NAME
`
`W. Archie Bleyer, MD, FRCP[Glasg]
`
`CURRICULUM VITAE*
`
`PRESENT TITLES Clinical Research Professor, Radiation Medicine, The Knight Cancer Institute at the
`Oregon Health and Sciences University, Portland
`Professor of Pediatrics, The University of Texas Medical School at Houston
`Senior Advisor, Children's Oncology Group Adolescent and Young Adult Cancer Committee
`
`IMMEDIATE PAST Director, Community Oncology, Cancer Medicine
`TITLES AND
`Professor of Pediatrics and Mosbacher Chair of Pediatrics
`University of Texas M.D. Anderson Cancer Center
`AFFILIATION
`
`CITIZENSHIP
`
`United States of America
`
`HOME ADDRESS
`AND OFFICE
`
`2884 NW Horizon Dr.
`Bend, Oregon 97701
`
`EMAIL ADDRESS
`
`ableyer@gmail.com
`
`Telephone: 541-617-9259
`Cell:
`541-610-4 782
`
`WEBSITES
`
`creator and manager: www.stcharlesresearch.org www.comedsoc.org
`
`WEB BIOSKE TCH www .masskickers .org/wp/ archie-bleyer
`www. ohsu .edu/xd/ education/ schools/ school-of-medicine/ departments/ clinical(cid:173)
`departments/radiation-medicine/about/faculty-staff/archie-bleyer.cfm
`
`EDUCATION
`
`Postgraduate
`Training
`
`1969-1970
`
`1961-1965 B.S. in Life Sciences, Massachusetts Institute of Technology,
`Cambridge, Massachusetts
`1963-1965 Thesis: 24/7 renal physiology in the ambulatory rat
`Leonard Kleinman, MD, Edward Radford, MD, Harvard School of Public Health
`1965-1969 M.D., University of Rochester School of Medicine and Dentistry,
`Rochester, New York
`Internship (Medicine-Pediatrics), University of Washington and
`Children's Hospital and Medical Center, Seattle, Washington
`1970-1971 Residency in Pediatrics, University of Washington Hospital and
`Children's Hospital and Medical Center, Seattle, Washington
`1971-197 4 Clinical Associate, Laboratory of Chemical Pharmacology and Attending
`Physician, Pediatric Branch, National Cancer Institute, Bethesda, Maryland
`1974-1975 Senior Fellow, Hematology/Oncology, Seattle Children's Hospital,
`Seattle, Washington
`1984-1986 Fellow, Radiation Oncology, University of Washington, Seattle, Washington
`
`MENTORSHIP
`with NOBEL
`LAUREATES
`
`Vernon Ingram, Massachusetts Institute of Technology
`Salvador Luria, Massachusetts Institute of Technology
`E. Donnell Thomas, Fred Hutchinson Cancer Research Center
`
`CREDENTIALS
`Board and Other
`Certifications
`
`National Board of Medical Examiners Examination, July 1, 1970
`American Board of Pediatrics, June 1, 1975, Certificate #18103
`Pediatric Hematology-Oncology, American Board of Pediatrics, June 1, 1976, Certificate #217
`Recertified in Pediatrics and in Pediatric Hematology-Oncology, May 9, 1986, Certificate #217
`Certified in Pediatric Advance Life Support, January 19, 1996
`National Cancer Institute Investigator No. 5105
`
`' Abbreviated; full CV available upon request
`
`NEPTUNE GENERICS 1009- 00001
`
`APOTEX 1009-0001
`
`

`
`Archie Bleyer, M.D.
`
`Licensure
`Inactive
`Active
`
`States ofWashington (License 11608 1970-1990) and Texas (License H7391 1990-2007)
`State of Oregon, License No. MD26481 (since March 2006, emeritus after January 1, 2011)
`
`2 of31 pages
`
`EXPERIENCE/SERVICE
`
`Military
`Service
`
`July 1, 1971 -
`May 15, 1974
`
`United States Public Health Service, NIH, NCI, Bethesda, Maryland
`Surgeon (Lieutenant Commander)
`
`Academic
`Appointments:
`
`1975-1978
`
`1978-1983
`
`1979-1983
`
`1982-1990
`
`1983-1990
`
`1984-1990
`
`1990-1999
`
`1990-1999
`
`1990-2004
`
`2000-2004
`
`1996-1998
`1990-
`
`2005-
`
`2006-
`
`2007-
`
`2008-2015
`
`Assistant Professor of Pediatrics and Adjunct Assistant Professor of
`Medicine, University ofW ashington; Assistant Member,
`Fred Hutchinson Cancer Research Center, Seattle, Washington
`Associate Professor of Pediatrics and Adjunct Associate Professor of Medicine,
`University ofWashington; Associate Member, Fred Hutchinson Cancer
`Research Center, Seattle, Washington
`Adjunct Associate Professor of Radiation Oncology, University ofWashington,
`Seattle, Washington
`Director, Jennifer Sacco Research Laboratories, Children's Hospital and Medical
`Center, Seattle, Washington
`Professor of Pediatrics, University of Washington; Adjunct Professor of
`Medicine & Radiation Oncology, University ofWashington;
`Full Member, Fred Hutchinson Cancer Research Center; Seattle, Wash.
