DAVID P. ROTELLA, Ph.D.
`Margaret & Herman Sokol Professor of Medicinal Chemistry
`Department of Chemistry & Biochemistry
`Montclair State University
`1 Normal Avenue
`
`Montclair NJ 07043
`Voice: 973-655-7204
`Fax: 973-655-7772
`
`Email: rotellad@mail.montclair.edu
`
`Summary of Accomplishments:
`
`Montclair State University-Obtained $2.5MM, 5 year drug discovery research grant from
`Defense Threat Reduction Agency and an additional $300K in pharmaceutical industry research
`funding in three years.
`Wyeth Research-led chemistry teams in CNS drug discovery projects and key leader for
`collaboration with Solvay Pharmaceuticals. Delivered a clinical candidate, managed chemists in
`group that delivered another.
`Lexicon Pharmaceuticals- Beginning from a screening hit, in less than one year, led project
`team that identified potent, selective, orally bioavailable inhibitors of PDE7A.
`Bristol-Myers Squibb-First to publish the discovery of novel phosphodiesterase type 5 inhibitors
`with better in vitro potency and selectivity compared to sildenafil. Contributed to discovery of 2
`clinical candidates (PDE5 inhibitor, DPP4 inhibitor).
`Cephalon—Responsible for initial conception and development of several programs. Key leader in
`collaborations with Kyowa Hakko and Schering Plough. Discovered CEP 1347, which advanced
`to phase III trials for Parkinson’s Disease.
`
`Experience:
`
`Montclair State University July 2011-present
`Margaret and Herman Sokol Professor of Chemistry, Department of Chemistry and Biochemistry;
`joint appointment in Sokol Institute of Pharmaceutical Life Sciences
`Independent Consultant, February 2010-present
`Established consulting agreements with pharmaceutical companies and law firms to advance drug
`discovery programs and provide expert information on selected topics in drug development
`Wyeth Research/Pfizer, 2005-February 2010
`Principal Research Scientist III, chemistry team leader. Directed up to 20 chemists. Member of
`Princeton Chemical Science leadership team.
`
`Lexicon Pharmaceuticals, 2003-2005
`Senior Group Leader, responsible for multiple drug discovery programs. Directed up to 18 FTES
`with 4 direct reports. Member of department leadership team.
`
`Bristol-Myers Squibb PRI, 1997-2003
`Principal Scientist, cardiovascular and metabolic disease drug discovery
`Cephalon, Incorporated, 1991-1997
`Group Leader, CNS and cancer drug discovery.
`
`School of Pharmacy, University of Mississippi
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`Assistant Professor, Department of Pharmacognosy 1987-1991
`Adjunct Professor, Department of Medicinal Chemistry, 2009-present
`• School of Pharmacy, University of Pittsburgh, 2010-present
`Adjunct Professor, Department of Pharmaceutical Sciences
`• Center for Drug Discovery, Northeastern University, 2010-present
`Adjunct Professor
`• Registered pharmacist, Pennsylvania, 1981-1991, 2010-present
`
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`Education:
`• Postdoctoral Scholar, Department of Chemistry, The Pennsylvania State University,
`1985-1987, under the direction of Prof. K. S. Feldman.
`• Ph.D. Medicinal Chemistry, The Ohio State University, 1985, under the direction of Prof.
`D. T. Witiak.
`• B.S. Pharm., Magna cum laude, School of Pharmacy, University of Pittsburgh, April
`1981.
`
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`Professional Service:
`
` American Chemical Society, Organic and Medicinal Chemistry Divisions
`Fellow, Royal Society of Chemistry
`
`Division of Medicinal Chemistry, American Chemical Society:
`• Five year term as Vice Chair/Long Range Planning Committee chair, Program Chair,
`Chair and past Chair (2004-2008). These roles required leadership and collaborative
`interactions nationally and internationally.
