EXHIBIT A
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`PETITIONER'S EXHIBITS
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`Exhibit 1003 Page 225 of 1040
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`CURRICULUM VITAE
`(updated 26 February 2016)
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`Eduardo Agustin Padlan
`
`Address:
`
`Tel:
`E-mail:
`
`Born:
`
`4006 Simms Drive
`Kensington, Maryland 20895 USA
`00+1-301-933-2660
`eapadlanmail-2008@yahoo.com, eduardo.padlan@gmail.com
`
`August 31, 1940
`Manila, Philippines
`
`Citizenship: USA (Naturalized 1993)
`
`Education:
`B.S., major in Physics, University of the Philippines, 1960
`Ph.D., Biophysics, Johns Hopkins University, 1968
`M.S., Computer Science, Johns Hopkins University, 1984
`
`Occupation: Consultant, Volunteer Teacher
`
`Scientific Interests: Molecular Immunology, Protein Structure & Function
`
`Employment History:
`Research:
`Laboratory of Molecular Biology, National Institute of Diabetes and
`Digestive and Kidney Diseases, National Institutes of Health
`[Retired, 2000]: Research Physicist, 1997-2000; Visiting Scientist,
`1987-97, 1974-78; Expert, 1983-87; Visiting Associate, 1971-74
`Department of Biophysics, Johns Hopkins University: Research Scientist,
`1978-83; Research Associate, 1969-71
`
`Teaching:
`Adjunct Professor, Marine Science Institute, College of Science,
`University of the Philippines Diliman, 2002-2013
`Adjunct Professor, Institute of Chemistry, College of Arts and Sciences,
`University of the Philippines Los Baños, 2002-2005
`Visiting Professor, Graduate School, University of Santo Tomas, 2003
`Visiting Professor, College of Science, University of the Philippines
`Diliman, 1998, 1999, 2000, 2001, 2002
`Affiliate Professor, School of Science and Engineering, Ateneo de Manila
`University, 2000-2001, 2001-2002
`Adjunct Professor, Department of Biochemistry and Molecular Biology,
`Medical University of South Carolina, 1992
`Faculty, Foundation for Advanced Education in the Sciences, National
`Institutes of Health, 1984-97
`
`1
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`PETITIONER'S EXHIBITS
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`Exhibit 1003 Page 226 of 1040
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`Faculty, Department of Physics, College of Arts and Sciences, University
`of the Philippines Diliman: Assistant Professor, 1968-69;
`Instructor, 1961-63;
`Assistant Instructor, 1960-61
`
`Other:
`
`Student Assistant, College of Arts and Sciences, University of the
`Philippines, 1959-60
`
`Other Professional Activities:
`Editor, ImmunoMethods Vol. 1 No. 2, 1992.
`Co-Editor, Protein Engineering Section, Current Opinion in
`Biotechnology, Vol. 8, 1997.
`Co-Editor, Selected Essays on Science and Technology for Securing a Better
`Philippines, Vol. 1 (The University of the Philippines Press,
`Diliman, Q.C.) 2008.
`Co-Editor, Philippine Science Letters, 2008-14
`Member, Advisory Board, Molecular Immunology, 1980-99
`Member, Editorial Board, Receptor, 1990-96
`Member, Editorial Board, Macromolecular Structures, 1993-97
`Consultant, Merck Sharpe and Dohme, 1989-91
`Consultant, Biogen Inc, 1991-96
`Consultant, MedImmune Inc, 1991-92
`Consultant, T Cell Sciences Inc, 1992-95
`Consultant, IDEC Pharmaceuticals Corp, 1995-2003
`Consultant, SmithKline Beecham, 1996-97
`Consultant, Medarex Inc, 1996-97; 2003-2005
`Consultant, Tanox Biosystems, 1998-99
`Consultant, System Research Inc, 2003-2004
`Consultant, Biogen Idec, 2003-2005
`Consultant, BioMedics Inc, 2004-2008
`Member, Scientific Advisory Board, BioMedics Inc, 2009-2012
`Consultant, NeoGenix Oncology Inc, 2007; 2012
`Consultant, PharMab Inc, 2007-2008
`Consultant, Sutherland Asbill & Brennan LLP, 2008
`Consultant, A&G Pharmaceutical Inc, 2011
`Consultant, Synthetic Biologics Inc, 2013
`Consultant, Tanabe Research Laboratories, U.S.A., Inc, 2015
`
`Membership in Academies and Honor Societies:
`National Academy of Science and Technology, Philippines (Corresponding
`Member, elected 2003)
`Philippine-American Academy of Science and Engineering (Founding Member; served as
`President, 1999)
`Phi Kappa Phi International Honor Society (elected 1960)
`Sigma Pi Sigma Physics Honor Society (elected 1961)
`Phi Sigma Biological Honor Society (Alpha Chi Chapter) (elected 1969)
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`PETITIONER'S EXHIBITS
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`Exhibit 1003 Page 227 of 1040
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`Membership in Professional Societies:
`American Crystallographic Association, 1967-99
`American Society for Biochemistry and Molecular Biology, 1976-present
`American Association of Immunologists, 1977-present
`Philippine Society for Biochemistry and Molecular Biology (Honorary Member), 2007-
`present
`
`1.
`
`Patents:
`27 Granted, 4 pending in the US:
`F.J.R.do Couto, R.L.Ceriani, J.A.Peterson and E.A.Padlan.
