Jack HIRSH, M.D.
`
`Curriculum Vitae
`(Long Version)
`
`
`
`
`
`
`
`
`BUSINESS ADDRESS
`
`McMaster University Medical Centre
`1280 Main Street West
`Hamilton, Ontario L8S 4K1, Canada
`
`Telephone:
`Fax:
`
`E-mail:
`
`(905) 521-2100 ext. 76758
`(905) 521-4972
`hirshj@mcmaster.ca
`
`University of Melbourne Medical School
`Royal Melbourne Hospital
`Clinical School
`
`
`
`EDUCATION
`
`University Training
`
`1953 - 1958
`
`
`
`
`
`Degrees and Professional Qualifications
`
`
`M.B.B.S. (Melbourne)
`
`M.R.A.C.P.
`
`
`
`M.D. (Melbourne)
`
`
`F.R.A.C.P.
`
`
`
`F.R.C.P. (C)
`
`
`
`F.A.C.P.
`
`
`
`F.A.C.C.P.
`
`
`D.Sc.(Honourary) McMaster
`Fellow, Royal Society of Canada
`Canada Medical Hall of Fame
`Officer of the Order of Canada
`
`APPOINTMENTS
`
`1959-1961
`
`
`
`Resident Medical Officer 1, 2, 3
`
`
`
`1
`
`
`
`
`
`
`
`
`
`
`
`
`
`1958
`1962
`1962
`1969
`1973
`1982
`1986
`1999
`1999
`2000
`2000
`
`
`
`MYLAN - EXHIBIT 1005
`
`

`
`
`
`Royal Melbourne Hospital, Victoria, Australia
`
`Assistant Hematologist
`Royal Melbourne Hospital, Victoria, Australia
`
`Research Fellow, Department of Internal Medicine
`Washington University, St. Louis, Missouri, U.S.A.
`(Professor S. Sherry)
`
`Research Assistant, Department of Hematology
`Postgraduate Medical School
`London, England (Professor J.V. Dacie)
`
`Visiting Research Scientist, Department of Medicine and Blood and
`Vascular Research Unit, University of Toronto, Ontario, Canada (Dr. F.
`Mustard)
`
`Senior Lecturer, Department of Medicine
`University of Melbourne, St. Vincent's Hospital, Melbourne, Australia
`
`Associate Professor, Departments of Pathology and Medicine
`McMaster University, Hamilton, Ontario, Canada
`
`Professor, Departments of Pathology and Medicine
`McMaster University, Hamilton, Ontario, Canada
`
`Coordinator, Hamilton District Coordinating Committee for Hematology
`McMaster University Medical Centre, Hamilton, Ontario, Canada
`
`Professor and Chairman, Department of Medicine
`McMaster University, Hamilton, Ontario, Canada
`
`Associate Member, Department of Clinical Epidemiology and Biostatistics
`McMaster University, Hamilton, Ontario, Canada
`
`Professor of Medicine
`McMaster University, Hamilton, Ontario, Canada
`
`Director
`Hamilton Civic Hospitals Research Centre, Hamilton, Ontario, Canada
`
`Vice President, Research, Vascular Therapeutics, Inc.
`
`Professor Emeritus, Department of Medicine
`McMaster University, Hamilton, Ontario, Canada
`
`Vice-President, Research; GlycoDesign, Inc., Toronto, Ontario, Canada
`
`Vice-President, Research
`Hamilton Health Sciences
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`1963-1964
`
`
`1964-1965
`
`
`1965
`
`
`
`
`1965-1966
`
`1966-1970
`
`
`1970-1971
`
`
`1971-1981
`
`
`1978
`
`
`
`
`1981-1988
`
`
`1983-1994
`
`
`1988-1994
`
`
`1988-2003
`
`
`1994-1999
`
`
`
`1994-Present
`
`
`1999-2003
`
`2000-2002
`
`
`
`
`
`
`
`2
`
`

`
`
`
`Vice-President, Research, Inflazyme, Inc., Vancouver, Canada
`
`Consultant, Intellectual Property and Commercialization to the Faculty of
`Health Sciences, McMaster University and the Hamilton Health Sciences
`Corporation
`
`
`
`
`2003-2004
`
`2003-Present
`
`
`
`
`
`GRANTS AND SCHOLARSHIPS
`
`1964
`
`The Royal Australasian College of Physicians Travelling Scholarship
`during appointment with Professor J.V. Dacie
`
`
`
`
`
`U.S. Public Health Service Fellowship under a training grant during
`appointment with Professor S. Sherry
`
`Visiting Scientist - Fellowship Programme of the Canadian Heart
`Foundation
`
`Wellcome Travel Grant
`
`Ontario Ministry of Health Research Grant
`
`Medical Research Council
`
`Canadian Heart and Stroke Foundation Grants
`
`Ministry of Health
`
`Heart and Stroke Foundation of Canada - The Effects of Low Molecular-
`Wieght and Standard Heparin on Bone Resorption (Principle Investigator:
`S. Shaughnessy)
`
`Heart and Stroke Foundation of Canada - Optimal Heparin Neutralization
`(Principle Investigator: K. Teoh)
`
`Heart and Stroke Foundation of Canada - Heparin-Binding Proteins and
`the Variability of Anticoagulant Response (Principle Investigator: E.
`Young)
`Heart and Stroke Foundation of Canada B Effects of low-molecular-
`weight and standard heparin on bone resorption (Principle Investigator: S.
`Shaughnessy)
`
`Ontario Research Development Challenge Fund
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`1964
`
`
`1965
`
`
`
`
`
`
`
`
`1965
`
`1970-1988
`
`1970-1993
`
`1970-2003
`
`1992-1997
`
`1994-1997
`
`
`1994-1997
`
`
`1994-1997
`
`1998-2002
`
`
`1999-2003
`
`
`
`
`
`AWARDS AND DISTINCTIONS
`
`
`
`
`3
`
`

