`(57)
`
`ABSTRACT
`
`The invention relates to processes for producing an inununo(cid:173)
`globulin or an immunologically functional immunoglobulin
`fragment containing at least the variable domains of the
`immunoglobulin heavy and light chains. The processes can
`use oue or more veclors which produce both the heavy and
`light chains or fragments thereof in a single cell. The inven(cid:173)
`tion also relates to the vectors used to produce the immuno(cid:173)
`globulin or fragment, and to cells transformed with the vec(cid:173)
`tors.
`
`Sanofi/Regeneron Ex. 1 026, pg 81 0
`
`Merck Ex. 1026, pg 836
`
`

`
`US 6,331,415 C1
`Page2
`
`FOREIGN PATENT DOCUMENTS
`
`EP
`FP
`EP
`EP
`EP
`EP
`FP
`EP
`wo
`wo
`wo
`wo
`wo
`wo
`wo
`wo
`wo
`wo
`wo
`
`060057
`0 114 506
`102634
`0171496
`173494
`177343
`165997
`0481790
`81/02426
`wo 82/03088
`83/00164
`~7/02671
`89/00999
`89/01783
`92/16553
`93/07899
`93/10817
`93/21319
`97/30087
`
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`1211983
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`3/1989
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`
`

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`US 6,331,415 C1
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`

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