`
`PH
`
`Most scientists agree that the three essential parameters in the success of a biomedical
`experiment are:
`
`A. The scientific problem formulated in a defined question.
`
`B. The laboratory animal, healthy and untraumatized.
`
`C. The process of active product delivery; the most problematic variable of all three!
`
`For a third of a century, Innovative Research of America has assumed the leadership role
`
`in improved time release technology. The main mission is t.o standardize the technology of
`
`drug delivery. Our proven Time Release Hormone and Drug Pellets help investigators take
`
`charge of product delivery and expand their abilities to do meaningful and reproducible
`
`research.
`
`ADVANTAGES OF THE PELLET DELIVERY SYSTEM
`
`i- a- ‘ready-to.'—a_dIr_ii.niste'r pellet foria-_s'i1_n_p_le_ subqgtafiejousi ’
`
`
`
`-:_-_a-hefizer--met.h:od toiaivioiid--the
`
`
`
`I
`
`Uslieiing In The Age Oflnnovative Research
`
`Astraleneca Ex. 2044 p. 2
`
`
`
`HORMONE AND DRUG PELLETS FOR BIOMEDICAL RESEARCH
`
`
`
`Since it is not easy to administer drugs and hormones orally to research animals.
`
`several delivery methods have been devised as alternatives. However, most scientists
`
`continue to labor with unreliable injectables to conduct their research.
`
`Because of this inadequacy. biomedical research is as confusing as it is challenging
`
`and as frustrating as it is creative. The options of scientists to address scientific questions
`
`are not only dependent, but are also limited by the process of active product delivery.
`
`Traditionally, product delivery into the experimental animal has been the procedure most
`
`subject to variables and the most difficult to standardize effectively. The very process
`
`of having to accurately administer drugs to experimental animals can become a logistic
`
`nightmare for scientists.
`
`CHANGING THE TIME COURSE OF DRUG DELIVERY
`
`We. Tell Ti111c—Relea-we Pellets W.l1at Time It is
`
`Astraleneca Ex. 2044 p. 3
`
`
`
`IRA TABLE OF CONTENTS
`
`Find a Product in this Catalog ........................................................ .. 5
`
`Ordering information I General Policy 8: Terms ............. .. 6, 7, 44, 84
`
`Sales of Anabolic Steroids ............................................................. .. 8
`
`Category Index.......................................................................... .. 10-15
`
`Alkaloids
`Amino Acids
`Androgens
`Antibiotics
`Anti-Inflammatory Agents
`Anti-Neoplastics
`Catecholamines
`Corticoids and Diuretics
`
`Estrogens
`Fatty Acids
`Nucleotide Related Products
`Progestins
`Prostaglandins
`Thyroids
`Vitamins
`
`Placebo Pellets lntorunertim I 4;’-3:r"i:::-e
`
`--_';
`
`Alphabetical Product Listing ................................................... .. 21-42
`
`Stock Pellet Price Schedules ................................................... .. 45-71
`
`Pellets for lmmuno-Deficient Mice
`
`17B-Estradiol [Tamoxifen & Sample References ................... .. 73-77
`
`Androgens I Anti-Androgens 8 Sample References ............. .. 78-80
`
`Trochar 8: Recommended Implantation Procedure ............. ..81, 123
`
`Doxycycline 8: Tetracycline Pellets in Mice ............................ .. 85-86
`
`Hormone + Hormone Pellets ................................................... .. 89-92
`
`Custom Pellets ........................................................................ .. 93-108
`
`Selected References ............................................................. ..109-122
`
`Order Forms ............................................................ .. Back of Catalo -
`
`Patents ................................................................. .. Inside Back Cover
`
`*Fm-further assisrance, view our website at:
`vmvw.r'nnovrsrch.com
`
`We Add Time To Your Day
`
`Astrazeneca Ex. 2044 p. 4
`
`
`
`PRODUCT DESIGN AND FEATURES
`
`
`
`The Pellet Implantation Methodology provides solutions to:
`
`consistency in timing repeated product administrations.
`
`controlling the amount of product administered.
`
`stability of the product preparation.
`
`safety of the experimenter.
`
`neurophysiological trauma to the animal from excessive handling.
`
`freeing valuable research time.
`
`eliminating unnecessary and unstimulating laboratory practices.