`
`
`
`Eric Susman Prize
`
`Canadian Cardiovascular Society Research Achievement Award
`
`Outstanding Service Award, Heart and Stroke Foundation of Ontario
`
`American College of Chest Physicians
`"Presidential Citation" - 52nd Annual Scientific Meeting, San Francisco,
`California
`
`18th Annual Paul Aggeler Lecturer, San Francisco, California
`
`Distinguished Service Award, The American Society of Hematology
`
`Carl deGruchy Memorial Lecturer & Award, Haematology Society of
`Australia
`
`Distinguished Research Professorship, Heart and Stroke Foundation of
`Ontario
`
`Dr. Kenneth M. Brinkhous Distinguished Career Award
`Committee
`for
`the Fourth Biannual Awards
`for Contributions
`Hemostasis
`International Society on Thrombosis and
`the
`XIIth Congress of
`Haemostasis, Tokyo, Japan
`
`to
`
`Governor-in-Council Appointee, Government of Canada
`
`Trillium Award - Ministry of Health
`
`The Hamilton Netherlands Experience European Society, Netherlands
`Thrombosis Foundation
`
`Seymour Lectureship, Distinguished Service to Internal Medicine Award
`Wesley Foundation, Wichita, Kansas
`
`Sol Sherry Lecturer of the American Heart Association
`Council of Thrombosis of the American Heart Association, Atlanta,
`Georgia
`Ham-Wasserman Lecture
`38th Annual American Society of Hematology Meeting; Orlando, Florida
`
`Editorial Excellence, American College of Chest Physicians
`
`Fellow of the Council on Arteriosclerosis, Thrombosis and Vascular
`Biology (ATVB)
`
`PrixGalien Canada, Research Award
`
`Honourary D.Sc. (McMaster University)
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`1970
`
`1982
`
`1984
`
`1986
`
`
`1987
`
`1987
`
`1988
`
`
`1989
`
`
`1989
`
`
`1990
`
`1992
`
`1993
`
`
`1993
`
`
`1993
`
`1996
`
`
`1996
`
`1997
`
`
`1999
`
`1999
`
`
`
`4
`
`

`
`
`
`
`1999
`
`2000
`
`2000
`
`2000
`
`
`2000
`
`
`2002
`
`
`2003
`
`2006
`
`2008
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`Fellow, Royal Society of Canada
`
`Canadian Medical Hall of Fame Laureate
`
`Member of the Order of Canada
`
`Member of the Council of Arteriosclerosis, Thrombosis and Vascular
`Biology (ATVB)
`
`Gairdner Foundation International Award for Achievement in Medical
`Science
`
`Golden Jubilee Medal for Exceptional Qualities and Outstanding Service
`to Canada
`
`Cornerstone Awardee, Hamilton Health Sciences Corporation
`
`Henry M. Stratton Medal, American Society of Hematology
`
`CHEST 2008 Distinguished Fellow Honor Award, American College of
`Chest Physicians (ACCP)
`
`
`
`
`
`Community of Distinction Award, McMaster University
`
`
`2008
`
`2009 McMaster Lifetime Innovation Award
`
`2012 Hemostasis & Thrombosis Research Society Lifetime Achievement
`Award
`
`2012 Queen Elizabeth II Diamond Jubilee Medal
`
`
`
`EDITORIAL BOARD
`
`
`1975
`
`1976
`
`1980
`
`1980
`
`1983
`
`1984
`
`1985
`1985-1994
`1985
`
`1986-1993
`1986
`
`1987
`
`1987
`
`1988
`
`1989
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`Haemostasis
`Blood
`Thrombosis Research
`American Journal of Hematology
`Review of Haematological Practice
`International Editorial Board of Drugs
`Arteriosclerosis
`Thrombosis & Haemostasis
`USP Surgical Drugs and Devices Advisory Panel
`International Committee for Fibrinolysis
`Primary Care Emergency Decisions
`Bailliere Tindall, W.B. Saunders Company Ltd.
`Archives of Internal Medicine
`Churchill Livingstone Medical Journals
`STA Communications Inc., The Canadian Journal of Diagnosis
`
`
`
`
`
`5
`
`

