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`10.20.2015 12:27 pm
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`326491
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`Source :journal of the Naticmai Cancer institute. Monographs
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`Volume :
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`13
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`1092
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`11%: 117-23
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`Author : Lee M,DraoL:E EvI,.Zia F,GazcEar A,OEe Hfiepler C3,.Beiiot F,Tarr C,i~{ris R,Mo0£iy TW
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`_"_[i_t__l_g;__: Epidermal growth factor receptor mcmoclonafi antibodies inhibit the growth of Eung cancer cell lines.
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`APOTEX EX. 1020-001
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`APOTEX EX. 1020-002
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`15:355‘i3
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`Number 33
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`Eizmmei E«rodm°
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`APOTEX EX
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`. 1020-003
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`EI)IT€)RIAL STAFF
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`Scientific Elditar: Jaxrmz L. Muizmime, Ml),
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`Muntmgraph Cianrdinatort Edwin 3%.. Haugh
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`Manuscript Cmzerdizzawrsx I-ieien B. B§ac};.wcmd., Julia $‘3%i"1¥;€}.I1 Redmmd.
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`M’axms~;::riy£ Edfitnrsz Meiisga Anarimwsg Bunnie fiavis, M.a3*§.Ey'n K. fNc'.i.3s:)r‘2
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`Praciucfi-¢:m Staff: Eizzine: Ftica Beck, Wayne: Bixiingér, Camh: J. Radrzr
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`VMARKETINQ» ;S'I3%FF
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`Marketing Ifiirecmrt Vlean C%L:riffiz1 Baum
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`Fropcmia fear mazarwgmphs shouké be suhmitmci in Trim E§dét(3r~in»C'h.ie;°.:§} Jwrmzi cf she Na:‘imm.§ Cancer
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`Instiiuzxs, Bammdag MI} 20% M.
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`Jmxrnal ofthe Natianafl (‘lancer institute Iwianugrapha are: far 24332:. by the Sfiupmmemient of}3‘«z>c::2::m2nts,
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`APOTEX EX. 1020-004
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`Bialagjy 0farza' Navei T7'zerape0;ezic Apprmzches far
`Epirizeliai Cancers {If the Aaradigesrive Tract
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`1992
`Numiver 1.3
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`(ZaI2tents0
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`/
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`ix
`
`
`Preface
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`‘
`
`1
`.Inimiimitir3x&
`Jack A. Ruth, Watm Ki Eiong, Iamas L. Muishirze
`Rule ofBiniog and Prevention in Aerodigestijve True: Cancesrs
`3
`Pam: Greenwaid, Haxfiei R. Stem
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`Freveniiozx and Themgestive T Cancers
`Melaaxzzxiar Apgaraacheg
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`lfack 15;. R9111, Tapas Mukhmpadhyay, Michaei A. Tainsky, Kang Fang, Man G. Cassnn, Fan} M. Schneider
`
`e {as Gem Famiiy in Human No11--Small~CéIl Lung czanm
`0
`23
`Rabazn 30 C. Siseboss, Sjoerd Rudenhuiés
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`
`Isiarfiy Even 0 the Nmpiastic magi’VVVVVVVVVVVVVV0tion at Respira EgithefiVVVVM
`Micémwi 31 Eixmr; Rlmda Aiani, Frank Cutting. Lisa
`Fmis, Anita L. Sabich, Ifzmnis A. Eiandem,
`Iili M. Siegfritd. Eva Ezabiz, Paws}
`Brawn
`myvc F5 mus. fixmgz-mi ‘rumors and Tr fie}! L-in
`Patients with Smailwfleil "Lung Cancer
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`3::
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`0
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`_
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`Bruce 3 iahnmn, Lfohn R‘ Hremxam Daniei (3. 113136, Adi
`G:azdax
`M05213 far Cempmventian of piraztnry Cam:vvvvvvvH
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`C. Mnszm, Kamiaia V. N. Rm. (fatal 3. Ifmaisac, Gary I. Ktsiioff
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`Chemnprewxntisre Stufiies in Barr°ett’s Esugahagusz .9. Made! Praxnalimaut
`51
`Lgsmn far Esophageal Aéenncarcinnma
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`Sampiimr. M. Erian Fennerify
`Eiarindzr S. ifrarewal, Rigzhard
`WWWm
`An Animai Mada! for {lira} Cancer
`55$
`Timmas I. Skxga, Erma B. Kfiimtmewflunti
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`Expan ad‘SurfacA.a9ocxa0' ted
`A Bbiseriminani fietwem Bieiagir: Subsets
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`
`in P~E{m~=Sm ‘Lung (Ia:
`61
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`R‘ Iimiia Limmiia, iames EL. Mulshine, Seth M. Sminberg, Add F. Gazdar
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`'£‘umm°.1igeu Phermtygra, Bfiulaficé Stagng, and Prnwask in Rem! and Knack fiquammzs Caminnms
`5?
