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` 1999
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`Astrazeneca Ex
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`effects, and precautions” must be =“sar,ne~.—in,,.Iangua,ge__ ~_=product“may...be—Qbtained,from the.man.uf,acturer.
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`contents
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`-Manufacturers’ II1deXl‘(White Pages)
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`Lists all pharmaceutical manufacturers participating in PHYSICIANS’ DESK REFERENCE.
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`products and the page number of those described in PDRA. /
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`Brand and "Generic Name Index (PinkAPagets).
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`The main section or thebook.‘ Includes entries‘ for over 2,200 pharmaceuticals. A‘Listings are
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`Astrazeneca EX. 2046 p. 10
`
`

`
`'
`PRODU.'CT‘~:INFORMAT|0Nif?
`‘NOVARTlS*:PHARMACEUTICALS/2025
`HOW'S‘UPP,LlED:~.
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`build; cigarette ‘smoking ‘alcohol abuse; 0 sede‘ tax-y‘ life-
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`During pregnancy. Althoughithepossi 7'
`there ‘st "a~’greater"'r1sk?of‘having‘ a child born with 4a birth
`defect‘~1f_you take estrogens'du1in"g'preg'nan'cy. A male child
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`the urinary systemand ‘sex organs.»A‘female'child may have
`an increased risk ofdevelopiiigcancer of ‘the vagina or ‘cer-
`vix in her teens or twenties. Estrogen is not -‘efl'ectiv‘e -in pre-'
`venting miscarriage (abortion). In addition} estrogenlshould
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`periods (years) after menopause will keep youriskin soil; and
`suppleand keep.you:feelingyoung. There is no evidence for
`these claims, and such long-term treatment may. carry seri-
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`DANGERS 0_F"E TRQGEN p
`Canc.e.nof ;th.e.'ztt,er.us: The.ri_s1<.. of «.caa<ser:. of the.-.ut.erUS
`increases the longer estrogens are -used and whendarger
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`quickly. Three other studies showed that the-risk for uterine
`cancerstayed high for ,8_.,to, more than 15, years,a_fter_stop,—
`ping estrogen treatment..Because of this risk, it is impor-
`tant to take tlw*¢lou_1._est dose ofestrogen that will control your
`symptoms, and to,ti1ke,i1! ozLly'~as_l9ng as you need;:it.‘.' Using
`progestin therapy together with estrogen therapy may re-
`duce the higher. risk of uterine cancer related to estrogen
`use (see OTHER INFORMATION).
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`there is no danger of developing cancer of th_e'1‘.iteru
`‘Cancer of the breast. The majority of studies
`no‘ association between thevusual doses used_for estro