`US5792852 (Granted August 11, 1998):
`Polynucleotides encoding modified antibodies with human milk fat globule
`specificity
`
`I.Pastan, I.Benhar, E.A.Padlan, S.-H.Jung and B.K.Lee.
`US5889157 (Granted March 30, 1999):
`Humanized B3 antibody fragments, fusion proteins, and uses thereof
`
`A.Black, N.Hanna, E.A.Padlan and R.A.Newman.
`US6001358 (Granted December 14, 1999):
`Humanized antibodies to human gp39, compositions containing thereof
`
`M.N.Blackburn, W.R.Church, G.Z.Feuerstein, M.S.Gross, A.J.Nichols,
`E.A.Padlan, A.H.Patel and D.R.Sylvester.
`US6005091 (Granted December 21, 1999):
`Nucleic acids encoding immunoglobulin domains
`
`I.Pastan, I.Benhar, E.A.Padlan, S.-H.Jung and B.K.Lee.
`US6287562 (Granted September 11, 2001):
`Methods of inhibiting the growth of cells bearing LewisY antigens using
`B1, B3, or B5 targeted immunoconjugates
`
`F.J.R.do Couto, R.L.Ceriani, J.A.Peterson and E.A.Padlan.
`US6315997 (Granted November 13, 2001):
`Use of modified antibodies with human milk fat globule specificity
`
`M.N.Blackburn, W.R.Church, G.Z.Feuerstein, M.S.Gross, A.J.Nichols,
`E.A.Padlan, A.H.Patel and D.R.Sylvester.
`US6391299 (Granted May 21, 2002):
`Anti-factor IX/IXa antibodies
`
`A.Black, N.Hanna, E.A.Padlan and R.A.Newman.
`US6440418 (Granted August 27, 2002):
`Methods of treating autoimmune diseases with gp39-specific antibodies
`
`2.
`
`3.
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`4.
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`5.
`
`6.
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`7.
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`8.
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`3
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`PETITIONER'S EXHIBITS
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`Exhibit 1003 Page 228 of 1040
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`9.
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`10.
`
`11.
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`12.
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`13.
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`14.
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`15.
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`16.
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`17.
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`18.
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`P.S.Mezes, R.A.Richard, K.S.Johnson, J.Schlom, S.V.S.Kashmiri, L.Shu and
`E.A.Padlan.
`US6495137 (Granted December 17, 2002):
`Humanized anti-tag-72 monoclonal antibodies using human subgroup 4 kappa
`light chains
`
`A.Black, N.Hanna, E.A.Padlan and R.A.Newman.
`US6506383 (Granted January 14, 2003):
`Methods of suppressing immune responses to transplanted tissues and organs
`with gp39-specific antibodies
`
`B.L.Daugherty, G.E.Mark III and E.A.Padlan.
`US6797492 (Granted September 28, 2004):
`Method for reducing the immunogenicity of antibody variable domains
`
`S.V.S.Kashmiri, E.A.Padlan and J.Schlom.
`US6818749 (Granted November 16, 2004):
`Variants of humanized anti-carcinoma monoclonal antibody CC49
`
`F.J.R.do Couto, R.L.Ceriani, J.A.Peterson and E.A.Padlan.
`US6936706 (Granted August 30, 2005):
`Modified antibodies with human milk fat globule specificity and uses
`
`A.Black, N.Hanna, E.A.Padlan and R.A.Newman.
`US7074406 (Granted July 11, 2006):
`Treating allergic diseases with humanized anti-CD40L antibody
`
`P.S.Mezes, R.A.Richard, K.S.Johnson, J.Schlom, S.V.S.Kashmiri, L.Shu and
`E.A.Padlan.
`US7179899 (Granted February 20, 2007):
`Composite antibodies of humanized human subgroup IV light chain capable of
`binding to TAG-72
`
`S.V.S.Kashmiri, E.A.Padlan and J.Schlom.
`US7256004 (Granted August 14, 2007; Divisional of US6818749):
`Variants of humanized anti-carcinoma monoclonal antibody CC49
`
`S.V.S.Kashmiri, J.Schlom and E.A.Padlan.
`US7569673 (Granted August 4, 2009):
`Humanized anti-TAG-72 CC49 for diagnosis and therapy of human tumors
`
`S.V.S.Kashmiri, J.Schlom and E.A.Padlan.
`US7589181 (Granted September 15, 2009):
`Minimally immunogenic variants of SDR-grafted humanized antibody CC49 and their use
`
`19.
`
`S.V.S.Kashmiri, E.A.Padlan and J.Schlom.
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`PETITIONER'S EXHIBITS
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`Exhibit 1003 Page 229 of 1040
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`US7763719 (Granted July 27, 2010; Divisional of US7256004):
`Variants of humanized anti-carcinoma monoclonal antibody CC49
`
`S.Kashmiri, R.M.Kashmiri, J.Schlom and E.A.Padlan.
`US7855276 (Granted December 21, 2010):
`Framework Residue Substituted Humanized Col-1 Antibodies and Their Use
`
`S.V.S.Kashmiri, J.Schlom and E.A.Padlan.
`US7915396 (Granted March 29, 2011; Divisional of US7589181):
`Nucleic acid molecules encoding minimally immunogenic variants of SDR-
`grafted humanized antibody CC49
`
`S.V.S.Kashmiri, J.Schlom and E.A.Padlan.
`US7919607 (Granted April 5, 2011; Divisional of US7569673):
`Nucleic acids encoding humanized anti-tag 72 CC49 antibodies
`
`S.V.S.Kashmiri, E.A.Padlan and J.Schlom.
