Wzrsv
}xzr5<FDDK=5IDNnf}EofEfIGL5
`
`"*)+
`
`FM)579;0)b)opwfm)boe)tfmfdujwf)ybouijof)cbtfe)HTT1MZ)joijcjups0)fyijcjut)
`b)tvqfsjps)qsp$mf)xifo)dpnqbsfe)up)tjubhmjqujo)boe)wjmebhmjqujo
`P2)!pnbt@5YB5[z~~v}srty@5`B5Xt|yru @5XB5_rx|w@5`B5`r|O5
`EUvyzxv5\xv}yvz~5cyr~r5Z~s[5;5VB5^Z@5Uzsvrty5r5uv5ez@5
`Zv~rB
`
`Fbdlhspvoe)boe)EjntN5U\5EGIJ5z5r5v}5r yzv5srvu5WccA\i5zyzsz 5
`z y5r5yzxy5 vt5ru5r5}5|$5r v5z5z 5 yr 5yr5svv5uv~ r vu5
` 5yrv5r5}x5ur z5w5rt z5r}5z5zB5[vv@5v5t~rv5 yv5z5z5
`v"trt5ru5ur z5w5rt z5w5U\5EGIJ5r%v5zx}v5r}5uzx5z y5 yr 5w5
`z rx}z z5ru5z}urx}z zB
`VftvmutN5 T}}5 yvv5 t~u5 uvAuvvuv }5 zyzsz vu5 }r~r5 WccA\i5
`rt zz 5z5[rjz r5r B5XWID5r}v5w5zyzsz z5w5WccA\i5rt zz 5K5
`y5 5uv5vv5DBG5~xC|x5w5U\5EGIJ@5DBK5~xC|x5w5z}urx}z z5ru5
`GBI5 ~xC|x5 w5 z rx}z zB5 [vv@5 yz}v5 yv5 zyzsz 5 vt5 v~rzvu5
`yzxy5 vv5 FH5 y5 5 uv5 z y5 U\5 EGIJ5 <XWID5 DBK5 ~xC|x=@5 yv5 XWID5
`ztvrvu5 5 RED5 ~xC|x5 w5 z}urx}z z5 ru5 z rx}z zB5 !v5 v$vt 5 w5 U\5
`EGIJ@5 z}urx}z z5 ru5 z rx}z z5 5 x}tv5 }vrtv5 z5 VIKU}CJ]5 ~ztv5
`vv5t~rvu5r%v5xzzx5 yv5t~u5vz yv5HI5~z55EJ5y5svwv5
`r5r}5x}tv5tyr}}vxvB5T}}5 yvv5t~u5vutvu5x}tv5ThV5 5r5
`z~z}r5v v 5yv5xzv5y }5svwv5 yv5x}tv5}ru5<U\5EGIJ5s5HI9@5
`z rx}z z5 s5 IG9@5 z}urx}z z5 s5 HK9O5 r}}5 r 5 E5 ~xC|x=B5 \5 t r @5 }5
`U\5 EGIJ5 z}}5 z~vu5 x}tv5 }vrtv5 r%v5 ru~zz r z5 w5 yv5 r~v5
`uv5 EJ5 y5 svwv5 yv5 v 5 <ThV5 sFI9=B5 jyz}v5 z rx}z z5 z~vu5
`x}tv5 }vrtv5yv5r5EDAw}u5yzxyv5uv5<ED5~xC|x=5r5ru~zz vvu@5
`z}urx}z z5 vv5 z y5 yr 5 uv5 r5 z y 5 v$vt B5 !@5 yv5 ur z5 w5
`rt z5w5vyrtzx5x}tv5 }vrtv5z5z5w}}5 yv5uv5U\5EGIJ5R5
`z rx}z z5R5z}urx}z zB
`GpodmvtjpoN5 jv5 tt}uv5 yr 5 U\5 EGIJ5 tr5 sv5 vt}zztr}}5 uz$vv zr vu5
`w~5z}urx}z z5ru5z rx}z z5s5r5}xv5}r zx5zyzsz z5w5}r~r5WccA
`\i5rt zz 5ru5r5}xv5}r zx5z~v~v 5w5x}tv5 }vrtv5r 5 yv5r~v5