`American Cancer Society Professor of Clinical Oncology, University of
`Washington, Seattle, Washington
`Head, Division of Pediatrics, and Chair, Department of Pediatrics,
`The University of Texas M.D. Anderson Cancer Center, Houston, Texas
`Head, Division of Hematology/Oncology, Department of Pediatrics, The
`University of Texas Medical School, Houston, Texas
`Professor of Pediatrics, The University of Texas M. D. Anderson Cancer
`Center, Houston, Texas
`Director, Community Oncology, Division of Cancer Medicine, The University
`of Texas M.D. Anderson Cancer Center, Houston, Texas
`Instructor, ASCO/AACR Workshops on Clinical Trials, Vail, Colorado
`Professor of Pediatrics, The University of Texas School of Medicine -Houston,
`Texas
`Clinical Research Professor, Oregon Health and Science University, Portland,
`Oregon
`Chair, Data Safety Monitoring Committee, Blood Brain Barrier Consortium,
`Department of Neurosurgery, Oregon Health and Sciences University
`Senior Advisor and Health Services Research Collaborator, Cancer
`Medicine, Oregon Health and Science University
`www.ohsu.edu/ohsuedu/academic/som/radmedicine/news 10042007 .cfm
`Trainee Mentorships: Kristin Bingen, PhD, Assist. Prof. Pediatrics,
`Medical College of Wisconsin; Melissa Y. Carpentier, PhD, Indiana
`University School of Medicine; Jennifer McNeer, MD, Dept. Pediatrics,
`University of Chicago; Ally Gallagher, OHSU Medical Student; Kayo
`Nakata-Yamada, Assistant Section Chief, Center for Cancer Control and
`Statistics, Osaka Medical Center for Cancer and Cardiovascular Diseases;
`Frank Chien, Medical Student, Jefferson Medical College; Rebecca
`Johnson, MD, UW, Asst. Prof. Pediatrics, UW
`
`NEPTUNE GENERICS 1009-00002
`
`APOTEX 1 009 - 0002
`
`

`
`Archie Bleyer, M.D.
`
`Hospital
`Appointments:
`
`3 of31 pages
`
`1975-1990
`
`StaffPhysician, Children's Hospital and Medical Center, Seattle,
`Washington
`1995-2001 Medical Staff, Hermann Hospital, Houston, Texas
`1995-1997 Medical Staff, Northwest Texas Healthcare System, Amarillo, Texas
`2005-2011 Medical Director, Clinical Research, St. Charles Cancer Treatment Center,
`Bend, Oregon
`2006-2014 Chair, Institutional Review Board, St. Charles Health System,
`CentraliEastem Oregon
`
`Medical Society
`
`2006-2008 Member, Oregon Medical Association (OMA #27244)
`
`2015-2017 Member, Board ofDirectors
`Oregon Society
`of Medical Oncology
`
`HONORS AND A WARDS
`
`1969
`
`1969
`
`1969
`1971
`1975-1978
`1976-1979
`
`1978-1983
`1984-1990
`
`1990-2003
`
`1992
`
`1991-1992
`1992-2002
`1994
`
`1994
`
`1996
`1997
`1998
`1998
`1998-2001
`1998-2004
`1999
`2000
`
`2000
`
`2000
`2000
`2001
`
`M.D. "with honor and with distinction in research",
`University of Rochester School of Medicine and Dentistry
`Collier Prize for "compassionate and understanding care of the sick," University of Rochester
`School of Medicine and Dentistry
`Obstetrics-Gynecology Award for Scholarship, University of Rochester
`Resident's Prize, North Pacific Pediatric Society
`Junior Faculty Clinical Fellowship Award, American Cancer Society
`Faculty Development Award in Clinical Pharmacology, Pharmaceutical Manufacturers
`Association Foundation
`Scholar Award, Leukemia Society of America
`American Cancer Society Professor of Clinical Oncology,
`University ofWashington School of Medicine
`Mosbacher Pediatrics Chair,
`The University of Texas MD Anderson Cancer Center, Houston, Texas
`The Best Doctors in America 1992-1993
`Naifeh S, Smith GW, Woodward/White, Aiken, SC
`Chair-Elect, Childrens Cancer Study Group
`Chair, Children's Cancer Group
`The Best Doctors in America, 1994-1995
`Naifeh S, Smith GW, Woodward/White, Aiken, SC
`1st Place, International Health and Medical Film Festival, Category of Patient Care for
`"Mending Spirits: Children after Cancer" (Greichen L, ed.)