`
`
`
`
`
`
`
`The National Medical Journal of India, Oxford University Press
`Arteriosclerosis and Thrombosis
`American Journal of Medicine
`
`1989
`1990
`1998
`
`
`
`
`
`
`
`EXECUTIVE POSITIONS
`
`1972-1975
`
`1973-1975
`
`
`
`
`
`Minister's Committee on the Pill, (Federal Government)
`
`Chairman, Publications Committee, Executive Committee, Council on
`Thrombosis, American Heart Association
`
`Chairman, Subcommittee on Hemostasis, American Society of
`Hematology
`
`Member, Scientific Subcommittee, Canadian Heart Foundation
`
`Member, Council on Thrombosis. American Society of Hematology
`
`Chairman, Medical Members Committee, Ontario Heart Foundation
`
`Chairman, Medical Members Committee, Ontario Heart Foundation
`
`Member, Task Force on Thromboembolism, Ontario Council of Health
`
`Chairman, Subcommittee on Diagnosis, Prophylaxis and Treatment of
`Venous Thromboembolism, International Committee on Thrombosis and
`Hemostasis
`
`Chairman, Council of the International Society on Thrombosis and
`Hemostasis
`
`Member, Board of Directors, Canadian Heart Foundation
`
`President, Canadian Hematology Society
`
`Member, Canadian Association of Professors of Medicine
`
`Member, Health Research Personnel Review Committee
`
`Member, Health Research and Development Council of Ontario
`
`Co-Chairman, National Committee on Antithrombotic Drugs, American
`College of Chest Physicians
`
`Chairman, Subcommittee on Heparin,
`Thrombosis & Haemostasis
`
`International Committee on
`
`the
`Member, Council of
`Hemostasis (By Election)
`
`International Society of Thrombosis and
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`1973-1975
`
`
`1973-1980
`
`1975-1988
`
`1978-1984
`
`1978-1984
`
`1978-1981
`
`1978-1981
`
`
`1978-1980
`
`
`1980-1988
`
`1980-1982
`
`1981-1988
`
`1982-1987
`
`1984-1987
`
`1985
`
`
`
`
`1986-1989
`
`
`1988
`
`
`
`
`
`6
`
`

`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`Member, American Heart Association Council on Thrombosis
`
`International Congress of Cardiology on Cardiovascular
`Member,
`Pharmacotherapy and Cardiomyopathies, ISFC
`
`Member, Task Force on Research Development, Medical Research
`Council of Canada
`
`Member, Subcommittee on Control of Anticoagulation, International
`Committee for Standardization in Haematology
`
`Member, Scientific Advisory Committee for Clinical Development of
`Hirudin
`
`Member, GUSTO Steering Committee
`
`Member, Medical Research Council of Canada
`
`Member, The Lectureship and Awards Committee, ISTH
`
`Member, Society for Cardiovascular Pathology, Inc.
`
`Member, Sol Sherry Thrombosis Center Committee
`
`Member, Council of
`Cardiology
`
`the
`
`International Society and Federation of
`
`Member, Subcommittee on Control of Anticoagulation (Mannucci)
`
`Member, Safety and Monitoring Committee for GUSTO II
`
`Haemotologic Oncology Task Force
`
`Scientific Committee for the XIIIth International Congress on Fibrinolysis
`and Thrombolysis
`Search Committee for the Head of Service, Cardiothoracic Surgery,
`Hamilton Civic Hospitals
`
`ORBIT Safety and Data Monitoring Committee
`
`ISTH/SSC Subcommittee on Control of Anticoagulation
`Member,
`(Barrowcliffe)
`
`ESSENCE Study Data and Safety Monitoring Committee
`
`Scientific International Committee of the XIVth International Congress on
`Thrombosis
`
`Data and Safety Monitoring Board of the TIMI 11B trial
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`1989
`
`
`
`1989
`
`
`1989
`
`
`1989
`
`
`1990
`
`
`
`
`1990
`
`1990-1993
`
`1990
`
`1990
`
`1991
`
`1993
`
`
`
`
`
`
`
`
`
`
`1993
`
`1993
`
`1994
`
`
`
`
`
`
`
`1994-1996
`
`
`
`
`
`
`
`
`
`
`
`
`
`1995
`
`
`1995
`
`1995
`
`
`1995
`
`1996
`
`
`1996
`
`
`
`7
`
`

`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`Member, Scientific Advisory Board, Canadian Medical Discoveries Fund,
`Inc.
`
`Member, Steering Committee of the Cardiovascular Research Health
`Network
`
`Scientific Subcommittee on Thrombosis and Vascular Biology; The
`American Society of Hematology
`
`Scientific Advisory Committee; Clinical Trials Research Institute
`
`Member of the Council on Arteriosclerosis, Thrombosis and Vascular
`Biology (ATVB)
`
`
`Member, Data and Safety Monitoring Board for CREATE Study
`
`Member, Task Force on Antithrombotic Agents
`
`Member, Data and Safety Monitoring Board for PAI-039 (Wyeth)
`
`Member, Data and Safety Monitoring Board for ACTIVE Study
`
`Member, Data Safety and Monitoring Board of the PICASSO Program
`
`Member, Data Safety and Monitoring Board for RELY Study
`
`Member, Data Safety and Monitoring Board for CURRENT (OASIS 7)
`
`Distinguished Emeritus Status, American Society of Hematology
`
`
`
`1997
`
`
`1997
`
`
`
`
`
`
`1997-2001
`
`
`1999
`
`2000
`
`
`
`
`
`
`
`
`
`
`
`
`2001
`
`2001-2002
`
`2002
`
`2002
`
`2002
`
`2006
`
`2006
`Study
`
`2010
`
`
`
`
`
`
`
`
`
`
`
`MEDICAL SOCIETIES
`
`1963
`
`1970
`
`
`
`
`
`
`
`
`
`The Royal Australasian College of Physicians
`
`American Society of Hematology
`American Heart Association (Council on Thrombosis)
`American Society of Cardiology
`Canadian Society for Clinical Investigation
`Canadian Society of Hematology
`Central Society for Clinical Research
`College of Physicians and Surgeons of Ontario
`International Society on Hemostasis and Thrombosis
`Ontario Medical Association
`Royal College of Physicians and Surgeons of Canada
`
`
`
`
`
`
`
`8
`
`