`uvB5!vv5ur r5vuzt 5 U\5EGIJ5 5 yrv5 r5 }5 tv5urz}5 uv5vxz~v5
`z5y~rB5 !z5#}v5w5 U\5EGIJ5 yr5 svv5 t#~vu5 z5 t}zztr}5 zr}5z5
`yvr} y5} vv5ru5 v5F5uzrsv zt5r zv B
`
`"**"
`
`Mnqspwfnfout)jo)2)dfmm)gvodujpo)qbsbnfufst)evsjoh)961xffl)usfbunfou)
`xjui)wjmebhmjqujo)jo)qbujfout)xjui)njme)izqfshmzdbfnjb
`N2)I2)JpmfzE@5TB5ftyvzvF@5jB5TB5ftyvsr~G@5cB5`B5az}H@5ZB5_r}r(cid:127)(cid:127)vI@55
`UB5XB5WzxJ@5TB5`rzKO5
`Ear z@5X5[rv@5hz vu5f r v@5Far z@5Urv}@5fz v}ru@55
`GXu@5Wzrsv v@5eyv~@5hz5W°v}uw@5Zv~r@5H`vu@5_u5hz@5
``r}~®@5fvuv@5I`vuztr}5Z@5` 5Wv5`rr@5Yrtv@5Jcyr~rjz v@5
`cztv @5hz vu5f r v@5K\f\U@5ar zr}5evvrty5Vtz}@5crur@5\ r}B
`
`Fbdlhspvoe) boe) Ejnt?) iz}urx}z z5 z5 r5 v 5 ru5 v}vt zv5 WccAH5
`zyzsz 5 yr 5 z~v5 x}tv~zt5 t }5 z5 r zv 5 z y5 v5 F5 uzrsv v5
`<gFW`=5ru5~uvr vA A~r|vu5yvx}tv~zr5s5ztvrzx5(A5r(cid:127)u58Atv}}5
`vzvv5 5x}tvB5!z5 u5r5uv r|v5 5rv5 yv5v$vt 5w5
`
`f5GJG
`
`z}urx}z z55~uv}Arvvu58Atv}}5wt z5uzx5IFAvv|5 vr ~v 5w5
`r zv 5z y5}v5rurtvu5gFW`B
`Qbufsjbmt) boe) Qfuipet?) !z5 ~} ztv v@5 ru~zvu@5 rr}}v}Ax5
`}rtvsAt }}vu5 u5v}}vu5GDJ5~z}u}5yvx}tv~zt5<TEV5JBFKBI9=5
`r zv 5 z y5 gFW`B5 f ruru5 ~vr}5 v 5 vv5 vw~vu5 r 5 jvv|5 D5 ru5
`jvv|5 IF5 w5 vr ~v 5 z y5 z}urx}z z5 ID5 ~x5 u5 <5 Q5 EIJ=5 5 }rtvs5 <5
`Q5EID=B5\}z5 vtv 5 r v5<\fe=5r5 tr}t}r vu5 s5 uvt} z5 w5VA
`v zuv5}vv}@5ru58Atv}}5wt z5r5vr}r vu5z y5r5~uv}5 yr 5uvtzsv5
`\fe5r5r5wt z5w5rs} v5x}tv5}vv}5<z}z5vtv 5 v5ru5x}tv5
`vz zz =@5 yv5r v5w5tyrxv5w5x}tv5<r v5vz zz =@5ru5r5 v zr z5
`wrt B
`Vftvmut?)T 5srv}zv@5~vr5rxv5Q5JGBE5@5U`\5Q5GDBF5|xC~F@5YcZ5Q5KBE5~‘5
`ru5TEV5Q5JBK9=B5T5y5sv}@5z}urx}z z5zxz#tr }5ztvrvu5z}z5
`vtv 5 v5<?EK9=@5x}tv5vz zz 5<?HD9=5ru5r v5vz zz 5<?GF9=B5
`<YzxB5E=
`!v5vtz5w5 yv5 v zr z5wrt 5ru5 r}5z}z5vtv z5<\fe5ThVDA
`FHD~z(cid:127)=5 uzx5 ~vr}5 r5 tyrxvuB5 !v5 vyrtv~v 5 w5 8Atv}}5 wt z5