`Re-Elected Chair, Children's Cancer Group
`The Best Doctors in America: Central Region, 1996-1997 Woodward/White, Aiken, SC
`Mark E. Nesbit Lecturer, University of Minnesota
`Robert M. Heavenrich Lecturer, Michigan State University
`Faculty, ASCO/AACR Workshops on Clinical Trials, Vail, Colorado
`Top Doctors in Houston, Inside Houston, 1998, 2002
`Partners in Courage Award, American Cancer Society
`Amanda Toll Lecturer, Children's Hospital National Medical Center, Washington, District of
`Columbia
`Nitschke-Kaskaske Lecturer, University of Oklahoma Department of Pediatrics, Oklahoma
`City, Oklahoma
`Irene Lefton Memorial Lecture, North Shore University Hospital, Long Island, New York
`National Registry, Who's Who 2000 (Designated Life Member)
`Children's Oncology Group Legacy Award
`
`NEPTUNE GENERICS 1009-00003
`
`APOTEX 1 009 - 0003
`
`

`
`Archie Bleyer, M.D.
`
`4 of31 pages
`
`2001
`2001
`
`2001
`2001
`
`2001
`2002
`2003-2004
`
`2001-2005
`
`2004-2005
`2005
`
`2005
`2005
`2006
`2011
`2014
`
`2015
`2015
`
`Burkholder Lecture, Mountain States Tumor Institute, Boise, Idaho
`1st AFLAC Children's Cancer Center Visiting Professor, Children's Healthcare of Atlanta,
`Emory University and Egleston Children's Hospital, Atlanta
`lOth Felix Feldman Lecturer, Maimonides Medical Center, New York, New York
`5th Annual Henry and Eleanor Carlson Lecturer, University of South Dakota School of
`Medicine, Souix Falls, South Dakota
`Honored Member in America's Registry of Outstanding Doctors, 2000-2003
`21st Century Award for Achievement, International Biographical Centre, Cambridge, England
`Mosbacher Pediatrics Chair Emeritus,
`The University of Texas MD Anderson Cancer Center, Houston, Texas
`America's Top Doctors, Castle Connolly Guide, 2001, 2002,2003, 2004
`Only University of Texas MD. Anderson Cancer Center Pediatrician Listed
`America's Top Pediatricians, Consumers' Research Council of America, Washington D.C.
`Leading Health Professionals ofthe World, International Biographical Centre, Cambridge,
`England
`Living Wellness Award, The Wellness Community, Washington D.C.
`Melissa Living Legacy Foundation Award, Teens Living with Cancer
`Distinguished Career Award, American Society of Pediatric Hematology and Oncology
`Member Commitment Award, Live Strong Young Adult Alliance
`Dr. Archie Bleyer AYA Trailblazer Award, Critical Mass Young Adult Cancer Alliance,
`initiating annual awards
`Special Recognition Award, American Society of Clinical Oncology
`University of Rochester School of Medicine & Dentistry Distunguished Alumnus Award
`
`LECTURESHIPS AND VISITING PROFESSORSHIPS
`
`1984
`1985
`
`First James Whitcomb Riley Visiting Professor, Indiana University, Indianapolis, Indiana
`Jolm A Burns School of Medicine Visiting Professor, Department of Pediatrics, University of Hawaii, Honolulu,
`Hawaii
`Jennie? Memorial Lectureship, Royal Alexandra Hospital for Children, New South Wales, Australia
`1985?
`1986 Visiting Professor, University of North Carolina, Departments of Pediatrics and Pathology, Chapel Hill, North
`Carolina
`1986 Visiting Professor, Medical College of Georgia, Department of Pediatrics, Augusta, Georgia
`1986 Visiting Professor, Vanderbilt University, Departments of Neurology and Pediatrics, Nashville, Tennessee
`1986 Visiting Professor, Children's Hospital of Los Angeles, University of Southern California, Los Angeles
`1986 Visiting Professor, St. Louis University, Department of Pediatrics, St. Louis
`1986 Visiting Professor, University of Chicago School of Medicine, Departments of Medicine and Pediatrics, Wyler
`Children's Hospital, and Michael Reese Hospital and Medical Center, Chicago, Illinois
`1987 Visiting Professor, Ohio State University School of Medicine, Department of Pediatrics, Children's Hospital,
`Columbus, Ohio
`1987 Visiting Professor, University of Rochester Departments of Radiation Oncology & Pediatrics, Rochester, New York
`1987 Visiting Professor, University ofNijmegen, Institute of Pediatrics and Sint Radboud Hospital, Nijmegen,
`Netherlands
`1987 Visiting Professor, Dana Farber Cancer Institute, Departments of Medical Oncology and Pediatric Oncology, Boston
`1988 Visiting Professor, Lorna Linda University, Departments of Pediatrics and Neurosurgery, Lorna Linda, California
`1988
`Consultant and Seminar Participant, Preuss Foundation
`1989 Visiting Professor, Childrens Hospital of Orange County, Orange County, California
`1990 Visiting Professor, Johns Hopkins University, Johns Hopkins Cancer Center, Baltimore, Maryland
`1990 Visiting Professor, New York University Medical Center, Departments of Pediatrics and Medicine, New York, New
`York
`1990 Visiting Professor, Columbia River Oncology Program, Portland, Oregon
`1991 Visiting Professor, Orlando Regional Cancer Center, Orlando
`1991
`Lecturer, Tomorrow Children's Institute Continuing Education Course, Orlando
`1991 Visiting Professor, Department of Pediatrics, Stanford University Medical School, Palo Alto
`
`NEPTUNE GENERICS 1009-00004
`
`APOTEX 1 009 - 0004
`
`

`
`Archie Bleyer, M.D.
