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`15
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`m ‘rm-: UNITED s1-/n-as PATENT AND TRADEMARK -orrtc:
`335.033 T135 BOARD OF PATENT APPEALS AND INTERFBREHCES
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`lute:-Ierence No. 102.572
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`Examinenixt-Chief
`Mary F. Dowttey
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`)J
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`1 J
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`)
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`Cabilly at It
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`v.
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`Ban et at
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`ummm
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`1.
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`1. Arthur Riggs. deetare met state that
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`I am 1 ettézea of the Unttod stttes
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`residing in Laverne. Cattfot-nta. My Curriculum Vitae I‘: amehed u Cthitly at at
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`I an 0 co-inventor of the United States Patent 4.816.361 eotttted
`Exhibit No. 1.
`hnmnnogtobuttn Prep'u-afloat‘.
`I
`‘Recombinant
`2.
`I hove been employed by the City of Hope in Dun:-to. Ctlifomtn from
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`June I969 to the present as Director. Department of Biology.
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`‘
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`3-
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`D011!!! Iht period of July 1980 through September 1980.
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`I was at
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`Ctenenteeh on etbbotteat from the City of Hope. My tntenttou was to explore the
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`‘- ponibility of producing Antibodies in bnetertn. After my say at Geumeeh.
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`I
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`returned to the City of Hope where I
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`for-mullted n propout whetoby Oenenteoh would
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`ustct
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`in the funding of this pro}set (cabmy Exhibit No. 2).
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`The proposal in; bued in
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`lubmhlid
`I
`part on eanvetuttons between Dr." Hey:-taker. Shtttuet Csbitty and myself.
`ttztt proposal
`for nvtuv by Genet-ttoch on October 5. 1981.
`Included to this propoett
`wu I
`resentch pin:
`for
`the ctontng. bnetertnl expression.
`ind tltet-Itien of both
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`heavy and tight chain gene:
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`from a monoclonal mtibody direetett 0;-clan humus
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`earctnoembryonie antigen (CEA).
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`Ftmhen-nore.
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`I
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`suggested in tho. propose!
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`that
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`(Cnbmy Exhibit No. 2. Bite: No. 00922) a single; bgctu-ht gu-gin could be’ eonltnteted.
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`which contained both heavy and tight ehttn genes
`dttcuuod during our outlet eonvennttons,
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`for co-exp:-eeeiott. an idea
`V
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`-4.
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`My experimental pttn inetudod the collaboration of Dr. Shntuet Cahmy.
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`fettow in my laboratory it
`a post doctoral
`i Senior Scientist at Genentoch.
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`the City of Hope. and Dt. Herbert
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`I-ieynetzer.
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`GNE-MED-02012
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`GNE—GSKOOD0341 5
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`GNE-HGS 00082026
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`GNE-LILLY-BMS 0008075
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`MERCK v. GENENTECH
`MERCK V. GENENTECH
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`GENENTECH 2022
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`GNE-REG00080759
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`DECLARATION OF ARTHUR RIGGS
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`16
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`I discussed this proposed project with Dr. John Shively “'55 15¢-C“? 01'
`5.
`Hope. who was involved in the’ study of anti-CEA antibodies.
`I rcquested hm! him a
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`hybfidbml. can line [hit cxprcssed these antibodies.
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`1
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`recoiveci
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`lhit 63" 1139
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`(CE.A.65-E3) on or about February. 1981.
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`5.
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`During the parted of these studies I worked closely with D2. Csblliw who
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`was tmdct my direct supervision.
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`In addition.
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`1 maintained regular contact with Dr.
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`Heyneker.
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`.
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`_
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`7.
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`I ftmhur declarc that all statsmcnu mad: at my WM 1=M""¢4I¢ 49° "W
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`and that an stntatnantc made on information and bcliaf an belicvud :9 be mac; 134
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`further um these statements wen: mud: with the knowledte that willtul mu
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`statement: and the like :6 made are punishable by tin: or
`under section 1001 of ‘rule 18 of the United states Code.
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`imp:-banned. or beat.
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` Dana:
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`/_‘’,[.23/_42/
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`GNE-MED-02013
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`GNE-REG00080760