`vv5 rtt~rzvu5 s5 r5 uvtvrv5 z5 yv5 x}tv5 ThVDAFy5 <sv vvAx5
`uz$vvtv5z5 yv5ru{ vu5~vr5tyrxv5nT`0o5Q5(cid:144)EBK5%5DBI5~‘(cid:143)y@5cQDBDDF=5
`ru5z5TEV5<sv vvAx5uz$vvtv5z5T`05Q5(cid:144)DBG5%5DBE9@5cPDBDDE=B
`Gpodmvtjpot?5 \5 r zv 5 z y5 ~z}u5 yvx}tv~zr@5 z~vu5 8Atv}}5
`wt z5z5~rz rzvu5 yxy 5IFA|5 vr ~v 5ru5uv}zv5 rzvu5
`z~v~v 5z5x}tv~zt5t }B
`Tpkkjmo‘_’]t’Ojq\modn
`
`"**#
`
`Zjmebhmjqujo)jt)tbgf)boe)xfmm)upmfsbufe)jo)qbujfout)xjui)njme)ps)npefsbuf)
`sfobm)jnqbjsnfou
`X2)!vsfoE@5fB5UzvF@5cB5`yzuvvFO5
`Ear z@5X5[rv@5hz vu5f r v@5Far z@5Urv}@5fz v}ruB
`
`Fbdlhspvoe)boe)Ejnt?5iz}urx}z z5z5r5 v 5ru5v}vt zv5WccAH5zyzsz 5
` yr 5z~v5x}tv~zt5t }5z5r zv 5z y5 v5F5uzrsv v5<gFW`=5s5
`ztvrzx5 s y5 (A5r(cid:127)u5 8Atv}}5vzvv5 5x}tvB5V}zztr}5ur r5yrv5
`y5 yr 5 z}urx}z z@5 r 5 uv5 w5 ID5 5 EDD~x5 urz}@5 v$vt zv}5 vutv5
`[sTEt@5 z y5 r5 }vrsz}z 5 #}v5 z~z}r5 5 }rtvsB5 T~x5 r zv 5 z y5
`gFW`@5 yv5vr}vtv5w5|zuv5uzvrv5rxv5w~5FDHD9B5!v5v5
`w5 yz5rs rt 5z5E=5 5v 55 yv5vr}vtv5w5~z}u55~uvr v5vr}5
`z~rz~v 5 z5 yv5 rwv 5 ur rsrv5 w5 yv5 z}urx}z z5 x}sr}5 uvv}~v 5
`xr~5 ru5 F=5 5 vr~zv5 yv5 rwv 5 #}v5 w5 z}urx}z z5 ~ yvr5
`z5r zv 5z y5~z}u55~uvr v5vr}5z~rz~v 5z5t~rz5 5 yv5
`z y5~r}5|zuv5wt zB5`v rs}z~5z5 yv5~r{5v}z~zr z5r yr5
`w5 z}urx}z z@5 z y5 r5 ~zz 5 w5 tyrxvu5 ux5 <FG9=5 vtv vu5 z5 yv5
`zvB
`Qbufsjbm) boe) Qfuipet?5 Z}~v}r5 #} r z5 r v5 <ZYe=5 r5 tr}t}r vu5
`s5 yv5`WeW5~v yuN5t $5w5JD5 5PMD5~_C~zCEBKG5~F5ru5GD5 5PJD5
`~}C~z(cid:127)CEBKG5~F5vv5vu5 5uv#v5~z}u5ru5~uvr v5vr}5z"tzvt@5
`vvt zv}B5cyrv5G5rwv 5ur r5w~5L5}vu5~ yvr5ru5K5}vu5
`ruuA5 yvr5 uzv5z y5z}urx}z z5vv5vuB
`Vftvmut?5T5 r}5w5ELJH5r zv 5vtvzzx5z}urx}z z5<vz yv5r5~ yvr5
`5z5t~szr z5z y5 yv5rxv =5yru5`WeWAv z~r vu5~z}u5<5Q5EJID=5
`
`n Vildagiiptin
`
`OPlecebo (cid:9)
`
`l Difference
`
`Jjh2)5)Ectusbdu)4==4
`
`50
`
`-2
`
`Z 40 -
`E (cid:9)
`.