`• Three year term as academic councilor (2012-2014)
`• Treasurer, 2015-2017
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`Gordon Research Conference on Medicinal Chemistry
`• 2012 vice chair elect
`• 2013 vice chair
`• 2014 chair
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`Co-editor, 3rd edition, Comprehensive Medicinal Chemistry 2014-present
`
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`Co-editor, 7th edition, Burger’s Medicinal Chemistry 2007-present
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`Senior Editor, Royal Society of Chemistry series on Drug Discovery, 2008-present
`
`Co-editor, “Successful Drug Discovery”, (2014), Wiley VCH
`
`Co-editor, “Analogue-Based Drug Discovery”, volume 3, (2012), Wiley VCH
`
`Program co-chair, National Medicinal Chemistry Symposium (2010)
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`Scientific Advisory Board National Medicinal Chemistry Symposium (2014)
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`Scientific Advisory Board Frontiers in Medicinal Chemistry 2014-2015
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`Organizer and conference co-chair for “Frontiers in CNS and Oncology Medicinal Chemistry”,
`Siena, Italy, October 7-9, 2007, jointly organized with European Federation for Medicinal
`Chemistry.
`
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`Current Research Funding:
`
`
`• Discovery of Novel Botulinum Toxin Protease A Inhibitors, 9/29/14-9/28/19, $2.5MM,
`Defense Threat Reduction Agency
`• Protein Kinase Inhibitors for Parasitic Diseases, 3/1/14-2/28/15, $90,000, Celgene
`Corporation
`• Research Support, 9/1/11-8/31/16, $50,000 annually, Margaret and Herman Sokol
`Endowment
`
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`Past Research Funding:
`
`
`• Protein Kinase Inhibitors for Parasitic Diseases, 3/1/13-2/28/14, $115,000, Celgene
`Corporation
`• Protein Kinase Inhibitors for Parasitic Diseases, 3/1/12-2/28/13, $90,000, Celgene
`Corporation
`• Purchase of LCMS, 10/1/13, $70,000, Shimadzu Corporation
`• Lactam Inhibitors of Phospholipase A2, 7/1/88-6/30/90, direct costs $25,000, Mississippi
`Affiliate, American Heart Association
`• Novel Calmodulin Inhibitors, 7/1/89-6/30/91, direct costs $35,000, Elsa U Pardee Foundation
`• Phospholipase A2 Inhibitors as Novel Anti-inflammatory Agents, 7/1/89-6/30/91, direct costs
`$200,000, American Lung Association
`
`
`Publications:
`
`1. "Stereocontrolled Syntheses for the Six Diasteromeric 1,2-Dihydroxy-4,5-
`Diaminocyclohexanes: Pt(ll) Complexes and P388 Antitumor Properties", Donald T. Witiak,
`David P. Rotella, Joyce A. Filppi, and Judith Galucci, J. Med. Chem. 30, 1327 (1987).
`
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`2. "Synthesis and P-388 Antitumor Properties of the Four Diastereomeric Dichloro 1-Hydroxy-3,4-
`diaminocyclohexane Pt(II) Complexes" , Donald T. Witiak, David P. Rotella, Yong Wei, Joyce A. Filppi
`and Judith C. Gallucci J. Med. Chem. 32, 214 (1989).
`
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`3. "Mechanistic and Preparative Studies of the Intramolecular Photocyclization of Methylated 2-(4-
`Pentenyl)tropones", Ken S. Feldman, Jon H. Come, Benedict J. Kosmider, Pamela M. Smith, David P.
`Rotella and Ming-Jung Wu, J. Org. Chem. 54, 592 (1989).
`
`4. "Homoallylically Controlled Epoxidation of D 4-cis-1,2-Disubstituted Cyclohexenes", David P.
`Rotella, Tetrahedron Letters, 1913 (1989).
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`g -Butyrolactone
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`5. "Application of an Intramolecular Tropone-Alkene Photocyclization to the Total Synthesis of (±)
`Dactylol", Ken S. Feldman, Ming-Jung Wu and David P. Rotella, J. Am. Chem. Soc. 111, 6457 (1989).
`
`6. ”Chloroperoxidase Mediated Halogenation of Phenols", Cheryl F. Wannstedt, David P. Rotella and
`Jerome F. Siuda, Bull. Contamin. Environ. Toxicol. 44, 282 (1990).
`
`7. "Stereocontrolled Iodolactonization of Erythro and Threo Tertiary Amides", David P. Rotella and
`Xun Li, Heterocycles 31, 1205 (1990).
`
`8. "The Total Synthesis of (±) Dactylol and Related Studies", Ken S. Feldman, Ming-Jung Wu and
`David P. Rotella, J. Am. Chem. Soc. 112, 8490 (1990).
`
` "Synthesis and Structural Analysis of Stereospecific 3,4,5-Trisubstituted
`9.
