Ma)’ 25, 1948.
`
`J. T. HAYWARD-BUTT
`INHALER FOR ANALGESIC OR ANAESTHETIC PURPOSES
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`2,442,004
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`Filed Aug." 17, 1945
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`NU MARK Ex.1017 p.1
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`

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`Patented May 25,‘ 1948
`
`2,442,004
`
`UNITED STATES PATENT OFFIhCEl itQ
`
`INHALER FOR ANALGESIG OR ANAES-
`THETIC PURPOSES
`
`John Terry Hayward-Butt, Bude, North
`Cornwall, England
`
`Application August 17, 1945, Serial No. 611,107
`In Great Britain January 29, 1945
`4 Claims.
`(Cl. 128-200)
`
`1
`This invention is for improvements in or relat-
`ing to inhalers for analgesic or anaesthetic pur-
`poses, and has particular reference to inhalers
`which are small and compact enough to be car-
`ried in the pocket and are robust in construction.
`Various forms ofportable inhalers are already
`known but these sufier from the disadvantage
`that the relatively small charge of the volatile
`inhalant supported on fibrous absorbent material
`hasto be replenished comparatively frequently.
`It is an object of the present invention to pro-
`vide an inhaler for analgesic or anaesthetic pur-
`poses which in addition to the properties of light-
`ness, compactness and robustness also possesses
`the property or having a relatively large capacity
`so that repeated re-charging at short intervals is
`unnecessary. Further it is an object of the in-
`vention to provide an inhaler which is simple to
`charge and use, can be stored in charged condi-
`tion indefinitely and is rendered ready for use in-
`stantly.
`invention, there is
`According to the present
`provided a pocket inhaler for analgesic or an-
`aesthetic purposes which comprises a perforated
`nose-piece, a chamber containing fibrous absorb-
`ent material for the Volatile liquid analgesic or
`anaesthetic substance, one or more air inlets for
`directing air through the absorbent material and
`thence to the nose-piece, a container connected
`with the said ‘chamber adapted to hold a supply
`of the volatile liquid and means for feeding the
`liquid to the absorbent material. The charge of
`volatile liquid may be carried in a frangible
`ampoule or like sealed container and the appa-
`ratus may be provided with means for breaking
`the ampoule to liberate the liquid.
`As in the case of known inhalers air is drawn
`by the patient through the absorbent material
`moistened with the liquid and thence through the
`perforated nosepiece into the lungs.
`The apparatus may be used for the administra-
`tion of a wide variety of volatile analgesic‘ or
`anaesthetic materials. The apparatus may con-
`veniently be of cylindrical form, the nose-piece,
`chamber for absorbent and the liquid container
`or the container for the ampoule may be screw-
`coupled in series.
`The liquid container may be of the unspillable
`variety so that flooding of the absorbent chamber
`is prevented and the means for feeding the 1_iquid_
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`l0
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`l5
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`20
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`30
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`2
`to the chamber for the absorbent may convenient-
`ly consist of a wick, one end of which is embedded
`in fibrous absorbent
`(comprising, e. g., cotton
`wool, which may be in the form of ‘dental
`rolls) and the other end of which dips into‘ the
`liquid. The absorbent may consist of other
`fibrous material or of a. coil of the wick itself.
`Alternative means for feeding the liquid may em-
`body a device for passing a predetermined volume
`of liquid to the abosrbent as required.
`.
`,
`The end of the liquid container or a cap cov-
`ering the nose-piece may constitute‘ a measure for
`the liquid so that over-filling of the container is
`prevented.
`The apparatus is intended to be held in the
`hand and volatilisation of the liquid is thereby
`increased. Alternatively, the apparatus may em-
`body a simple form of electric heater.
`-
`Means may be provided, e. g., a fingerhole or a
`adjustable valve for controlling the flow of air
`throughthe apparatusand the air inlet, or inlets,
`may be so arranged that ascrew cap over the
`nose-piece constitutes an air-tight seal.