`US8029788 (Granted October 4, 2011):
`Variants of humanized anti-carcinoma MAb CC49
`
`20.
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`21.
`
`22.
`
`23.
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`24. M.Numazaki, T.Nakamura, S.Usuda and E.A.Padlan.
`US8101179 (Granted January 24, 2012)
`Anti-CD20 monoclonal antibody
`
`S.V.S.Kashmiri, J.Schlom and E.A.Padlan.
`US8535890 (Granted September 17, 2013)
`Methods to determine immunogenicity of humanized anti-tag 72 CC49
`
`antibodies
`
`S.V.S.Kashmiri, J.Schlom and E.A.Padlan.
`US8828717 (Granted September 9, 2014)
`Framework residue substituted humanized COL-1 antibodies and their use
`
`S.V.S.Kashmiri, J.Schlom and E.A.Padlan.
`US8835167 (Granted September 16, 2014)
`Humanized anti-tag 72 CC49 for diagnosis and therapy of human tumors
`
`A.Black, N.Hanna, E.A.Padlan and R.A.Newman.
`US20030170233:
`Treating autoimmune diseases with humanized anti-CD40L antibody
`
`S.V.S.Kashmiri, J.Schlom and E.A.Padlan.
`US20020408703:
`Minimally immunogenic variant of humanized COL-1 antibody against
`carcinoembryonic antigen (CEA)
`
`F.J.R.do Couto, R.L.Ceriani, J.A.Peterson and E.A.Padlan.
`
`25.
`
`26.
`
`27.
`
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`US20060216303:
`Processes and products with modified antibodies of human milk fat globule
`specificity
`
`E.A.Padlan.
`US20090004208:
`Method for designing hypoallergenic molecules for use in allergy
`desensitization with lessened chance of anaphylaxis, or as vaccines
`against allergic reactions
`
`E.A.Padlan.
`US61/208,482 02/24/2009(Provisional patent application);
`US12/658,726 02/16/2010 (Non-provisional patent application):
`Method for designing molecules for use in directing the antibody response
`to a chosen region of a protein antigen
`
`J.Maynard, A.Nguyen and E.A.Padlan
`US20150353628 12/10/2015
`HUMANIZED PERTUSSIS ANTIBODIES AND USES THEREOF
`
`3
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`Granted, 2 pending in other countries, different from those in the US:
`B.A.Helm and E.A.Padlan.
`AU6532498 (Granted June 29, 1998):
`Inhibition of IgE-mediated allergies by a human IgE-derived oligopeptide
`
`M.N.Blackburn, W.R.Church, G.Z.Feuerstein, M.S.Gross, A.J.Nichols,
`E.A.Padlan, A.H.Patel and D.R.Sylvester.
`ZA9700347 (Granted October 6, 1998); CZ9802225 (Granted January 12, 2000);
`NZ331014 (Granted January 28, 2000):
`Anticoagulant agents useful in treatment of thrombosis
`
`R.L.Ceriani, F.R.J.do Couto, E.A.Padlan and J.A.Peterson.
`AU6396494 (Granted June 8, 1994); DE69332930T (Granted February 26, 2004):
`Peptides and anti-sense peptides with broad neoplastic specificity
`
`I.Pastan, I.Benhar, E.A.Padlan, S.-H.Jung, B.K.Lee, M.Willingham,
`U.Brinkmann and L.Pai.
`WO9613594 (1996-05-09):
`Tumor-specific antibody fragments, fusion proteins, and uses thereof
`
`D.Fitzgerald,
`
`E.A.Padlan.
`WO2015/048129 (2015-04-02)
`AVIAN INFLUENZA VIRUS POLYPEPTIDES AND METHODS OF THEIR USE
`
`Various Other Scientific Activities:
`Guest Lecturer, Course on Immunology, University of Pennsylvania
`
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`PETITIONER'S EXHIBITS
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`Exhibit 1003 Page 231 of 1040
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`Medical School, 1979, 1981, 1985, 1986, 1987
`Guest Lecturer, Course on Immunology, Institute for Medical
`Research, 1980
`Guest Lecturer, Course on Peptide and Protein Chemistry, US Food
`and Drug Administration, 1984
`Guest Lecturer, Course on Immunoglobulins: Molecular Probes of the
`Nervous System, Cold Spring Harbor Laboratory, 1986
`Guest Lecturer, Biotechnology Course, Department of Chemistry,
`Georgetown University, 1988, 1990
`Guest Lecturer, Course on Peptides and Proteins, U.S. Patent
`Office, 1988
`Guest Instructor, Course on Immunochemical Techniques for Chemists,
`Philadelphia Section of the American Chemical Society, 1988
`Guest Lecturer, BIO-TRAC 8: Immunochemistry and Monoclonal Antibody
`Production, Foundation for Advanced Education in the Sciences,
`National Institutes of Health, 1994, 1995
`Co-chair, Minisymposium on "Three-Dimensional Structure of
`Immunoglobulins: Anti-Hapten Antibodies at High Resolution;
`Antibody-Protein Interaction; and New Insights into the
`Three-Dimensional Structure of Fc", American Association of
`Immunologists Meeting, FASEB Meeting, Atlanta, GA, 1991
`Instructor, Course on Protein Crystallography, Department of