`Phospholipids", Xun Li and David P. Rotella, Lipids 29, 211-224 (1994).
`
`10. "The Effect of Pyrrolo[3,4-c]Carbazole Derivatives on Spinal Cord ChAT Activity" David P.
`Rotella, Marcie A. Glicksman, J. Eric Prantner, Nicola Neff and Robert L Hudkins, Bioorganic and
`Medicinal Chemistry Letters. 5,1167-1170 (1995).
`
`11. "Microbial Metabolites of Ophiobolin A and Antimicrobial Evaluation of Ophiobolins", Erguang
`Li, Alice M. Clark, David P. Rotella and Charles D. Hufford, J. Nat. Products 58, 74-81, (1995).
`
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`12. "Stereoselective Synthesis of Erythro a -Amino Epoxides" David P. Rotella, Tetrahedron Letters
`35, 5453-5456 (1995).
`
`13. "Genesis and Degradation of Ab
` Protein by Cultured Human Neuroblastoma Cells", Robert Siman,
`John T. Durkin, E. Jean Husten, Mary J. Savage, Seetha Murthy, Suzanne Mistretta, David P. Rotella,
`Sankar Chatterjee, Bruce Dembofsky, Roger Poorman and Barry D. Greenberg, Recent Advances in
`Alzheimer's Disease and Related Disorders, John Wiley and Sons (1995).
`
`14. “Facile Lewis Acid-Mediated Ring Opening of 4-Hydroxypyrrolidin-2-ones by Amino Acid Esters”,
`David P. Rotella, Synlett, 479-480 (1996).
`
`15. “Solid Phase Synthesis of Olefin and Hydroxyethylene Peptidomimetics”, David P. Rotella, J. Am.
`Chem. Soc. 118, 12246-12247 (1996).
`
`16. "Neurotrophic 3,9-Bis[(alkylthio)methyl]- and -Bis(alkoxymethyl)-K-252a Derivatives", Masami
`Kaneko, Yutaka Saito, Hiromitsu Saito, Tadashi Matsumoto, Yuzuru Matsuda, Jeffry L. Vaught, Craig
`A. Dionne, Thelma S. Angeles, Marcie A. Glicksman, Nicola T. Neff, David P. Rotella, James C. Kauer,
`John P. Mallamo, Robert L. Hudkins, Chikara Murakata, J. Med. Chem. 40, 1863-1869 (1997).
`
`17. “An Update on COX-2 and Farnesyltransferase Inhibitor Development”, David P. Rotella, Curr.
`Opin. Drug Discovery and Development, 1, 165-174 (1998).
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`18. “Rank-Order of Potencies for Inhibition of the Secretion of Ab 40 and Ab 42 Suggests that Both are
`Generated by a Single g -Secretase”, John T. Durkin, Seetha Murthy, E. Jean Husten, Stephen P. Trusko,
`Mary J. Savage, David P. Rotella, Barry D. Greenberg and Robert Siman, J. Biol. Chem. 274, 20499-
`20504 (1999).
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`19. “N-3 Substituted Imidazaquinazolinones: Potent and Selective PDE5 Inhibitors as Potential Agents
`for Treatment of Erectile Dysfunction” David P. Rotella, Yeheng Zhu, Zhong Sun, John Krupinski,
`Ronald Pongrac, Laurie Seliger, Diane Normandin, John E. Macor, J. Med. Chem. 43, 1257-1263
`(2000).
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`20. “Optimization of Substituted N-3-Benzyl Imidazoquinazolinone Sulfonamides as Potent and
`Selective PDE5 Inhibitors” David P. Rotella, Yeheng Zhu, Zhong Sun, John Krupinski, Ronald Pongrac,
`Laurie Seliger, Diane Normandin, John E. Macor, J. Med. Chem. 43, 5037-5043 (2000).
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`21. “Phosphodiesterase 5 Inhibitors: Discovery and Therapeutic Utility”, David P. Rotella, Drugs of the
`Future 26, 153-162 (2001).
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`22. “Osteoporosis: Challenges and New Opportunities for Therapy”, Curr. Opin. In Drug Discovery
`and Development 5, 477-486 (2002).
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`23. “Phosphodiesterase Type 5 Inhibitors: Current Status and Potential Applications”, Nature Reviews
`Drug Discovery 1, 674-683 (2002).
