Curriculum Vitae of Salvatore D. Lepore
`(October 2016)
`
`
`EDUCATION
`Postdoctoral Fellow (2000), Eli Lilly and Company (with Michael R. Wiley), Indianapolis, IN
`Ph.D. Organic Chemistry (1997), Purdue University (with Merritt B. Andrus), West Lafayette, IN
`B.S. Chemical Engineering cum laude (1992), University of South Florida, Tampa, FL
`
`
`
`PROFESSORIAL EXPERIENCE
`(FAU Department of Chemistry & Biochemistry)
`Professor (2011 - present)
`Associate Professor (2006 – 2011)
`Assistant Professor (2000 – 2006)
`
`
`FAU Multicultural Pre-Medical Society Teaching
`Appreciation Award Recipient (2002)
`FAU Presidential Research Award (2001)
`(Only two awards given across all faculty ranks)
`Petroleum Research Foundation Graduate Fellow
`(1994-1996)
`Dow Chemical Outstanding Junior of the Year
`Award Recipient (1991)
`Tau Beta Pi National Engineering Honor Society
`(1991)
`National Science Foundation Undergraduate
`Summer Research Grantee (1991)
`University
`of South
`Florida
`Scholarship Recipient (1990)
`
`Faculty/Staff
`
`and OTHER
`
`SCHOLARLY
`
`RESEARCH
`ACTIVITIES
`REFEREED WORKS
`Career total is 35 blind peer-reviewed papers
` Not including patents, reviews, and book
`chapters
` Average impact factor (IF) last five years (5.3)
`Roy, A.; Bhat, B. A.; Lepore, S. D. Asymmetric
`Protonation of Cumulenolates: Synthesis of Allenyl
`Aldehydes Facilitated by an Organomanganese
`Auxiliary. Org. Lett. 2016, 18, 1230.
`Nagy, E.; St.Germain, E.; Cosme, P.; Maity, P.;
`Terentis, A. C.; Lepore, S. D. Ammonium Catalyzed
`Cyclitive Additions: Evidence
`for a Cation-π
`Interaction with Alkynes. ChemComm 2016, 52,
`2311.
`Jana, S.; Suresh, V.; Lepore, S. D. Synthesis of
`Novel C-Pivot Lariat 18-Crown-6 Ethers and their
`Efficient Purification. Synlett 2015, 26, 1977.
`Roy, A.; Bhat, B. A.; Lepore, S. D. Organo-
`Manganese η2-Auxiliary Directed Reactions: A
`Diastereoselective Approach to 2,3-Allenols. Org.
`Lett. 2015, 17, 900.
`
`
`
`
`
`RELATED PROFESSIONAL EXPERIENCE
`Associate Editor - Perspectives
`in Medicinal
`Chemistry (Libertas Academica)
`Open access journal. 2006 - Present
`Grant Reviewer: Ad-Hoc National Institutes of
`Health, SBC-A Study Section (Feb, 2014)
`Scientific Advisory Board Member - CHS Pharma
`Consultant for Akerman Senterfitt (law firm), ASE
`Pharmaceuticals,
`Florida
`Crystals,
`Sunol
`Biomolecular, Unison Pharmaceuticals, and
`Xcovery. 2003 – Present
`Chief Scientist, Custom Synthesis Incorporated (an
`FAU spin-out company). 2004 – 2006.
`Chemical Engineer – Delta Environmental
`Consultants (now Antea USA) Tampa, FL 1991 -
`1993.
`
`
`
`HONORS and AWARDS
`University of Rome
`(La Sapienza) Visiting
`Professor Fellowship (Fall 2015)
`FAU College of Science Researcher of the Year
`Award (2012) (Full Professor Category)
`FAU College of Science Researcher of the Year
`Award (2011) (Associate Professor Category)
`FAU Distinguished Science Teacher of the Year
`(2009 and 2003)
`(One award given within College of Science)
`FAU University Researcher of the Year Award
`(2006) (Assistant Professor Category)
`H. Lee Moffitt Cancer Center Honoree (2006)
`
`
`
`1
`
`MYLAN - EXHIBIT 1004
`
`

`
`Al-huniti, M. H.; Lepore, S. D. Zinc(II) Catalyzed
`Conversion of Alkynes to Vinyl Triflates in the
`Presence of Silyl Triflates. Org. Lett. 2014, 16,
`4154.
`Bhat, B. A.; Maki, S. L.; St.Germain, E. J.; Maity, P.;
`Lepore, S. D. Annulation Reactions of Allenyl
`Esters: an Approach
`to Bicyclic Diones and
`Medium-Sized Rings. J. Org. Chem. 2014, 79,
`9402.
`Al-huniti, M. H.; Lu, S.-Y.; Pike, V. W.; Lepore, S. D.
`Enhanced
`Nucleophilic
`Fluorination
`and
`Radiofluorination of Organosilanes Appended with
`Potassium-Chelating Leaving Groups, J. Fluor.
`Chem. 2014, 158, 48.
`Al-huniti, M. H.; Lepore, S. D. Stereoretentive
`Copper
`(II) Catalyzed Ritter Reactions of
`Secondary Cycloalkanols. Adv. Synth. Catal. 2013,
`355, 3071.