`'
`It will be understood that the absorbent cham-.
`ber and liquid container may be arranged’ con-
`centrically.
`_
`I
`The whole apparatus may be sufiiciently; small
`to be carried in the pocket, e. g., like a pen or_ like
`a pencil torch, though it will be understood that
`partsmay vary in relative size, shape and ar-
`rangement.
`‘
`3
`‘
`The apparatus may conveniently be made of
`metal or of synthetic resin or of both and the
`liquid container may be transparent.
`V
`‘
`:
`.
`_
`The nose-piece and the rest of the apparatus
`may if desired be connected by a length of ‘rub-
`ber tubing which enables the chambers for the
`fibrous material and liquid to be fixed, e. g., to the
`patient’s head, by means of one or more adjust-
`able elastic straps. Alternatively. the complete
`apparatus may be held as above-described and the
`nose-piece may be connected by rubber tubing to
`a cap for the patient’s nose.
`When the liquid charge is contained in an
`ampoule this is preferably made of glass or of ,
`plastic and the means to liberate the liquid may
`be such as to break, crush, pierce or otherwise
`open the ampoule.
`_
`'
`’
`The ampoule may conveniently be cylindrical
`shape and may fit snugly within the casing of
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`the apparatus falls to the ground on the pin 21
`the apparatus. It may be held resiliently in place
`the ampoule is not broken.
`Within the casing by means of fibrous material.
`The inhaler is operated by holding it in the
`Means for breaking the ampoule may consist
`hand and driving the pin 21 against a hard sur-
`of a piston moving within the casing and ‘pro-
`faceto break the ampoule 22 and liberate the
`vided with astriking pin or rod passing through
`liquid 2| which saturates the fibrous material 23
`the end cap of the apparatus and pressed away
`and 24 and the wick 20. The cap I2 is now With-
`from the ampoule by lneans of a spring of such
`drawn and the nose-piece I3 inserted in the nos-
`stifiness that accidental dropping of the appa-
`tril. Air is aspirated through the perforated
`ratus even “on the rod fails to ‘drive the piston
`plate is over the Wick 20 through the slot I6 and
`against the ampoule.
`'
`thence to the nose-piece.
`Vaporisation of the ..
`When the apparatus is required for use the end
`Volatile: liquid’ is“ assistedjby. the warmth of the
`is driven. against,ai1ia1‘d»surface7sé as to force}
`hand;
`‘-
`I
`»-
`-
`I
`-
`the pin and itsipiston against the end of the am-
`Referring to Figure 2, a frangible ampoule 33 is
`poule to break it between the piston and the in-
`151
`held loosely in position by inwardly-extending
`ner end of the nose—piece unit.
`~
`. ;_)_r.oj_ections 3A.and.by a screwthreaded plunger 35.
`Suflicient absorbent fibrous materia1_pisi-pro--A A
`.'I”he,end. face of the plunger 35 remote from the
`vided in the container to soak up the ‘whole-~of;
`—
`i ampoule is grooved, as at 36, for rotation of the
`the contents of the ampoule.
`plungeme; g:; by‘ means of a coin or by means
`Volatilisation of the analgesic or .anae_sthetic..- 1
`if of‘ a..flange 31 attached to the end of the screw
`liquid into the air stream is effected by passing--
`air, e. g. from the nose-piece end of:the.—apparatus.v --
`cap 3_8._for~ the purpose of breaking the ampoule
`" ; .:and.liberati“ne theliquid.
`over a wick wound around the tube a-ttached.to'..the'
`-
`Referring to‘ Figure 3, the casing II is divided
`nose-piece and thence through one or more holes A
`aszirifigiire 2 by a transverse wall 3| provided
`or slots into the tube to the nose—piece.
`with an axially-projectihg tube 32 and wick 28.