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`24.
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`25. “SB-480848. GlaxoSmithKline”, Curr. Opin. Invest. Drugs 5, 348-351 (2004).
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`26. “Novel Second Generation Approaches for the Control of Type 2 Diabetes”, J. Med. Chem. 47,
`4111-4112 (2004).
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`“Tadalafil (Lilly/ICOS)”, Curr. Opin. Invest. Drugs 4, 60-65 (2003).
`
`2-Benzylpyrrolidine-Substituted
`of
`and Structure Activity Relationships
`“Discovery
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`Aryloxypropanols as Calcium-Sensing Receptor Antagonists”, Wu Yang, Yufeng Wang, Jacques
`Roberge, Zhengping Pa, Yalei Yu, David P. Rotella, Ramakrishna Seethala, R. Michael Lawrence, Jean
`H. M. Feyen, John K. Dickson, Bioorg. Med. Chem. Lett. 15,1225-1228 (2005).
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`28. “Phosphodiesterase Inhibitors: Potential CNS Applications”, Nicholas J. Brandon, David P. Rotella,
`Annual Reports in Medicinal Chemistry, 42, 3-12 (2007)
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`29.
`“Potent Non-nitrile Dipeptidic Dipeptidyl Peptidase IV Inhibitors”, Ligaya M. Simpkins, Scott
`Bolton, Zulan Pi, James C. Sutton, Chet Kwon, Guohua Zhao, David R. Magnin, David J. Augeri, Timur
`Gungor, David P. Rotella, Zhong Sun, Yajun Liu, William S. Slusarchyk, Jovita Marcinkeviciene, James
`G. Robertson, Aiying Wang, Jeffrey A. Robl, Karnail S. Atwal, Robert Zahler, Rex A. Parker, Mark S.
`Kirby, Lawrence G. Hamann, Bioorg. Med. Chem. Lett. 17, 6476-6480 (2007).
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`30.
`“Alzheimer’s Disease: A Light at the End of the Tunnel?”, Albert J. Robichaud, David P. Rotella,
`Drug. Development Res. 2009, 70, 57-59.
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`31. “Tetrahydrocarbazole-based Serotonin Reuptake Inhibitors/Dopamine D2 Partial Agonists for the
`Potential Treatment of Schizophrenia”, David P. Rotella, Geraldine R. McFarlane, Alexander Greenfield,
`Cristina Grosanu, Albert J. Robichaud, Rajiah Aldrin Denny, Rolf W. Feenstra, Sara Núñez-García, Jan-
`Hendrik Reinders, Martina van der Neut, Andrew McCreary, Chris G. Kruse, Kelly Sullivan, Farhana
`Pruthi, Margaret Lai, Jean Zhang, Dianne M. Kowal, Tikva Carrick, Steven M. Grauer, Rachel L.
`Navarra, Radka Graf, Julie Brennan, Karen L. Marquis, Mark H. Pausch, Bioorg. Med. Chem. Lett. 2009,
`19, 5552-5555.
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`32.
`“WS-50030 [7-{4-[3-(1H-inden-3-yl)propyl]piperazin-1-yl}-1,3-benzoxazol-2(3H)-one]: A Novel
`Dopamine Receptor Partial Agonist/Serotonin Reuptake Inhibitor with Preclinical Antipsychotic-Like
`and Antidepressant-Like Activity”, Julie A. Brennan, Karen L. Marquis, Mark H. Pausch, Chad E. Beyer,
`Zoe Hughes, Radka Graf, Steven Grauer, Qian Lin, Sharon Rosenzweig-Lipson, Farhana Pruthi,
`Claudine Pulicicchio, David P. Rotella, Albert J. Robichaud, Deborah L. Smith, Rolf Feenstra, Chris G.
`Kruse, Andrew McCreary, Pierre Broqua, Wouter Grotier, Martina van der Neut, J. Pharmacol. Exp.
`Ther. 2010, 332, 190-201.
`
`33.
`“Potent Dihydroisoquinolone-Based Dopamine D2 Partial Agonist/Serotonin Reuptake Inhibitors
`for Treatment of Schizophrenia”, Yinfa Yan, Ping Zhou, David P. Rotella, Rolf Feenstra, Chris G. Kruse,
`Martina van der Neut, Jan-Hendrik Reinders, Farhana Pruthi, Dianne Kowal, Tikva Carrick, Margaret
`Lai, Karen L. Marquis, Mark H. Pausch, Albert J. Robichaud, Bioorg. Med. Chem. Lett. 2010, 20, 2983-
`2986.
