·.J·
`
`'I
`
`'
`
`~ . ...
`''i''
`
`;:.
`
`••
`
`PATENT DOCKET 150Cl
`
`*" ~
`
`RECEIVED
`
`IN THE UNITED STATES PATENT AND TRADEMARK OFFICE
`
`In re Application of:
`
`SHMUEL CABILLY ET AL.
`
`Serial No. 07/205,419
`
`Filed: 06/10/88
`
`For: RECOMBINANT IMMUNOGLOBULIN
`PREPARATIONS
`
`)
`)
`)
`)
`)
`)
`)
`)
`)
`)
`)
`)
`
`Art Unit: 185
`
`SEP 2 5 1991
`
`Examiner-in-Chief:
`BOARD OF PATENT APPEALS
`Mike Nisbet
`AND INTERFERENCES
`
`460 Point San Bruno Boulevard
`South San Francisco, CA 94080
`(415) 266-1994
`
`INFORMATION DISCLOSURE STATEMENT
`
`Honorable Commissioner of Patents
`and Trademarks
`Washington, D.C. 20231
`
`Sir:
`
`The following items are supplied to the United States Patent and Trademark
`Office to advance the prosecution of the subject application.
`This application is a continuation of U.S.S.N. 06/483,457, now issued as US
`Patent 4,816,567. The
`'567 patent is directed to the production of chimeric
`immunoglobulin heavy or light chains. The claims of the '567 patent do not
`exclude the additional expression of light or heavy chain, respectively, and
`therefore cover the production of chimeric immunoglobulins. Therefore, in the
`interests of good order, all of the citations of record in the parent also should
`be made of record here. These citations are listed in Group I below. Copies of
`the citations are not supplied since they are available in the file history of
`the parent.
`If they should be missing for some reason the undersigned will
`supply an additional copy upon request.
`In addition, this application presently is involved in interference 102,572
`with US Patent 4,816,397 to Boss et al. Group II below contains the citations of
`record from the face of the Boss Patent, copies of which are supplied herewith.
`Further citations have come
`to the attention of the undersigned,
`in
`particular from applications related to the Boss and Cabilly Patents. These are
`
`/
`
`Sanofi/Regeneron Ex. 1 013, pg 433
`
`Merck Ex. 1013, pg 459
`
`
`
`'I
`
`'
`
`~ . ...
`''i''
`
`;:.
`
`••
`
`PATENT DOCKET 150Cl
`
`*" ~
`
`RECEIVED
`
`IN THE UNITED STATES PATENT AND TRADEMARK OFFICE
`
`In re Application of:
`
`SHMUEL CABILLY ET AL.
`
`Serial No. 07/205,419
`
`Filed: 06/10/88
`
`For: RECOMBINANT IMMUNOGLOBULIN
`PREPARATIONS
`
`)
`)
`)
`)
`)
`)
`)
`)
`)
`)
`)
`)
`
`Art Unit: 185
`
`SEP 2 5 1991
`
`Examiner-in-Chief:
`BOARD OF PATENT APPEALS
`Mike Nisbet
`AND INTERFERENCES
`
`460 Point San Bruno Boulevard
`South San Francisco, CA 94080
`(415) 266-1994
`
`INFORMATION DISCLOSURE STATEMENT
`
`Honorable Commissioner of Patents
`and Trademarks
`Washington, D.C. 20231
`
`Sir:
`
`The following items are supplied to the United States Patent and Trademark
`Office to advance the prosecution of the subject application.
`This application is a continuation of U.S.S.N. 06/483,457, now issued as US
`Patent 4,816,567. The
`'567 patent is directed to the production of chimeric
`immunoglobulin heavy or light chains. The claims of the '567 patent do not
`exclude the additional expression of light or heavy chain, respectively, and
`therefore cover the production of chimeric immunoglobulins. Therefore, in the
`interests of good order, all of the citations of record in the parent also should
`be made of record here. These citations are listed in Group I below. Copies of
`the citations are not supplied since they are available in the file history of
`the parent.
`If they should be missing for some reason the undersigned will
`supply an additional copy upon request.
`In addition, this application presently is involved in interference 102,572
`with US Patent 4,816,397 to Boss et al. Group II below contains the citations of
`record from the face of the Boss Patent, copies of which are supplied herewith.
`Further citations have come
`to the attention of the undersigned,
`in
`particular from applications related to the Boss and Cabilly Patents. These are
`
`/
`
`Sanofi/Regeneron Ex. 1 013, pg 433
`
`Merck Ex. 1013, pg 459
`
`
`
`07/102,572
`
`Page No. 2
`
`submitted herewith as Groups III and IV.
