Ecofl ac® plus
`
`The right solution every step of the way
`
`Basic Care
`
`Hospira, Exh. 2013, p. 1
`
`

`
`Has everything been said
`about IV containers?
`
`Infusion therapy is a fundamental and irreplaceable part of patient
`care. Because of its nature, infusion therapy bears different risks
`for both the patient and the healthcare professional. The conse-
`quences of those risks on the health of the individual are often
`underestimated and can represent heavy costs for the hospital.
`
`Based on clinical evidence, B. Braun has identified the major risks
`that can occur during the main steps of the infusion therapy
`process. B. Braun’s integrated product system contributes to
`safe and efficient workflows, improving patients’ quality of
`life and the safety of healthcare professionals.
`
`Ecoflac® plus is B. Braun’s IV container solution for safe infusion
`therapy. With an extensive portfolio of standard solutions, plasma
`volume replacement, premixed solutions and ready-to-use drugs,
`Ecoflac® plus stands as the state-of-the-art IV container system
`that offers safe and convenient application of all IV procedures.
`Based on its ergonomic design, it contributes to the prevention
`of some of the most common risks throughout the whole
`infusion therapy.
`
`Microbiological
`Contamination
`
`Particulate
`Contamination
`
`Chemical
`Contami-
`nation
`
`Sharps
`Injury
`
`prevents
`
`Medication
`Error
`
`DEHP
`Exposure
`
`Drug
`Incompatibility
`
`For more information about risk
`prevention in infusion therapy, visit:
`
`www.safeinfusiontherapy.com
`
`2
`
`Hospira, Exh. 2013, p. 2
`
`

`
`Delivery & storage
`
`Prior drug admixture
`
`Drug admixture
`
`Prior drug delivery
`
`Drug delivery
`
`Disposal
`
`Portfolio
`
`Your partner in every step
`
`Delivery & storage
`
`Prior drug admixture
`n solution identification
`n compatibility check
`
`Drug admixture
`n with transfer devices
`n with dispensing pins
`
`Prior drug delivery
`
`Drug delivery
`
`Disposal
`
`Portfolio
`
`Hospira, Exh. 2013, p. 3
`
`

`
`Microbiological
`Contamination
`
`Particulate
`Contamination
`
`Chemical
`Contami-
`nation
`
`prevents
`
`Sharps
`Injury
`
`Medication
`Error
`
`DEHP
`Exposure
`
`Drug
`Incompatibility
`
`4
`
`Hospira, Exh. 2013, p. 4
`
`

`
`Delivery & storage
`
`Easy to open and access
`The Ecofl ac® plus carton box
`has an integrated dispenser
`feature which allows easy
`opening without scissors or
`sharp instruments, reducing
`the risk of injury and of
`damaging the contents.
`
`Ergonomic design
`The container is light and
`has an ergonomic design to
`optimize its handling. With
`its oval shape, Ecoflac® plus
`lies securely in your hand.
`Unlike glass bottles, it is virtu-
`ally unbreakable, so that even
`if dropped by accident no glass
`splinters are created and no
`spillage occur.
`
`Delivery and storage
`
`Easy to identify
`The clear labelling on the
`Ecoflac® plus transport boxes
`allows an easy and fast iden-
`tification of the solution.
`The use of a color code, which
`is consistent with the single
`unit labels, helps preventing
`medication errors caused by
`incorrect drug selection.1,2
`
`Easy to store and count
`The Ecoflac® plus IV containers
`are easy to count and store,
`either standing upright or
`laying on their side. This also
`allows you to optimize the
`space in the storage area.
`
`User benefits
`
` n Clear labelling allows easy identification of solution
` n Dispenser feature facilitates opening and access
` n Single units are easy to count and store
` n Light and ergonomic design to optimize handling
` n Virtually unbreakable to avoid any risk of spillage
`or contamination
`
`Hospira, Exh. 2013, p. 5
`
`

`
`Microbiological
`Contamination
`
`Particulate
`Contamination
`
`Chemical
`Contami-
`nation
`
`prevents
`
`Sharps
`Injury
`
`Medication
`Error
`
`DEHP
`Exposure
`
`Drug
`Incompatibility
`
`6
`
`Hospira, Exh. 2013, p. 6
`
`