`
`Scientists from several research disciplines have documented in scientific literature that
`
`our Pellet Delivery System is effective, consistent, reproducible, economical, reliable, and
`
`safe for the animal. See Selected References on pages 109-122.
`
`Onl}-' Time Release Pellets Re:1ll_\_.-' Know What Time [1 15
`
`Astrazeneca Ex. 2044 p. 5
`
`
`
`PRODUCT SPECIFICATIONS
`
`AVAILABLE SHAPES AND SIZES
`
`Stock pellets are round and range in diameter from US” ('3 mm) to H2” (1.25 cm) depending on the
`dose and the release rate. Our Custom Pellets Department will also design various pellet shapes and
`smaller sizes (Page 94) to meet your research needs. Please refer to the Custom Pellets section on pages
`93-108.
`
`AVAILABLE DOSAGES
`
`Most of the stock products in this catalog are available in 20 different dosages ranging from 1 microgram
`(0.001 mg) per pellet up to 200 milligrams (200 mg) per pellet within the specified release rate. Doses of
`pellets listed in this catalog reflect the total amount of net active product released over the indicated
`period of time.
`
`AVAILABLE RELEASE RATES
`
`Stock products are designed to release continuously for 21 days, '60 days, or 90 days. Please refer to our
`Custom Pellets section on pages 93- 108 for other release rates tailored for the duration of the experiment.
`
`AVAILABLE PRODUCTS
`
`In our continuing quest to make available new stock items that are particularly in demand, we have added
`several products to the original categories. In addition to the listed pelletized products, Innovative
`Research of America has an efficient Custom Pellets Department to prepare products that are not available
`as stock items.
`
`SELECTED REFERENCES
`
`A sample of publications that employed our delivery system in a broad spectrum of products can be found
`on pages 109-122.
`
`Consistent Dose—Dependent Release
`
`Astrazeneca Ex. 2044 p. 6
`
`
`
`FINDING A PRODUCT IN THIS CATALOG
`
`
`
`The PRODUCTS in this catalog are arranged in ALPHABETICAL ORDER and are identified by
`a CATALOG NUMBER and 21 PRICE SCHEDULE with a PAGE NUMBER.
`
`The catalog number and price schedule reflect a release rate of 21 days, 60 days, or 90 days.
`
`To illustrate with 17B-Estradiol as an example:
`
`EXAMPLE
`
`Product
`
`21-Day Release
`Catalog
`Price Schedule!
`Number
`Page Number
`
`60-Day Release
`Catalog
`Price Schedule?
`Number
`Page Number
`
`90-Day Release
`Catalog
`Price Schedule!
`Number
`Page Number
`
`17B — Estradiol
`
`E - 121
`
`B-21f48
`
`
`
`SE - 121
`
`B-60f49
`
`NE - 121
`
`B-9050
`
`The above example indicates that l'Fl3-Estradiol is available in three release forms each having a
`
`different catalog number and price code, i.e.
`
`E - 121 is a 21-day release form with a price code of B-21, found on page 48.
`
`SE - 121 is a 60-day release form with a price code of B-60, found on page 49.
`
`NE - 121 is a 90-day release form with a price code of B-90, found on page 50.
`
`The PAGE NUMBER next to the PRICE SCHEDULE indicates the page where the actual price
`
`for the product appears.
`
`When ordering please use the PRODUCT NAME, CATALOG NUMBER, RELEASE
`
`RATE and DOSE. Most products are available in 20 different dosages. Products are sold in
`
`Lots of 25, 50, 100. and 200 pellets. Please indicate the quantity of pellets being ordered.
`
`Beginning on Page. 10 we have grouped some of our catalog items in related categories
`
`alphabetically. We hope the listing will help in noting items of potential interest.
`
`Time-Release Pellets... Alw.ays On Time.
`
`Astrazeneca Ex. 2044 p. 7
`
`
`
`
`
`
`0 Internet I E-Mail
`
`Innovative Research of America, Inc.