`Biochemistry and Molecular Biology, Medical University of
`South Carolina, 1992
`Co-Instructor, Course on Proteins, Foundation for Advanced Education
`in the Sciences, National Institutes of Health, 1984-91
`Instructor, Course on Protein Crystallography, Foundation for
`Advanced Education in the Sciences, National Institutes of
`Health, 1992, 1995
`Organizer, Mid-Atlantic Protein Crystallography Workshop, Center for
`Advanced Research in Biotechnology, Rockville, MD, 1995
`Instructor, Course on Protein Crystallography, College of Science,
`University of the Philippines Diliman, 1998
`Co-Instructor, Course on Cellular and Molecular Immunology,
`College of Science, University of the Philippines Diliman, 1998
`Co-Organizer, Session on Structural Biology, NIH Immunology Retreat,
`Airlie House, VA, 1998
`Co-Instructor, Course on Proteins, Department of Chemistry, School of
`Science and Engineering, ADMU, 2000-2001
`Instructor, Course on Immunology, Department of Biology, School of
`Science and Engineering, ADMU, 2001-2002
`Co-Instructor, Course on Advanced Biochemistry, UPIC, 2001-2002
`Co-Instructor, Current Topics course, UPNIMBB, 2001-2002
`Guest Lecturer, Course on Protein Chemistry, Institute of Chemistry,
`UPLB, 2002
`Guest Lecturer, Current Topics course, Institute of Biological Sciences,
`
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`UPLB, 2002
`Guest Lecturer, Course on Molecular Biology, Graduate Studies, UPLB, 2002
`Guest Lecturer, Course on Advanced Biochemistry, UPIC, 2002
`Guest Lecturer, Course on Molecular Aspects of Cancer Therapy, UPIC, 2002
`Guest Lecturer, Course on Marine Biotechnology II, UPMSI, 2002
`Guest Lecturer, Course on Marine Biochemistry, UPMSI, 2002
`Co-Instructor, Course on Biological Structures, UPMSI, 2003
`Co-Instructor, Course on Principles of Instrumentation in Molecular
`Biology, UPNIMBB, 2003
`UPLB, 2003
`Guest Lecturer, Course on Protein Chemistry, Institute of Chemistry,
`Guest Lecturer, Course on Human Genetics, Graduate Studies, UPLB, 2003
`Guest Lecturer, Current Topics course, UPNIMBB, 2003
`Co-Instructor, Current Topics in Biomolecular Sciences, Graduate School, UST, 2003
`Guest Lecturer, Course on Immunology, UPNIMBB, 2004
`Instructor, Seminar Course on Protein Structure and Engineering, UPMSI, 2004
`Co-Instructor, Special Topics: Targeted Marine Natural Products for Improved Therapeutic
`Efficacy, UPMSI, 2004
`Co-Instructor, Special Topics: Biomedically Important Peptides and Proteins, UPMSI, 2004
`Co-Instructor, Seminar Course on Protein Structure and Engineering, Graduate Studies,
`UPLB, 2004
`Instructor, Seminar Course on the Immunoglobulins: Structure, Function and Evolution,
`UPMSI, 2004
`Co-Instructor, Course on Marine Biotechnology I, UPMSI, 2004
`Guest Lecturer, Course on Principles of Instrumentation in Molecular Biology, UPNIMBB,
`
`2004
`
`Co-Instructor, Course on Marine Biotechnology I, UPMSI, 2005
`Co-Instructor, Special Topics: Targeted Marine Natural Products for
`Improved Therapeutic Efficacy, UPMSI, 2005
`Co-Instructor, Course on Biological Structures, UPMSI, 2005
`Co-Instructor, Course on Principles of Instrumentation in Molecular
`Biology, UPNIMBB, 2005
`Guest Lecturer, Course on Cellular and Molecular Immunology, UPNIMBB, 2006
`Guest Lecturer, Course on Molecular Biophysics, UPNIMBB, 2006
`Guest Lecturer, Course on Biological Structures, UPMSI, 2006
`Guest Lecturer, Special Topics Course, Graduate Studies, UPLB, 2006
`Guest Lecturer, Course on Proteins, UPIC, 2007
`Guest Lecturer, Special Topics Course on Molecular Biology, Graduate
`Studies, UPLB, 2007
`Guest Lecturer, Graduate Seminar Series, Graduate Studies, UPLB, 2007
`Guest Lecturer, Course on Cellular and Molecular Immunology, UPNIMBB, 2007
`Guest Lecturer, Course on Immunology, ASM+PH, 2007
`Guest Lecturer, Course on Cancer: Molecular Mechanisms and Targets of
`Diagnostics and Therapeutics, UPMSI, 2007
`Guest Lecturer, Course on Biophysics, UPNIMBB, 2008
`Co-Instructor, Special Topics Course on Writing a Scientific Paper, UPMSI, 2008
`Guest Lecturer, Course on Principles of Instrumentation in Molecular
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`PETITIONER'S EXHIBITS
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`Exhibit 1003 Page 233 of 1040
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`Biology, UPNIMBB, 2008
`Guest Lecturer, Course on Cancer: Molecular Mechanisms and Targets of
`Diagnostics and Therapeutics, UPMSI, 2008