`immunoglobulin mRNA
`The Group III items relate to the expression of
`microinjected into Xenopus (frog) oocytes (unfertilized eggs).
`These are
`substantially cumulative to Valle et al. (1982) of record in the parent to the
`instant case, but are cited as of interest and to complete the record. Work of
`this sort is readily distinguishable from the instant claims in that the oocytes
`are not transformed with DNA, but instead are used to transiently express mRNA
`preparations.
`For the most part the citations in Group IV are concerned with hybridoma or
`myeloma cells transformed with DNA encoding either an immunoglobulin light or
`heavy chain, or relate to the processing or secretion of immunoglobulins from
`hybridoma and myeloma cells. Thus, they are substantially cumulative to Rice et
`al. (1982), which is of record in the parent, or are of theoretical interest
`only. These disclosures are clearly distinguishable from the instant claims in
`that the cells are not transformed with exogenous DNA encoding both of the heavy
`and light chains.
`
`GROUP I
`
`U.S. Pat. 4,444,878
`u.s. Pat. 4,512,922
`u.s. Pat. 4,518,584
`u.s. Pat. 4,704,362
`EPO 0057107
`EPO 0073656
`EPO 0068763
`EPO 0120694
`Dolby et al. Proc Natl. Acad. Sci. 77(10):6027-6031 (1980)
`Rice et al. Proc. Natl. Acad. Sci. 77:7862-7865 (1982)
`Accolla et al. Proc. Natl. Acad. Sci. 77(1):563-566 (1980)
`Raso et al. Cancer Res. 41:2073-2078 (1981)
`Nisonoff et al. Arch. Biochem. Biophys. 93:460-462 (1960)
`Glennie et al. Nature 295:712-714 (1982)
`Eisen Immunolo&Y Harper & Row, Publishers, pp. 415 and 428-436 (1974)
`Hozumi et al. Nuc. Acids. Res. 5(6):1779-1799
`Wetzel et al. Gene 16:63-71 (1981)
`
`Sanofi/Regeneron Ex. 1 013, pg 434
`
`Merck Ex. 1013, pg 460
`
`
`
`··:
`
`,.,_, :·
`
`07/102,572
`
`Page No. 3
`
`Williams et al. Science 215:687-689 (1982)
`Falkner et al. Nature 298:286-288 (1982)
`Boss et al. Gene Expressions-Proc. Cetus-UCLA Symposium pp. 513-522, March 26-
`April 1, 1983
`Amster et al. Nucleic Acid Research 8(9):2055-2065 (1980)
`DeBoer et al., Rodriguez et al. (Ed.) Promoters 462-481 (1982)
`Gough Tibs 6(8):203-205 (August, 1981)
`Morrison J. of Immunolo~y 123(2):793-800 (August, 1979)
`Kohler Proc. Natl. Acad. Sci. 77(4):2197-2199 (April, 1980)
`Roberts Promoters 452-461 (1982)
`Kemp et al. Proc. Natl. Acad. Sci. 78(7):4520-4524 (July, 1981)
`Valle et al. Nature 300:71-74 (November 4, 1982)
`Microbiolo~y 3rd edition, Harper Int. Ed. 338-379 (1980)
`Hitzeman et al. Science 219:620-625 (1983)
`Mercereau-Puijalon et al. Expression of Eukaryotic Viral and Cellular Genes
`Pettersson et al. (Ed.) 295-303 (1981) Academic Pr.
`Keshet et al. Nucleic Acids Res. 9(1):19-30 (1981)
`Taniguchi et al. Proc. Natl. Acad. Sci. 77(9):5230-5233 (1980)
`Ohsuye et al. Nucleic Acids Res. 11(5):1283-1295 (1983)
`Kadonaga et al. J. Biol. Chern. 259(4):2149-2154 (1984)
`Maniatis Molecular Clonin~ p.433 (September, 1985)
`Fujisawa et al. Nucleic Acids Res. 11(11):3581-3591 (1983)
`Roberts Promoters Structures and Function Rodriguez, R. L. (Ed.) 452-461 (1982)
`
`GROUP II
`
`U.S. Pat. 4,403,036
`U.S. Pat. 4,642,334
`EPO 0037723
`EPO 041313
`EPO 041767
`EPO 055945
`EPO 075444
`EPO 088994
`EPO 0125023
`Adams et al. Biochemistry 19:2711-2719 (1980)
`
`Sanofi/Regeneron Ex. 1 013, pg 435
`
`Merck Ex. 1013, pg 461
`
`
`
`•r· . ,.