`Mondal, D.; Li, S. L.; Bellucci, L.; Laino, T.; Tafi, A.;
`Guccione, S.; Lepore, S. D. Stereoretentive
`Chlorination of Cyclic Alcohols Catalyzed by
`Titanium (IV) Tetrachloride: Evidence for a Front-
`Side Attack Mechanism. J. Org. Chem. 2013, 78,
`2118.
`Mondal, D.; Bellucci, L.; Lepore, S. D. A Direct and
`Stereoretentive Synthesis of Amides from Cyclic
`Alcohols. Eur. J. Org. Chem. 2011, 7057.
`Maity, P.; Lepore, S.D. Catalytic synthesis of non-
`racemic azaproline derivatives via a kinetic-
`resolution
`based
`cyclization
`of
`β-alkynyl
`hydrazines. Angew. Chem. Int. Ed. 2011, 50, 8338.
`Bhowmick, M.; Lepore, S. D. Manganese η2-
`Complexes as Auxiliaries for Stereoselective Aldol
`Additions:
`Efficient
`Synthesis
`of Highly
`Functionalized Allenyl Carbinols. Organic Lett.
`2010, 12, 5078.
`Bhowmick, M.; Sappidi, R.; Fields, G.B.; Lepore,
`S.D. Efficient Synthesis of Fmoc-Protected
`Phosphinic Pseudodipeptides: Building Blocks for
`the Synthesis of Matrix Metalloproteinase Inhibitors
`(MMPIs). Biopolymers (Peptide Science) 2010, 96,
`1.
`Lu, S.-Y.; Lepore, S. D.; Li, S. Y.; Mondal, D.; Cohn,
`P. C.; Bhunia, A. K.; Pike, V. W. Nucleophile
`Assisting Leaving Groups: A Strategy for Aliphatic
`18F-Fluorination J. Org. Chem. 2009, 74, 5290-
`5296.
`Maity, P.; Lepore, S.D. Anion Catalyzed Addition of
`-Silylallenyl Esters to Aldehydes: A New Entry into
`[3.2.1] Bicyclic Natural Products J. Am. Chem. Soc.
`2009, 131, 4196.
`
`
`
`2
`
`Maity, P.; Lepore, S.D. Selective One-Pot
`Synthesis of Allenyl and Alkynyl Esters from -
`Ketoesters. J. Org. Chem. 2009, 74, 158.
`Lepore, S.D.; Mondal, D.; Li, S.Y.; Bhunia, A.K.
`Stereoretentive Halogenations and Azidations with
`Titanium(IV) Enabled by Chelating Leaving Groups
`Angew. Chem. Int. Ed. 2008, 47, 7511.
`Lu, S. Y.; Li, S. Y.; Lepore, S. D.; Pike, V. W.
`(18F)Fluorination of Alkyl Sulfonate is Enhanced by
`Arylsulfonate-Based Nucleophile Assisting Leaving
`Groups (NALGs) Under Microwave Irradiation. J.
`Labelled Compd. Radiopharm. 2007, 50 (Suppl. I),
`S5.
`Lepore, S.D.; Bhunia, A.K.; Mondal, D.; Cohn, P.C.;
`Lefkowitz, C. Rapid Conversion of Hindered
`Arylsulfonates to Alkyl Chlorides with Retention of
`Configuration. J. Org. Chem. 2006, 71, 3285.
`Silvestri, M.A.; He, C.; Khoram, A.; Lepore, S.D.
`Synthesis
`of
`Methyl
`2-Oxo-5-Vinyl-2,5-
`Tetrahydrofuran-3-Carboxylate. Tetrahedron Lett.
`2006, 47, 1625.
`Lepore, S.D.; Bhunia, A.K.; Cohn, P. Arylsulfonate
`Based Nucleophile Assisting Leaving Groups
`(NALGs). J. Org. Chem. 2005, 70, 8117.
`Silvestri, M.A.; Bromfield, D.C.; Lepore, S.D.
`Michael-Stork Addition of Cyclopentyl Enamine to
`Allenyl Ketones and Esters. J. Org. Chem. 2005,
`70, 8239.
`Lepore, S.D.; Khoram, A.; Bromfield, D.C.; Cohn,
`P.; Jairaj, V.; Silvestri, M.A. Studies on the
`Manganese Mediated Isomerization of Alkynyl
`Carbonyls to Allenyl Carbonyls. J. Org. Chem.
`2005, 70, 7443.
`Lepore, S.D.; He, Y.J. Deconjugative Conversion of
`α-Alkynyl Esters to α,α-Disubstituted β-Alkynyl
`Esters. J. Org. Chem. 2005, 70, 4546.
`Lepore, S.D.; He, Y.J.; Damisse, P. Studies on the
`Base-Promoted Conversion of Conjugated Alkynyl
`Esters to α-Substituted α-Allenyl Esters. J. Org.
`Chem. 2004, 69, 9171.
`Lepore, S.D.; He, Y.J. Use of Sonication for the
`Coupling of Sterically Hindered Substrates in the
`Phenolic Mitsunobu Reaction. J. Org. Chem. 2003,
`68, 8261.