`
`Prior drug admixture –
`solution identification
`
`Delivery & storage
`
`Prior drug admixture
`
`Medication error: causes and consequences
`Medication errors are errors in prescribing, dispensing or administering of a drug, irrespective of whether such errors lead to
` adverse consequences or not.3,6 Depending on the drug in use and the specific factors of each individual case, errors and irregu-
`larities in IV drug preparation and administration can have a broad range of consequences ranging from harmless to fatal.4
`The National Patient Safety Agency Report 2004 (UK) and the IOM report 2000 (USA) highlighted that medication errors are
`responsible for a wide number of deaths every year.3 In 2010, the World Alliance for Patient Safety estimated that globally, the
`cost of medication errors would amount to € 4.5 to € 21.8 billion.6
`Resulting in higher patient morbidity, increased length of hospital stay and healthcare costs medication errors are therefore a
`recognized and well documented worldwide problem.
`
`B. Braun safety labels
`Incorrect drug selection is a common dispensing error which
`may be caused by similar drug labels/packaging.3
`Research showed that clear labels, based on a strong visual
`differentiation between high alert medications and standard
`solutions help reduce medication error.1,2
`
`Based on these findings, B. Braun‘s unique safety labelling con-
`cept helps reduce the risk of medication errors caused by look-
`alike labels. Developed together with clinical experts, the concept
`enables a strong visual differentiation between different solu-
`tions, by the use of: color codes, large sized text, geometric
`designs and contrasting backgrounds.
`EAN barcode and/or data matrix codes are also used to allow
`easy scanning and the accurate recording of the variable
`information on the labels.
`
`A prospective study in 35 community pharmacies in the
`United Kingdom identified the incidence, nature and root
`causes for medication errors.5
`The results of this study showed that a large range of
`medication errors occur in community pharmacies. The
`most common types of incidents were: selection errors
`(60.3%), followed by labelling (33.0%) and bagging errors
`(6.6%). Most of the incidents were caused either by mis-
`reading prescription (24.5%), similar drug names (16.8%),
`selecting previous drug or dose from the patient’s medica-
`tion record or the pharmacy computer (11.4%) or similar
`packaging (7.6%).
`
`Color and large text
`The use of color eases distinguishing
`the different solutions names. Large
`size text helps in identifying the
`critical information at a glance.
`
`Contrasting backgrounds
`Contrasting backgrounds are also
`used for a better differentiation of
`concentrated solutions.
`
`Geometric design
`Geometric shapes, such as triangles,
`are used to create a differentiating
`element between high alert medication
`and standard solutions which have
`linear design labels.
`
`User benefits
`
` n Easy product differentiation, even from a distance
`
` n Safety labels help reducing medication errors and
`increase patient safety
`
` n Barcode and/or data matrix codes allow easy and
`accurate recording
`
`Hospira, Exh. 2013, p. 7
`
`

`
`Microbiological
`Contamination
`
`Particulate
`Contamination
`
`Chemical
`Contami-
`nation
`
`Sharps
`Injury
`
`prevents
`
`preventsprevents
`
`Medication
`Error
`
`DEHP
`Exposure
`
`Drug
`Incompatibility
`
`8
`
`Hospira, Exh. 2013, p. 8
`
`

`
`Delivery & storage
`
`Prior drug admixture
`
`Prior drug admixture –
`compatibility check
`
`The risk of PVC in IV containers
`IV containers made with Polyvinyl Chloride (PVC) can have negative effects on IV medication delivery and compromise the
`patient receiving the required amount of IV medication due to a sorption effect.
`Some drugs tend to interact and sorb to PVC infusion containers, leading to a loss of pharmacologically active compounds.
`As a result, the medication is not evenly distributed, preventing the patient from getting the full or correct dose.7
`Examples of drugs lost from aqueous solutions during infusion from a flexible PVC container include: Calcitriol, Carmustine,
`Diazepam, Heparin sodium, Isosorbide dinitrate, Nitroglycerin, Warfarin sodium.7 Other materials such as Polyethylene (PE) show
`no or a significantly lower sorption effect compared to PVC.
`
`High drug compatibility
`Ecoflac® plus is made of a pure
`medical grade polyethylene
`(PE) which is chemically inert
`and toxicologically safe.
`Polyethylene is a flexible and
`resistant material which pro-
`vides an excellent compatibility
`with a maximum number of
`pharmaceuticals, reducing the
`risk of interactions.
`
`PVC
`
`PVC free container
`Ecoflac® plus is free of PVC to
`avoid errors in dosage due to
`PHT
`adsorption of the drug to the
`container material. It is also
`DEHP
`free of latex, in order to pre-
`vent any allergic reactions for
`PVC-free DEHP-free
`both the user and the patient.
`
`LATEX
`
`LATEX-free
`
`ConComp database
`ConComp is a comprehensive informa-
`tion source for all your compatibility
`questions on IV drugs, container mate-
`rials and IV solutions. The database is
`easy to use and accessible for free to
`all registered medical professionals.
`All data is supplied as abstracts taken
`from hundreds of original publications
`and internal research. It is updated
`continually in response to customer‘s
`needs.
`
`Fore more details, do not hesitate to
`contact your local B. Braun representa-
`tive or visit our website at
`www.concomp-partner.com
`
`User and patient benefits
`
` n Container material compatible with most drugs
`
` n DEHP-free, PVC-free and latex-free
`
` n Reduces the risk of medication errors thanks to
`chemically inert material
`
` n Support for all compatibility questions through the free
`ConComp database
`
`Hospira, Exh. 2013, p. 9
`
`

