`
`PubMed
`
`V
`
`Abstract '
`
`J Urol. 1989 Ju|;142(1):89-91.
`
`High dose ketoconazole for the treatment of hormone
`refractory metastatic prostate carcinoma: 16 cases and
`review of the literature.
`
`Jubelirer SJ1, Hogan T.
`
`'-"Author information
`
`Abstract
`
`We treated 16 patients who had hormone refractory metastatic prostate
`
`cancer with 400 mg. ketoconazole orally every 8 hours. None of the patients
`
`had an objective response, although 6 (37.5 per cent) had stable disease (2
`
`of whom had a subjective decrease in bone pain). The median duration of
`
`stable disease was 6.8 months (range 2 to 12 months) and side effects were
`
`seen in 14 patients. Nausea, vomiting or anorexia was noted in 10 patients,
`
`rash and pruritus in 2, transient abnormal liver function tests in 1 and
`
`transient pulmonary infiltrates in 1. Nine prior studies investigating the use of
`
`ketoconazole in hormone refractory metastatic prostate cancer were
`
`reviewed. Only 1 complete response was reported. A partial response was
`
`noted in 14 per cent of the patients. Most of the patients had stable or
`
`progressive disease. High dose ketoconazole as a single agent appears to
`
`have limited use in patients who have failed prior systemic therapy.
`
`PMID: 2659829 [PubMed — indexed for MEDLINE]
`
`.;':I
`
`3-
`
`Publication Types, MeSH Terms, Substances
`
`Link0ut - more resources
`
`http://www.ncbi.n|m .nih.gov/pubmed/2659829
`
`1/2
`
`MYLAN PHARMS. INC. EXHIBIT 1028 PAGE 1
`
`
`
`11/12/2015 High dose ketoconazole for the treatment of hormone refractory metastatic prostate carcinoma: 16 cases and review of the literature. - PubMed - N...
`
`PubMed Commons
`
`'3 0 comments
`
`How to ioin PubMed Commons
`
`http://www.ncbi .n| rn .ni h.gov/pubm ed/2659829
`
`2/2
`
`MYLAN PHARMS. INC. EXHIBIT 1028 PAGE 2
Accessing this document will incur an additional charge of $.
After purchase, you can access this document again without charge.
Accept $ Charge
Still Working On It
This document is taking longer than usual to download. This can happen if we need to contact the court directly to obtain the document and their servers are running slowly.
Give it another minute or two to complete, and then try the refresh button.
A few More Minutes ... Still Working
It can take up to 5 minutes for us to download a document if the court servers are running slowly.
Thank you for your continued patience.
This document could not be displayed.
We could not find this document within its docket. Please go back to the docket page and check the link. If that does not work, go back to the docket and refresh it to pull the newest information.
Your account does not support viewing this document.
You need a Paid Account to view this document. Click here to change your account type.
Your account does not support viewing this document.
Set your membership
status to view this document.
With a Docket Alarm membership, you'll
get a whole lot more, including:
- Up-to-date information for this case.
- Email alerts whenever there is an update.
- Full text search for other cases.
- Get email alerts whenever a new case matches your search.
One Moment Please
The filing “” is large (MB) and is being downloaded.
Please refresh this page in a few minutes to see if the filing has been downloaded. The filing will also be emailed to you when the download completes.
Your document is on its way!
If you do not receive the document in five minutes, contact support at support@docketalarm.com.
Sealed Document
We are unable to display this document, it may be under a court ordered seal.
If you have proper credentials to access the file, you may proceed directly to the court's system using your government issued username and password.
Access Government Site