`
`5 of31 pages
`
`1991
`1991
`1991
`1991
`1992
`1992
`1993
`1993
`1993
`1993
`1993
`1994
`1998
`2000
`2000
`
`2001
`2001
`2001
`2004
`2004
`2005
`2005
`
`Visiting Professor, University oflrvine, California, Children's Medcial Research Foundation, Orange, California
`Visiting Professor, Mountain Valley Medical Center, Mountain Valley, California
`Visiting Professor, Children's Hospital of Northern California, Oakland
`Visiting Professor, Orlando Cancer Center and Arnold Palmer Hospital for Women and Children
`Visiting Professor, Yale University Medical Center, New Haven, Connecticut
`Consultant, University of Vermont Medical Center, Burlington
`Lecturer, Marshfield Clinic, Marshfield, Wisconsin
`Visiting Professor, University of Texas Southwestern Medical Center, Dallas, Texas
`Visiting Professor, Orlando Cancer Center and Arnold Palmer Childrens Hospital
`Extramural Advisory Committee, Duke University Comprehensive Cancer Center
`Extramural Advisory Committee, Duke University Comprehensive Cancer Center
`Visiting Professor, University of Iowa, Iowa City, Iowa
`Mark E. Nesbit Professor, University of Minnesota
`Nitschke-Kaskaske Visiting Professor, University of Oklahoma Department of Pediatrics, Oklahoma City, Oklahoma
`Visiting Professor, North Shore University Hospital, Schneider Children's Hospital, and Long Island Jewish
`Hospital, New York
`Burkholder Lecture, Mountain States Tumor Institute, Boise, Idaho
`lOth Felix Feldman Lecturer, Maimonides Medical Center, New York
`1st Aflac Children's Cancer Center Visiting Professor, Emory University, Atlanta
`Ludvina Knapp Memorial Lecturer, Children's Mercy Hospital, Kansas City, Kansas
`2nd Ronald L. Chard, Jr., Memorial Lecturer, Children's Hospital Regional Medical Center, Seattle
`Mayo Clinic Oncology Society Distinguished Speaker, Rochester, Minnesota
`Meet the Expert Survivorship Presenter, ASCO, 41st Annual Meeting, Orlando, Florida*
`
`[2006+
`2007
`2011
`2011
`2011
`2013
`
`2013
`2013
`
`2014
`2015
`
`Only special distinctions recorded]
`Inaugural Speaker: Katie Miller Young Adult Cancer Conference. Des Moines University, Des Moines, Iowa
`Keynote Speaker, Nordic/Baltic Pediatric Hematology-Oncology Organization (NOPHO), Torcu, Finland
`Keynote Speaker, Puerto Rico Hematology-Oncology Association
`Inaugural Speaker: Disney Family Cancer Center Adolescent and Young Adult Cancer Program, Burbank, California
`Inaugural Speaker: Angie Fowler Adolescent and Young Adult Clinic, University Hospital, Cleveland and Rainbow
`Babies Children's Hospital, Cleveland
`Founding Member, Critical Mass Young Adult Cancer Alliance
`Inaugural Speaker: David Stroud Adolescent and Young Adult Program, University of Southern California,
`Los Angeles
`Inaugural Speaker: Reid Sacco Adolescent and Young Adult Clinic, Tufts University Medical Center, Boston
`Elected to Board of Directors, Oregon Medical Oncology Society
`
`INSITUTIONAL SERVICE
`
`Academic Administrative Appointment/Responsibilities
`
`1975-1990 Children's Cancer Group (CCG): Chair, Low-Risk Acute Lymphoblastic Leukemia Study CCG-161
`1975-1978 Chair, VM-26 Phase II Study Committee, CCGt
`1976-1979 Children's Hospital and Medical Center (CHMC) Tumor Clinic: Associate Director
`1978-1982 Chair, Brain Tumor Strategy Group, CCG*
`1979-1982 CoEditor, Pharmacy Script, CHMC 0
`1980-1987 American Board of Pediatrics Sub-Board in Pediatric Hematology-Oncology
`1980-1984 Chair, Pharmacy and Therapeutics Committee, CHMC0
`1980-1989 Associate Chair, Leukemia and Lymphoma Studies, Children's Cancer Group
`1982-1986 Chair, Acute Lymphoblastic Leukemia Strategy Group, Children's Cancer Group
`1983-1990 Director, Jennifer Sacco Research Laboratories, CHMC0
`1985
`Co-Chair, Biennial Meeting, Professors of Clinical Oncology, American Cancer Society (ACS)
`
`'www.asco.org/ac/1, 1003,_12-0030 15,00.asp
`ICCG- Childrens Cancer Group
`CCHMC - Children's Hospital and Medical Center, Seattle, Washington
`
`NEPTUNE GENERICS 1009-00005
`
`APOTEX 1 009 - 0005
`
`

`
`Archie Bleyer, M.D.