`
`Microbiological
`Contamination
`
`Particulate
`Contamination
`
`Chemical
`Contami-
`nation
`
`prevents
`
`Sharps
`Injury
`
`Medication
`Error
`
`DEHP
`Exposure
`
`Drug
`Incompatibility
`
`10
`
`Hospira, Exh. 2013, p. 10
`
`

`
`Delivery & storage
`
`Prior drug admixture
`
`Drug admixture
`
`Drug admixture –
`with transfer devices
`
`A complete product system for safe and convenient drug admixture
`Pharmacies and wards need to admix numerous drugs quickly with simple and cost effective products. Healthcare
`management pays particular attention to safety for patients and hospital care workers as they may be exposed to various
`risks during drug admixture.
`Using a safety device helps prevent the risks of sharps injuries, chemical, microbiological and particulate contamination.8
`Ecoflac® plus is compatible with a variety of needle-free admixture devices, to make the drug admixture simpler, quicker
`and safer. Dedicated needle-free transfer devices such as Ecoflac® Mix or Ecoflac® Connect have been designed specifically
`to be used in combination with Ecoflac® plus.
`
`Ecoflac® Connect
`Ecoflac® Connect is a needle-
`free closed system9 admixture
`device for single-dose medica-
`tion vials. As a closed system,
`it aims at reducing contamina-
`tion of medication and health-
`care professional exposure to
`potentially toxic medication.
`
`The fact that the vial remains
`connected with the system all
`along the infusion reduces the
`risk of medication error. The
`ergonomic design of Ecoflac®
`Connect also allows a conve-
`nient manipulation and a
`secure connection with the
`Ecoflac plus.
`
`Ecoflac® Mix
`Ecoflac® Mix is a transfer cap
`for transferring fluids between
`an Ecoflac® plus container and
`a single dose medication vial.
`It provides a stable connection
`between the container and the
`vial and is especially designed
`to be used with Ecoflac® plus.
`
`Transofix®
`Transofix® is a transfer spike for
`large containers. Thanks to its
`wide internal diameter, it allows
`excellent flow even with non-
`evacuated glass vials. It is
`needle-free in order to prevent
`any risk of needlestick injuries.
`The broad grip flanges provide
`a good grip for easy handling.
`
`User and patient benefits
`
` n High compatibility with needle-free admixture devices to
`prevent sharp injuries
`
` n Standing container facilitates drug transfer
`
` n Closed system transfer devices minimize the risk of
`microbiological and chemical contamination
`
` n Reduced steps needed for drug admixtures
`
`For more information about our complete admixture devices
`portfolio, please contact your local B. Braun representative.
`
`Hospira, Exh. 2013, p. 11
`
`

`
`Microbiological
`Contamination
`
`Particulate
`Contamination
`
`Chemical
`Contami-
`nation
`
`prevents
`
`Sharps
`Injury
`
`Medication
`Error
`
`DEHP
`Exposure
`
`Drug
`Incompatibility
`
`12
`
`Hospira, Exh. 2013, p. 12
`
`

