`
`15
`
`m ‘rm-: UNITED s1-/n-as PATENT AND TRADEMARK -orrtc:
`335.033 T135 BOARD OF PATENT APPEALS AND INTERFBREHCES
`
`lute:-Ierence No. 102.572
`
`Examinenixt-Chief
`Mary F. Dowttey
`
`)J
`
`1 J
`
`)
`
`Cabilly at It
`
`v.
`
`Ban et at
`
`ummm
`
`1.
`
`1. Arthur Riggs. deetare met state that
`
`I am 1 ettézea of the Unttod stttes
`
`residing in Laverne. Cattfot-nta. My Curriculum Vitae I‘: amehed u Cthitly at at
`
`I an 0 co-inventor of the United States Patent 4.816.361 eotttted
`Exhibit No. 1.
`hnmnnogtobuttn Prep'u-afloat‘.
`I
`‘Recombinant
`2.
`I hove been employed by the City of Hope in Dun:-to. Ctlifomtn from
`
`June I969 to the present as Director. Department of Biology.
`
`‘
`
`3-
`
`D011!!! Iht period of July 1980 through September 1980.
`
`I was at
`
`Ctenenteeh on etbbotteat from the City of Hope. My tntenttou was to explore the
`
`‘- ponibility of producing Antibodies in bnetertn. After my say at Geumeeh.
`
`I
`
`returned to the City of Hope where I
`
`for-mullted n propout whetoby Oenenteoh would
`
`ustct
`
`in the funding of this pro}set (cabmy Exhibit No. 2).
`
`The proposal in; bued in
`
`lubmhlid
`I
`part on eanvetuttons between Dr." Hey:-taker. Shtttuet Csbitty and myself.
`ttztt proposal
`for nvtuv by Genet-ttoch on October 5. 1981.
`Included to this propoett
`wu I
`resentch pin:
`for
`the ctontng. bnetertnl expression.
`ind tltet-Itien of both
`
`heavy and tight chain gene:
`
`from a monoclonal mtibody direetett 0;-clan humus
`
`earctnoembryonie antigen (CEA).
`
`Ftmhen-nore.
`
`I
`
`suggested in tho. propose!
`
`that
`
`(Cnbmy Exhibit No. 2. Bite: No. 00922) a single; bgctu-ht gu-gin could be’ eonltnteted.
`
`which contained both heavy and tight ehttn genes
`dttcuuod during our outlet eonvennttons,
`
`for co-exp:-eeeiott. an idea
`V
`
`-4.
`
`My experimental pttn inetudod the collaboration of Dr. Shntuet Cahmy.
`
`fettow in my laboratory it
`a post doctoral
`i Senior Scientist at Genentoch.
`
`the City of Hope. and Dt. Herbert
`
`I-ieynetzer.
`
`GNE-MED-02012
`
`GNE—GSKOOD0341 5
`
`GNE-HGS 00082026
`
`GNE-LILLY-BMS 0008075
`
`MERCK v. GENENTECH
`MERCK V. GENENTECH
`IPR2016-01373
`GENENTECH 2022
`
`3 2
`
`GNE-REG00080759
`
`
`
`.
`DECLARATION OF ARTHUR RIGGS
`
`‘
`
`‘
`
`16
`
`I discussed this proposed project with Dr. John Shively “'55 15¢-C“? 01'
`5.
`Hope. who was involved in the’ study of anti-CEA antibodies.
`I rcquested hm! him a
`
`hybfidbml. can line [hit cxprcssed these antibodies.
`
`1
`
`recoiveci
`
`lhit 63" 1139
`
`(CE.A.65-E3) on or about February. 1981.
`
`5.
`
`During the parted of these studies I worked closely with D2. Csblliw who
`
`was tmdct my direct supervision.
`
`In addition.
`
`1 maintained regular contact with Dr.
`
`Heyneker.
`
`.
`
`_
`
`7.
`
`I ftmhur declarc that all statsmcnu mad: at my WM 1=M""¢4I¢ 49° "W
`
`and that an stntatnantc made on information and bcliaf an belicvud :9 be mac; 134
`
`further um these statements wen: mud: with the knowledte that willtul mu
`
`statement: and the like :6 made are punishable by tin: or
`under section 1001 of ‘rule 18 of the United states Code.
`
`imp:-banned. or beat.
`
` Dana:
`
`/_‘’,[.23/_42/
`
`GNE-MED-02013
`
`GNE-LGSKOOO0341 6
`
`GNE-HGS 00082027
`
`GNE-LILLY-BMS 00080760
`
`GNE-REG00080760
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