`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`American Society for Experimental Pathology
`
`American Society for Clinical Investigation
`
`Association of American Physicians
`
`Canadian Hemophilia Society
`
`Canadian Association of Professors of Medicine
`
`American College of Physicians, Fellow
`
`International Society of Hematology
`
`Canadian Atherosclerosis Society, Charter Member
`
`Canadian Society of Internal Medicine
`
`Canadian Atherosclerosis Society (President-Elect)
`
`
`
`
`
`
`
`
`
`
`
`1971
`
`1973
`
`1975
`
`1975
`
`1981
`
`
`
`
`
`
`
`1982
`
`1982
`
`1983
`
`1984
`
`1993-1995
`
`
`
`
`
`
`
`EXTERNAL REFEREE
`
`1989
`
`
`
`
`
`Research & Development, Blood Services
`The Canadian Red Cross Society
`
`
`
`
`
`9
`
`

`
`
`
`PUBLICATIONS - ORIGINAL ARTICLES
`
`
`
`
`
`Orginal Publications 1964-1966
`
`1.
`
`Paroxysmal nocturnal hemoglobinuria: An acquired dyshemopoiesis.
`Austr Ann Med 13:24-31, 1964
`J. Hirsh, B. Ungar, J.S. Robinson
`
`Histiocytic medullary reticulosis: A case report.
`Austr Ann Med 13:269-274, 1964
`J. Hirsh, B. Ungar, W.E. King, T.R. Lubbe
`
`A case of thrombocytopenic purpura associated with chlorpropamide therapy.
`Med J Austr 2:988-990, 1964
`A. Morley and J. Hirsh
`
`Effect of fibrin and fibrinogen proteolysis products of clot physical properties.
`Am J Physiol 209:415-424,1965
`J. Hirsh, A.P. Fletcher, N. Alkjaersig, S. Sherry
`
`Increased platelet adhesiveness in recurrent venous thrombosis and pulmonary
`embolism.
`Br Med J 2:797-799, 1965
`J. Hirsh, J.A. McBride
`
`The development of urokinase as a thrombolytic agent: Maintenance of a sustained
`thrombolytic state in man by its intravenous infusion.
`J Lab Clin Med 65:713, 1965
`
`A.P. Fletcher, N. Alkjaersig, S. Sherry, E. Genton, J. Hirsh, F. Bachmann
`
`Persistent post-splenectomy thrombocytosis and thrombo-embolism: A consequence
`and continuing anemia.
`Br J Hematol 12:44-53, 1966
`J. Hirsh, J.V. Dacie
`
`Thromboembolism and
`thrombocytosis.
`Austr Ann Med 15:112-128, 1966
`J. Hirsh, J.A. McBride, J.V. Dacie
`
`increased platelet adhesiveness
`
`in post-splenectomy
`
`Platelet adhesiveness: A comparison of the rotating bulb and glass-bead column
`methods.
`Thromb Diath Haemorrh 16:100-104, 1966
`J. Hirsh, J.A. McBride, H. Pailing-Wright
`
`
`2.
`
`
`3.
`
`
`4.
`
`
`5.
`
`
`6.
`
`
`7.
`
`
`8.
`
`
`9.
`
`
`
`
`
`10.
`
`The protein requirement for platelet surface reaction.
`
`
`
`10
`
`

`
`
`
`J Clin Invest 45:1013, 1966
`M.F. Glynn, M.A. Packham, J. Hirsh, J.F. Mustard
`
`
`
`Orginal Publications 1967-1969
`
`1.
`
`Hypofibrinogemia without increased fibrinolysis in leukemia.
`Lancet 1:418-420, 1967
`J. Hirsh, J.G. Buchanan, G.C. de Gruchy, A.G. Baikie
`
`Hypofibrinogenemia in acute leukemia with extensive fibrinous pericarditis.
`Austr Ann Med 16:333-336, 1967
`J. Hirsh, H. Ekert, L.I. Taft, J.H.Colebatch, J. Spensley
`
`Spontaneous bruising associated with a defect in the inter-action of platelets with
`connective tissue.
`Lancet 2:18-21, 1967
`J. Hirsh, D.J. Castelan, P.B. Loder
`
`Resolution of acute massive pulmonary embolism after pulmonary arterial infusion of
`streptokinase.
`Lancet 2:593-597, 1967
`J. Hirsh, G.S. Hale, I.G. McDonald, R.A.McCarthy, J.F. Cade
`
`Distribution of platelet hexokinase and the effect of collagen.
`Nature 216:1317-1318, 1967
`J.C.G. Doery, J. Hirsh, P.B. Loder, G.C. de Gruchy
`
`The effect of collagen on platelet glycolysis and nucleotide metabolism.
`Br J Hematol 14:563-573, 1968
`P.B. Loder, J. Hirsh, G.C. de Gruchy
`
`The effect of platelet age on platelet adherence to collagen.
`J Clin Invest 47:466-473, 1968
`J. Hirsh, M.F. Glynn, J.F. Mustard
`
`Effect of activation of the fibrinolytic mechanism on experimental platelet-rich thrombi in
`rabbits.
`J Lab Clin Med 72:245-255, 1968
`J. Hirsh, M.R. Buchanan, M.F. Glynn, J.F. Mustard
`
`Effect of streptokinase on hemostasis.
`Blood 32:726-737, 1968
`J. Hirsh, M.R. Buchanan, M.F. Glynn, J.F. Mustard
`
`Heparin in the treatment of venous thromboembolic disease: Administration, control and
`results.
`Med J Austr 2:153-159, 1968
`E.F. O'Sullivan, J. Hirsh, R.A. McCarthy, G.C. de Gruchy
`
`Isoproterenol in massive pulmonary embolism: Hemodynamic and clinical effects.
`
`
`
`
`2.
`
`
`3.
`
`
`4.
`
`
`5.
`
`
`6.
`
`
`7.
`
`
`8.
`
`
`9.
`
`
`10.
`
`
`11.
`
`
`
`11
`
`