`Lepore, S.D.; Wiley, M.R. Application of Aryloximes
`as Solid-Phase Ketone Linkers. Organic Lett.
`2003, 5, 7.
`Lepore, S.D.; Schacht, A.L.; Wiley, M.R.
`Preparation of 2-Hydroxybenzamidines from 3-
`Aminobenz-isoxazoles. Tetrahedron Lett. 2002, 43,
`8777.
`
`

`
`by FAU to Sigma-Aldrich in 2010. Currently an
`Aldrich catalog item (specialty reagent).
`Argade, A.B.; Goodson, T.; Herron, D.K.; Joseph,
`S.; Lepore, S.D; Marquart, et al. Preparation of
`(hetero)aromatic ether amides as inhibitors of
`Factor Xa and/or thrombin. WO 2006057845 (Eli
`Lilly, 2006)
`Lepore, S.D.; Wiley, M.R. Solid phase synthesis of
`ketone
`group
`containing molecules. WO
`2001036362 (Eli Lilly, 2001)
`Wiley, M.R.; Lepore, S.D. Use of aryloxime linkers
`in the solid-phase synthesis of 3-amino-1,2-benz-
`isoxazoles and polycyclic heterocyclic analogs. WO
`2000027627 (Eli Lilly, 2000)
`Wiley, M.R.; Lepore, S.D. Preparation of amino-
`benzisoxazole compounds and
`libraries as
`thrombin inhibitors. WO 2000027199 (Eli Lilly,
`2000)
`
`
`CONTRACTS and GRANTS RECEIVED
` 2014
`“Synthesis of a Bridged Bicyclic Natural Product
`Using Allenyl Esters” (4/14 - 3/17)
`Agency: NIH (NIGMS), GM110651
`Direct Costs: $210,000 Indirect Costs: $101,320
`
`“New Natural Product Derived HIV Entry Inhibitors”
`and “Ultrafast Silicon F18-Fluorination for PET
`Medical Imaging”
`Agency: FAU Seed Grants (two awarded)
`Direct Costs: $15,500 and $22,900
`
`2013
`“Total Synthesis of Garsubellin A" (9/13 - 9/14)
`Agency: Indo-US Science and Technology Forum
`Direct Costs: $38,000
`Indirect Costs: $0
`
`FAU Matching Funds: $8,000
`
`2011
`"Elucidation of Reactions Mediated by Sulfidic
`Carbonate and Clay Depositions" (1/12 - 12/13)
`Agency: Amer. Chem. Soc. PRF (51785-ND2)
`Direct Costs: $100,000
`Torrey Pines Institute (8/11 - 8/12)
`Direct Costs: $40,100
`Indirect Costs: $3,208
`
`2010
`“New Methods for the Expedited Synthesis of C11
`and F18 PET Tracers” (4/10 – 1/13)
`Agency: NIH (1R21MH087932-01A1)
`Direct Costs: $450,000 Indirect Costs: $200,250
`
`
`Zhang, Z.; Lepore, S.D. Synthesis of cyclo-
`pentadienyl manganese
`tricarbonyl
`resins as
`potential olefin traceless supports. Tetrahedron
`Lett. 2002, 43, 7357.
`Lepore, S.D. The use of 18-crown-6 as an ionizable
`phase label for the expedited synthesis of small-
`molecules. Tetrahedron Lett. 2001, 42, 6437.
`Lepore, S.D.; Wiley, M.R. Studies on the Synthetic
`Compatibility of Aryloxime Linkers in the Solid
`Phase Synthesis of 3-Aminobenzisoxazoles. J.
`Org. Chem. 2000, 65, 2924.
`Lepore, S.D.; Wiley, M.R. Use of the Kaiser Oxime
`Resin
`in
`the Solid Phase Synthesis of 3-
`Aminobenzisoxazoles. J. Org. Chem. 1999, 64,
`4547.
`Andrus, M.B.; Lepore, S.D.; Turner, T.M. Total
`Synthesis of Stipiamide and Designed Polyenes as
`New Agents
`for
`the Reversal of Multidrug
`Resistance. J. Am. Chem. Soc., 1997, 119, 12159.
`Andrus, M.B.; Lepore, S.D.; Sclafani, J.A. Selective
`Dihydroxylation of Non-Conjugated Dienes in Favor
`of the Terminal Olefin. Tetrahedron Lett. 1997, 38,
`4043.
`Andrus, M.B.; Lepore, S.D. Synthesis of Stipiamide
`and a New Multidrug Resistance Reversal Agent,
`6,7-Dehydrostipiamide. J. Am. Chem. Soc., 1997,
`119, 2327.
`Andrus, M.B.; Lepore, S.D. Asymmetric Additions
`to Dichlorophenyl Dioxane, a New Chiral Acetal.
`Tetrahedron Lett. 1995, 36, 9149.
`
`
`
`BOOK CHAPTERS and REVIEWS
`Lepore, S.D.; Mondal, D.; Li, S.Y. SynForm 2009,
`2, A16.
`Li, S. Y.; Lepore S.D. 2-(2-methoxyethoxy)-ethyl 2-
`(chlorosulfonyl)-benzoate.
` Encyclopedia
`of
`Reagents for Organic Synthesis 2008 (2nd ed., vol.