`
`en al 30 -
`L •
`
`26
`
``al
`2
`7, 16-
`•
`
`4
`
`P<0.001
`
`.4x+Mii?
`
`ISR @ mM G ucose
`(Insulin Secretory Tone)
`
`30
`
`2
`
`O
`
`20 4
`
`10 -
`
`co
`c
`
`C
`tu
`2
`
`0
`
`so
`
`4 (cid:9)
`
`Pc0.001 (cid:9)
`
`250
`
`P=0.015
`
`E
`
`200
`
`E
`C
`; (cid:9) 150
`ea
`2 (cid:9) 100
`
`Fs (cid:9)
`
`50
`
`lg
`
`LE (cid:9)
`
`-50
`
`-100
`
`Glucose Sensitivity (cid:9)
`(Slope) (cid:9)
`
`Rate Sensitivity
`(Derivative factor)
`
`"!#
`
`Mylan EX 1019, Page 1
`
`(cid:9)
`(cid:9)
`
`"*)+
`
`FM)579;0)b)opwfm)boe)tfmfdujwf)ybouijof)cbtfe)HTT1MZ)joijcjups0)fyijcjut)
`b)tvqfsjps)qsp$mf)xifo)dpnqbsfe)up)tjubhmjqujo)boe)wjmebhmjqujo
`P2)!pnbt@5YB5[z~~v}srty@5`B5Xt|yru @5XB5_rx|w@5`B5`r|O5
`EUvyzxv5\xv}yvz~5cyr~r5Z~s[5;5VB5^Z@5Uzsvrty5r5uv5ez@5
`Zv~rB
`
`Fbdlhspvoe)boe)EjntN5U\5EGIJ5z5r5v}5r yzv5srvu5WccA\i5zyzsz 5
`z y5r5yzxy5 vt5ru5r5}5|$5r v5z5z 5 yr 5yr5svv5uv~ r vu5
` 5yrv5r5}x5ur z5w5rt z5r}5z5zB5[vv@5v5t~rv5 yv5z5z5
`v"trt5ru5ur z5w5rt z5w5U\5EGIJ5r%v5zx}v5r}5uzx5z y5 yr 5w5
`z rx}z z5ru5z}urx}z zB
`VftvmutN5 T}}5 yvv5 t~u5 uvAuvvuv }5 zyzsz vu5 }r~r5 WccA\i5
`rt zz 5z5[rjz r5r B5XWID5r}v5w5zyzsz z5w5WccA\i5rt zz 5K5
`y5 5uv5vv5DBG5~xC|x5w5U\5EGIJ@5DBK5~xC|x5w5z}urx}z z5ru5
`GBI5 ~xC|x5 w5 z rx}z zB5 [vv@5 yz}v5 yv5 zyzsz 5 vt5 v~rzvu5
`yzxy5 vv5 FH5 y5 5 uv5 z y5 U\5 EGIJ5 <XWID5 DBK5 ~xC|x=@5 yv5 XWID5
`ztvrvu5 5 RED5 ~xC|x5 w5 z}urx}z z5 ru5 z rx}z zB5 !v5 v$vt 5 w5 U\5
`EGIJ@5 z}urx}z z5 ru5 z rx}z z5 5 x}tv5 }vrtv5 z5 VIKU}CJ]5 ~ztv5
`vv5t~rvu5r%v5xzzx5 yv5t~u5vz yv5HI5~z55EJ5y5svwv5
`r5r}5x}tv5tyr}}vxvB5T}}5 yvv5t~u5vutvu5x}tv5ThV5 5r5
`z~z}r5v v 5yv5xzv5y }5svwv5 yv5x}tv5}ru5<U\5EGIJ5s5HI9@5
`z rx}z z5 s5 IG9@5 z}urx}z z5 s5 HK9O5 r}}5 r 5 E5 ~xC|x=B5 \5 t r @5 }5
`U\5 EGIJ5 z}}5 z~vu5 x}tv5 }vrtv5 r%v5 ru~zz r z5 w5 yv5 r~v5
`uv5 EJ5 y5 svwv5 yv5 v 5 <ThV5 sFI9=B5 jyz}v5 z rx}z z5 z~vu5
`x}tv5 }vrtv5yv5r5EDAw}u5yzxyv5uv5<ED5~xC|x=5r5ru~zz vvu@5
`z}urx}z z5 vv5 z y5 yr 5 uv5 r5 z y 5 v$vt B5 !@5 yv5 ur z5 w5
`rt z5w5vyrtzx5x}tv5 }vrtv5z5z5w}}5 yv5uv5U\5EGIJ5R5
`z rx}z z5R5z}urx}z zB
