`
`39
`
`IN THE UNITED S‘l'A.‘l"§ PA.TEh'l‘ AND TRADEMARK OFFICE
`BEFORE THE BOARD OF’ PATENT APPEALS AND INTERIERENCES
`
`.... ,.
`
`Interference N0. 102.572
`Ezsntiner-in-Chief
`Mary 1’. Downey
`
`))
`
`)
`0 )
`)
`
`Cahilly et
`
`:1
`
`'
`
`V
`30:: et :1
`
` mm
`
`1.
`
`I.Sh.mnelCabi1!y.deelan:ndsra1etha.t1::naeiti:euo!the=:ateof
`
`lsru.-.1. My Curr-ieultxm Vitae is attached as Cabilly Exhibit
`residing in Bath.
`Israel.
`No. 19.
`1 In a co-invemer at United States Patent. 4.815.561 entitled "R.aeornb&rmn
`
`Inrrxuncglobuun Prepxratians’.
`
`0
`
`I was a Post Doctoral Fellow in
`‘£980 until October, 1984.
`Front Deeornber.
`2-
`Dr. Art Rut: laboratory It the City of Hepe. Duane. Califomit
`1 60- P1689303
`employed by the weiznmu:
`Institute of Science as a scientist.
`in Rchovot. Israel.
`
`0
`
`3.
`
`I began my involvement
`
`in the project
`
`to express antibodies in bacteria
`
`on or about December. 1980.
`
`In response re 1::
`
`invitsuon from Dr. An Riggs to join
`
`his laboratory.
`4.
`
`I came to the City of Hope.
`In September. 1981. I received. c:aA.65-E3 cell:
`
`from Dr. John Shivcly :1
`
`the City cf Hope (Cebiny smut Ne. 20. am: R0. 00970).
`
`I used the CE.A..66-E3 can:
`
`PoIyA mRNA was purified. from the total
`total RNA.
`from Dr. Shivoly's lab re ext:-set
`man. by using an oligo-d'I‘ cenuxooc cotuan (Cabilly Exhibit No. 20. Bates No. 0097!»
`
`Following the isolatian of the :nRNA. I gave I sample of it to Wi1_1iam Hebe:
`00974).
`at Genemcch for the preparation of an acct: colony eDNA library ,(Cabi1ly Exhibit
`
`No. 11. Bass No. 00941 and Cahilly Exhibit No. 20. Bate: Ne. 00989)
`
`'
`
`fragment
`the Pstl-Pvul
`I modified pKCEAu'p207-1" by cleaving out
`5.
`the ampieiuin resistance gene.
`fining it
`in and religating the blunt ends
`(czbilly
`
`from
`
`Exhibit N0‘ 20. Bane: Nos. 00995-00997) to yield the plasmid pKCEAttp207-Fdelta. The
`
`plesrntd is
`
`resistant
`
`to tetracycline but
`
`sensitive to ampicillin.
`
`transfer-med competent E.eo1i cells with pKC$Atrp20‘7-1*de:ta.
`I
`6.
`isalated successful
`transfotmenu.
`treated them with calcium chloride and
`retrznsferrned these eemeetaut cell: with pGamrnaCEA1nt2 which confers
`
`I
`
`then
`
`resistance
`
`GNE-MED-02037
`
`% G N E-’G0SK0000‘3440
`
`MERCK v. GENENTECH
`MERCK V. GENENTECH
`IPR2016-01373
`GENENTECH 2028
`
`GNE-LILLY-BMS 00080784
`
`GNE-HGS 00082051
`
`GNE-RFGOOORn7RA
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