`Grezgnry TX waif, fhamas E, Carey
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`at‘ Expressian :1 phaspheryza9;a% Iain NormvvvvH
`vs
`3.11% fiigagiastic Keratinacyim
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`
`
`Tlmmas E. Carey, mam Laurikainen, Tfémnkam S, Nair, ’I‘imo:hy S. Reinke, banaid E. Caazsling,
`Cimgery Wolf, Caster Van Wags, Monica Lisbm, Qganthia Marceie
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`APOTEX EX. 1020-005
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`Kemtinacyte Bifferentiatim Markers: Involncrin, Transgiufmminase, and Toxicity‘
`Rmbart H. Rice, Qin Qin. Arm-:2 P§_§at0,.,e4.mc1mw L Fiiwita
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`Csnntral nfSquamvzmsnifiemnfi;fi ai Ceiisz
`Rule nf Retintzifis
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`087
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`93
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`Arman M. Jamn, Cliara N¢rv§., Thmnias M. Voliberg
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`Suppmssitm by Retixmic Acixi ofEpidermal VGmw'tt’: Facwrwfieceptor Aumphasphoryfiatian “
`and fiilyeosytafinn in Caiturezi Human Heat?! anti Ntsck Squamnus Carcinoma {lens
`Inn 8. Kim, Peter A. Eiteck, Gary E. Gallick, Iain S. ma, Mari»: Biicik, Wmm K‘ Hang. Rm:i:«zm {man
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`
`101
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`13»cis~Reiinoic Aerie! arsfi Cancer {Zhemapmventiem
`Scott M. L§.ppmai3. Wmm. Ki Hang
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`
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`113
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`Epidermal {§‘»mwi1z Factor Receptur Mnnacianal Antibodies Inhibit the Growth of hung
`Cancer Cell! Lines
`
`111'}
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`M. LEE1, M. Dragui, F. Zia, A0. Gazdar, ii. 036, G. Bepler, F. B61101, C. Tm‘, R. Kris, T. W. Mtxaiy ‘
`
`Egnidermal Grswtfih Factnr Reaeptszxr as a Target for Thvemgry with
`afintireaeptnr Manmsimlafi Aniihodiw
`..'f:)}m Mmdgiscahn
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`125
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`0
`Systatic Bewiem BomGastrin~a3£asing €12 Ants
`David H, C33’, Rabat! T. Jensen, N§.ng«Yi Jiang, 3awmTr.:«wn0 Lin, Anthur E. Bogden, Jacques»Pim’e Mcreau
`
`Mala: Genetienai atTlliistimitaceprieé Mammaan Bo.in~¥;ike zptiii
`James Barbs:-y. Etsukn ‘Nada, Martha Curjay, Jamas Way, Zalzra Fathi. Hagit Shapira, Richard Barkins,
`iames Wu, Timothy Siaitazy, Eiaina Mann, Richard Fclclman
`
`
`iiflrects atfiemwpepfi onn g mama-.9: am‘0
`P311! A. Bum}, J12? Bavié G. Bienharz, mxziefi Chan, Manrean Tagawa, Wxiilip Jewetft
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`0
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`3
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`141‘
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`1;;
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`153
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`163
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`Differential fitimtllation at‘ the Grawth air‘ Lungemetasmaizing Tumor Cells by Lang (Faméfina)
`Gmwth Factors: Idaniificatiun of Traxxsfert'in~iike Mitogens in Lung Tissueaflanditimaed Medium.