`8) pg. 6629.
`Lepore, S.D.; Mondal, D. Recent Advances in
`Heterolytic
`Nucleofugal
`Leaving
`Groups
`Tetrahedron 2007, 63, 5103-5122.
`
`
`
`PATENTS and APPLICATIONS
`Lepore, S.D.; Silvestri, Maximilian. Non-oxidative
`Termination of Ruthenium Catalyzed Olefin
`Metathesis Reactions. App. No. 62149836 (FAU,
`2015).
`Lepore, S.D. Nucleophile Assisting Leaving
`Groups. US 8,822,707 B2 (FAU, 2014). Licensed
`
`
`
`3
`
`

`
`2002
`Torrey Pines Institute (8/10 - 8/11)
`Direct Costs: $40,100
`Indirect Costs: $3,208
`“Manganese 2-Bond as a Solid-Phase Traceless
`
`Linker for the Expedited Synthesis of Olefins”
`2009
`(summer fellowship) (5/02 – 8/02)
`“Identification of Active Compounds in Treated
`Agency: ACS PRF (Type G), 36633-G1
`Calendula Extracts” (12/09 – 11/10)
`Direct Costs: $8,000
`
`Indirect Costs: none
`Agency: Unison Pharmaceuticals, Inc.
`
`Direct Costs: $20,077
`Indirect Costs: $9,436
`“Enantioselective Conversion of Alkynes to Allenes:
`
`Application
`to
`the Synthesis of Anti-HIV
` “Synthesis of NALG Compounds" (11/09 - 11/10)
`Compounds” (3/02 – 2/03)
`Agency: NIH (NIMH)
`Agency: Florida Atlantic University – Research
`Direct Costs: $18,800
`Initiation Award
`
`Direct Costs: $5,000
`2005
`
`“Sulfonate resins for the synthesis of 18F-labeled
`“Synthesis of azaphilone analogs as HIV entry
`PET tracers” (6/02 – 5/06)
`inhibitors” (6/05 – 5/10)
`Agency: NIH (PO # 263-MD-212362)
`Agency: NIH (NIGMS), S06 GM073621-01
`Direct Costs: $42,186
`
`Indirect Costs: $9,214
`Direct Costs: $545,000 Indirect Costs: $223,500
`
`
`Donation of methylcyclopentadienyl manganese
`2004
`tricarbonyl (MMT)
`“Synthesis of quinazoline derivatives” (9/04 – 6/05)
`Agency: Ethyl Corporation
`Agency: The Scripps Research Institute (Florida)
`Estimated value: $12,000 Indirect Costs: none
`Direct Costs: $14,592
`Indirect Costs: $5,909
`
`2001
`
`“Chemical synthesis of sucrose derivatives and
`“Manganese 2-Bond as a Solid-Phase Traceless
`subsequent antimicrobial testing” (10/04 – 6/06)
`Linker or the Expedited Synthesis of Olefins” (9/01
`Agency: Florida Crystals Corporation
`– 8/03)
`Direct Costs: $20,000
`Indirect Costs: $8,100
`Agency: ACS PRF (Type G), 36633-G1
`
`Direct Costs: $25,000
`
`
`Indirect Costs: none
`Chemical synthesis of “Product C” (8/03 – 7/04)
`
`Agency: Florida Crystals Corporation
`“Synthesis and SAR Study of Isochromophilone II –
`Direct Costs: $9,700 Indirect Costs: $2,425
`an HIV Prophylactic Agent” (7/01 – 6/02)
`
`Agency: Florida Atlantic University – Presidential
`2003
`Research Development Award
`“Synthesis of Pyran Bicyclic Natural Products”
`Direct Costs: $25,000
`
`
`Indirect Costs: none
`(5/1/03 – 4/30/05)
`
`Agency: NIH (NIGMS), R15 GM067635-01
`“Development of a New Method for the Solid-Phase
`Direct Costs: $100,000
`Indirect Costs: $39,000
`Synthesis of Medicinally-Relevant Alkenes” (3/01 –
`
`2/02)
`“Solid-Phase Approach to the Synthesis of C11
`Agency: FAU – Research Innovation Award
`PET Tracers” (3/03 – 2/06)
`Direct Costs: $5,000
`
`
`Indirect Costs: none
`Agency: NIH (NIMH), R03 MH66963-01
`Direct Costs: $139,000
`Indirect Costs: $55,000
`
`“Purchase of an NMR for Teaching Creative
`Problem Solving Skills in the Chemistry Laboratory
`Program at FAU” (9/03 – 8/05)
`Agency: NSF (DUE), 0311369
`Direct Costs: $133,620 FAU-Match: $116,520
`Indirect Costs: $8,990
`
`“Chemical synthesis of simplified analogs of
`verbenaloside an anti-tumor agent” (9/03 – 8/05)
`Agency: FAU Center of Excellence
`Direct Costs: $70,000
`
`Indirect Costs: none
`
`
`
`
`
`4
`
`Indirect Costs: $1,200
`
`
`
`Indirect Costs: none
`
`
`
`PROCEEDINGS
`(including 20 invited lectures and one chaired
`session)
`Nagy, E.; Lepore, S. D. Studies on Ammonium-
`Catalyzed Cyclitive Additions to Alkynes: A General
`Approach to Diheteroatom Heterocycles. ACS Div.