`
`
`
`Med J Austr 2:201-205, 1968
`I.G. McDonald, J. Hirsh, G.S. Hale, J.F. Cade, R.A. McCarthy
`
`Radioimmunoassay of fibrinogen and its proteolysis products.
`Thromb Diath Haemorrh 20:1-6, 1968
`K. Catt, J. Hirsh, D. Castelan, G. Tregear, H. Niall
`
`Severe post-partum in abruptio placentae: Failure to respond to fibrinogen infusion:
`Therapeutic implications.
`Med J Austr 2:1182-1183, 1968
`C. Barbaro, J. Hirsh
`
`Streptokinase therapy in acute major pulmonary embolism: Effectiveness and problems.
`Br Med J 4:729-734, 1968
`J. Hirsh, G.S. Hale, I.G. McDonald, R.A. McCarthy, A. Pitt
`
`Platelet-phosphonexokinase levels in Down's syndrome.
`Lancet 2:894-895, 1968
`J.C. Doery, J. Hirsh, O.M. Garson, G.C. de Gruchy
`
`Latex-bound antifibrinogen test for plasma fibrinogen assay.
`J Clin Path 21:638-642, 1968
`D. Castelan, J. Hirsh, M. Martin
`
`Erythrocyte and platelet glucose 6-phosphate dehydrogenase in normal and mutant
`Caucasians
`Scand J Haematol 6:5-9, 1969
`J.C.G. Doery, J. Hirsh, G.C. de Gruchy
`
`Acute thrombocytopenic purpura due to guinine sensitivity.
`Med J Austr 1:453-458, 1969
`M.A. Burgess, J. Hirsh, G.C. de Gruchy
`
`Placental barrier to coagulation factors: Its relevance to the coagulation defect at birth
`and to hemorrhage in the newborn.
`Br Med J 2:281-283, 1969
`J.F. Cade, J. Hirsh, M. Martin
`
`Aspirin: Its effects on platelet glycolysis and adenosine diphosphate.
`Science 165:65-67, 1969
`J.C.G. Doery, J. Hirsh, G.C. de Gruchy
`
`Streptokinase in acute major pulmonary embolism.
`Israel J Med Sci 5:844-848, 1969
`J. Hirsh, G.S. Hale, I.G. McDonald, R.A. McCarthy
`
`
`12.
`
`13.
`
`
`14.
`
`
`15.
`
`
`16.
`
`
`17.
`
`
`18.
`
`
`19.
`
`
`20.
`
`
`21.
`
`
`22.
`
`Arterial thrombosis in a patient with chronic thrombocytopenia: Successful treatment with
`intra-arterial infusion of streptokinase.
`Med J Austr 2:1304-1306, 1969
`J. Hirsh, E.F. O'Sullivan, A.S. Gallus, E.J. Gilford
`Orginal Publications 1970
`
`
`
`
`
`12
`
`

`
`
`
`Streptokinase therapy in acute major pulmonary embolism.
`Am Heart J 79:574-578, 1970
`J. Hirsh, I.G. McDonald, G.S. Hale
`
`Evaluation of the standard dosage schedule with streptokinase.
`Blood 35:341-349, 1970
`J. Hirsh, E.F. O'Sullivan, M. Martin
`
`Evaluation of subcutaneous calcium heparin therapy in the treatment of thromboembolic
`disease.
`Med J Austr 1:15-17, 1970
`J. Hirsh, E.F. O'Sullivan, A.S. Gallus, M. Martin
`
`Clinical experience with anticoagulant therapy during pregnancy.
`Br Med J 1:270-273, 1970
`J. Hirsh, J.F. Cade, E.F. O'Sullivan
`
`Saddle pulmonary embolism: A surgical emergency?
`Lancet I: 269-271, 1970
`I.G. McDonald, J. Hirsh, G.S. Hale, J. Clarebrough, J.P. Richardson
`
`Platelet glycolytic enzymes: Effect of cellular disruption procedures on activity.
`Br J Hematol 19:145-157, 1970
`J.C.G. Doery, J. Hirsh, G.C. de Gruchy
`
`Neonatal coagulation defect due to anticonvulsant drug treatment in pregnancy.
`Lancet I: 265-268, 1970
`K. Mountain, J. Hirsh, A.S. Gallus
`
`Energy metabolism in human platelets: Inter-relationship between glycolysis and
`oxidative metabolism.
`Blood 36:159-168, 1970
`J.C.G. Doery, J. Hirsh, I. Cooper
`
`Dosage regimens for streptokianse treatment: Evaluation of a standard dosage
`schedule.
`Austr Ann Med 19:12-16, 1970
`J. Hirsh
`
`The rate of resolution of pulmonary embolism and its effects on early survival.
`Austr Ann Med 19:46-53, 1970
`I.G. McDonald, J. Hirsh, G.S. Hale
`
`Streptokinase in the treatment of major pulmonary embolism: Experience with twenty-
`five patients.
`Austr Ann Med 19:54-59, 1970
`J. Hirsh, I.G. McDonald, G.S. Hale
`
`
`
`
`1.
`
`2.
`
`
`3.
`
`
`4.
`
`
`5.
`
`
`6.
`
`
`7.
`
`
`8.
`
`
`9.
`
`
`10.
`
`
`11.
`
`
`
`
`
`13
`
`

