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`4/13/04 CANCERWK 19
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`4/13/04 Cancer Wkly. Plus 19
`2004 WLNR 542429
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`Cancer Weekly
`Copyright 2004 Cancer Weekly via NewsRx.com & NewsRx.net
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`April 13, 2004
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`Section: Expanded Reporting
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`European launch of Faslodex reported
`Breast Cancer
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`Astraleneca announced the first European launches of its new breast cancer drug Faslodex ( fulvestrant) in Germany
`and Sweden, with Austria following imminently.
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`The novel drug - an estrogen receptor antagonist with no agonist effects - is for the treatment of advanced breast cancer
`in postmenopausal women whose cancer has progressed on previous anti-estrogen treatments such as tamoxifen.
`Fulvestrant has been launched in the U.S. since May 2002, and more recently in Brazil in July 2003.
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`Fulvestrant was approved for launch in the European Union (EU.) on 12 March 2004, making it the first new type of
`hormonal treatment for estrogen receptor—positive breast cancer to be approved in the E.U. since 1995. The launch of
`the drug in Germany, Sweden, and Austria therefore provides new hope to the thousands of women suffering from
`advanced disease ir1 these countries. Further launches throughout Europe are expected during the course of this year.
`
`Commenting on the launch, professor Kurt Possinger, head of the oncology department at Humboldt University of
`Berlin, Germany, explains, "The availability of ‘Faslodex' in these countries is very exciting as women who have
`progressed on prior tamoxifen therapy now have a new additional and effective treatment option which may help
`extend the window of endocrine therapy and delay the use of cytotoxic chemotherapies with their well—recognized and
`unwanted side-effects.
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`In addition, unlike other endocrine therapies used in postmenopausal women, ‘Faslodex' is a once-monthly injection
`which enables clinicians to have greater contact with their patients to review progress and free women of the worry of
`remembering to take a daily tablet, allowing them to focus on their life and not their illness."
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`Breast cancer affects one in nine women at some point in their lives and although many tumors are detected early and
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`treated successfully, a large number of women still go on to be diagnosed with advanced breast cancer. The goal of
`treatment for these women is to achieve an effective disease response and to enable the patient to maintain good
`quality of life for as long as is feasibly possible.
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`Honnonal agents such as aromatase inhibitors and tamoxifen are standard therapy in postmenopausal women with
`advanced breast cancer, providing an effective and well—tolerated treatment option. However, in time tumour cells can
`grow resistant to treatment with these honnonal therapies and as a result there is a need for new agents to which tumors
`are not resistant. Fulvestrant is an exciting new type of therapy, which brings new choices for women with advanced
`disease, extending the sequence of 'patient-friendly‘ honnonal therapies that can be used to control the disease.
`
`Fulvestrant works differently to any other treatment available, although like the other honnonal therapies it interferes
`with the effect of the hormone ‘estrogen’ on tumour growth. Many breast cancers are dependent on the presence of
`estrogen to grow. Of the current therapies, aromatase inhibitors (e. g. Arimidex (anastrozole)) work by reducing the
`amount of estrogen in a woman's body, and tamoxifen (an anti-estrogen) blocks estrogen receptors. However, ta-
`moxifen also mimics some of the actions of estrogen, which can result in unwanted side effects. In contrast, fulvestrant
`works by blocking and removing the estrogen receptors i11 the breast cancer cells and, Lmlike tamoxifen, does r1ot
`mimic the actions of estrogen.
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`Fulvestrant offers durable responses and has tolerability benefits compared with aromatase inhibitors and tamoxifen.
`Fulvestrant is effective following disease progression on prior anti-estrogen and aromatase inhibitor therapy in addi-
`tion both therapies are effective following fulvestrant therapy. Fulvestrant therefore meets a key umnet need for
`women with advanced breast cancer, since it can be added in to the sequence of well—tolerated hormonal therapies and
`may delay the need to resort to cytotoxic chemotherapies with their well-recogmzed side effects.
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`This article was prepared by Cancer Weekly editors from staff and other reports. Copyright 2004, Cancer Weekly via
`NewsRx.com & NewsRx.net.
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`Copyright © 2004 Cancer Weekly via NewsRx.com & NewsRx.net
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`INDEX REFERENCES
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`COMPANY: ASTRAZENECA PLC
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`NEWS SUBJECT: (Health & Family (1HE30); World Organizations (IIN77); European Union (lEU94))
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`(Pharmaceuticals & Biotechnology (1PHl3); Healthcare (IHEO6); Endocrinology & Metabolism
`INDUSTRY:
`(1EN72); Internal Medicine (1IN54); Healthcare Practice Specialties (IHE49); Cancer Dmgs (lCA21); Oncology &
`Hematology (lON95))
`
`REGION: (Western Europe (lWE4 1); Austria (IAU39); Scandinavia (ISCZ7); Germany (lGEl6); Europe (lEU83);
`Northern Europe (1NO0 1); Central Europe (lCE50))
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`© 2015 Thomson Reuters. No Claim to Orig. US Gov. Works.
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`Language: EN
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`OTHER INDEXING: (ASTRAZENECA; EUROPEAN UNION; HUl\/IBOLDT UNIVERSITY) (Arimidex; Breast
`Cancer; Cancer Weekly; Commenting; Faslodex; Kurt Possinger)
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`KEYWORDS: AstraZeneca; Therapy; Women's Health; All News; Consumer News; Oncology
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`Word Count: 841
`4/13/04 CANCERWK 19
`END OF DOCUMENT
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`© 2015 Thomson Reuters. No Claim to Orig. US Gov. Works.
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