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`34.
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`“Drug Discovery 2012 and Beyond”, David P. Rotella, ACS Med. Chem. Lett. 2012, 3, 172-174.
`
`35.
`“Recent Results on Protein Kinase Inhibition for Tropical Diseases”, David P. Rotella, Bioorg.
`Med.Chem. Lett. 2012, 22, 6788-6793.
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`36.
`“Discovery and Development of Boceprevir”, David P. Rotella, Expert Opin. Drug Discovery
`2013, 8, 1-9.
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`37.
`“The Spectral Properties of (-)-Epigallocatechin-3-O-Gallate (EGCG) Fluorescence in Different
`Solvents: Dependence on Solvent Polarity”, Vladislav Snitsarev, Michael N. Young, Ross M. S. Miller,
`David P. Rotella, PLoS One, 2013, 8(11) e79834.
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`38.
`“Toward the Discovery of Drug Like Epigallocatechin Gallate Analogs as Hsp90 Inhibitors”, Rohit
`Bhat, Amna Adam, Jungeun Jasmine Lee, Ellen C. Henry, Thomas A. Gasiewicz, David P. Rotella,
`Bioorg. Med. Chem. Lett. 2014, 24, 2263-2266.
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`39.
`“Structure-activity Studies of (-)-Epigallocatechin Gallate Derivatives as HCV Entry
`Inhibitors” Rohit Bhat, Amna Adam, Jungeun Jasmine Lee, Gaspard Deloison, Yves Rouillé,
`Karin Séron, David P. Rotella, Bioorg. Med. Chem. Lett. 2014, 24, 4162-4165.
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`40.
`“Progress in the Discovery and Development of Hsp90 Inhibitors”, Rohit Bhat, Sreedhar
`Reddy Tummalapalli, David P. Rotella, invited perspective J. Med. Chem. 2014, 57, 8718-8728.
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`Patents:
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`1. "Diastereomeric Mono- and Di-Substituted Diaminocyclohexane Compounds and Methods of
`Preparation Thereof" Donald T. Witiak and David P. Rotella, US 5,206,400.
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`2. "K252a Functional Derivatives Potentiate Neurotrophin-3 Activity for the Treatment of Neurological
`Disorders" Marcie A. Glicksman, Robert L. Hudkins, David P. Rotella, Nicola Neff and Chikara
`Murakata, US 5,468,872.
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`3. “K252 Derivatives Which Enhance Neurotrophin-Induced Activity” Marcie A. Glicksman, Robert L.
`Hudkins, David P. Rotella, Nicola Neff and Chikara Murakata, US 5,516,772.
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`4. “Quinazolinone Inhibitors of cGMP Phosphodiesterase”, David P. Rotella, John E. Macor, David
`Cushman, Joseph Yevich, US 6,087,368
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`5. “Quinoline Inhibitors of cGMP Phosphodiesterase”, Yingzhi Bi, David P. Rotella, Guixue Yu, John
`E. Macor, US 7,378,430 .
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`6. “2-Substituted cyclic amines as calcium sensing receptor modulators”, Ashvinikumar Gavai, Roy J.
`Vaz, John K. Dickson, Jacques Y. Roberge, Wu Wang, Timur Gungor, James R. Corte, David P.
`Rotella, Yufeng Wang, Wu Yang, US 7,105,537.
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`7. “Preparation of substituted piperidines and pyrrolidines as calcium sensing receptor modulators”,
`John K. Dickson, Michael R. Lawrence, Jacques Y. Roberge, David P. Rotella, Wu Yang, US
`7,265,145.
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`Book Chapters:
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`“Recent Results in Phosphodiesterase Inhibitor Development and CNS Applications”,“Cyclic-
`Nucleotide Phosphodiesterases in the Central Nervous System: From Biology to Drug
`Discovery”, John Wiley and Sons, 2014 115-144, Anthony West, Nicholas J. Brandon, editors.
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`“Monoaminergic Targets for Treatment of Schizophrenia”, “New Approaches to Psychiatric Drug
`Discovery”, Royal Society of Chemistry Press, 2012, 33-47, Zoran Rankovic, editor.