`Organic Chemistry Symposium. Bryn Mawr, PA
`July (2016).
`Jana, S.; Roy, A.; Lepore, S. D. Diversification
`reactions of γ-silyl allenyl esters: selective
`conversion to γ-disubstituted allenes and all-carbon
`
`

`
`quaternary centers. Abstracts of Papers, ACS
`National Meeting, San Diego, March (2016)
`Jana, S.; Al-huniti, M. H,.; Lepore, S. D. Crown
`Ether Nucleophilic Catalysts (CENCs) for the
`Ultrafast Fluorination of Silicon. Abstracts of
`Papers, ACS National Meeting, San Diego, March
`(2016)
`Maki, S. L.; St.Germain, E. J.; Yadavalli, K. P.;
`Maity, P.; Lepore, S. D. Construction of congested
`bridged bicyclic systems: Progress towards the first
`total synthesis of an anti-thrombotic natural
`product. Pacifichem, Honolulu, HI, December
`(2015)
`Lepore, S. D. Stereoselective construction of
`functionalized
`allenes
`and
`subsequent
`diversification. Invited lecture for University of
`Siena, Italy, October (2015) and University of Rome
`(La Sapienza) Italy, November (2015)
`Lepore, S. D. New Methods for the Stereoselective
`Synthesis of Functionalized Allenes Using a
`Traceless Organomanganese Auxiliary.
`Invited
`lecture for the Department of Chemistry, Kyoto
`University (Kyoto, Japan) April (2015)
`Nagy, E.; Lepore, S. D. Ammonium-catalyzed
`alkyne additions: A unified method for the synthesis
`of isoxazolidines and pyrazolidines. Abstracts of
`Papers, ACS National Meeting, Boston, MA,
`August (2015)
`Nagy, E.; Roy, A.; Lepore, S. D. Regio- and
`stereoselective additions to enynes containing an
`organo-manganese auxiliary
`leading
`to highly
`substituted allenyl aldehyde products. Abstracts of
`Papers, ACS National Meeting, Denver, CO, (2015)
`Roy, A.; Lepore, S. D. Asymmetric isomerization of
`alkynyl to allenyl aldehydes bearing a traceless
`organo-manganese η2-auxiliary. Abstracts of
`Papers, ACS National Meeting, Denver, CO, March
`(2015)
`Roy, A.; Lepore, S. D. Stereoselective synthesis of
`allenyl alcohols using an organomanganese η2-
`auxiliary: A new entry to furo-furanone natural
`products. Abstracts of Papers, ACS National
`Meeting, Denver, CO, March (2015)
`Nagy, E.; St.Germain, E.; Maity, P.; Lepore, S. D.
`Ammonium catalyzed cyclitive additions: Evidence
`for a cation-π interaction with alkynes. Abstracts of
`Papers, ACS National Meeting, Dallas, TX, March
`(2014)
`Roy, A.; Lepore, S.D. Diastereoselective Additions
`to Allenyl Aldehydes Directed by an Organo-
`Manganese η2-Auxiliary. ACS National Organic
`Symposium (Seattle, WA) June (2013).
`
`
`
`5
`
`Lepore S.D. New Reactions Enabled by
`Nucleophile Assisting Leaving Groups (NALGs)
`Invited lecture for the Department of Diagnostic
`Radiology at the Yale University School of Medicine
`(New Haven, CT) October (2012)
`Lepore S.D. Development of Nucleophile Assisting
`Leaving Groups (NALGs) for Enhanced Reactivity
`in Substitution Reactions.
`lecture
`for
`Invited
`Distinguished Lecture Series at Torrey Pines
`Institute for Molecular Studies (Port St. Lucie,
`Florida) July (2011)
`Lepore S.D. Development of Nucleophile Assisting
`Leaving Groups (NALGs) for Enhanced Reactivity
`in Substitution Reactions. Invited lecture for
`University of Rome, Italy (La Sapienza) & University
`of Athens, Greece, June (2011)
`Lepore, S.D. Development of Nucleophile Assisting
`Leaving Groups (NALGs) for Enhanced Reactivity
`in Substitution Reactions. Invited lecture for Emory
`University, Atlanta, March (2011)
`Mondal, D.; Li, S. Y.; Lepore, S. D. Revisiting
`reactions of
`thionyl chloride: Stereoretentive
`methods for the one-pot synthesis of halides and
`amides from alcohols. Pacifichem, Honolulu, HI,
`December (2010)
`Lepore, S.D. New Synthesis Methods Involving
`Allenyl Carbonyl Compounds and Development of
`Nucleophile Assisting Leaving Groups (NALGs).
