Coming to
`Terms with
`
`Cancer
`
`A Glossary of Cancer—Re1ated Terms
`
`Edward H. Laughlin, MD
`
`American
`Cancer
`Sucietw
`
`NOVARTIS EXHIBIT 2005
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`Roxane v. Novartis, IPR 2016-01461
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`NOVARTIS EXHIBIT 2005
`Roxane v. Novartis, IPR 2016-01461
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`
`Published by
`American Cancer Society
`Health Content Products
`1599 Clifton Road NE
`Atlanta, GA 30329, USA
`800—ACS—2345
`http://www.cancer.org
`
`Copyright ©2002 by Edward H. Laughlin, MD
`
`All rights reserved. Without limiting the rights under copyright reserved above, no part of this
`publication may be reproduced, stored in or introduced into a retrieval system, or transmitted, in
`any form or by any means (electronic, mechanical, photocopying, recording, or otherwise) without
`the prior written permission of the publisher.
`
`Printed in the United States of America
`
`54321
`
`0102030405
`
`Library of Congress Cataloging-lmPublication Data
`
`Laughlin, Edward H.
`Coming to terms with cancer 2 a glossary of cancer-related terminology
`/ Edward H. Laughlin.
`p. ; cm.
`Includes index.
`ISBN 0—944235-36-0
`1. Cancer——Dictionaries.
`
`[DNLM: 1. Neoplasms--Popular Works. 2.
`Neoplasms--Terminology-English. QZ 15 L374c 2001} I. Title.
`RC262 L35 2001
`616.99'4'003--dc21
`
`2001000346
`
`A Note to the Reader
`The information contained in this book is not intended as medical advice and should not be relied
`upon as a substitute for consulting with your physician. This information may not address all pos-
`sible actions, precautions, side effects, or interactions. All matters regarding your health require the
`supervision of a physician who is familiar with your medical needs. For more information, contact
`your American Cancer Society at 1-800-ACS—234S (wwW.cancer.org).
`
`Book design by Mouse Design Studio, Atlanta, GA
`Cover design by Jill Dible, Atlanta, GA
`Illustrations (pages 1, 3, 10,17, 35, 46, 63, 66, 110, 126, 127, 129, 136, 144, 165) by
`Angela Myrick
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`adrenalectomy
`
`_
`
`adrenalectomy Surgical removal of one or both adrenal glands. Removal of one
`adrenal gland (unilateral) is used to treat a tumor that has started in the gland
`or, less often, has spread there from a cancer elsewhere in the body.
`
`adrenaline This is the potent hormone epinephrine, produced in the inner
`portion (medulla) of both adrenal glands, whose actions include increased pulse
`(heart rate) and blood pressure. Epinephrine when mixed with local anesthetic
`drugs, such as lidocaine, prolongs anesthesia. See Epinephrine.
`
`Adriamycin‘° See Doxorubicin.
`
`advance directives Legal documents that tell the physician and family what a
`person wants for future medical care, including whether to start or when to stop
`life—sustaining treatment.
`
`advanced cancer A general term describing the stages of cancer in which the
`disease has spread from the primary site to other parts of the body. When the
`cancer has spread only to the surrounding areas, it is called locally advanced. If
`it has spread further by traveling through the bloodstream or lymph system, it
`is called metastatic.
`
`|;?: Advilq’ See Ibuprofen.
`
`aflatoxin A carcinogen (cancer-causing substance) from fungi (Arpergillm) con-
`taminating grain and peanuts raised in warm, wet climates, and stored in hot,
`damp surroundings. Aflatoxin, together with viral hepatitis, appears responsi-
`ble for the large numbers of cases of liver cancer (hepatocellular carcinoma or
`liver cell cancer) found in Equatorial Africa.
`
`afterbirth See Placenta.
`
`afterloading A type of treatment used in cancer radiation therapy (called
`brachytherapy) in which the radiation source is placed in tubes or in. a device
`previously positioned in or near a tumor. After the calculated radiation dose is
`given, the tubes and radioactive sources are usually removed. However, in some
`types of treatment, such as for prostate cancer, the radioactive seeds may be left
`permanently in place. The technique is used to treat a variety of malignant
`tumors that include breast, prostate, and head and neck cancers.
`
`agent Any substance or force able to affect the body.
`
`i AG334o Also known by the trade name Prinomastat“, this drug is a matrix
`metalloproteinase (MMP) inhibitor. MMPs are enzymes that help tumor cells to
`grow, invade surrounding tissue, and develop blood vessels that help cancer cells
`to spread to distant tissues. This drug prevents the action of these enzymes so
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`NOVARTIS EXHIBIT 2005
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`Roxane v. Novartis, IPR 2016-01461
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`NOVARTIS EXHIBIT 2005
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