`
`Delivery & storage
`
`Prior drug admixture
`
`Drug admixture
`
`No disinfection needed
`The two ports are kept germ-
`free until removal of the two
`sealant aluminum foils, so that
`disinfection of the ports is not
`required before use. Once re-
`moved, the absence of the pro-
`tective foils becomes a tamper
`evidence of the used port.
`
`Good resealability
`The elastomer of the port auto-
`matically reseals, reducing any
`risk of uncontrolled leakage,
`even with larger plastic spikes.
`During admixture, no particles
`are created when the port of
`Ecoflac® plus is pierced.
`
`Mini-Spike® 2
`Mini-Spike® 2 is a needle-
`free vented dispensing pin
`for injecting and withdrawing
`fluids from vials or semi-rigid
`containers. It integrates a
`swabbable valve which auto-
`matically closes upon syringe
`disconnection.
`
`Drug admixture –
`with dispensing pins
`
`Two separate ports
`The two separated and identi-
`cal ports can be used for either
`drug admixture or delivery.
`No additional step is needed to
`identify the points for injection
`and infusion.
`
`PVC
`
`Large neck ring
`The large neck ring area around
`the port is made of a puncture-
`resistant plastic to help prevent
`needlestick injuries or inadver-
`tent piercing of the container,
`in case a needle is used. The port
`material is chemically inert to
`avoid any interaction with drugs.
`
`PHT
`DEHP
`PVC-free DEHP-free
`
`LATEX
`
`LATEX-free
`
`Latex-free ports
`The port membrane on
`Ecoflac® plus is made of
`thermoplastic elastomere
`which is free of latex.
`The complete absence of
`latex eliminates the risk of
`allergic reactions for both
`the patient and the user.
`
`User benefits
`
` n Two identical ports - no additional step to identify the ports
` n Large neck ring helps prevent sharps injuries
` n Good resealability after admixture to reduce
`contamination risks
` n The absence of sealant on the used port provides tamper
`evidence and prevents further manipulation.
`
`For more information about our complete admixture devices
`portfolio, please contact your local B. Braun representative.
`
`Hospira, Exh. 2013, p. 13
`
`

`
`Microbiological
`Contamination
`
`Particulate
`Contamination
`
`Chemical
`Contami-
`nation
`
`prevents
`
`Sharps
`Injury
`
`Medication
`Error
`
`DEHP
`Exposure
`
`Drug
`Incompatibility
`
`14
`
`Hospira, Exh. 2013, p. 14
`
`

`
`Prior drug delivery
`
`Delivery & storage
`
`Prior drug admixture
`
`Drug admixture
`
`Prior drug delivery
`
`The risks of DEHP in PVC containers
`IV containers made with PVC can have negative effects on IV medication delivery due to plasticizer leaching.11 Leaching is
`the release of DEHP from PVC containers into the medication contained in the IV container, when in contact with certain drugs.
`DEHP has been shown to produce a wide range of toxic effects, particularly in male neonates where the infant’s reproductive
`system can be compromised. In fact, the European Union classified DEHP as a Category 2 reproductive toxicant for both fertility
`and developmental effects.10,11
`Amongst others, the following products are known to exacerbate leaching of DEHP from PVC Containers:
`Docetaxel, Etoposide, Cyclosporine, Paclitaxel, Teniposide7
`
`PHT
`DEHP
`PVC-free DEHP-free
`
`LATEX
`
`LATEX-free
`
`DEHP-free container
`Ecoflac® plus is free of DEHP
`as well as other additives and
`compounds that may poten-
`tially migrate into the finished
`preparation. It therefore helps
`improving the safety of high-
`risk populations.
`
`Compatible IV sets
`The Ecoflac® plus port is uni-
`versally compatible with all
`common IV administration
`set spikes.
`Intrafix® SafeSet is B. Braun’s
`IV set for safe, convenient
`and economical administration
`of infusion therapy. It is also
`free of DEHP.
`
`Easy and safe spiking
`The container standability
`allows an easy and safe
`spiking, preventing sharps
`injuries during insertion. The
`superior properties of the re-
`sealable port membrane also
`prevent coring of elastomeric
`particles when pierced.
`
`Tight connection
`Thanks to its good holding
`force Ecoflac® plus can be
`used safely with siliconized
`spikes. Once inserted, the
`spike stays firmly connected
`to the container, avoiding
`any risks of accidental
`disconnection.
`
`User and patient benefits
`
` n DEHP-free
`
` n Universal compatibility with all common IV sets
`
` n Easy and safe spiking of the port
`
` n Good holding force prevents risk of disconnection
`
`Hospira, Exh. 2013, p. 15
`
`