`
`6 of31 pages
`
`1985-1987
`1986-1989
`1987-1991
`1988-1990
`1988-1989
`
`1989
`1989-1991
`1989-1991
`1989-1992
`1990
`1990-1996
`1990-1994
`1990-1992
`1991-1992
`1991-1992
`1991-1993
`1991-1994
`1992-1994
`1992
`
`1992-2002
`1993-1994
`1993
`1993-1999
`1994-1995
`1994-1999
`1994-1995
`
`1995
`1996
`1996-1997
`1997
`1997
`1998
`1998
`1999-2000
`1999
`2000-2005
`2000-2004
`2001-2008
`2001-2005
`2005-2013
`2005
`2003-2007
`2007-2008
`2006-2012
`2008
`2009
`2004-2013
`
`Chair, Professional Education Conunittee, Washington Division, ACS *
`Associate Chair, New Agents and Pharmacology Studies, Children's Cancer Group
`National Board of Directors, Medical Director-at-Large, ACSt
`Program Director, ACS Clinical Oncology Fellowship Training Program, CHMC2
`Chair, Neuropsychologic Sequelae after Pre-Irradiation Methotrexate in Childhood Acute Lymphoblastic
`Leukemia study CCG-Q881, Children's Cancer Group
`Chair and Co-Coordinator, International Symposium on Pediatric Neuro-Oncology, Premier Session, Seattle
`Vice-Chair, Task Force on Children and Cancer, ACSt
`Vice Chair, Children's Cancer Group
`Chair, Publications Conunittee, Children's Cancer Group
`Co-Coordinator, International Symposium on Pediatric Neuro-Oncology, Philadelphia
`Chair, Pediatric Facilities Planning Conunittee, University of Texas MD Anderson Cancer Center (UTMDACC)
`Chair, Pediatrics Reimbursement Conunittee, UTMDACC+
`Principal Investigator, Children's Cancer Group
`Chair-Elect, Children's Cancer Group
`Co-Chair, United Way Campaign, Patient Care, UTMDACC+
`Chair, Clinical Trainees Research Project Competition Subcommittee, UTMDACC+
`Chair, Texas Outreach Conunittee, Physician Referral Service, UTMDACCl
`Coordinator, International Symposium on Pediatric Neuro-Oncology, Houston
`Chair, Search Conunittee, Head, Division of Diagnostic Imaging (Departments of Diagnostic Radiology and
`Nuclear Medicine), UTMDACC+
`Chair, Children's Cancer Group
`Medical Advisory Board, PediatriCare America
`Chair, Data Monitoring Conunittee, Children's Cancer Group
`Chair, Research Conunittee, Physicians Referral Service, UTMDACC+
`Chair, Conscious Sedation Steering Conunittee, UTMDACC+
`Chair, Scientific Review Conunittee, Physicians Referral Service, UTMDACC
`Children's Cancer Group: Co-Chair, Long Range Planning Committee, National Childhood Cancer Foundation,
`Arcadia, California
`Coordinator and Co-Chair, U.S.-Japan Symposium on Pediatric Oncology, Nagoya
`Coordinator, International Symposium on Pediatric Neuro-Oncology, Washinton, D.C.
`Coordinator and Co-Chair, U.S.-Japan Symposium on Pediatric Oncology, Houston
`Re-Elected Chair, Children's Cancer Group
`Founder, Adolescent and Young Adult Oncology program, UTMDACCt
`Chair, Physician Referral Service Clinical Research Conunittee, UTMDACC
`Chair, Faculty Celebration Entertainment Subconunittee, UTMDACC
`Faculty Co-Chair, Faculty Celebration Conunittee, UTMDACC
`Chair, Physician Referral Service-Children's Art Project Patient-Oriented Research Conunittcc, UTMDACC
`Chair, Adolescent and Young Adult Conunittee, Children's Oncology Group (C.O.G.)
`Director, Community Clinical Oncology Program, UTMDACC
`Chair, International Collaboration and Foreign Membership Conunittee, Children's Oncology Group
`Chair, Data and Safety Monitoring Board, North American Brain Tumor Consortium
`Founding Member, Live Strong Young Adult Alliance
`Chair, International Society of Pediatric Oncology (SlOP) Adolescent and Young Adult Organizing Conunittee
`Chair, PlanetCancer+ Medical Advisory Board
`Chair, ASCO§ Patient Communication Subconunittee
`Associate Editor, Adolescent and Young Adult Oncology, Journal of Pediatric Hematology-Oncology
`Co-Chair, LiveSTRONG Young Adult Alliance Institutional Review Board (IRE) Conunittee
`President, Central Oregon Medical Society
`Director, Aflac/CureSearch Adolescent and Young Adult Cancer Research
`
`'ACS- American Cancer Society
`+ UTMDACC- The University of Texas M.D. Anderson Cancer Center
`IUTMDACC- The University of Texas M.D. Anderson Cancer Center
`!Internet-based support organization for young adults with cancer
`
`NEPTUNE GENERICS 1009-00006
`
`APOTEX 1 009 - 0006
`
`

`
`Archie Bleyer, M.D.