`
`
`
`Anticoagulants after open-heart surgery.
`Med J Austr 2:5-6, 1970
`J.F. Cade, J. Hirsh, J.M. Clarebrough
`
`The activated partial thromboplastin time in the control of heparin treatment.
`Austr Ann Med 4:334-337, 1970
`J. Hirsh, E.F. O'Sullivan, A.S. Gallus, M. Martin
`
`Fetal effects of coumadin administered during pregnancy.
`Blood 36:623-627, 1970
`J. Hirsh, J.F. Cade, A.S. Gallus
`
`12.
`
`
`13.
`
`
`14.
`
`
`
`Orginal Publications 1971-1973
`
`1.
`
`Comparison of the effects of streptokinase and heparin on the early rate of resolution of
`major pulmonary embolism.
`CMAJ 104:488-491, & 516, 1971
`J. Hirsh, I.G. McDonald, G.A. Hale, E.F. O'Sullivan, V.M. Jelinek
`
`Effect of streptokinase therapy on experimental fibrin-rich arterial thrombi.
`Am J Path 62:7-16, 1971
`L. Jorgensen, J. Hirsh, M.F. Glynn, M.R. Buchanan, J.F. Mustard
`
`Divergent effects of aspirin and salicylate on glucose and glycogen metabolism in
`human platelets.
`Experentia 27:533-534, 1971
`J.C.G. Doery, J. Hirsh
`
`Major pulmonary embolism, a correlation of clinical findings, haemodynamics, pulmonary
`angiography and pathological physiology.
`Br Heart J 34:356-364, 1972
`I.G. McDonald, J. Hirsh, G.S. Hale, E.F. O'Sullivan
`
`The influence of drugs upon the anticoagulant activity of heparin.
`CMAJ 106:562-564, 1972
`E.D. Hodby, J. Hirsh, C. Adeniyi-Jones
`
`Coagulation studies in patients with acute infectious hepatitis.
`Br J Haematol 22(6): 751-761, 1972
`A.S. Gallus, C.R. Lucas, J. Hirsh
`
`A prospective study of the value of monitoring heparin treatment with the activated
`partial thromboplastin time.
`N Engl J Med 287:324-327, 1972
`D. Basu, A. Gallus, J. Hirsh, J.F. Cade
`
`Acute major pulmonary embolism as a cause of exaggerated respiratory blood pressure
`variation and pulsus paradoxus.
`Br Heart J 34:1137-1141, 1972
`I.G. McDonald, J. Hirsh, V.M. Jelinek, G.S. Hale
`
`
`
`
`2.
`
`
`3.
`
`
`4.
`
`
`5.
`
`
`6.
`
`
`7.
`
`
`8.
`
`
`
`14
`
`

`
`
`
`9.
`
`10.
`
`Small subcutaneous doses of heparin in prevention of venous thrombosis.
`N Engl J Med 288:545-551, 1973
`A.S. Gallus, J. Hirsh, R.J. Tuttle, R. Trebilcock, S.E. O'Brien, J.J. Carroll, J.H. Minden,
`S.M. Hudecki
`
`Relation between bleeding time and platelet connective tissue reaction after aspirin.
`Blood 41:369-377, 1973
`J. Hirsh, D. Street, J.F. Cade, H. Amy
`
`
`11. Australian Multicentre Trial of streptokinase in acute myocardial infarction.
`Lancet I: 57-60, 1973
`J.H.N. Bett, P.A. Castaldi, G.S. Hale, J.P. Isbister, K.H. McLean, E.F. O'Sullivan, J.C.
`Biggs, C.N. Chesterman, J. Hirsh, I.G. McDonald, J.J. Morgan, M. Rosenbaum
`
`von Willebrand's syndrome presenting as an acquired bleeding disorder in assosiation
`with a monoclonal gammopathy.
`Blood 42(3): 429-436, 1973
`M.J. Mant, J. Hirsh, J. Gauldie, J. Bienenstock, G.F. Pineo, K.H. Luke
`
`Preparation of human fibrinogen free of plasminogen by immunoadsorption.
`Haemostasis 1:210-214, 1972/1973
`K.H. Luke, J. Hirsh, J. Bienenstock, A. Zipursky, M.A. Johnston, K. Allman
`
`Energy metabolism in washed platelets responsive to ADP: Comparison with platelets in
`plasma.
`Br J Haematol 25:657-673, 1973
`J.C.G. Doery, J. Hirsh, J.F. Mustard
`
`Induction of aggregation of human blood platelets by ultra-violet light: Action spectrum
`and structural changes.
`Blood 42(4): 551-555, 1973
`J.C.G. Doery, R.C. Dickson, J. Hirsh
`
`time and disseminated
`thromboplastin
`time and partial
`Prolonged prothrombin
`intravascular coagulation not due to deficiency of Factors V and VIII.
`Br J Haematol 24:723-731, 1973
`M.J. Mant, J. Hirsh, G.F. Pineo, K.H. Luke
`
`Unexpected vitamin K deficiency in hospitalized patients.
`CMAJ 109:880-883, 1973
`G.F. Pineo, A.S. Gallus, J. Hirsh
`
`Relevance of preoperative and postoperative blood tests to postoperative leg-vein
`thrombosis.
`Lancet II: 805-809, 1973
`A.S. Gallus, J. Hirsh, M. Gent
`
`
`
`
`
`12.
`
`
`13.
`
`
`14.
`
`
`15.
`
`
`16.
`
`
`17.
`
`
`18.
`
`
`
`
`
`15
`
`