`
`http:r'!www-innovrsrch.com (website)
`
`2 North Tamjamj Trail
`
`pellets@innovrsrch.com (e-mail)
`
`Suite 404
`
`Sal-a50ta_ F]0rjda 34236 USA
`
`- Phone
`
`(941) 365-1406
`
`(941) 365-1506
`(300) 421-8171 (USA/Canada)
`
`0 Fax
`(941) 365-1703
`(941) 365-1803
`
`(800) 643-4345 (USA/Canada)
`
`(800) 648-6030 (USA/Canada)
`
`IRA’s website features our company profile,
`the latest product technology and on-line ordering.
`
`6 AMERICAN EXPRESS
`
`VISA AND MASTERCARD ACCEPTED.
`E Purchase Order Forms are in the back of the
`Wales.
`Custom Pellets Information Form on page 95
`
`'
`
`Bank Wire Payment Information
`Payment via bank wire should be directed as follows."
`
`lS
`THE DlT'FEK'ENCE
`CDNSISTENCY AND MNIFDRMHY.
`
`"'B“‘”“'""
`1800 Second SL, Suite I00
`Sarasota. Florida 34236
`
`Routing # (ABA) 26319138?
`Eleclronic Transfers # 263191337
`
`In favor of:
`Innovative Research of America
`
`Swift Code: BRBTUS33
`
`2 North Tamiami Trail
`Suite 404
`
`Sarasota, FL 34236
`
`Checking Account: #0000l478l6l54
`
`Llsliering In The Age Of lnnox--‘alive Researcli
`
`Astraleneca Ex. 2044 p. 8
`
`
`
`
`
`SALE OF CONTROLLED ANABOLIC STEROIDS
`
`within the United States
`
`
`(Telephone orders will not be accepted - orders & copy of DEA license may be mailed or faxed)
`
`Before we can prepare any orders of Anabolic Steroid Pellets, the Drug
`
`Enforcement Administration (DEA) requires us to obtain;
`
`1. A valid photocopy of the investigator’s DEA Registration
`
`containing Schedule 3N.
`
`2. A written Purchase Order showing the investigator’s DEA
`
`Registration Number and proper shipping address.
`
`CONTACT INNOVATIVE RESEARCH OF AMERICA
`
`BY PHONE. MAIL, FAX OR E-MAIL
`
`FOR MORE ORDERING INFORMATION - SEE PAGE 6
`
`SALE OF CONTROLLED ANABOLIC STEROIDS
`
`outside the United States (International)
`
`
`WE NO LONGER SHIP ANABOLIC STEROIDS
`
`outside the United States (International)
`
`DEA Controlled Anabolic Steroids
`
`Androstenediol
`
`19~Nortestosterone 17—Decanoate
`
`Androstenedione
`
`1 9—Nortestosterone 17—Dipropionate
`
`50t~Dihyclrotestosterone
`
`Fluoxymesterone
`
`Mesterolone
`
`Mesterone
`
`Methandriol
`
`Methandriol Dipropionate
`
`Stanozolol
`
`Testosterone
`
`Testosterone Acetate
`
`Testosterone Benzoate
`
`Testosterone Cypionate
`
`Testosterone Enanthate
`
`19-Nortestosterone
`
`Testosterone 17 3- Hem i succ i mate
`
`I 1-:
`
`Testosterone Propionate
`
`Time Release Pellets Always On Time
`
`Astraleneca Ex. 2044 p. I0
`
`
`
`VIA
`
`T-A
`
`See pages 73-80 regarding
`Hormone/Anti—H0rmone products
`for Immune-Deficient Mice
`
`and specific references.
`
`Your RC-SCEl1‘C]'] Time. Is Under Your Control
`
`Astrazeneca Ex. 2044 p.
`
`I
`
`I
`
`
`
`
`
`
`
`
`
`
`
`(continued)
`
`
`FATTY ACIDS
`
` .
`
`
`
`."%_-.-
`
`Use Time To Your Advantage
`
`AstraZeneca Ex. 2044 p. I6
`
`
`
`(continued)
`
`Consistent Results With Consistent Release
`
`Astrazeneca Ex. 2044 p. I?
`
`
`
`F
`ADVANTAGES OF OUR MDD PELLET SYSTEM | A
`
`. Saves time
`
`9 Ready-to-implant
`
`.
`
`lnsures controlled product release over time
`
`. Avoids “peak and valley” effects
`
`9 Guarantees consistent product preparation
`
`o Extends product life against spontaneous breakdown
`
`. Extends product life against host-related breakdown
`
`9 Minimizes experimental variables
`
`4»
`
`lnsures safety of the researcher
`
`. Reduces neurophysiological trauma to the animal!
