`
`33
`
`IN THE UNITED STATES PATENT AND TRADEMARK OFFICE
`BEFORE THE BOARD OF PATENT APPEALS AND INTERFERENCES
`
`Interference No. 102.572
`
`3)
`
`')
`Examine:-in-Chief
`)
`) May 1?. Downey
`
`Cabifly Ct
`
`11
`
`v.
`
`Boss cl ai
`
`
`
`1.
`
`1. Michel Rey. dcciare and cute that I Mn a citizen ed the United Stucs
`
`reciding in San Mateo, California. My Qxrrlculum Vitle is stacked :3 Clbiliy Exhibit
`No. 14.
`
`2.
`at Gcacnwch.
`
`From Deccmbcr 15. 1980133111 April. 20. 1934. 1 WI! I RGWINH 95535113!
`inc.
`(Gcnemech) located an 460 Point sen Bnmo Blvd... Scum San
`
`Prancisco. Caiifm-nit. During that time I reported
`
`to Dr. Herb Hcynclcet.
`
`1 mi
`
`prescntiy employed by Ge‘-ncncor.
`Francisco. California.
`
`Inc. as a Senior Research Associate.
`
`in South San
`
`It wns my general practice to due my notebook! on the data the work
`3.
`i began my involvement
`was done.
`in the prone: my express tnfiibodial diwctcd
`against human clrcinoembryonic antigen in bactci-it
`in Ju1y'.1982.
`I had received
`miemtiter dishes with culture:
`the: conuinsd cDNA from the hyhrldoinl can tine
`
`CEA-66-E3.
`
`1
`
`tnnsfcrrcd these nrrlyud cunures to :33: pins: uni allowed them to
`
`to nizroceuuienc fiium; hyercd
`later tmnsicrred the eeiohien in eupiiene.
`1
`screw.
`Lhcm emo eger pines and incubated them It 37'C. Once those cote-nies had
`
`sufficicniiy §i"O"l1o I
`
`lyaud the colcnica on these filters Ind treated than fat‘
`
`subsequent probing (Cabmy Exhibit No. 15. hate: N01. 00502 and 00504).
`
`-
`
`4.
`
`I usiucd in the sequencing of the heavy chain cDNA by subcionin;
`
`DNA into M13 vectors. preparing single-stranded template and carrying out
`
`the
`
`I also uzistcd in the sequencing of the heavy and iizht chain
`sequencing rcactiont.
`cDNA'u (Cabiiiy Exhibit No. 15. Elie: No. 00509-00516. 00521. 0052.2. 00528. and 00531).
`
`GNE-MED-02031
`
`GNE—”ésKoooo'3434
`
`MERCK v. GENENTECH
`MERCK V. GENENTECH
`IPR2016-01373
`GENENTECH 2026
`
`GNE-HGS 00082045
`
`GNE-LILLY-BMS 00080778
`
`GNE-REG00080778
`
`
`
`DECLARATION OF MICHAEL REY
`
`5.
`
`I sequenced a Pu] to Ava}! DNA {npnem of the ugh: chain following A
`
`primer
`
`rcpnir
`
`rcactlon that
`
`introduced an inltmion codcn 11110 W’ 3¢‘i“°n°°
`
`(Cabuly Exhibit No. 15. Bates No. 00530).
`
`5.
`
`1 prepared me pnsmms pKCEAu'p207-1" by dizostin: pKCEAIn‘-2 with
`
`Aval, filling in. digesting with Pet! and isolttlng the fragment by PAGE.
`
`The vector
`
`rrazznem was Prcpamd by cugutxng pBR322(XA.P) with scant. wins in. and
`
`This {remnant was alsc
`lsolatian by PAGE.
`redigcstiug with Pat! {allowed by fragment
`named
`in the oonstrueticn of pGarnxneCEAtr~p207-1‘.
`Th: purified frazmem Weft
`
`unwed.
`
`transformed into 3:011 and analyzcd by rsnxiction digest:
`
`to identify positive
`
`colonies (Cehmy Exhibit No. 15. Beta: Not. 00533-00537).
`
`7.
`
`wimm Hahn» and I anflyzcd cove-.-at
`
`tetracyclifie redstant
`
`uansforznamx fmm the pGammaCEAFABlrp207-1‘
`
`ligation by r*-‘-I1P*°ti°n
`
`Inllrfil
`
`end sequencing (Cabiny Exhibit No. 13. Beta Net. 00885-00887. 00889: Cabilly Exhibit
`
`15. Bale: Nos. 00551. 00543. and 00544).
`
`funher declare that an statements made cf my own knowledge we truc
`I
`8.
`end that an smemenu nude on inforrlulicn and belief are believed to be true: and
`
`tanks:
`
`that
`
`these sum-aunt: wcf¢ road: with the knowledge that W511!!!‘
`
`fl11=¢
`
`sum-nems and the ma. so’ made are punichabll by {me or imPfi9°nm°‘“- °' bmhv
`under section 1001 of ‘Blue 18 of the Unllcd States Code.
`
`Duted:
`
`’° ‘” 7’
`
`GNE-MED-02032
`
`GNE-HGLSKOOOON3435
`
`GNE-HGS 00082046
`
`GNE-LILLY-BMS 00080779
`
`GNE-REG00080779
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