`Garth L. Nicoiwng Philip (3, ~Cav.anaug}n,. 'l”a.katoshi Emu:
`Expert: 92‘Puma Efimwssinnzymin Mfimzéine and fiearaendoce Cells
`Eamjy A. Elippcr, Ciziazina 'B«R, Green, Rizzhard E. Mains
` “
`{3m2!m§ ofTamar Ceii Biology Thmugh Reguiation at Peptide Hnrrnane Processing
`116?
`Anthony
`Tresmn, hangs L. Mulshing, Frank Cuttizta
`WM
`Biemarieter Intemmiiate Emzipaims ami Saucer firavenfimz
`1?“?
`Frank: L, Meys.iv:.ens., Jr.
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` <<< < « ‘wm
`.Rmi«ma£ Targets for the Early Betacfinn of Lung Canoe:
`383
`Jmneas L1 1‘:/Iu.¥.shine., R. Hana Limwila, Sandra
`Jensen, fishy: L, Magnani, Melviti S.
`Gupta. Frank 5. Scott, Ingaiiii Avis, Kathryn Quiml, Michzwi J. Bimitn Aniémny M. Trcstmz,
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`Prahofih K,
`Cuzszitm
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`vi
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`APOTEX EX. 1020-006
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`axssmiaticm Retwesan .Hisml::agjcai Type am Neumendnerine Bifferzniiatiun am Iirug Sensitivfity :11’
`Lung €3a:ncer Cell L-ir;a3
`
`Adi F, Ciazdax, C. éiadoyaméa, Dzzvs.-‘id ‘e’e:1z0:1, ,§;=::e~Gzzh§3 Fark, Chun—Ming Tvsai, R, Rama Linmziia,
`James L. Maishirne. Bazaiei Ci. Ewe, Céiustzppe €3iacx:.gmc
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`fiamfiinatian Inznnunmhemgzy for A.£i1?a.z§ced ¥.samg {ifzmtm
`S‘te:phe;n
`‘femg, Eiimbctah A. Cérizrun, Jack A. R0211
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`Aimmuxmlagic E§f§’s:ctu~r Cells in Head and Neck Cancer
`¥3r:§m£:nim~ Vim.§o, am: Mdivatassieré. Xmas T. Ioimaorx, "1?22eres.a L. W.§“1ii£3i::§:=:
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`
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`E91
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`E97
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`383
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`309
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`311
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`Acknawlewrlgement :9 Manuscript Reviewers;
`
`0£~‘zma.n 3ar:§cs«3£?h£i€ge!. Pix.£}._ iflaaienai Heart, Lung, and Bicmd Instituzs, Bathesafia, '£s«"1a.ry§ami
`James F. Barzeay, MEI). , Qzberatory4:3f'8i01ogi2a.1 Chasxmistry, Nzazietmai Cancer Inszi£1132, Bethes»
`iia, Maryianci
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`fi»1iam‘;.aeI Eirrgr, M.3.'I1., BiV0m0a:‘i<e2s and Prsvesnaisan Ressearczh Bramsh, Naticanai Cancer I£1.5{§i£li€‘.‘-,
`Eaihesda, Mazjylaxxazl
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`{'33:}: Erzzwley. M’.D., 0?%Ia%.is;m.aI Caracas: institute, Bt:‘th\£sda, ?*/‘{é1:aE'}"I,2£§}d
`Pz:n»;-«>3! Iimwrz, M1), Pix. I1, '8iumm‘i.»:m and Frmexzniaza Reaearch Branch, Natianal {fzmcer
`Institute, Bet%1as;iz:,.Marykand
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`Pcmi Baum, Mfl, Uaxiveprsity {sf Csaioratjo Health S~::iencc,: Cimtetr, Denver, Ceiorado
`Yhamaus
`ffarey, }’§z...€.3., Uniwmrxity of Mi«:::higare., Ann Arlzm”, "Michigan
`Fmmfi: Casrirza, }’*iz.£3. , Biumarkers and Prevéentism Resaarch B‘:‘21nc.§;, Nazimiai C.ésn:;:§:r '§'n.stimtr:,
`Batizesda‘ Mmryiand
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`R’<2§m"z B, £)‘ic‘.§ms"()fl, Fi2.£)._. Lambardi Cancer Rasazmzh Cgnmr, W'a5hingmn, DC‘.