`Guest Lecturer, Course on Immunology, ASM+PH, 2008
`Co-Instructor, Special Topics Course on Writing a Scientific Paper, UPMSI, 2009
`Co-Instructor, Special Topics Course on Targeted Marine Natural Products
`for Improved Therapeutic Efficacy, UPMSI, 2009
`Guest Lecturer, Course on Principles of Instrumentation in Molecular
`Biology, UPNIMBB, 2009
`Co-Instructor, Special Topics Course on Writing a Scientific Paper, UPMSI, 2010
`Co-Instructor, Special Topics Course on Targeted Marine Natural Products
`for Improved Therapeutic Efficacy, UPMSI, 2010
`Guest Lecturer, Course on Biophysics, ADMU, 2010
`Guest Lecturer, Course on Principles of Instrumentation in Molecular
`Biology, UPNIMBB, 2010
`Co-Instructor, Special Topics: Marine Drug Discovery and Development,
`UPMSI, 2011
`Co-Instructor, Course on Biological Structures, UPMSI, 2011
`Guest Lecturer, 7th PMES/WM&E Research and Thesis Writing Seminar, 2011
`Co-Instructor, Special Topics Course on Writing a Scientific Paper, UPMSI, 2012
`Guest Lecturer, Seminar Series on Therapeutic Antibodies and Vaccine
`Design, UPIC, 2012
`Guest Lecturer, on Wastefulness vs. Parsimony in Nature, Institute of
`Biology, College of Science, UP Diliman, 2012
`Video-taped lecture on "Wastefulness and Parsimony", Diliman Interactive
`Learning Center, UP Diliman, 2012
`
`("UP" = University of the Philippines; "UPMSI" = Marine Science Institute, College of Science,
`UP Diliman; "UPNIMBB" = National Institute of Molecular Biology and Biotechnology, College
`of Science, UP Diliman; "UPIC" = Institute of Chemistry, College of Science, UP Diliman;
`"UPLB" = UP Los Baños; "UST" = University of Santo Tomas; "ADMU" = Ateneo de Manila
`University; "ASM+PH" = Ateneo School of Medicine and Public health; "PMES/WM&E" =
`Pilipinas Monitoring and Evaluation Society/WorkLand M&E, Inc.)
`
`Publications: 1 monograph; 3 edited volumes; 151 scientific papers; seven
`Editorials; one Letter to the Editor; and 55 newspaper articles
`popularizing science
`
`Monograph:
`Eduardo A. Padlan "Antibody-Antigen Complexes" (R.G. Landes Co., Austin)
`1994. [ISBN 1-57059-181-4]
`
`Edited Volumes:
`Eduardo A. Padlan "Strategies for Modeling Antibody Combining Site
`Structures", ImmunoMethods Vol. 1, No. 2 (Academic Press, San Diego)
`1992.
`
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`Birgit A. Helm and Eduardo A. Padlan "Protein Engineering", Current
`Opinion in Biotechnology Vol. 8, No. 4 (Current Biology Ltd, London)
`1997.
`
`Gisela P. Padilla-Concepcion, Eduardo A. Padlan and Caesar A. Saloma
`"Selected Essays on Science and Technology for Securing a Better
`Philippines, Vol. 1" (University of the Philippines Press, Quezon
`City) 2008.
`
`Scientific Papers:
`1. E.A.Padlan and W.E.Love (1968) "Structure of the Hemoglobin of the Marine Annelid Worm,
`Glycera dibranchiata, at 5.5 A Resolution" Nature 220(5165), 376-378. (This paper was featured in
`Science Report, The Times of London, October 25, 1968.)
`
`2. E.A.Padlan and W.E.Love (1971) "Alterations in the Projected Electron Density of Glycera
`Hemoglobin Accompanying Changes in Ligand State" In Probes of Structure and Function of
`Macromolecules and Membranes, Vol II (B.Chance, T.Yonetani and A.S.Mildvan, eds) (Academic
`Press, New York) pp 187-192.
`
`3. W.E.Love, P.A.Klock, E.E.Lattman, E.A.Padlan, K.B.Ward, Jr. and W.A.Hendrickson (1971)
`"The Structure of Lamprey and Bloodworm Hemoglobins in Relation to their Evolution and
`Function" Cold Spring Harbor Symp. Quant. Biol. 36, 349-357.
`
`4. S.Rudikoff, M.Potter, D.M.Segal, E.A.Padlan and D.R.Davies (1972) "Crystals of
`Phosphorylcholine-Binding Fab Fragments from Mouse Myeloma Proteins: Preparation and X-ray
`Analysis" Proc. Natl. Acad. Sci. U.S.A. 69(12), 3689-3692.
`
`5. E.A.Padlan, D.M.Segal, T.F.Spande, D.R.Davies, S.Rudikoff and M.Potter (1973) "Structure at
`4.5 A Resolution of a Phosphorylcholine-Binding Fab" Nature New Biol. 245(145), 165-167. (This
`paper was featured in Nature Vol. 245(5423), p 236, October 5, 1973.)
`
`6. E.A.Padlan and W.E.Love (1974) "Three-Dimensional Structure of Hemoglobin from the
`Polychaete Annelid, Glycera dibranchiata, at 2.5 A Resolution" J. Biol. Chem. 249(13), 4067-
`4078.
`
`7. E.A.Padlan, D.M.Segal, G.H.Cohen, D.R.Davies, S.Rudikoff and M.Potter (1974) "The Three-
`Dimensional Structure of the Antigen Binding Site of McPC603 Protein" In The Immune System
`(E.E.Sercarz, A.R.Williamson and C.F.Cox, eds) (Academic Press, New York) pp 7-14.