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`“Pioneer and Analogue Drugs”, “Analogue-based Drug Discovery”, volume 3, Wiley VCH, 2012,
`3-18, edited by Janos Fischer, C. Robin Ganellin, David P. Rotella
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`“SSRIs” David P. Rotella and Wayne E. Childers, “Analogue-Based Drug Discovery, volume 2,
`Wiley-VCH, 2010, 269-296, Janos Fischer and Robin Ganellin, editors.
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`“Medicinal Chemistry Challenges in the Discovery of Novel Antidepressants”, “Next Generation
`Antidepressants”, 2010, 102-118, Cambridge University Press, Chad E. Beyer, Stephen M. Stahl,
`editors.
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`“Drug Discovery for Non-Life Threatening Disorders”, “Burger’s Medicinal Chemistry”, volume
`5, 7th edition, John Wiley and Sons, 2010, 711-728, Donald J. Abraham and David P. Rotella, co-
`editors.
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`“Phosphodiesterase Enzymes, Inhibitors and Therapeutic Applications” “Comprehensive
`Medicinal Chemistry II” Elsevier Science, 2006, 919-957, Walter H. Moos editor.
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`Abstracts and Presentations:
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`“A Natural Product Template for Medicinal Chemistry” Merck Research Laboratories,
`Kenilworth NJ, March 2014.
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`“Progress Toward the Identification of Drug-Like Hsp90 Inhibitors based on (-)-Epigallocatechin
`Gallate”, Department of Medicinal Chemistry, University of Illinois at Chicago, October 2013.
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`“Design, Synthesis and Use of Novel Diamine Templates in Medicinal Chemistry” Eli Lilly
`Research Laboratories, May 2013.
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`“Structure-activity Relationships of Novel Inhibitors of the Brugia malayi Stress-activated
`Protein Kinase, Bm-MPK1” David P. Rotella, Sreedhar R. Tummalapalli, Agnieska Chojnowski,
`Tamara W. Kreiss, Deborah S. Mortensen, Veronique Plantevin, Stacie Canan, Vikram Khetani,
`Jerome B. Zeldis, Ronald Goldberg, John Siekierka, poster presentation American Society of
`Tropical Medicine and Health national meeting, Washington DC November 5, 2013.
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`“Novel inhibitors of the Brugia malayi stress-activated protein kinase, Bm-MPK1”, Mortensen
`DS, Khetani V, Satoh Y, Cathers B, Canan S, Zeldis J, Chojnowski AN, Patel A, Goldberg R,
`Rotella D, Siekierka J. poster presentation American Society of Tropical Medicine and Hygiene
`national meeting, Atlanta, GA, November 11-15, 2012.
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`“Antipsychotic-like profile of WS-50030, a combined partial D2 receptor agonist and selective
`serotonin reuptake inhibitor”, Julie Brennan, Karen Marquis, Claudine Pulichiccio, Mark Pausch,
`Steven Grauer, David P. Rotella, Rolf Feenstra, Andrew McCreary, poster presentation, Society
`for Neuroscience meeting 2008, Washington DC, November 2008.
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`“PDE5 Inhibitors: Comparison of Current Agents and Future Prospects”, David P. Rotella, 2nd
`Annual Phosphodiesterases in Drug Discovery and Development, November 8-9, 2004.
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`“Phosphodiesterase Type 5 Inhibitors: Is There Room for More?” David P. Rotella, American
`Society of Andrology 29th National Meeting, April 18, 2004.
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`“Effects of the M3 antagonist, darafenicin, on food intake and body weight in two models
`of obesity.” M.J. Cullen, M.A. Pelleymounter, D. Rotella, K Carlson and K. Behnia,
`Keystone Symposium: Obesity: New Insights into Pathogenesis and Treatment,
`Keystone, CO, January 21-26, 2003.
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`“Discovery and Optimization of PDE5 Inhibitors” David P. Rotella, Zhong Sun, Yeheng Zhu,
`Laurie Seliger, Ronald Pongrac, Diane Normandin, John Krupinski, John E. Macor, 220th
`National American Chemical Society Meeting, Washington DC, August 21-24, 2000, MEDI 322.