`
`7 of31 pages
`
`2011-2014
`2012-2014
`2012-2014
`2013-2014
`2010-2014
`2005-
`
`2010-
`
`Chair, Scientific Review Connnittee, St. Charles Health System, Central Oregon
`Co-Chair, Center for Disease Control Initative in Improving Enrollment of Adolescents on Cancer Clinital Trials
`Co-Chair, National Cancer Institute Adolescent and Young Adult Science Working Group on Epidemiology
`Member, St. Charles Health System Executive Values Analysis Connnittee
`Member, SARC Spore (NIH sarcoma grant) External Advisory Connnittee
`Oregon Health and Sciences University Data Safety Monitoring Board, Phase I and II Trials, Department of
`Neurosurgery
`Editorial Board, Journal of Adolescent and Young Adult Oncology
`
`Other Organizational Activities and Appointments/Responsibilities since 2000 *
`
`1998-2003
`2000-2002
`2000
`2000
`2001
`2001-2004
`2001-2002
`2001-2003
`2002-2003
`2002-2003
`2001-2004
`2002-2004
`2000
`2000
`2000-2006
`2000-2003
`2001-2004
`2001-2002
`2001-2002
`2001-2004
`2001-2002
`
`2002-2004
`2002-2005
`2003-2005
`2003-2004
`2003-2005
`2003-2006
`2004-2006
`2004-2005
`2005-2006
`2005-2006
`2005-2007
`2005-2008
`2005-2008
`2005-2008
`2007-2008
`2004-2009
`2005-2008
`2005-2007
`2001-2010
`
`National Dialogue on Cancer (President Bush Connnittee, currently known as C-Change)
`Convocation/Renaissance Connnittee, UTMDACC
`Special Emphasis Panel (Study Section), Cancer Control and Prevention, Division of Cancer Prevention, NCI
`Professional Liability Connnittee, UTMDACC
`Research Connnittee, Division of Pediatrics, UTMDACC
`Advisory Connnittee for Shared Resources, UTMDACC
`CORe Advisory Connnittee, UTMDACC
`Neurofibromatosis Research Group, UTMDACC
`Fellowship Applicant Interview Connnittee, Division of Cancer Medicine, UTMDACC
`Faculty Achievement Award- Clinical Research, UTMDACC
`Division of Cancer Medicine Executive Council, UTMDACC
`Cancer Center Support Grant Biostatistics Review Group, UTMDACC
`ASCO* I American Association for Cancer Research Methods in Clinical Cancer Research Program Connnittee
`Blue Ribbon Connnittee on Ascending Neuropathy After Intrathecal Chemotherapy Meeting, NCI and FDA
`Senior Consultant, International Consortium for Cure of Childhood Cancer in China (CURE)
`Special Emphasis Panel (Study Section), Cancer Control and Prevention, Division of Cancer Prevention, NCI
`Pediatrics Task Force, Cancer Education Connnittee, ASCOt
`Peer Review Connnittee, Children's Oncology Group
`Governance and Structure Task Force, ASCO
`Publications Connnittee, ASCO
`Scientific Advisory Board, The Effects of Radiotherapy on Brain and Behavior, Children's Hospital of
`Philadelphia and University of Pennsylvania
`Strategic Planning Subconnnittee, Publications Connnittee, ASCO
`Sarcoma Connnittee, Southwest Oncology Group
`Health Disparities Planning Connnittee, Texas Medical Center
`Roche Pediatric Advisory Board
`Neuropsychological, Cancer Control, and Chronic Disease Working Groups, Childhood Cancer Survivors Study
`Group Loop Professional Advisory Connnittee, The Wellness Community
`Pediatric Oncology Group of Ontario Research Unit Advisory Connnittee
`Lance Armstrong Foundation Grant Review Connnittee- Adolescent and Young Adult Programs
`Survivorship Task Force, ASCO*
`Editorial Board, ASCO* Clinical Cancer Advances 2006
`LiveStrong Young Adult Alliance Organzing Connnittee
`Young Survival Coalition Medical Education Symposium Planning Connnittee
`Cancer Communications Connnittee, ASCO*
`Advisory Board, Waiting Room Magazine: Cancer Uncensored; Changing the Way you See Cancer
`Robert Michael Educational Institute Clinical Advisory Board
`Medical Advisory Connnittee, Fertile Hope Foundation
`Roster of Cancer Experts, ASCOt
`ASCOt Patient Communication SubConnnittee
`Teenage Cancer Trust (United Kingdom) Steering Comittee
`
`*Full CV available upon request
`lASCO -Amercian Society ofClinical Oncology
`+ ASCO-American Society of Clinical Oncology
`
`NEPTUNE GENERICS 1009-00007
`
`APOTEX 1 009 - 0007
`
`

`
`Archie Bleyer, M.D.