`
`no "cessive handling
`
`o Generates more meaningful and reproducible results
`
`o Superior to conventional delivery methods
`
`0 Enhances experimental efficiency
`
`o Frees valuable time for creative research
`
`0 Saves money
`
`Time.-Release _Pe.llets... Alw'ays On Time.
`
`Astrazeneca Ex. 2044 p. I8
`
`
`
`
` PLACEBO / CONTROL
`PELLETS
`
`
`
`Matching Placebo pellets contain all the components of the hormone or drug pellet except the active
`product itself. The carrier-binder excepients of the matrix include Cholesterol, Lactose, Celluloses,
`Phosphates and Stearates.
`
`Although the matrixes in Placebo pellets have a different composition for different active products,
`
`Stock Placebo pellets are available in 20 different doses corresponding to those of active product
`pellets. Each dose is offered in either 21 Day, 60 Day, or 90 Day Release form.
`
`theyareallassignedthesamecatalognumberandareofferedatthesamepriceschedule.
`
`When inquiring or placing an order, please specify the active product you wish to correspond the
`Placebo pellets for. Please see the following examples:
`
`
`
`
`
`I
`
`'
`
`I
`
`II
`
`iI
`
`II
`
`I
`
`u_
`
`I
`I
`'
`
`
`
`
`Description
`
`Dose in Ingfpcllet
`
`Release in Days
`
`Placebo for “Active Product" j mg/pellet
`
`Placebo for “Active Product”*
`
`mg/pellet
`
`Placebo for “Active Product“
`
`__ mg/pellet
`
`21 Day
`
`60 Day
`
`90 Day
`
`*In place of “Active Product” specify the hormone or drug you are utilizing in your study.
`
`The following three pages are universal dose fprice schedules in all three release rates (21 Day, 60
`Day, and 90 Day) and are applicable as a matching Placebo for all products in the catalog except
`special physical size and preparations (page 94) which can be found under the Custom Pellet section
`on pages 93-108.
`
` *Please inquire directly with us 9"further assistance is required regarding a product ofinterest
`
`Astraleneca Ex. 2044 p. 19
`
`
`
`
`
`M
`
`Astrazeneca Ex. 2044 p. 20
`
`
`
`
`
`1..
`
`0.01 0
`
`0.025
`
`0.05
`
`0.1
`
`0.25
`
`0.5
`
`1.5
`
`2.5
`
`5.0
`
`$697
`
`$697
`
`$697
`
`$697
`
`$697
`
`$697
`
`$697
`
`$697
`
`$697
`
`$702
`
`$1 362
`
`$1362
`
`$1362
`
`$1362
`
`$1362
`
`$1362
`
`$1362
`
`$1362
`
`$1362
`
`$1379
`
`$2649
`
`$2649
`
`$2649
`
`$2649
`
`$2649
`
`$2649
`
`$2649
`
`$2649
`
`$2649
`
`$2674
`
`$481 6
`
`$4816
`
`$4816
`
`$4816
`
`$4816
`
`$4816
`
`$4816
`
`$4816
`
`$4816
`
`$4858
`
`7.5
`
`10.0
`
`15.0
`
`25.0
`
`35.0
`
`50.0
`
`75.0
`
`100.0
`
`150.0
`
`200.0
`
`$702
`
`$702
`
`$707
`
`$707
`
`$707
`
`$707
`
`$718
`
`$718
`
`$723
`
`$1379
`
`$1379
`
`$1 386
`
`$1386
`
`$1386
`
`$1386
`
`$1406
`
`$1406
`
`$1415
`
`$2674
`
`$2674
`
`$2674
`
`$2674
`
`$2674
`
`$2674
`
`$2734
`
`$2734
`
`$2744
`
`$4858
`
`$4858
`
`$4875
`
`$4875
`
`$4875
`
`$4875
`
`$4945
`
`$4945
`
`$4964
`
`A combination of multiple dosages in one lot, for any specified product, is also
`available. PLEASE INQUIRE.
`
`Sixty and Ninety day price schedules are on the following two pages.