`
`\
`
`··~·
`
`07/102,572
`
`Page No. 4
`
`Haley et al. DNA 1:155-162 (1982)
`Gough et al. Biochemistry 19:2702-2710 (1980)
`Iserentant et al. Gene 9:1-12 (1980)
`Seidman et al. Nature 271:582-585 (1978)
`
`GROUP III
`Stevens et al. J. Mol. Biol. 78:517-525 (1973)
`Deacon et al. Biochem. Soc. Trans. 4:818-820 (1976)
`Colman et al. Cell 17:517-526 (1979)
`Valle et al. Nature 291:338-340 (1981)
`Colman et al. J. Mol. Biol. 160:459-474 (September, 1982)
`
`Group IV
`Cowan et al. J. Mol. Biol. 90:691-701 (1974)
`Morrison et al. J. Immunol. 114:655-659 (1975)
`Mosmann et al. J. Immunol. 115:955-962 (1975)
`Levy et al. Proc. Nat. Acad. Sci. 75:2411-2415 (1978)
`Robertson et al. Nature 287:390-392 (1980)
`Mosmann et al. Cell 20:283-292 (1980)
`Yilde et al. Eur. J. Immunol. 10:462-467 (1980)
`Ochi e~ al. Nature 302:340-342 (March 24, 1983)
`Kemp et al. in Nagley et al., Ed. , Manipulation and Expression of Genes in
`Eukaryotes Proceedings of an International Conference, 12th International
`Congress of Biochemistry, in Australia 9-13 August, 1982 (1983)
`Picard et al. Proc. Nat. Acad. Sci. 80:417-421 (January, 1983)
`Oi et al. Proc. Nat. Acad. Sci. 80:825-829 (February, 1983)
`Hawley et al. Proc. Nat. Acad. Sci. 79:7425-7429 (December, 1982)
`Boss et al. Immunology Today 6(1):12-13 (1985)
`Lewin, Ed. Genes 3rd Edition, 359-360 (1987)
`Skerra et al. Science 240:1038-1040 (1988)
`Kohler et al. Eur. J. Immunol. 6:292-295 (1976)
`
`One copy of each item cited above in Groups II-IV is supplied, along with
`a completed Form PTQ-1449. The Examiner is requested to make the citations of
`record.
`
`Sanofi/Regeneron Ex. 1 013, pg 436
`
`Merck Ex. 1013, pg 462
`
`
`
`;...
`.
`
`'
`
`07/102,572
`
`Page No. 5
`
`This submission is understood to complement the results of the Examiner's
`
`own independent search. The submission of this Disclosure Statement should not
`be construed as a representation that a search was made, that the cited items are
`
`inclusive of all the relevant and material citations that may be available
`
`publicly, or that designation of membership in a Group means that all disclosure
`
`relates exclusively to that Group.
`The citation of any item is not an admission that the item is prior art.
`
`The right is reserved to antedate any item in adherence with standard procedures.
`Respectfully submitted,
`~· INC.
`
`Dated: September 18, 1991
`
`Max D, Hensley
`Reg. No. 27, 043
`
`Date of Signature
`
`Sanofi/Regeneron Ex. 1 013, pg 437
`
`Merck Ex. 1013, pg 463
Accessing this document will incur an additional charge of $.
After purchase, you can access this document again without charge.
Accept $ Charge
Still Working On It
This document is taking longer than usual to download. This can happen if we need to contact the court directly to obtain the document and their servers are running slowly.
Give it another minute or two to complete, and then try the refresh button.
A few More Minutes ... Still Working
It can take up to 5 minutes for us to download a document if the court servers are running slowly.
Thank you for your continued patience.
This document could not be displayed.
We could not find this document within its docket. Please go back to the docket page and check the link. If that does not work, go back to the docket and refresh it to pull the newest information.
Your account does not support viewing this document.
You need a Paid Account to view this document. Click here to change your account type.
Your account does not support viewing this document.
Set your membership
status to view this document.
With a Docket Alarm membership, you'll
get a whole lot more, including:
- Up-to-date information for this case.
- Email alerts whenever there is an update.
- Full text search for other cases.
- Get email alerts whenever a new case matches your search.
One Moment Please
The filing “” is large (MB) and is being downloaded.
Please refresh this page in a few minutes to see if the filing has been downloaded. The filing will also be emailed to you when the download completes.
Your document is on its way!
If you do not receive the document in five minutes, contact support at support@docketalarm.com.
Sealed Document
We are unable to display this document, it may be under a court ordered seal.
If you have proper credentials to access the file, you may proceed directly to the court's system using your government issued username and password.
Access Government Site