`
`Microbiological
`Contamination
`
`Particulate
`Contamination
`
`Chemical
`Contami-
`nation
`
`prevents
`
`Sharps
`Injury
`
`Medication
`Error
`
`DEHP
`Exposure
`
`Drug
`Incompatibility
`
`16
`
`Hospira, Exh. 2013, p. 16
`
`

`
`Delivery & storage
`
`Prior drug admixture
`
`Drug admixture
`
`Prior drug delivery
`
`Drug delivery
`
`
`
`Open system
`
`Closed system
`
`Drug delivery
`
`The risks of open system containers
`Intravenous fluid containers can be separated into two
`different types: open system containers and closed system
`containers.12 Open system containers must be externally
`vented in order to allow the container to empty, providing
`an opportunity for bacterial entry.12 This is the case for
`example with glass bottles or non-fully collapsible semi-
`rigid containers.13 Closed infusion containers are fully
`collapsible plastic containers which do not require external
`venting to empty.12,13,14
`Closed systems have been shown to significantly reduce the
`incidence of Central Line-associated Bloodstream Infection
`(CLABSIs) resulting from the ingress of external air into the
`container.12,13,14 Rosenthal et al. showed that switching from
`an open to a closed system container resulted in an overall
`reduction of CLABSI rates by 67%.13 The introduction of
`closed infusion systems not only reduces CLABSIs but also
`reduce attributable hospital costs and mortality.14
`
`Closed system container
`The design of the Ecoflac®
`plus allows complete emptying
`of the bottle without venting,
`which helps reduce the risk of
`contamination of the solution.
`With Ecoflac® plus, a constant
`flow rate is delivered to the
`patient over time, improving
`infusion monitoring and
`patient safety.
`
`Integrated hanger
`Ecoflac® plus can support
`itself during infusion thanks
`to its large integrated hanger.
`
`Accurate infusion monitoring
`The graduation scale on the
`Ecoflac® plus label is easy to
`read, even when the container
`is collapsing. It is designed for
`unvented use and accurately
`shows the delivered volume,
`taking into account the col-
`lapsibility of the container
`during the infusion.
`
`User and patient benefits
`
` n Closed system improves patient safety by reducing the
`risk of microbiological contamination
` n Easy to read graduation marks on label allow for accurate
`infusion monitoring
` n Constant flow rate increases patient safety
` n Integrated hanger at the bottom of the container
`
`Hospira, Exh. 2013, p. 17
`
`

`
`Microbiological
`Contamination
`
`Particulate
`Contamination
`
`Chemical
`Contami-
`nation
`
`prevents
`
`Sharps
`Injury
`
`Medication
`Error
`
`DEHP
`Exposure
`
`Drug
`Incompatibility
`
`18
`
`Hospira, Exh. 2013, p. 18
`
`

`
`Delivery & storage
`
`Prior drug admixture
`
`Drug admixture
`
`Prior drug delivery
`
`Drug delivery
`
`Disposal
`
`Disposal
`
`Environmental impact of PVC incineration
`Most of the medical waste is subject to incineration. Disposal of PVC via incineration is associated with the formation and re-
`lease of dioxin, a group of persistent and very toxic chemicals that are released in the air.15 Dioxins persist in the environment
`and accumulate in the food chain, resulting in measurable revels in animals and in human tissues.11,15,16
`PVC therefore creates a number of environmental health risks. By choosing PVC-free products such as Ecoflac® plus, you can
`help eliminate potential toxins and other safety hazards that could affect your staff, your patients and the environment.
`
`100% recyclable
`Ecoflac® plus can be easily
`recycled, as no additives are
`added for the production of
`the container.
`
`No toxic emissions
`Ecoflac® plus container is
`made of polyethylene which,
`like all hydrocarbons burns
`cleanly. When incinerated, the
`container biodegrades com-
`pletely and residue-free into
`the natural elements of our
`environment, water (H2O) and
`carbon dioxide (CO2).
`
`Low amount of waste
`Unlike most flexible bags,
`Ecoflac® plus containers have
`no outer packaging and there-
`by produce a lower amount of
`waste. It is also much lighter
`than glass containers.
`
`User benefits
`
` n Ecoflac® plus is easy to dispose off and only produces
`a low amount of waste
`
` n It is 100% recyclable
` n When incinerated, it only generates CO2 and H2O –
`no toxic emissions
`
`Hospira, Exh. 2013, p. 19
`
`

