`bb\F\WORK\030\10030\spec\10030.MJC
`
`ANTICONVULSANT ENANTIOMERIC ANINO ACID DERIVATIVES
`This application claims priority from U.S
`Provisional Application No 60/013522
`filed March 15
`1996
`FIELD OF THE INVENTION
`
`invention relates to novel
`The present
`enantiomeric compounds and pharmaceutical compositions
`in the treatment of epilepsy and other CNS
`useful
`disorders
`BACKGROUND OF THE INVENTION
`
`The predominant application of
`and prevention of
`drugs is the control
`anticonvulsant
`seizures associated with epilepsy or related central
`nervous system disorders
`Epilepsy refars to many
`types of recurrent seizures produced
`by paroxysmal
`excesive neuronal discharges in the brain the two
`main generalized seizures are petit rnal which is
`jerks akinetic seizures
`associated with myoclonic
`loss of consciousness
`but without
`transient
`convulsion and grand mal which manifests.in
`series of seizures and convulsions with
`continuous
`loss of consciousness
`for such disorders
`treatment
`The mainstay of
`has been the longterm and consistent administration
`of anticorivulsant drugs Most drugs in use are weak
`their action on neurons
`acids that presumably exer.t
`the central nervous system
`glial cells or both of
`these compounds are characterized by
`The majority of
`least one amide unit and one or
`the presence of at
`
`10
`
`15
`
`20
`
`25
`
`30
`
`MYLAN - EXHIBIT 1006
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