`
`Original Publications 1974
`
`1.
`
`Investigation of the mechanism of false positive 125 I-labelled fibrinogen scans.
`Br J Haemotol 26:469-473, 1974
`G.N.W. Kerrigan, M.R. Buchanan, J.F. Cade, E. Regoeczi, J. Hirsh
`
`Effects of sodium warfarin administered during pregnancy in mice.
`
`
`
`2.
`
`
`
`3.
`
`
`4.
`
`
`5.
`
`6.
`
`
`
`Am J Obstet Gynecol 118:819-823,1974
`J. Kronick, N.E. Phelps, D.J. McCallion, J. Hirsh
`
`Arteriovenous shunt thrombosis: Prevention of sulfinpyrazone.
`N Engl J Med 290:304-306, 1974
`A. Kaegi, G.F. Pineo, A. Shimizu, H. Trivedi, J. Hirsh, M. Gent
`
`Hot clot scan: A method for the accurate identification of experimental pulmonary emboli.
`Invest Radio 9:32-36, 1974
`J.F. Cade, E. Regoeczi, D.M. Hynes, E.S. Garnett, J. Hirsh
`
`Resolution of experimental pulmonary emboli with heparin and streptokinase in different
`dosage regimens.
`J Clin Invest 54:782-791, 1974
`J.F. Cade, J. Hirsh, E. Regoeczi, M. Gent, M.R. Buchanan, D.M. Hynes
`
`Effects of thrombolytic therapy on hemorrhage from post-operative wounds.
`Thromb Diath Haemorrh 32:592-599, 1974
`J.F. Cade, D. Basu, T.J. Muckle, J. Hirsh
`
`Original Publications 1975
`
`1.
`
`Mechanisms of elevated fibrin/fibrinogen degradation products in acute experimental
`pulmonary embolism.
`Blood 45:563-568, 1975
`J.F. Cade, J. Hirsh, E. Regoeczi
`
`Thrombolysis with a combination of small doses of streptokinase and small doses of
`heparin.
`Sem Thromb Haemost 2:14-32, 1975
`A.S. Gallus, J. Hirsh, J.F. Cade, A.G.G. Turpie, I.R. Walker, M. Gent
`
`The role of sulfinpyrazone in the prevention of arterio-venous shunt thrombosis.
`Circulation 52:497-499, 1975
`A. Kaegi, G.F. Pineo, A. Shimizu, H. Trivedi, J. Hirsh, M. Gent
`
`Platelet-inhibiting drugs in the prevention of clinical thrombotic disease.
`N Engl J Med 293:1174-1178, 1236-1240, 1296-1300, 1975
`E. Genton, M. Gent, J. Hirsh, L.A. Harker
`
`
`
`
`2.
`
`
`3.
`
`
`4.
`
`
`
`
`
`16
`
`

`
`
`
`Endotoxin-induced endothelial injury and repair. I. Endothelial cell turnover in the aorta
`of the rabbit.
`Exp Mol Path 23:379-385, 1975
`R.G. Gerrity, B.A. Caplan, M. Richardson, J.F. Cade, J. Hirsh, C.J. Schwartz
`
`
`5.
`
`
`
`Original Publications 1976
`
`1.
`
`Prevention of venous thrombosis with small, subcutaneous doses of heparin.
`JAMA 235:1980-1982, 1976
`
`A.S. Gallus, J. Hirsh, S.E. O'Brien, J.A. McBride, R.J. Tuttle, M. Gent
`
`Heparin kinetics in venous thrombosis and pulmonary embolism.
`Circulation 53(4): 691-695, 1976
`J. Hirsh, W.G. van Aken, A.S. Gallus, C.T. Dollery, J.F. Cade, W.G. Yung
`
`Impedance plethysmography using the occlusive cuff technique in the diagnosis of
`venous thrombosis.
`Circulation 53(4): 696-700, 1976
`R.D. Hull, W.G. van Aken, J. Hirsh, A.S. Gallus, G. Hoicka, A.G.G. Turpie, I.R. Walker,
`M. Gent
`
`Endotoxin-induced vascular endothelial injury and repair. II. Focal injury en face
`morphology 3H-thymidine uptake and circulating endothelil cells in the dog.
`Exp Mol Path 25:59-69, 1976
`R.G. Gerrity, M. Richardson, B.A. Caplan, J.F. Cade, J. Hirsh, C.J. Schwartz
`
`The effect of experimental hematoma on serum levels of fibrinogen-related antigen.
`Blood 47:855-859, 1976
`J.F. Cade, E. Regoeczi, J. Hirsh, M.R. Buchanan
`
`In vitro and in vivo functions of thrombin-treated platelets.
`Thromb Haemost 35:151-166, 1976
`H-J. Reimers, R.L. Kinlough-Rathbone, J-P Cazenave, A.F. Senyi, J. Hirsh, M.A.
`Packham, J.F. Mustard
`
`thrombocytopenic purpura: A syndrome of
`Thombotic
`comsumption.
`CMAJ 114:1108-1112, 1976
`P.B. Neame, J. Hirsh, G. Browman, J. Denburg, T.J. D'Souza, A. Gallus, M.C. Brain
`
`intravascular platelet
`
`Effects of penicillin G. and Cephalotin on platelet function in vivo.
`Proc Soc Explt Biol Med 152:641-644, 1976
`J-P Cazenave, H-J Reimers, A.F. Senyi, J. Hirsh, M.A. Packham, J.F. Mustard
`
`
`2.
`
`
`3.
`
`
`4.
`
`
`5.
`
`
`6.
`
`
`7.
`
`
`8.
`
`
`
`Original Publications 1977
`
`1.
`
`Prevention of venous thrombosis in patients with intracranial disease by intermittant
`
`
`
`
`
`17
`
`