`
`8. D.M.Segal, E.A.Padlan, G.H.Cohen, E.W.Silverton, D.R.Davies, S.Rudikoff and M.Potter
`(1974) "The Structure of McPC603 Fab and its Hapten Complex" In Progress in Immunology II,
`Vol 1: Immunochemical Aspects (L.Brent and
`J.Holborow, eds) (North Holland Publishing Co., Amsterdam) pp 93-102.
`
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`9. D.M.Segal, E.A.Padlan, G.H.Cohen, S.Rudikoff, M.Potter and D.R.Davies (1974) "The Three-
`Dimensional Structure of a Phosphorylcholine-Binding Mouse Immunoglobulin Fab and the Nature
`of the Antigen Binding Site" Proc. Natl. Acad. Sci. U.S.A. 71(11), 4298-4302. (This paper was
`featured among others in a report on antibody structure in Nature Vol. 253(5488), p 158, January
`17, 1975 and in Science Vol. 189(4208), pp 1075 and 1114, September 26, 1975.)
`
`10. E.A.Padlan, D.M.Segal, G.H.Cohen, D.R.Davies, S.Rudikoff and M.Potter (1975) "Structure
`of a Phosphorylcholine-Binding Mouse Myeloma Fab" Transplant. Proc. 7(2), 219-222.
`
`11. E.A.Padlan, W.A.Eaton and T.Yonetani (1975) "A Crystallographic Study of Deoxy
`Cobalt(II)Mesoporphyrin IX Myoglobin" J. Biol. Chem. 250(17), 7069-7073.
`
`12. L.W.Labaw, E.A.Padlan, D.M.Segal and D.R.Davies (1975) "An EM Study of
`Phosphorylcholine-Binding Fab' Immunoglobulin Fragment Crystals" J. Ultrastruct. Res. 51(3),
`326-339.
`
`13. E.A.Padlan and D.R.Davies (1975) "Variability of Three-Dimensional Structure in
`Immunoglobulins" Proc. Natl. Acad. Sci. U.S.A. 72(3), 819-823. (This paper was featured among
`others in a report on antibodies in Nature Vol. 257, pp 447-448(5526), October 9, 1975.)
`
`14. D.R.Davies, E.A.Padlan and D.M.Segal (1975) "Three-Dimensional Structure of
`Immunoglobulins" Ann. Rev. Biochem. 44, 639-667.
`
`15. D.R.Davies, E.A.Padlan and D.M.Segal (1975) "Immunoglobulin Structures at High
`Resolution" In Contemporary Topics in Molecular Immunology, Vol 4 (F.P.Inman and W.J.Mandy,
`eds) (Plenum Press, New York) pp 127-155.
`
`16. E.A.Kabat, E.A.Padlan and D.R.Davies (1975) "Evolutionary and Structural Influences on the
`Light Chain Constant (CL) Region of Human and Mouse Immunoglobulins" Proc. Natl. Acad. Sci.
`U.S.A. 72(7), 2785-2788.
`
`17. M.Pandin, E.A.Padlan, C.diBello and I.M.Chaiken (1976) "Crystalline Semi-Synthetic
`Ribonulease-S'" Proc. Natl. Acad. Sci. U.S.A. 73(6), 1844-1847.
`
`18. M.Pandin, E.A.Padlan, C.diBello and I.M.Chaiken (1976) "Crystallization of Solid Phase-
`Derived Semisynthetic Ribonuclease S'" In Peptides 1976 (A.Loffet, ed) (Editions de l'Universite
`de Bruxelles, Belgium) pp 319-321.
`
`19. M.Potter, E.A.Padlan and S.Rudikoff (1976) "Localized Insertion-Deletion Mutations: A
`Major Factor in the Evolution of Immunoglobulin Structural Variability" J. Immunol. 117(2), 626-
`629.
`
`20. E.A.Padlan, D.R.Davies, S.Rudikoff and M.Potter (1976) "Structural Basis for the Specificity
`of Phosphorylcholine-Binding Immunoglobulins" Immunochemistry 13(11), 945-949.
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`21. E.A.Padlan, D.R.Davies, I.Pecht, D.Givol and C.Wright (1977) "Model Building Studies of
`Antigen Binding Sites: The Hapten Binding Site of MOPC315" Cold Spring Harbor Symp. Quant.
`Biol. 41 Pt 2, 627-637.
`
`22. D.R.Davies and E.A.Padlan (1977) "Correlations Between Antigen-Binding Specificity and the
`Three-Dimensional Structure of the Antibody Combining Site" In Antibodies in Human Diagnosis
`and Therapy (E.Haber and R.M.Krause, eds) (Raven Press, New York) pp 119-132.
`
`23. M.Potter, S.Rudikoff, E.A.Padlan and M.Vrana (1977) "The Covalent Structure of the Antigen
`Binding Site: Antigen Binding Myeloma Proteins of the BALB/c Mouse" In Antibodies in Human
`Diagnosis and Therapy (E.Haber and R.M.Krause, eds) (Raven Press, New York) pp 9-28.
`
`24. E.A.Padlan (1977) "Structural Basis for the Specificity of Antibody Antigen Reactions and
`Structural Mechanisms for the Diversification of Antigen Binding Specificities" Quart. Rev.
`Biophys. 10(1), 35-65.
`
`25. E.A.Padlan (1977) "Structural Implications of Sequence Variability in Immunoglobulins" Proc.
`Natl. Acad. Sci. U.S.A. 74(6), 2551-2555.
`
`26. E.A.Padlan (1979) "Evaluation of the Structural Variation Among Light Chain Variable
`Domains" Mol. Immunol. 16(5), 287-296.