`GpodmvtjpoN5 jv5 tt}uv5 yr 5 U\5 EGIJ5 tr5 sv5 vt}zztr}}5 uz$vv zr vu5
`w~5z}urx}z z5ru5z rx}z z5s5r5}xv5}r zx5zyzsz z5w5}r~r5WccA
`\i5rt zz 5ru5r5}xv5}r zx5z~v~v 5w5x}tv5 }vrtv5r 5 yv5r~v5
`uvB5!vv5ur r5vuzt 5 U\5EGIJ5 5 yrv5 r5 }5 tv5urz}5 uv5vxz~v5
`z5y~rB5 !z5#}v5w5 U\5EGIJ5 yr5 svv5 t#~vu5 z5 t}zztr}5 zr}5z5
`yvr} y5} vv5ru5 v5F5uzrsv zt5r zv B
`
`"**"
`
`Mnqspwfnfout)jo)2)dfmm)gvodujpo)qbsbnfufst)evsjoh)961xffl)usfbunfou)
`xjui)wjmebhmjqujo)jo)qbujfout)xjui)njme)izqfshmzdbfnjb
`N2)I2)JpmfzE@5TB5ftyvzvF@5jB5TB5ftyvsr~G@5cB5`B5az}H@5ZB5_r}r(cid:127)(cid:127)vI@55
`UB5XB5WzxJ@5TB5`rzKO5
`Ear z@5X5[rv@5hz vu5f r v@5Far z@5Urv}@5fz v}ru@55
`GXu@5Wzrsv v@5eyv~@5hz5W°v}uw@5Zv~r@5H`vu@5_u5hz@5
``r}~®@5fvuv@5I`vuztr}5Z@5` 5Wv5`rr@5Yrtv@5Jcyr~rjz v@5
`cztv @5hz vu5f r v@5K\f\U@5ar zr}5evvrty5Vtz}@5crur@5\ r}B
`
`Fbdlhspvoe) boe) Ejnt?) iz}urx}z z5 z5 r5 v 5 ru5 v}vt zv5 WccAH5
`zyzsz 5 yr 5 z~v5 x}tv~zt5 t }5 z5 r zv 5 z y5 v5 F5 uzrsv v5
`<gFW`=5ru5~uvr vA A~r|vu5yvx}tv~zr5s5ztvrzx5(A5r(cid:127)u58Atv}}5
`vzvv5 5x}tvB5!z5 u5r5uv r|v5 5rv5 yv5v$vt 5w5
`
`f5GJG
`
`z}urx}z z55~uv}Arvvu58Atv}}5wt z5uzx5IFAvv|5 vr ~v 5w5
`r zv 5z y5}v5rurtvu5gFW`B
`Qbufsjbmt) boe) Qfuipet?) !z5 ~} ztv v@5 ru~zvu@5 rr}}v}Ax5
`}rtvsAt }}vu5 u5v}}vu5GDJ5~z}u}5yvx}tv~zt5<TEV5JBFKBI9=5
`r zv 5 z y5 gFW`B5 f ruru5 ~vr}5 v 5 vv5 vw~vu5 r 5 jvv|5 D5 ru5
`jvv|5 IF5 w5 vr ~v 5 z y5 z}urx}z z5 ID5 ~x5 u5 <5 Q5 EIJ=5 5 }rtvs5 <5
`Q5EID=B5\}z5 vtv 5 r v5<\fe=5r5 tr}t}r vu5 s5 uvt} z5 w5VA
`v zuv5}vv}@5ru58Atv}}5wt z5r5vr}r vu5z y5r5~uv}5 yr 5uvtzsv5
`\fe5r5r5wt z5w5rs} v5x}tv5}vv}5<z}z5vtv 5 v5ru5x}tv5
`vz zz =@5 yv5r v5w5tyrxv5w5x}tv5<r v5vz zz =@5ru5r5 v zr z5
`wrt B
`Vftvmut?)T 5srv}zv@5~vr5rxv5Q5JGBE5@5U`\5Q5GDBF5|xC~F@5YcZ5Q5KBE5~‘5
`ru5TEV5Q5JBK9=B5T5y5sv}@5z}urx}z z5zxz#tr }5ztvrvu5z}z5
`vtv 5 v5<?EK9=@5x}tv5vz zz 5<?HD9=5ru5r v5vz zz 5<?GF9=B5
`<YzxB5E=
`!v5vtz5w5 yv5 v zr z5wrt 5ru5 r}5z}z5vtv z5<\fe5ThVDA
`FHD~z(cid:127)=5 uzx5 ~vr}5 r5 tyrxvuB5 !v5 vyrtv~v 5 w5 8Atv}}5 wt z5
`vv5 rtt~rzvu5 s5 r5 uvtvrv5 z5 yv5 x}tv5 ThVDAFy5 <sv vvAx5
`uz$vvtv5z5 yv5ru{ vu5~vr5tyrxv5nT`0o5Q5(cid:144)EBK5%5DBI5~‘(cid:143)y@5cQDBDDF=5