`
`"Neurotrophic Derivatives of K252A. Profile of CEP 1347/KT7515 and SAR of Survival
`Promoting Analogs", Chikara Murakata, Masami Kanedo, Yuzuru Matsuda, Hiromitsu Saito,
`Yutaka Saito, Eriko Tanaka, Tatsuya Tamaoki, Tadashi Matsumoto, James C. Kauer, Robert L.
`Hudkins, David P. Rotella, Marcie A. Glicksman, Michael Saporito, Susan Carswell, Forrest
`Haun, Ernest Knight, Jr., Craig Dionne, Nicola T. Neff, Jeffry L. Vaught and John P. Mallamo,
`212th National American Chemical Society Meeting, August 25-29, 1996, Orlando, FL, MEDI
`211.
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`"Potent and Selective Neurotrophic Derivatives of K252a", John P. Mallamo, James C. Kauer,
`Robert L. Hudkins, David P. Rotella, Marcie A. Glicksman, Michael Saporito, Susan Carswell,
`Forrest Haun, Ernest Knight, Jr., Nicola T. Neff, Jeffry L. Vaught, Chikara Murakata and Masami
`Kaneko, Second Symposium on Medicinal Chemistry Approaches to Alzheimer's Disease,
`August 28-30 1995, Strasbourg, France.
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`"Neurotrophic Structure Activity Relationships for Potent and Selective Derivatives of K252a",
`Robert L. Hudkins, Chikara Murakata, Masami Kaneko, Yuzuru Matsuda, David P. Rotella,
`Craig A. Dionne, Ernest Knight, Jr., Marcie A. Glicksman, Nicola T. Neff and John P. Mallamo,
`Second Symposium on Medicinal Chemistry Approaches to Alzheimer's Disease, August 28-30
`1995, Strasbourg, France.
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`"Carbazole and Carboline Derivatives of K252C as Potential Small Molecule Neurotrophic
`Agents", David P. Rotella, Marcie A. Glicksman, J. Eric Prantner and Robert L. Hudkins, First
`Annual Medicinal and Bioorganic Chemistry Conference, Steamboat Springs Colorado, January
`29-February 2, 1995.
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`"The Effect of Hydroxyl Protection on Stereochemistry and Stereocontrol During Amide
`Iodolactonization" David P. Rotella, 202nd National Meeting of the American Chemical Society,
`August 25-30, 1991, New York, NY, ORGN 258.
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`"Conformationally Restricted Substrate Analogues as Potential Phospholipase A2 Inhibitors"
`David P. Rotella, Xun Li and John K. Baker, Fifth Annual National Meeting of the American
`Association of Pharmaceutical Scientists, November 4-6, 1990, Las Vegas, NV.
`
`"Synthesis and Preliminary 31P NMR Evaluation of Lactones as Substrates for Phospholipase
`A2" David P. Rotella, Xun Li and John K. Baker, invited poster presentation to the National
`Meeting of the American Association of Colleges of Pharmacy, Salt Lake City, UT, July 8-11,
`1990.
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`"Structure-Activity and Cytotoxicty Studies of Irreversible Calmodulin Antagonists Based on a
`Natural Product Model" David P. Rotella, Qingwu He, John M. Pezzuto and Carl L. Tipton,
`poster presentation at the National Medicinal Chemistry Symposium, Austin, TX, July 29-August
`2, 1990.
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`"Homoallylically Controlled Epoxidation of D 4-cis-1,2-Disubstituted Cyclohexenes", David P.
`Rotella, 197th National Meeting of the American Chemical Society, Dallas, TX , April 9-14,
`1989, ORGN 34.
`
`''Synthesis and Biological Evaluation of Novel Hydroxycyclohexanediamine Pt(II) Complexes as
`Potential Antitumor Agents", David P. Rotella and Donald T. Witiak, 191st National Meeting of
`the American Chemical Society, New York, NY, April 16-21, 1986, MEDI 54.
`
`"Synthesis and Antitumor Activity of Novel Pt(II) Hydroxycyclohexanediamine Complexes",
`D.P. Rotella, D.T. Witiak, and J.A. Filppi, First International Biotechnology Conference,
`Columbus, OH, November 13-15, 1985.
`
`''Synthesis and Antimetastatic Properties of Stereoisomeric Bisdioxopiperazines'', D.T. Witiak,
`B.S. Zwilling, B.K. Trivedi, R.V. Nair, and D.P. Rotella, 183rd National Meeting of the
`American Chemical Society, Kansas City, MO, August 25-30, 1982.
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