`
`8 of31 pages
`
`2005-2009
`2007-2010
`2007-2012
`2005-2013
`2008-2014
`2011-2014
`2009-2015
`2001-
`2003-
`2004-
`2005-
`2006-
`2008-
`2008-
`2012-
`2012-
`
`Lance Annstrong Foundation Grant Review Committee- Survivorship Programs
`Founding Member, City Club of Central Oregon
`LiveStrong Young Adult Alliance Steering Committee
`Board of Directors, Tour des Chutes Foundation, Central Oregon
`Bioethics Committee, St Charles Medical Center
`Values Analysis Committee, St Charles Health System, Central Oregon
`Board of Directors, Cancer Adventures (www.canceradventures.org)
`Melissa's Living Legacy Teens Cancer Foundation Medical Advisory Board
`Young Survival Coalition* Medical Advisory Committee
`National Medical Advisory Board, I'm Too Young for Us Surivorship Foundation
`Young Adult Canada Cancer Medical Advisory Board (www.realtimecancer.org)
`National Professional Advisory Board, The Wellness Community
`First Descents Medical Advisory Board (www.firstdescents.org)
`Professional Advisory Board, Cancer Support Community
`Scientific Advisory Board, Cure Search for Children's Cancer
`Teen Cancer America Medical Advisory Group
`
`EDITORIAL BOARD and JOURNAL REVIEWER since 2010
`
`Editorial Boards: J Adol Young Adult Oncol
`Reviewer:
`NEJM
`Lancet
`JNCI
`J Clin Oncol
`
`JAMA
`British Medical J
`Cancer
`Medical Oncology
`
`Pediatr Blood Ca
`J Pediat Hem/Oncol
`J Ca Surv
`Intl J Oncol
`
`J Ca Epi Bio Prev
`Cancer Causes &
`Control
`Cancer Treat Rev
`Women's Health Issues
`
`RESEARCH GRANTS
`
`Extramural
`Grant Support
`
`Dr. Bleyer has received a total of $87,365,461 Direct Costs as the Principal
`Investigator of research grants, of which $75,743,461 was awarded by the NIH, $10,000,000
`was for a Texas statewide cancer early detection and prevention research progam, and
`$1,100,000 was for the M.D. Anderson Community Oncology Research Base.
`
`OTHER GRANTS since 2005
`
`2007-2010
`
`Principal Investigator, DEFEATcancer (www.DEFEATcancer,info)
`Lance Armstrong Foundation, $150,000
`
`PUBLICATIONS
`
`a. Articles in Peer Reviewed Journals
`
`1. Bleyer WA and Rosen MG. Meperidine-induced changes in the maternal and fetal electroencephalograms of the
`guinea pig. Electroenceph Clin Neurophysiol 24:249-58, 1968.
`2. Rosen MG, Bleyer WA. Bidirectional transfer of meperidine across the guinea pig placenta. Am J Obstet Gynec
`101:918-22, 1968.
`3. Bleyer WA, Au WY, Lange WA Sr, et al. Studies on the detection of adverse drug reactions in the newborn I.
`Fetal exposure to maternal medications. JAMA 213:2046-8, 1970.
`4. Bleyer WA, Breckenridge RT. Studies on the detection of the adverse drug reactions in the newborn. II. The effects of
`prenatal aspirinonnewbomhemostasis. JAMA 213:2049-53, 1970.
`
`*National organization for support of young women with or at high risk of breast cancer
`
`NEPTUNE GENERICS 1009-00008
`
`APOTEX 1 009 - 0008
`
`

`
`Archie Bleyer, M.D.
`
`2 of31 pages
`
`5. Bleyer WA, Hakami N, Shepard TH. The development of hemostasis in the human fetus and newborn. J Pediatr
`79:828-53, 1971.
`
`6. Bleyer WA, Marshall RE. Barbiturate withdrawal syndrome in a passively addicted infant. JAMA 221:185-6, 1972
`
`7. Graw RG, Yankee RA, Leventhal BG, et al. Bone marrow transplantation in acute leukemia employing
`cyclophosphamide. Exptl Hematol 22:118-25, 1972.
`
`8. Bleyer WA, Drake JC, Chabner BA. Neurotoxicity and elevated cerebrospinal-fluid methotrexate concentration in
`meningeal leukemia. N Eng/ J Med 289:770-4, 1973.
`
`9. Duttera MJ, Bleyer W A, Pomeroy TC, et al. Irradiation, methotrexate toxicity and the treatment of meningeal
`leukemia. Lancet 2:703-7, 1973.
`
`10. Yancy ST, Bleyer WA. Characteristics and response to certain cancer chemotherapeutic agents of an acute
`lymphocytic leukemia arising in a BALB/c x DBA/2 fl mouse. Cancer Research 34:1866-9, 197 4.