`ru5z5TEV5<sv vvAx5uz$vvtv5z5T`05Q5(cid:144)DBG5%5DBE9@5cPDBDDE=B
`Gpodmvtjpot?5 \5 r zv 5 z y5 ~z}u5 yvx}tv~zr@5 z~vu5 8Atv}}5
`wt z5z5~rz rzvu5 yxy 5IFA|5 vr ~v 5ru5uv}zv5 rzvu5
`z~v~v 5z5x}tv~zt5t }B
`Tpkkjmo‘_’]t’Ojq\modn
`
`"**#
`
`Zjmebhmjqujo)jt)tbgf)boe)xfmm)upmfsbufe)jo)qbujfout)xjui)njme)ps)npefsbuf)
`sfobm)jnqbjsnfou
`X2)!vsfoE@5fB5UzvF@5cB5`yzuvvFO5
`Ear z@5X5[rv@5hz vu5f r v@5Far z@5Urv}@5fz v}ruB
`
`Fbdlhspvoe)boe)Ejnt?5iz}urx}z z5z5r5 v 5ru5v}vt zv5WccAH5zyzsz 5
` yr 5z~v5x}tv~zt5t }5z5r zv 5z y5 v5F5uzrsv v5<gFW`=5s5
`ztvrzx5 s y5 (A5r(cid:127)u5 8Atv}}5vzvv5 5x}tvB5V}zztr}5ur r5yrv5
`y5 yr 5 z}urx}z z@5 r 5 uv5 w5 ID5 5 EDD~x5 urz}@5 v$vt zv}5 vutv5
`[sTEt@5 z y5 r5 }vrsz}z 5 #}v5 z~z}r5 5 }rtvsB5 T~x5 r zv 5 z y5
`gFW`@5 yv5vr}vtv5w5|zuv5uzvrv5rxv5w~5FDHD9B5!v5v5
`w5 yz5rs rt 5z5E=5 5v 55 yv5vr}vtv5w5~z}u55~uvr v5vr}5
`z~rz~v 5 z5 yv5 rwv 5 ur rsrv5 w5 yv5 z}urx}z z5 x}sr}5 uvv}~v 5
`xr~5 ru5 F=5 5 vr~zv5 yv5 rwv 5 #}v5 w5 z}urx}z z5 ~ yvr5
`z5r zv 5z y5~z}u55~uvr v5vr}5z~rz~v 5z5t~rz5 5 yv5
`z y5~r}5|zuv5wt zB5`v rs}z~5z5 yv5~r{5v}z~zr z5r yr5
`w5 z}urx}z z@5 z y5 r5 ~zz 5 w5 tyrxvu5 ux5 <FG9=5 vtv vu5 z5 yv5
`zvB
`Qbufsjbm) boe) Qfuipet?5 Z}~v}r5 #} r z5 r v5 <ZYe=5 r5 tr}t}r vu5
`s5 yv5`WeW5~v yuN5t $5w5JD5 5PMD5~_C~zCEBKG5~F5ru5GD5 5PJD5
`~}C~z(cid:127)CEBKG5~F5vv5vu5 5uv#v5~z}u5ru5~uvr v5vr}5z"tzvt@5
`vvt zv}B5cyrv5G5rwv 5ur r5w~5L5}vu5~ yvr5ru5K5}vu5
`ruuA5 yvr5 uzv5z y5z}urx}z z5vv5vuB
`Vftvmut?5T5 r}5w5ELJH5r zv 5vtvzzx5z}urx}z z5<vz yv5r5~ yvr5
`5z5t~szr z5z y5 yv5rxv =5yru5`WeWAv z~r vu5~z}u5<5Q5EJID=5
`
`n Vildagiiptin
`
`OPlecebo (cid:9)
`
`l Difference
`
`Jjh2)5)Ectusbdu)4==4
`
`50
`
`-2
`
`Z 40 -
`E (cid:9)
`.
`
`en al 30 -
`L •
`
`26
`
``al
`2
`7, 16-
`•
`
`4
`
`P<0.001
`
`.4x+Mii?
`
`ISR @ mM G ucose
`(Insulin Secretory Tone)
`
`30
`
`2
`
`O
`
`20 4
`
`10 -
`
`co
`c
`
`C
`tu
`2
`
`0
`
`so
`
`4 (cid:9)
`
`Pc0.001 (cid:9)
`
`250
`
`P=0.015
`
`E
`
`200
`
`E
`C
`; (cid:9) 150
`ea
`2 (cid:9) 100
`
`Fs (cid:9)
`
`50
`
`lg
`
`LE (cid:9)
`
`-50
`
`-100
`
