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`v Copyright© 1999 and published by Medical Economics Company, Inc. at Montvale, NJ 07645-1742. All rights reserved. None of.the content of this publication
`_ . may be reproduced, stored in a retrieval system, resold, redistributed, or transmitted in any form or by any means (electronic, mechanical, photocopying, record-
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`Astrazeneca Ex
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`Lists all pharmaceutical manufacturers participating in PHYSICIANS’ DESK REFERENCE.
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`Astrazeneca EX. 2046 p. 10
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`PRODU.'CT‘~:INFORMAT|0Nif?
`‘NOVARTlS*:PHARMACEUTICALS/2025
`HOW'S‘UPP,LlED:~.
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`defect‘~1f_you take estrogens'du1in"g'preg'nan'cy. A male child
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`the urinary systemand ‘sex organs.»A‘female'child may have
`an increased risk ofdevelopiiigcancer of ‘the vagina or ‘cer-
`vix in her teens or twenties. Estrogen is not -‘efl'ectiv‘e -in pre-'
`venting miscarriage (abortion). In addition} estrogenlshould
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`periods (years) after menopause will keep youriskin soil; and
`suppleand keep.you:feelingyoung. There is no evidence for
`these claims, and such long-term treatment may. carry seri-
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`DANGERS 0_F"E TRQGEN p
`Canc.e.nof ;th.e.'ztt,er.us: The.ri_s1<.. of «.caa<ser:. of the.-.ut.erUS
`increases the longer estrogens are -used and whendarger
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`discontinued, this increased’ riskv of cancer seems .to.-fa.1l;.ofl"
`quickly. Three other studies showed that the-risk for uterine
`cancerstayed high for ,8_.,to, more than 15, years,a_fter_stop,—
`ping estrogen treatment..Because of this risk, it is impor-
`tant to take tlw*¢lou_1._est dose ofestrogen that will control your
`symptoms, and to,ti1ke,i1! ozLly'~as_l9ng as you need;:it.‘.' Using
`progestin therapy together with estrogen therapy may re-
`duce the higher. risk of uterine cancer related to estrogen
`use (see OTHER INFORMATION).
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`there is no danger of developing cancer of th_e'1‘.iteru
`‘Cancer of the breast. The majority of studies
`no‘ association between thevusual doses used_for estro