`Invited lecture for The Scripps Research Institute
`(Jupiter, Florida) (November 2010)
`Maity, P.; Lepore, S.D. Organocatalytic amination
`of allenyl esters and subsequent cyclization to form
`azaproline derivatives. Abstracts of Papers, 240th
`ACS Nat. Meeting, Boston, MA August (2010)
`Li, S.; Lepore, S.D. Stereoretentive and mild
`halogenation of cyclic alcohols catalyzed by
`titanium (IV) reagents: Evidence for a new front-
`side attack mechanism. Abstracts of Papers, 240th
`ACS Nat. Meeting, Boston, MA August (2010)
`Lepore, S.D. New Synthesis Methods Involving
`Allenyl Carbonyl Compounds and Development of
`Nucleophile Assisting Leaving Groups (NALGs),
`Invited Lecture for Brigham Young University March
`(2009)
`Lepore, S.D.; Mondal, D. New Titanium (IV)
`Mediated Reactions with Chelating Leaving
`Groups:
`Stereoretentive
`One-Step
`Benzoylamination
`of
`Secondary
`Alcohols.
`Abstracts of Papers, 237th ACS Nat. Meeting, Salt
`Lake City, UT, March (2009)
`Lepore, S.D. SESSION CHAIR: Total Synthesis of
`Complex Molecules: (Oral session #30422) at the
`237th ACS National Meeting, Salt Lake City, UT,
`March (2009)
`
`

`
`Maity, P.; Lepore, S.D. Reductive Aldol as a Novel
`Method for Substituted [3.n.1] Bicycle Formation:
`Progress Toward the Total Synthesis of Vitisinol D.
`Abstracts of Papers, 236th ACS National Meeting,
`Philadelphia, PA, August (2008)
`Lepore, S.D.; Maity, P.; Sappidi, R. Selective One-
`Pot Synthesis of Allenyl and Alkynyl Esters:
`Applications to Mukaiyama-type Additions to Form
`Nonracemic 2-Alkynyl-3-hydroxy Esters. Abstracts
`of Papers, 236th ACS National Meeting,
`Philadelphia, PA, August (2008)
`Mondal, D.; Li, S.Y. Lepore, S.D. Stereoretentive
`and Rapid Synthesis of Secondary Halides and
`Azides using New Chelating Leaving Groups with
`Titanium (IV) Reagents. Abstracts of Papers,
`236th ACS National Meeting, Philadelphia, PA,
`August (2008)
`Lepore, S.D. New Synthesis Methods Involving
`Allenyl Carbonyl Compounds and Development of
`Nucleophile Assisting Leaving Groups (NALGs).
`Invited lecture for The Scripps Research Institute
`(La Jolla) November (2007)
`Lepore, S.D. New Synthesis Methods Involving
`Allenyl Carbonyl Compounds and Development of
`Nucleophile Assisting Leaving Groups (NALGs).
`Invited lecture for University of California at San
`Diego, November (2007)
`Lepore, S.D. Development of New Leaving Groups.
`Invited lecture and short course for the University
`(degli Studi) of Catania (Sicily, Italy) October (2007)
`Lepore, S.D.; Mondal, D; Li, S. New Titanium (IV)
`Reactions Using Nucleophile Assisting Leaving
`Groups (NALGs): Stereoretentive Alkyl Halide and
`Azide Syntheses. European Symposium on
`Organic Chemistry (ESOC) at University College
`Dublin, Ireland, July (2007)
`Lepore, S.D. New Synthesis Methods Involving
`Allenyl Carbonyl Compounds and Development of
`Nucleophile Assisting Leaving Groups (NALGs).
`Lecture for Eli Lilly and Co. April (2007)
`Lepore, S.D. New Synthesis Methods Involving
`Allenyl Carbonyl Compounds and Development of
`Nucleophile Assisting Leaving Groups (NALGs)
`Invited lecture for Purdue University Chemistry
`Department, March (2007)
`Lepore, S.D.; Mondal, D.; Li, S. Accelerated
`reactions using nucleophile assisting
`leaving
`groups (NALGs): Applications to stereospecific
`alkyl halide synthesis. 233rd ACS National Meeting,
`Chicago, IL, March (2007)
`Lepore S.D. New Synthesis Methods Involving
`Allenyl Carbonyl Compounds and Development of
`Nucleophile Assisting Leaving Groups (NALGs).
`
`
`
`6
`
`Invited lecture for Moffitt Cancer Center, November
`22 (2006)
`Lepore S.D. New Synthesis Methods Involving
`Allenyl Carbonyl Compounds and Development of
`Nucleophile Assisting Leaving Groups (NALGs).
`lecture
`for University of Rome
`(La
`Invited
`Sapienza), Italy, September 29 (2006)
`Lepore, S.D.; Mondal, D.; Cohn, P.C.; Li, S.
`Accelerated Reactions Using Nucleophile Assisting
`Leaving Groups
`(NALGs): Applications
`to
`Stereospecific Alkyl Halide Synthesis.