`
`11. Graw RG, Gralnick HR, Henderson ES, et al. Bone marrow transplantation following combination chemotherapy
`immunosuppression (B.A.C.T.) in patients with acute leukemia. Transpl Proc 6:349-54, 1974.
`
`12.
`
`Jacobs SA, Bleyer WA, Chabner BA, Johns DG. Altered plasma pharmacokinetics of methotrexate administered
`intrathecally. Lancet 1:455-6, 1975.
`
`13. Bleyer WA, Blaese RM, Bujak JS, Herzig GP, Graw RG, Jr. Long-term remission from acute myelogenous
`leukemia after bone marrow transplantation and recovery from acute graft-versus-host reaction and prolonged
`immuno-incompetence. Blood 45:171-81, 1975.
`
`14. Bleyer W A, Frisby SA, Oliverio VT. The uptake and binding of vincristine by murine leukemia cells.
`Biochem Pharm 24:633-9, 1975.
`
`15. Bender RA, Bleyer WA, Frisby SA, Oliverio VT. Alteration of methotrexate uptake in human leukemia cells by
`other drugs. Cancer Res 35:1305-8, 1975.
`
`16. Dedrick RL, Zaharko D, Bender RA, Bleyer WA and Lutz RJ. Pharmacokinetic considerations on resistance to
`anticancer drugs. Cancer Chemother Rep 59:795-804, 1975.
`
`17. Waalkes P, BleyerWA, Jacobs SA, et al. Potential biochemical markers in Burkitt's lymphoma.
`Cancer Chemother Rep 59:721-7, 1975.
`
`18. Bleyer WA. Surveillance of pediatric adverse drug reactions- a neglected health care problem. Pediatrics 55:308-
`10, 1975.
`
`19. Pizzo P A, Bleyer WA, Pop lack DB, Leventhal BG. Reversible dementia temporally associated with intraventricular
`therapy with methotrexate in a child with acute myelogenous leukemia. J Pediatr 88:131-3, 1976.
`
`20. DiChiro G, Hammock K, Bleyer WA. Spinal descent of cerebrospinal fluid in man. Neurology 26:1-8, 1976.
`
`21. Bleyer W A, Skinner AL. Fatal perinatal hemorrhage after maternal anticonvulsant therapy. JAMA 23 5:626-7,
`1976.
`
`22. Gutin PH, Green, MR, Bleyer WA, Bauer VL, Wiem.ik PH, Walker MD. Methotrexate pneumonitis induced by
`intrathecal methotrexate therapy. A case report withpharmacokinetic data. Cancer 38:1529-34, 1976.
`
`23. Bender RA, Bleyer W A, Drake JC, Ziegler JL. In vitro correlates of clinical response to methotrexate in acute
`leukemia and Burkitt's lymphoma. Br J Cancer 34:484-92, 1976.
`
`24. Wood JH, Poplack DG, Bleyer WA, Onnnaya AK. Primate model for the chronic study ofintraventricularly- or
`intrathecally-administered drugs and intracranial pressure. Science 195:499-501, 1977.
`
`25. Davis RF, Eichner JM, Bleyer WA, Okamoto G. Hypocalcemia, hyperphosphatemia and dehydration following a
`single hypertonic phosphate enema. J Pediatr 90:484-5, 1977.
`
`26. Pop lack DG, Bleyer WA, Wood JH, Kostolich M, Savitch JL, Ommaya AK. A primate model for study of
`methotrexate pharmacokinetics in the central nervous system. Cancer Res 37:1982-5, 1977.
`
`27. Bleyer WA, Dedrick RL. The clinical pharmacology of intrathecal methotrexate. 1. Distribution kinetics in
`nontoxic patients after lumbar injection. Cancer Treat Rep 61:703-8, 1977.
`
`28. Bleyer WA. Methotrexate: clinical pharmacology, current status and therapeutic guidelines. Cancer Treatment Rev
`4:87-101, 1977.
`
`NEPTUNE GENERICS 1009-00009
`
`APOTEX 1 009 - 0009
`
`

`
`Archie Bleyer, M.D.
`
`3 of31 pages
`
`29. Bleyer WA. Current status of intrathecal chemotherapy for human meningeal neoplasms. Natl Cancer Jnst Monogr
`46:171-8, 1977.
`
`30. Griffin TW, Rasey JS, Bleyer WA. The effect of photon irradiation on blood-brain barrier permeability to
`methotrexate in mice. Cancer 40:1109-11, 1977.
`
`31. Bleyer WA. Clinical pharmacology of intrathecal methotrexate. 2. An improved dosage regimen derived from age(cid:173)
`related pharmacokinetics. Cancer Treat Rep 61:1419-25, 1977.
`
`32. Hammond GD, Bleyer WA, Hartmann JR, Hays DM, Jenkin RDT. Perspectives in pediatric oncology. Cancer
`41:29-35, 1978.
`
`3