`
`
`
`pneumatic compression of the calf.
`Neurology 27(5): 435-438, 1977
`A.G.G. Turpie, A.S. Gallus, W.S. Beattie, J. Hirsh
`Relationship between the anticoagulant and antithrombotic effects of heparin in
`experimental venous thrombosis.
`Blood 49(2): 171-184, 1977
`H.M. Chiu, J. Hirsh, W.L. Yung, E. Rogoeczi, M. Gent
`
`Combined use of leg scanning and impedance plethysmography in suspected venous
`thrombosis: An alternative to venography.
`N Engl J Med 296:1497-1500, 1977
`R.D. Hull, J. Hirsh, D.L. Sackett, P.J. Powers, A.G.G. Turpie, I.R. Walker
`
`Increased heparin clearance in experimental pulmonary embolism.
`J Lab Clin Med 90:204-216, 1977
`H.M. Chiu, W.G. van Aken, J. Hirsh, E. Regoeczi, A.A. Horner
`
`Vasoactive substances in pulmonary embolism.
`Thromb Haemost 38:167, 1977
`M.H. Todd, J.B. Forrest, J. Hirsh
`
`Normalization of platelet survival in an experimental model after platelet exposure to
`thrombin in vitro or ADP in vivo.
`Thromb Haemost 38(1): 124, 1977
`G. Meuleman, M.R. Buchanan, A.R. Giles, J. Hirsh
`
`2.
`
`3.
`
`
`
`4.
`
`
`5.
`
`
`6.
`
`
`
`Original Publications 1978
`
`1.
`
`Plasma fibrinopeptide A levels in symptomatic venous thromboembolism.
`Blood 51:1189-1195, 1978
`I.M. Yudelman, H.L. Nossell, K.L. Kaplan, J. Hirsh
`
`Determination of sulphinpyrazone in patient plasma by gas chromatography.
`Thromb Res 12:247-255, 1978
`J. Rosenfeld, M.R. Buchanan, P.J. Powers, J. Hirsh, H.J.M. Barnett, R.K. Stuart
`
`A comparison of the effects of aspirin and dipyridamole on platelet aggregation in vivo
`and ex vivo.
`Thromb Res 13:517-529, 1978
`M.R. Buchanan, J. Hirsh
`
`Thrombogenic effect of high dose aspirin in rabbits: Relationship to inhibition of vessel
`wall synthesis of PGI2-like activity.
`J Clin Invest 62:892-895, 1978
`J.G. Kelton, J. Hirsh, C.J. Carter, M.R. Buchanan
`
`Impedance plethysmography: The relationship between venous filling and sensitivity and
`specificity for proximal vein thrombosis.
`Circulation 58:898-902, 1978
`
`
`
`
`2.
`
`
`3.
`
`
`4.
`
`
`5.
`
`
`
`18
`
`

`
`R.D. Hull, D.W. Taylor, J. Hirsh, D.L. Sackett, P.J. Powers, A.G.G. Turpie, I.R. Walker
`
`
`
`Sex differences in the antithrombotic effects of aspirin.
`Blood 52:1073-1076, 1978
`J.G. Kelton, J. Hirsh, C.J. Carter, M.R. Buchanan
`
`A randomized trial of aspirin and sulfinpyrazone in threatened stroke.
`N Engl J Med 299:53-59, 1978
`The Canadian Cooperative Study Group
`
`In vivo hemostatic function and survival of young and old platelets.
`Blood 52(1): 159, 1978
`M.A. Blajchman, A.F. Senyi, J. Hirsh, E. Genton
`
`The prolonged effect of sulfinpyrazone on collagen-induced platelet aggregation in vivo.
`Thromb Res 13:883-892, 1978
`M.R. Buchanan, J. Rosenfeld, J. Hirsh
`
`
`
`
`6.
`
`
`7.
`
`
`8.
`
`
`9.
`
`
`
`Original Publications 1979
`
`1.
`
`The direct assay for platelet associated IgG: Lack of association between antibody level
`and platelet size
`Blood 53:73-80, 1979
`J.G. Kelton, P.B. Neame, J. Bishop, M. Ali, J. Gauldie, J. Hirsh
`
`The use of electromyography to detect muscle contraction responsible for falsely
`positive impedance plethysmographic results.
`Thromb Res 14:811-816, 1979
`L. Biland, R.D. Hull, J. Hirsh, M. Milner
`
`The value of adding impedance plethysmography to 125I-fibrinogen leg scanning for the
`detection of deep vein thrombosis in high risk surgical patients: A comparitive study
`between patients undergoing general surgery and hip surgery.
`Thromb Res 15:227-234, 1979
`R.D. Hull, J. Hirsh, D.L. Sackett, P.J. Powers, A.G.G. Turpie, I.R. Walker, J.A. McBride
`
`Shortening of the bleeding time in rabbits by hydrocortisonedue to inhibition of
`prostacyclin (PGI2) generation by the vessel wall.
`J Clin Invest 63(5): 1026-1036, 1979
`M.A. Blajchman, A.F. Senyi, J. Hirsh, Y. Surya,