`Ischia
`Advanced School of Organic Chemistry, Ischia,
`Naples (Italy), September 16-21 (2006)
`Lepore S.D. Development of New Leaving Groups
`and New Methods Involving Allenyl Carbonyl
`Compounds. Invited lecture for University of
`Florida Chemistry Department Organic Seminar
`Series, January 26 (2006)
`Lepore S.D.; Bhunia, A.K. Arylsulfonate based
`nucleophile assisting leaving groups. Pacifichem,
`Honolulu, HI, December (2005)
`Lepore, S.D., Bhunia, A.K.; Cohn P. Design of
`arylsulfonate based nucleophile assisting leaving
`groups. Invited lecture for NIH (Mental Health),
`August (2005)
`Lepore S.D.; Bhunia, A.K. Arylsulfonate based
`nucleophile assisting leaving groups. 230th ACS
`National Meeting, Washington DC, August (2005)
`Lepore S.D.; Bhunia, A.K.; Cohn P. Arylsulfonate
`based nucleophile assisting leaving groups. Invited
`lecture for ACS Florida Annual Meeting and
`Exhibition (FAME), May (2005)
`Lepore S.D. Bhunia, A.K.; Nucleophile Assisting
`Leaving Groups (NALGs). Invited lecture for
`Florida State University Chemistry Department
`Organic Seminar Series, December (2004)
`Lepore, S.D. New Methods for the Preparation of
`Highly
`Functionalized
`Allenyl
`Carbonyl
`Compounds. FAU Center for Molecular Biology
`and Biotechnology (CMBB) October (2004).
`Bromfield, D.C.; Silvestri, M.A.; Lepore, S.D. New
`chemical methods for the synthesis of geniposidic
`acid, an antiviral marine natural product. Florida
`Marine Biotechnology Conference October (2004)
`Silvestri, M.A.; Lepore, S.D. The Development of a
`Novel Diels-Alder Reaction Involving Allenyl Esters
`as Heterodienes. XI International Symposium of
`Marine Natural Products, Sorrento,
`Italy,
`September (2004)
`Lepore, S.D. New methods for the preparation of
`allenyl esters and their application in hetero-Diels-
`Alder reactions. Annual Organic Faculty of Florida
`(OFF) Conference, Orlando, FL, March (2004)
`
`

`
`COURSES TAUGHT and DEVELOPED
`
`Undergraduate Courses
` CHM 2200 - Introduction to Organic Chemistry
` CHM 2210 - Organic Chemistry 1
` CHM 2211 - Organic Chemistry 2
` CHM 3060 - Chemical Literature
` CHM 4220 - Organic Chemistry 3
` CHM 4294 - Organic Chemistry 3
`
`
`
`Graduate Courses
` CHM 6428 - Medicinal Chemistry
` CHM 6225 - Advanced Organic Chemistry
` CHM 6730 - Synthesis and Characterization
` CHM 5944 - Introduction to Chemical Research
`
`
`
`
`
`ACADEMIC SERVICE
`
`Departmental (Chemistry & Biochemistry)
`Graduate Program & Admissions Committee
`(2008-present)
`Master Researcher (significant mentoring duties)
`(2012 – present)
`Graduate Program Committee Chair (2006-2008)
`Graduate Admissions Committee Chair (2003-
`2006)
`Instrumentation Committee (2007-present)
`
`College (of Science)
`College Graduate Programs Committee (2007 –
`2012)
`(NTT) Faculty Promotion
`Non-Tenure-Track
`Committee (2012 – present)
`
`University
`University Research Committee (2009 - 2012)
`University Intellectual Property Committee (2005 –
`2014)
`Chair of University Faculty Council Library
`Committee (2003-2006, 2007-2012 ex officio).
`
`
`
` Synthesis of α-
`Lepore, S.D. and He, Y.
`tributylstannyl-α-allenyl esters and their application
`in the Lewis acid mediated reaction with aldehydes.
`South Eastern Regional Meeting of the American
`Chemical Society, Atlanta, GA, September (2003)
`Lepore, S.D. and He, Y. Studies on the base-
`promoted convesion of conjugated alkynyl esters to
`α-substituted α-allenyl esters. South Eastern
`Regional Meeting of
`the American Chemical
`Society, Atlanta, GA, September (2003)
`Bromfield, D.C.; Jairaj, V.; Lepore, S.D. Studies on
`the Manganese-Mediated Isomerization of Alkynyl
`Carbonyls to Allenyl Carbonyls. BioTech 2003.
`He, Y.; Lepore, S.D. Base-promoted Alkylation
`Reactions of Alkynyl Esters. BioTech 2003.
`Lepore, S.D. New Methods for the Preparation of
`Highly
`Functionalized
`Allenyl
`Carbonyl
`Compounds. Invited Lecture for Barry University
`Science Seminar Series (2003)
`Lepore, S.D.; Vinod, J.; Tatalovich, J.E. Studies
`towards the total synthesis of Isochromophilone II:
`Intramolecular Diels-Alder reactions of allenyl
`carbonyls. 223rd ACS National Meeting, Orlando,
`FL, April (2002)
`Lepore, S.D.; Zongren, Z. Studies toward the
`development
`of
`cyclopentadienylmanganese
`tricarbonyl resins as traceless olefin linkers. 223rd
`ACS National Meeting, Orlando, FL, April (2002)
`Jairaj, V.; Lepore, S.D. Studies Toward the Total
`Synthesis of Isochromophilone II: Intramolecular
`Diels-Alder Reactions of Allenyl Carbonyls.