`It will be understoodithatpany one of a num-
`The chamber 39. is charged‘ with volatile liquid
`belt. or alternative: means’ may; be provided-’for
`through. the. screwed-on.» cap; 40; the amount‘—,_—of
`breaking,.piercii1g"or:opening:the a.mpouler._ Thus;
`theiampoulermaybe broken by means ofga screw
`liquid: being su_ch.,tliat.. liquid: does» not flow, di-
`rectly through the tube. _32.—.
`In(this-c_ase;.-the~.ap,-
`plunger or by: means of a“ lever‘ operated from
`parvatus. is instantlysreadys for u_s.e:as.1ong, as any
`outsidethe: casi’n'g; suitablesmeans being‘: provided
`liquid- remains in it and: requires: only they re-
`torguard; against”accidental'.breakage or the. am-
`moval —of. the nose-cap. and insertion in the
`poule'.”'”‘
`i‘
`i
`nostril.
`.
`’
`.
`._
`._.
`~—
`~
`V
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`Following is 1a.: descriptionzby. way"of example
`andswitli reference;-to.the’; accompanying. diagram.-
`.
`as
`—
`y
`Iiclaimz
`g A
`1. A pocket inhaler foranalgesic or anaesthetic;
`matic drawing; of; three for1i1si:.of*inhaler made’ in
`purposes. which comprises. a. substantially cylin-
`accordance with the. present’ invention;
`drical. casing, a. nose-piece projecting; from one
`’ In the drawing,
`.
`end oi saictcasing and.’ terminating within._the
`Eigure I’ shoWsTpar.tly: in‘ central‘”se'ction.' an in.-
`casing. in a, perforatedrtubular extension, fibrqus
`haler provided with a supply of volatileanalgesic
`absorbent. material-. for. a volatilediquidi analgesic
`or anaesthetic. liquid in
`sealed: ampoule;
`or anaesthetic substance associated W_1th.the.said.
`Figure-2 shows anialtern-a.tive; form of inhaler,
`tubular extension, an ampou1e,— containing. a
`also in: section in which the 1iqui'c1»is..contairiec1' in
`charge of the said liquid. within.the/ceasing; adja,
`a, sealed frangibl'e'cor‘itainer‘: br.oke‘n..by—ineans of
`cent to thefibrous material.and.means:.for breakt-
`ascrevv-threaaed:p1unger€; aria:
`i
`‘
`v
`ing the ampoule to liberate the liquid; -
`_
`V
`1
`~.
`Figure 33siiows-.ingsection another form. of ap-
`2. An inhaler as claimed in claim 1’ wherein the.
`paratus.in.wnich the Iiquidiiscontainedzin. annri-’
`means for breaking the ampou1e:c,ornprises.a_.pis-
`s'pi11ab1e»cnemtei_-
`the casing.
`ton spring-loaded’ to. urge. it. away. from the.’-a'J:n_-,-,
`Similar
`réie1~enc_e- numerals denote ‘similar
`poule and: a striking. pin secured. to; said piston
`parts llfli-'-é‘tig'hGl1t_ the: figures. off the ‘drawing.
`V
`and passing through and; projéctingjbeyon-d'Ith,e
`Referring to the"-three‘ figures, H7 is _a. casing
`end of the cylindricali casing remote from. the
`which is preferably metal and has- a screw-
`nose cap.
`‘
`‘
`~-
`3,
`tiireadedrvapo ‘ "ti'g‘ht nose-eaprlzt atone end. A
`3. A.pocket.Iinhaler’ for analgesjic-or anaesthetic
`
`nose-piece Is:
`vieeawitnnostriisguara lepro-
`purposes which comprises a substantially cylin-
`jsetsq from the casing. I I "and? terminates. Within
`drical casing, a- nose-piece projecting, frorxi_.o;1e
`the casing» in a. tubular ex‘-tension» I5:
`is
`end‘ of said casing passing. through a: perforated
`slotted or otherwise perforated at l6« and ‘at its
`end plate or said casingand’ termi_nating.withii5i-'
`innerfeiidt preferably te'r-i'nih_'at'esV in a solid" head
`the casing. in. a. perforated..t.ubulai°.. extension,
`I-T: The tubular extension l5?is»in.1:)osition
`wick-like fibrous a;bsorbent.materia1'for alvola-.
