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`HOW ZYTIGA® (abiraterone acetate) </br>WORKS
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`ZYTIGA Inhibits Androgen Production at 3 Sources—
`Including the Tumor Itself
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`Oral, once‐daily ZYTIGA works by interrupting the androgen‐making process at an important step. ZYTIGA inhibits a key step in androgen
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`production at three sources:
`the testes
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`,t
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`he adrenal glands
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`, AND the tumor itself. Watch the following videos to learn How ZYTIGA Works:
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`How ZYTIGA Works
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`You may be aware that the male body naturally produces hormones called androgens. The most well known androgen in men is testosterone. For
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`men with mCRPC, androgens play a role in fueling the disease. While not the only source, androgen is produced primarily in the testes and some
`is also produced by the adrenal glands, which are located above the kidneys. We know now that the tumor itself is also a source of androgen
`production. While there are other key factors that contribute to the disease, androgen is one such factor.
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`Reducing the production of androgen is key in helping you and your doctor manage your illness.
`ZYTIGA may cause serious side effects including:
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`High blood pressure ﴾hypertension﴿, low blood potassium levels ﴾hypokalemia﴿, and fluid retention ﴾edema﴿.
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`Tell your healthcare provider if you get any of the following symptoms:
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`Dizziness
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`Fast heartbeats
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`Feel faint or lightheaded
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`Headache
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`Confusion
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`Muscle weakness
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`Pain in your legs
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`Swelling in your legs or feet
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`Oral, once‐daily ZYTIGA works by interrupting the androgen‐making process at an important step.
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`WHAT IS ZYTIGA ?
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`ZYTIGA (abiraterone acetate) is a prescription medicine that is used along with prednisone. ZYTIGA is used to treat men with castrationresistant
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`prostate cancer (prostate cancer that is resistant to medical or surgical treatments that lower testosterone) that has spread to other parts of the body.
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`IMPORTANT SAFETY INFORMATION
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`Who should not take ZYTIGA (abiraterone acetate)?
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`Do not take ZYTIGA if you are pregnant or may become pregnant. ZYTIGA may harm your unborn baby. Women who are pregnant or who may
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`become pregnant should not touch ZYTIGA without protection, such as gloves.
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`ZYTIGA is not for use in women or children. Keep ZYTIGA and all medicines out of the reach of children.
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`Before you take ZYTIGA , tell your healthcare provider if you:
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`Have heart problems
`Have liver problems
`Have a history of adrenal problems
`Have a history of pituitary problems
`Have any other medical conditions
`Plan to become pregnant (See "Who should not take ZYTIGA ?")
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`Are breastfeeding or plan to breastfeed. It is not known if ZYTIGA passes into your breast milk. You and your healthcare provider should decide if
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`you will take ZYTIGA or breastfeed. You should not do both. (See "Who should not take ZYTIGA ?")
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`Take any other medicines, including prescription and nonprescription medicines, vitamins, and herbal supplements. ZYTIGA can interact with
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`many other medicines.
`If you are taking ZYTIGA :
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`Take ZYTIGA and prednisone exactly as your healthcare provider tells you.
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`Take your prescribed dose of ZYTIGA one time a day. Your healthcare provider may change your dose if needed.
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`Do not stop taking your prescribed dose of ZYTIGA or prednisone without talking to your healthcare provider first.
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`Take ZYTIGA on an empty stomach. Do not take ZYTIGA with food. Taking ZYTIGA with food may cause more of the medicine to be
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`absorbed by the body than is needed and this may cause side effects.
`No food should be eaten 2 hours before and 1 hour after taking ZYTIGA .
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`Swallow ZYTIGA tablets whole. Do not crush or chew tablets.
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`Take ZYTIGA tablets with water.
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`Your healthcare provider will do blood tests to check for side effects.
`Men who are sexually active with a pregnant woman must use a condom during and for one week after treatment with ZYTIGA . If their sexual
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`partner may become pregnant a condom and another form of birth control must be used during and for one week after treatment with ZYTIGA .
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`Talk with your healthcare provider if you have any questions about birth control.
`ZYTIGA may cause serious side effects including:
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`High blood pressure (hypertension), low blood potassium levels (hypokalemia), and fluid retention (edema).
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`Tell your healthcare provider if you get any of the following symptoms:
`Dizziness
`Fast heartbeats
`Feel faint or lightheaded
`Headache
`Confusion
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`7/23/2015
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`HOW ZYTIGA® (abiraterone acetate) </br>WORKS
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`https://www.zytiga.com/print/aboutzytiga/howzytigaworks
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`Talk with your doctor ﴾https://www.zytiga.com/doctor‐discussion‐guide﴿ to see if ZYTIGA is right for you.
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`The testes are two egg‐shaped male reproductive organs located in the scrotum. They produce sperm and the male hormone, testosterone.
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`The adrenal glands are endocrine glands that sit at the top of the kidneys.
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`Androgens are hormones produced by the body that control the development and maintenance of masculine characteristics.
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`Muscle weakness
`Pain in your legs
`Swelling in your legs or feet
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`Adrenal problems may happen if you stop taking prednisone, get an infection, or are under stress.
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`Liver problems. You may develop changes in liver function blood test. Your healthcare provider will do blood tests to check your liver before
`treatment with ZYTIGA and during treatment with ZYTIGA .
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`The most common side effects of ZYTIGA include:
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`Weakness
`Joint swelling or pain
`Swelling in your legs or feet
`Hot flushes
`Diarrhea
`Vomiting
`Cough
`High blood pressure
`Shortness of breath
`Urinary tract infection
`Bruising
`Low red blood cells (anemia) and low blood potassium levels
`High blood sugar levels, high blood cholesterol and triglycerides
`Certain other abnormal blood tests
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`Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
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`THESE ARE NOT ALL THE POSSIBLE SIDE EFFECTS OF ZYTIGA .
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`FOR MORE INFORMATION, ASK YOUR HEALTHCARE PROVIDER OR PHARMACIST.
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`Tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal
`supplements.
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`ZYTIGA can interact with many other medicines.
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`You should not start or stop any medicine before you talk with the healthcare provider who prescribed ZYTIGA .
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`Know the medicines you take. Keep a list of them with you to show to your healthcare provider and pharmacist when you get a new medicine.
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`Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA.
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`Visit www.fda.gov/medwatch (http://www.fda.gov/medwatch), or call 1800FDA1088 (18003321088).
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`© Janssen Biotech, Inc. 2015. All rights reserved.
`
`This site is published by Janssen Biotech, Inc. (http://www.janssenbiotech.com), which is solely responsible for its contents. The material on this site is intended only as informational
`or as an educational aid and it is not intended to be taken as medical advice. The ultimate responsibility for patient care resides with a healthcare professional.
`
`This information is intended for the use of patients and caregivers in the United States and Puerto Rico only. Laws, regulatory requirements, and medical practices for
`pharmaceutical products vary from country to country. The Prescribing Information included here may not be appropriate for use outside the United States and Puerto Rico.
`
`Capitalized product names are trademarks of Janssen Biotech, Inc.
`
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`LAST UPDATED APRIL 21, 2015
`
`7/23/2015
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`HOW ZYTIGA® (abiraterone acetate) </br>WORKS
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`https://www.zytiga.com/print/aboutzytiga/howzytigaworks
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`(http://www.janssenbiotech.com/)
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`Source URL:https://www.zytiga.com/about‐zytiga/how‐zytiga‐works
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`7/23/2015
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`HOW ZYTIGA® (abiraterone acetate) </br>WORKS
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`https://www.zytiga.com/print/aboutzytiga/howzytigaworks
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`4/4
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`WCK1053
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