`
`27. M.A.Navia, D.M.Segal, E.A.Padlan, D.R.Davies, N.Rao, S.Rudikoff and M.Potter (1979)
`"Crystal Structure of Galactan-Binding Mouse Immunoglobulin J539 Fab at 4.5 A Resolution"
`Proc. Natl. Acad. Sci. U.S.A. 76(8), 4071-4074.
`
`28. M.Potter, E.B.Mushinski, S.Rudikoff, C.P.J.Glaudemans, E.A.Padlan and D.R.Davies (1979)
`"Structural and Genetic Basis of Idiotypy in the Galactan-Binding Myeloma Proteins" Ann.
`Immunol. (Inst. Pasteur) 130(2), 263-271.
`
`29. S.Rudikoff, Y.Satow, E.A.Padlan, D.R.Davies and M.Potter (1981) "Kappa Chain Structure
`from a Crystallized Murine Fab: Role of Joining Segment in Hapten Binding" Mol. Immunol.
`18(8), 705-711.
`
`30. R.G.Mage, K.E.Bernstein, N.McCartney-Francis, C.B.Alexander, G.O. Young-Cooper,
`E.A.Padlan and G.H.Cohen (1984) "The Structural and Genetic Basis for Expression of Normal
`and Latent VHa Allotypes of the Rabbit" Mol. Immunol. 21(11), 1067-1081.
`
`31. E.W.Silverton, E.A.Padlan, D.R.Davies, S.Smith-Gill and M.Potter (1984) "Crystalline
`Monoclonal Antibody Fabs Complexed to Hen Egg White Lysozyme" J. Mol. Biol. 180(3), 761-
`765.
`
`32. E.A.Padlan, G.H.Cohen and D.R.Davies (1985) "On the Specificity of Antibody/Antigen
`Interactions: Phosphocholine Binding to McPC603 and the Correlation of the Three-Dimensional
`Structure and Sequence Data" Ann. Inst. Pasteur/Immunol. 136C(2), 271-276. (with Discussion by
`E.A.Padlan and D.R.Davies, pp 293-294)
`
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`33. E.A.Padlan and W.E.Love (1985) "Refined Crystal Structure of Deoxy Hemoglobin S. I.
`Restrained Least-Squares Refinement at 3.0 A Resolution" J. Biol. Chem. 260(14), 8272-8279.
`
`34. E.A.Padlan and W.E.Love (1985) "Refined Crystal Structure of Deoxy Hemoglobin S. II.
`Molecular Interactions in the Crystal" J. Biol. Chem. 260(14), 8280-8291.
`
`35. E.A.Padlan (1985) "Quantitation of the Immunogenic Potential of Protein Antigens" Mol.
`Immunol. 22(11), 1243-1254.
`
`36. D.R.Davies, T.N.Bhat, G.H.Cohen and E.A.Padlan (1985) "Comparative Structures of Mouse
`Antibody Combining Sites" In Investigation and Exploitation of Antibody Combining Sites
`(E.Reid, G.M.W.Cook and D.J.Morre, eds) (Plenum Press, New York) pp 51-60.
`
`37. N.McCartney-Francis, E.A.Padlan, G.H.Cohen and R.G.Mage (1986) "Localization of Rabbit
`Kappa Light Chain Allotypic Determinants" Mol. Immunol. 23(5), 475-488.
`
`38. Y.Satow, G.H.Cohen, E.A.Padlan and D.R.Davies (1986) "The Phosphocholine Binding
`Immunoglobulin Fab McPC603: An X-ray Diffraction Study at 2.7 A" J. Mol. Biol. 190(4), 593-
`604.
`
`39. E.A.Padlan, G.H.Cohen and D.R.Davies (1986) "Antibody Fab Assembly: The Interface
`Residues Between CH1 and CL" Mol. Immunol. 23(9), 951-960.
`
`40. E.A.Padlan and D.R.Davies (1986) "A Model of the Fc of Immunoglobulin E" Mol. Immunol.
`23(10), 1063-1075.
`
`41. D.R.Davies, E.A.Padlan and G.H.Cohen (1986) "Fab Assembly: An Analysis of Different
`CH1:CL Combinations" In Progress in Immunology, VI. (B.Cinader and R.G.Miller, eds)
`(Academic Press, Orlando, FL) pp 145-149.
`
`42. E.A.Padlan, G.H.Cohen and D.R.Davies (1987) "Studies of the Tertiary and Quaternary
`Structure of Antibody Constant Domains" In Biological Organization: Macromolecular Interactions
`at High Resolution (R.M.Burnett and H.J.Vogel, eds) (Academic Press, Orlando, FL) pp 193-214.
`
`43. K.Suguna, R.R.Bott, E.A.Padlan, E.Subramanian, S.Sheriff, G.H.Cohen and D.R.Davies
`(1987) "Structure and Refinement at 1.8 A Resolution of the Aspartic Proteinase from Rhizopus
`chinensis" J. Mol. Biol. 196(4), 877-900.
`
`44. K.Suguna, E.A.Padlan, C.W.Smith, W.D.Carlson and D.R.Davies (1987) "Binding of a
`Reduced Inhibitor to the Aspartic Proteinase from Rhizopus chinensis: Implications for a
`Mechanism of Action" Proc. Natl. Acad. Sci. U.S.A. 84(20), 7009-7013.