`
`Microbiological
`Contamination
`
`Particulate
`Contamination
`
`Chemical
`Contami-
`nation
`
`prevents
`
`Sharps
`Injury
`
`Medication
`Error
`
`DEHP
`Exposure
`
`Drug
`Incompatibility
`
`20
`
`Hospira, Exh. 2013, p. 20
`
`

`
`Delivery & storage
`
`Prior drug admixture
`
`Drug admixture
`
`Prior drug delivery
`
`Drug delivery
`
`Disposal
`
`Portfolio
`
`Portfolio
`
`Ready-to-use drugs
`The Council of Europe recommends that ready to use formats be used instead of pharmacy preparations, if a suitable pharma-
`ceutical equivalent with a marketing authorization is available.17 Before preparation, the pharmacist should verify whether a
`pharmaceutical equivalent is available on the national market, taking into consideration the pharmaceutical form and strength.17
`
`The use of ready to use solutions increases patient and healthcare professional safety by:
`n providing higher accuracy of dosing and contributing to the prevention of medication errors.
`n reducing the risk of particle infiltration and contamination of the solution during preparation.
`n reducing the risk of sharp injuries thanks to the elimination of the use of needles.
`
`In addition, ready-to-use solutions hep reduce medication preparation steps and time.
`
`1
`1
`
`3
`3
`
`5
`5
`
`7
`7
`
`9
`9
`
`2
`2
`
`4
`4
`
`6
`6
`
`8
`8
`
`10
`10
`
`Extensive solutions portfolio
`Besides its extensive portfolio
`of standard IV and plasma vol-
`ume replacement solutions, a
`large portfolio of ready-to-use
`(RTU) injectable drugs are
`available in Ecoflac® plus.
`These include analgesic,
` anti-infective, as well as pre-
`mixed potassium solutions.
`
`Ready to use in a single step
`By reducing the overall prepa-
`ration time and material costs
`required for admixing drugs,
`ready-to-use solutions provide
`you with a good cost-efficacy
`ratio administering drugs.18
`
`User and patient benefits
`User and patient benefits
`
` n Extensive range of ready-to-use drugs available
`n Extensive range of ready-to-use drugs available
`
` n Increases patient safety by reducing the risk of medication
`n Increases patient safety by reducing the risk of medication
`and dosage errors
`and dosage errors
`
` n Less manipulation reduces the risks of contamination
`n Less manipulation reduces the risks of contamination
`
` n Reduced admixture steps, time and overall material costs
`
`Hospira, Exh. 2013, p. 21
`
`

`
`Literature
`
`1.
`
`
`
`
`Tissot E, Cornette C, Limat S, Mourand J, Becker M, Etievent
`J et al. (2003) Observational study of potential risk factors
`of medication administration errors. J Qual Improve 25(6):
`264-68
`
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`Hospira, Exh. 2013, p. 22
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`

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`Hospira, Exh. 2013, p. 23
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`Hospira, Exh. 2013, p. 23
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`

`
`Ordering information
`
`50 ml
`
`100 ml
`
`250 ml
`
`500 ml
`
`1,000 ml
`
`For more information about the products available in Ecofl ac® plus
`in your country, please contact your local B. Braun representative.
`
`Standard IV solutions
`
`Plasma volume replacement
`
`Ready-to-use anti-infective
`
`Ready-to-use analgesic
`
`Ready-to-use sedative
`
`Ready-to-use potassium
`
`Safety is not given until all components of a process chain have
`been cross-matched and synergized to create an integrally reli-
`able system. This is always the case with infusion systems from
`
`B. Braun, and just one of the reasons why Ecofl ac® plus off ers
`you intuitively safe and reliable handling. We set standards with
`Ecofl ac® plus and all of our products for safe infusion therapy!
`
`For more information about
`risk prevention in infusion
`therapy, visit:
`
`www.safeinfusiontherapy.com
`
`B. Braun Melsungen AG | Hospital Care | 34209 Melsungen | Germany
`Tel. +49 5661 71-0 | www.bbraun.com
`
`Hospira, Exh. 2013, p. 24