`axially in'the;c'asmg H>’by_«ine’é.hs:of~1_6o"ating plates
`tile liquid analgesic or. anaesthetic substance
`l3:"a.n'dv I9, the latte'r;lo"eing" provided with (}he- or
`wound around the.—sai-d. tubular extension and
`more holes for-— the a'dr'ni_ssi'o'r’i' or _'air to the an-
`over the perforations thereoi} a. frangible am-
`nular’spacebetween‘thecasing I land the tubular
`poule .containir.ig. acharge-of. the saidliquid; with.-.
`extension--ll 5: The«tubu1ar'e'Xtensioh 15 is wound
`ingthe casing. adj.aQent.to,tl‘ie:i’ibrous—rnater.ial
`means for breaking ..the, ampoule. to. lib.er;ate..-the
`YV.1:t,l.'j1j‘V_a[‘>fi‘7l.Q.l.§_I of-_' fibrous liqiiid- absorbent material
`111:. Referring-to~F'igure~1; the~v‘e'1atiie~1iquici 2 I‘ is
`liquid.
`—
`r V_
`V
`-V—
`_
`V
`-_A'
`l
`held‘ in _a sealed irang_ib1e- ampoule ?2‘af1d‘.is*'held
`4. A pocket inhaler for analgesic or anaesthetic
`in position in the-casing betweenpiugs-of fibrous
`purposes which .com:01_‘ises a— substantially? ~cy1__i_n_-
`material, 23 and 24. That; end‘ o_i..tne ‘casing. re-
`drical casin3'._ «a. nose-piece iprojectingfrom. one
`fncte from; the ‘I'10:'s.e-piece‘ is ‘closed by" means of
`end, of said casing—passing,_through aa_perI,orated
`a sé’l‘.e\7iiZcap_25‘ previdegiwith ‘a central’ here 25
`end plate of. said. casing and. terminating within
`thrcuehj .Wh_i‘cl‘1, 5, . pin. 21‘ or] a piston 28. .‘passes.
`the casing in a slotted tubular extension,;-agwick
`of
`fibrous
`liquid-abs~or_bing.
`.material..;;wound
`This piston is held ‘away from the ampoule ‘22 by
`means.v.of.. a_ spring -29. which. users against the
`around» at least the slotted portion-.o:E~{said..tubu—
`abfJ.tizléht;3ll.' ana:is. O‘I7.'siich stiffness trnteven if
`lar extension-land? terminating adjacent a...f'rari._,-.
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`NU MARK Ex.1017 p.3
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`2,442,004
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`5.
`gible sealed glass ampoule containing a charge
`or analgesic or anaesthetic volatile liquid and
`means for breaking the said ampoule and 1iber-
`ating the liquid.
`JOHN ‘TERRY HAYWARD-BUT1‘.
`
`REFERENCES CITED
`The following references are of record in the
`file of this patent:
`UNITED STATES ‘PATENTS
`Date
`Name
`T
`Dow _______________.. Apr. 7, 1903
`
`Number
`724,680
`
`Number
`938.757
`1.585.912
`2,395,109
`
`Number
`193%}:
`91,49
`
`5
`
`10
`
`6
`
`Date
`Name
`Ferguson .........__ Aug. 30, 1910
`Heublein .......... May 25, 1926
`Fonda ........... _.. Feb. 19, 1946
`
`FOREIGN PATENTS
`- Date
`Country
`Great Britain ....—— Mar. 23, 1905
`Great Britain _____- June 21, 1923
`France __._-;______ May 30, 1908
`(Addition to No. 387,491)
`
`NU MARK Ex.1017 p.4