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`bb\P;\WORKC\030\10030\apeC\10030 .MJC
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`ANTICONVULSANT'ENANTIOMERIC AMINO JACID DERIVATIVES
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`FIELD OVITHE INVENTION
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`T he present invention relates to novel
`enantiomeric compounds and pharmaceutical compositions
`useful in the treatment of epilepsy and other CNS
`disorders.
`BKCKGROUND OF THE INVENTION
`The predominant application of
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`anticonvulsant drugs is the control and prevention of
`seizures associated with epilepsy or related central
`nervous system disorders., Epilepsy refers to m~any
`type s of recurrent seiz ures produced by paroxysmal
`excessive neuronal discharges in the brain; the two
`main generalized seizures are petit mal, which is
`associated with mybclonic jerks, akinetic seizures,
`transient loss of consciousness, but without
`convulsion; and grand mal which manifests in a
`continuous series of seizures and convulsions with'
`loss of consciousness.
`The mainstay of treatment for such disorders
`has been the long-term and consistent administration
`of anticonvulsant drugs. Most drugs in use are weak
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`acids that, presumably, exert their action on neurons,
`glial cells or both of the central nervous system.
`The majority of these compounds are characterized by
`30 the presence of at least one amide unit and,.one or
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`MYLAN - EXHIBIT 1035