`BioTech 2002
`Zhang, Z.; Lepore, S.D. Studies towards the
`development of a cyclopentadienylmanganese tri-
`carbonyl resin as a traceless olefin. BioTech 2002
`Lepore, S.D.; Jairaj, V.; Tatalovich, J.E. Study of
`the electronic and steric effects of the reaction of
`hydroxyl-protected-1-lithioalkynols with several
`electrophiles. South Eastern Regional Meeting of
`the American Chemical Society, Savannah, GA,
`September (2001)
`Lepore, S.D. Development of New Solid-Phase
`Methods for the Synthesis of Small Molecules.
`Invited lecture for Florida International University
`Chemistry Department Seminar Series (2001)
`Lepore, S.D. Studies Toward the Total Synthesis
`of Isochromophilone II - an HIV Entry Inhibitor.
`CMBB (2001)
`Lepore, S.D. Development of New Solid-Phase
`Methods for the Synthesis of Small Molecules.
`CMBB (2000)
`
`
`
`
`
`7
`
`

`
`GRADUATE STUDENT & POSTDOC GUIDANCE
`
`Current Doctoral Students
`Animesh Roy, Elijah St.Germain, Susovan Jana,
`Samantha Maki, Edith Nagy (NSF Fellow, award
`number 1257290), Krishna Yadavalli, and Shannon
`Dougherty
`Former Graduate Students
`Mohammed Al-huniti (PhD, 2014): University of
`North Carolina (Greensboro) Postdoctoral Fellow
`(Prof. Mitchell P. Croatt)
`Pradip Maity (PhD, 2011): Assistant Professor at
`CSIR-National Chemical Laboratory, Pune India
`(Aug 2015); Postdoctoral fellow at the University of
`Texas Southwestern Medical Center (Prof. Uttam
`Tambar) (2012 – 2015)
`Songye Li (PhD): Yale Postdoctoral Fellow
`(Prof. Henry Huang)
`Debo Mondal (PhD): Postdoctoral Fellow at Baylor
`University (Prof. Kevin Pinney)
`Yuanjun He (PhD): Senior Research Scientist
`(permanent position), Scripps Florida
`Anita Khoram (MS): Chemist at Florida Surface
`Chemists
`Deborah Bromfield (MS): Assistant Professor of
`Chemistry at Florida Southern College.
`Pamela Cohn (MS): Assistant Prof. of Chemistry at
`Richard Stockton College (Galloway, NJ); Doctoral
`student at Univ. of Florida; Postdoc at Case
`Western (Prof. Rowan);
`Chang He (MS): Nutraceutical industry
`
`Former Postdoctoral Fellows
`Manish Bhowmick: Senior Scientist at Sigma-
`Aldrich Corp. (Natick, MA)
`Technology
`Maximillian Silvestri: Strategic
`Leader, Energy Services Division, Nalco Company
`(Sugarland, TX)
`Anjan Bhunia: Synthesis Team Leader (overseeing
`12-14 chemists), Chembiotek, TCG, Lifesciences
`(Calcutta, India)
`Zhanhui Xu: Research Associate, Chemistry
`Department, Zhengzhou University (China)
`Vinod Jairaj: Head of Synthetic Chemistry Division,
`International Institute of Biotechnology
`and
`Toxicology (IIBAT) (India)
`
`PROFESSIONAL SERVICE
`Manuscript Reviews
`Eur. J. Med. Chem. (top 10th percentile reviewer)
`J. American Chemical Society
`J. Organic Chemistry
`Org. Biomol. Chem.
`Organic Letters
`Tetrahedron Letters
`Tetrahedron
`Perspectives in Med. Chem.
`
`Proposal Reviews
`NIH SBC-A Study Section
`American Cancer Society
`National Science Foundation
`Oak Ridge Associated Universities
`American Chemical Society PRF
`
`
`
`COMMUNITY SERVICE
`Heroes Class - invited to address middle school
`students
`in summer (2009) emphasizing
`the
`importance of scientific discoveries (such as the
`story of aspirin) in our daily lives.
`Invited lectures to FAU Life-Long Learning Center
`and to FAU charitable donors audience: “From
`Concept to Capsule: A Tour of the Prescription
`Drug Discovery Process” (2008/09)
`Palm Beach Post (6/20/05) “FAU hopes $4 million
`grant boosts research reputation” by Kimberly Miller
`Sun-Sentinel (3/6/05) “Recent FAU graduate seeks
`chance to ‘expand my mind’” by Glenn Singer
`Lecture presentation to the Science National Honor
`Society at C.W. Flanagan High School (Pembroke
`Pines, FL) (2003 & 2004)
`Lecture presentation to High School Science
`Teachers at Boynton Beach Community High
`(2003)
`Palm Beach County Science Fair Judge (2002 &
`2004)
`Miami Herald (9/24/03) “Bush gives research a $10-
`million boost” by Jasmine Kripalani
`Appeared on the local television news (News
`Channel 5) on 7/18/02 in an interview with Jean
`Apodaca. This science-related segment concerned
`the drug gamma hydroxybutyrate (GHB).
`
`
`
`8
`
`

`
`Zongren Zhang: Senior Scientist, Department of
`Radiology, Washington University School of
`Medicine
`
`Visiting Professor
`Dr. Bilal A. Bhat (2013-2014) from the Indian
`Institute of Integrative Medicine
`
`
`
`9