`Glucose Sensitivity (cid:9)
`(Slope) (cid:9)
`
`Rate Sensitivity
`(Derivative factor)
`
`"!#
`
`Mylan EX 1019, Page 1
`
`(cid:9)
`(cid:9)
Accessing this document will incur an additional charge of $.
After purchase, you can access this document again without charge.
Accept $ Charge
Still Working On It
This document is taking longer than usual to download. This can happen if we need to contact the court directly to obtain the document and their servers are running slowly.
Give it another minute or two to complete, and then try the refresh button.
A few More Minutes ... Still Working
It can take up to 5 minutes for us to download a document if the court servers are running slowly.
Thank you for your continued patience.
This document could not be displayed.
We could not find this document within its docket. Please go back to the docket page and check the link. If that does not work, go back to the docket and refresh it to pull the newest information.
Your account does not support viewing this document.
You need a Paid Account to view this document. Click here to change your account type.
Your account does not support viewing this document.
Set your membership
status to view this document.
With a Docket Alarm membership, you'll
get a whole lot more, including:
- Up-to-date information for this case.
- Email alerts whenever there is an update.
- Full text search for other cases.
- Get email alerts whenever a new case matches your search.
One Moment Please
The filing “” is large (MB) and is being downloaded.
Please refresh this page in a few minutes to see if the filing has been downloaded. The filing will also be emailed to you when the download completes.
Your document is on its way!
If you do not receive the document in five minutes, contact support at support@docketalarm.com.
Sealed Document
We are unable to display this document, it may be under a court ordered seal.
If you have proper credentials to access the file, you may proceed directly to the court's system using your government issued username and password.
Access Government Site