`
`
`
`Astrazeneca Ex. 2044 p. 21
`
`
`
`
`
`
`
`PLACEBO PELLETS
`
`PRICE SCHEDULE
`
`Cat. No. SC-1 11
`
`A combination of multiple dosages in one lot, for any specified product, is also
`available. PLEASE INQUIRE.
`
`
`
`Astrazeneca Ex. 2044 p. 22
`
`
`
`fl
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`
`A combination of multiple dosages in one lot, for any specified product, is also
`available. PLEASE INQUIRE.
`
`
`
`Astrazeneca Ex. 2044 p. 23
`
`
`
`BIOMEDICAL RESEARCH IN LABORATORY ANIMALS
`
`TIME RELEASE PELLETS FOR
`
`._'.l?éj'-iii':C0nti'n'i1.iJus Pain_i1_1 I)RUG
`
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`Release Pellets Arethe Best Alternative
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`Time Release Pellets
`for Biomedical Research from IRA
`DOSE
`
`
`
`RELEASE
`
`O)))))))))))))))))))
`
`O))))))))))))))
`Q>>>>>>)>>>)>
`
`
`Tl.-VIE
`
`
`
`Our Team at IRA is working
`
`to meet the responsibility that
`
`Innovative Science demands
`
`and Innovative Scientists
`
`deserve.
`
`i
`
`$4»
`
`'2".--———-
`
`Astraleneca Ex. 2044 p. 24
`
`
`
`
`
`Astraleneca Ex. 2044 p. 26
`
`
`
`ALPHABETICAL PRODUCT LISTING
`
`Dose/Price Schedules For Matching Placebo Pellets Appear On Pages 17-19.
`
`21-Day Release
`(_T::l:1lug f’:'iI:u
`!-lc|:edu|L-r'
`.\u1nhe:‘ I’a;.I,L'-. NlI]'I1l}l1'I‘
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`
`90-Day Release
`C2'Il:'I.lIJ$.'. Price SI:!1aduIe!
`Nulnln;-r Pa[.-.I;- Numlauzr
`
`Acebutolol
`
`Acetarsone
`
`Acetopromazine
`
`'N—Aeetyi-L-Cysteine
`
`A
`
`.. _.
`
`.
`
`.
`
`In
`
`
`
`(Daminomycin)
`
`I
`
`Adenosine
`
`l.’._‘.39*-*_i€=IX»“~0eton'e Powder. =
`
`Adrenosterone
`
`C-101
`
`B-165
`
`C-102
`
`0-212
`
`0-2273
`
`K-111
`
`K413
`
`N-111
`
`G-11?
`
`NC-101
`
`B-90!50
`
`.
`
`B-BOMB
`
`E-60:'58
`
`C-60!52
`
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`
`0.9055
`
`Astrazeneca Ex. 2044 p. 27
`
`
`
`ALPHABETICAL PRODUCT LISTING
`
`DosefPriee Schedules For Matching Placebo Pellets Appear On Pages 17-19.
`
`21-Day Release
`Ciltillllg l’ri::I.‘
`SL'ItI.*du|I:.v‘
`:\umher Page Number
`
`60-Day Release
`Calallag Price Scln;-(lulu!
`‘1\'umher I’age Nulnher
`
`90-Day Release
`(‘.a|Ial<.Ig Price SL'h|.‘(lll|I‘.'J"
`-.\Eumher Page Nmuller
`
`SA—104
`
`3-90:49
`
`NA-104
`
`9-90x50
`
`SB-167 _ 9-90:49
`90.119
`A-GOI46
`
`.
`
`-so-181
`SA—105
`
`B—60f49
`B-60149
`
`NB-167
`NG-118
`
`ND-1'81
`NA—105
`
`3:-90:50
`A—9DI4?
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`Astrazeneca Ex. 2044 p. 28
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`ALPHABETICAL PRODUCT LISTING
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`Astrazeneca Ex. 2044 p. 29
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`ALPHABETICAL PRODUCT LISTING
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`24
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`Astrazeneca Ex. 2044 p. 30
`
`
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`ALPHABETICAL PRODUCT LISTING
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`D0se!Price Schedules For Matching Placebo Pellets Appear 011 Pages 17-19.
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`Astrazeneca Ex. 2044 p. 3 I
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`Astrazeneca Ex. 2044 p. 32
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