`Au,m':2 Davie, M.iL2., University 0f fviazyiand Céamter {Z‘.’enz.e:r,
`'8a1ti;m::2r::, Pviaryimid
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`W&~2z;n Ki Hang, M.,2"}., Un:ivarsii‘y zrf ’I‘t::c.;1s M. 1).. fixndmrson Czmcer {'3_e.r:0:.e:r, E-Im:st{):1, Texax
`1Z)ar:ier.Z’ C. Ihde, M, £1, .{}e:pmy Birecmr, 'Na:i.m1ai Camzer Enmtmta, Baahesxia‘ tsiargeiand
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`Csmtezr, .Bezhesda, Maryiand
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`faizn £9’. J'm.s:s, M3,, Biujmarkszrs and Fmwmicm Research Branch. .Naiim1a§ Cza:m:s:r itsstimte,
`Eeflmsda., Ma2*y1aud
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`Phiiiip £3. Kezxgrzyk, P:‘:,1}.0, Maiecuiar {)r2.m§w:%g}/. 11142.. (}aiE§1::r3burg, Maryianci
`.B:2rr:3z"z 3. Ifrarrzer, ,-Mil)‘ . .D:§‘vis2.io,r.§ (sfCancer §‘r¢‘£»'°€ti£i(?I’.t
`;m—s;i Cmxtroh Nagietmal Cam:er '§'nssaim:e,
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`£3. And=::rsa}n (‘fan-szm‘ Center, Hm1sI:;>n, Texas
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`Mcz.r.¥c zezeizr. M.éf3._. 952.233., Pittsbu.rgh Czznmr Emszizute, fitwisburgh, Pzmnsyh:ar;.ia
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`‘vii
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`APOTEX EX. 1020-007
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`

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`Epidermal Grmvtlz Factcar Receptnr M0noeh3na.l A0nt:i‘£mdi&s inhibit
`the Gmwth af Lung Cancer Cell Lines‘
`
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`high affinity in E‘£‘1’lK1~SB§‘l§§s§§*€E.H hang cancer £3”-¥S{1.I;C} mils,
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`Thu: szgjiécicrmzzl g.r<:<wih fE£C!.£Jf recepéor {‘E.i1‘rF~iI?i} is .21 I236
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`MA'i‘ERl'ALS AND ME’? H6138
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`Ceii ifiuiture
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`
`R.2mpi<:r Binding
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`"file z1b§2it3.>' 0f MAE70 108 to §.flhib5’E .E’.-GER iiziziding was
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`fvmb £08
`
`£17
`
`APOTEX EX. 1020-008
`
`

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`3 is
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`tigfiaa) was jproatiuced after ingestion atf rnice with {;‘_i~eI.{3
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`Sigma Cimrnistai C0.
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`Wffkh 103 Bimiijng Studies
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`Previrzsttslsg, we fauna that m'i'~EiZ"i¥r7 btstanti with high
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`APOTEX EX. 1020-009
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