`
`45. S.Sheriff, E.W.Silverton, E.A.Padlan, G.H.Cohen, S.J.Smith-Gill, B.C.Finzel and D.R.Davies
`(1987) "Three-Dimensional Structure of an Antibody-Antigen complex" Proc. Natl. Acad. Sci.
`U.S.A. 84(22), 8075-8079.
`
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`46. B.Helm, P.Marsh, D.Vercelli, E.Padlan, H.Gould and R.Geha (1988) "The Mast Cell Binding
`Site on Human Immunoglobulin E" Nature 331(6152), 180-183.
`
`47. S.Sheriff, E.Silverton, E.Padlan, G.Cohen, S.Smith-Gill, B.Finzel and D.R.Davies (1988)
`"Antibody-Antigen Complexes: Three-Dimensional Structure and Conformational Change" In
`Structure and Expression Vol I: From Proteins to Ribosomes (R.H.Sarma and M.H.Sarma, eds)
`(Adenine Press, Albany, NY) pp 49-53.
`
`48. E.A.Padlan and E.A.Kabat (1988) "Model-Building Study of the Combining Sites of Two -
`(1->6)Dextran Antibodies" Proc. Natl. Acad. Sci. U.S.A. 85(18), 6885-6889.
`
`49. D.R.Davies, S.Sheriff and E.A.Padlan (1988) "Antibody/Antigen Complexes" J. Biol. Chem.
`263(22), 10541-10544.
`
`50. I.Chretien, B.A.Helm, P.J.Marsh, E.A.Padlan, J.Wijdenes and J.Banchereau (1988) "A
`Monoclonal Anti-IgE Antibody Against an Epitope (Amino Acids 367-376) in the CH3 Domain
`Inhibits IgE Binding to the Low Affinity IgE Receptor (CD23)" J. Immunol. 141(9), 3128-3134.
`
`51. C.C.Hyde, S.A.Ahmed, E.A.Padlan, E.W.Miles and D.R.Davies (1988) "Three-Dimensional
`Structure of the Tryptophan Synthase Multi-Enzyme Complex from Salmonella typhimurium:
`Evidence for a Substrate Tunnel Between Active Sites" J. Biol. Chem. 263(33), 17857-17871.
`
`52. D.Vercelli, B.Helm, P.Marsh, E.Padlan, R.S.Geha and H.Gould (1989) "The B Cell Binding
`Site on Human Immunoglobulin E" Nature 338(6217), 649-650.
`
`53. D.Vercelli, B.Helm, P.Marsh, E.Padlan, H.Gould and R.S.Geha (1989) "The IgE Binding Site
`for Low-Affinity Fc Receptors" In Progress in Allergy and Clinical Immunology, Proceedings of
`the 13th International Congress of Allergology and Clinical Immunology, Montreux,
`Schwitzerland, Oct. 16-21, 1988 (W.J.Pichler, B.M.Stadler, C.Dahinden, A.R.Pecoud, P.C.Frei,
`C.Schneider, A.L.de Weck, eds) (Hogrefe and Huber Publishers, Toronto) pp 101-104.
`
`54. D.R.Davies, S.Sheriff, E.A.Padlan, E.W.Silverton, G.H.Cohen and S.J.Smith-Gill (1989)
`"Three-Dimensional Structures of Two Fab Complexes with Lysozyme" In The Immune Response
`to Structurally Defined Proteins: The Lysozyme Model (S.J.Smith-Gill and E.E.Sercarz, eds)
`(Adenine Press, New York) pp 125-132.
`
`55. E.A.Padlan, E.W.Silverton, S.Sheriff, G.H.Cohen, S.J.Smith-Gill and D.R.Davies (1989)
`"Structure of an Antibody-Antigen Complex: Crystal Structure of the HyHEL-10 Fab-Lysozyme
`Complex" Proc. Natl. Acad. Sci. U.S.A. 86(15), 5938-5942.
`
`56. C.Chothia, A.M.Lesk, A.Tramontano, M.Levitt, S.J.Smith-Gill, G.Air, S.Sheriff, E.A.Padlan,
`D.Davies, W.R.Tulip, P.M.Colman, S.Spinelli, P.M.Alzari and R.J.Poljak (1989) "Conformations
`of Immunoglobulin Hypervariable Regions" Nature 342(6252), 877-883.
`
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`Exhibit 1003 Page 239 of 1040
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`57. D.R.Davies, S.Sheriff and E.Padlan (1989) "A Comparative Study of Two Fab-Lysozyme
`Crystal Structures" Cold Spring Harbor Symp. Quant. Biol. 54 Pt 1, 233-238.
`
`58. D.R.Davies, E.A.Padlan and S.Sheriff (1990) "Comparative Structures of Two Lysozyme-
`Antilysozyme Complexes" In Use of X-Ray Crystallography in the Design of Antiviral Agents
`(W.G.Laver and G.M.Air, eds) (Academic Press, San Diego, CA) pp 199-202.
`
`59. E.A.Padlan (1990) "On the Nature of Antibody Combining Sites: Unusual Structural Features
`That May Confer on These Sites an Enhanced Capacity for Binding Ligands" PROTEINS: Struct.
`Funct. Genet. 7(2), 112-124.
`
`60. E.A.Padlan (1990) "X-ray Diffraction Studies of Antibody Constant Regions" In Fc Receptors
`and the Action of Antibodies (H.Metzger, ed) (American Society for Microbiology, Washington,
`D.C.) pp 12-30.
`
`61. A.Black, E.A.Padl