throbber
Sigma-Aldrich is an Approved Contract
`Supplier to Washington University
`
`Contract pricing is available on many
`of the items in this catalog
`
`For additional information, please contact
`Sigma-Aldrich at (BOO) 521-8956
`
`Or contact Nancy Novack at
`(BOO) 396-0803 x8661
`Cell Phone: (314) 406-0630
`nnovack@sial.com
`
`LUYE1040
`Luye Pharma Group Ltd., et al. v. Alkermes Pharma Ireland Ltd.
`IPR2016-01096
`
`

`

`I@
`
`14.60
`1 g
`54.65
`5 g
`25 g 213.10
`
`500 g
`1 kg
`2.5 kg
`
`32.45
`43.70
`98.15
`
`~BER
`2·([2-bls(CARBOXYMETHYL)AMIN0-5-METHYL·
`PHENOXY]METHYL)-6-METHOXY ·
`8-bis(CARBOXYMETHYL)AMINOQUINOLINE
`See: Quin 2 Page 913
`2·([2-bis(CARBOXYMETHYL)AMINO·S·METHYL·
`PHENOXY]METHYL)-6-METHOXY ·8-bis·
`(CARBOXYMETHYL)AMINOQUINOLINE-tetrakis-
`(ACETOXYMETHYL) ESTER
`See: Quin 2-AM Page 913
`3,3'-bls(N,N·di[CARBOXYMETHYL]AMINOMETHYL)·
`THYMOLPHTHALEIN
`See: Thymolphthalein Complexone Page I 008
`CARBOXYMETHYLAMYLOSE
`c 4947 Sodium Salt
`Contains up to 4% ethanol
`I@
`[12768-31 -9]
`R: 36/37/38 S: 26-36
`CARBOXYMETHYLCELLULOSE
`Sodium Salt
`A completely water-soluble
`polymer; not an ion exchanger.
`CM-Cellulose cation exchanger is listed in the
`Chromatography Section Page 1932
`USP Grade See. Page 2209
`[9004-32-4]
`C 5678 Low viscosity
`Viscosity of 4% aqueous solution at 25•c: 50-
`200 cps
`C 4888 Medium Viscosity
`Viscosity of 2% aqueous solution at 25•c: 400-
`800 cps
`C 5013 High Viscosity
`Viscosity of 1% aqueous solution at 25•c: 1500-
`3000 cps
`CARBOXYMETHYL-CELLULOSE HYDRAZIDE
`See under: Affinity Chromatography Media Page 1964
`S-CARBOXYMETHYL·L·CYSTEINE
`1 g
`6.30
`C 775 7 Crystalline
`5g
`11.15
`[638·23-3] C5H9NO,S FW 179.2
`1I!'D
`25 g
`23.95
`100 g
`86.45
`25 mg 245.40
`
`MPOUNDS
`
`25 mg
`100 mg
`
`US$
`27.40
`84.65
`
`s-CARBOXYFLUORESCEIN
`c 4916 DIACETATE
`(5-CFDA)
`[:@
`Approx 95% (HPLC)
`73
`Ref.: Br.uning, J.W., et al., J. lmmunol. Methods.,
`•
`fW 460 4
`33 (1980).
`f~~~ii.{3~k452'~3~h7 /38 s~ 45-26-36/37/39-
`22
`27.90
`25 mg
`6-CARBOXYFLUORESCEIN Dl·
`84.25
`100 mg
`c 5041 ACETATE
`(6-CFDA)
`[:@
`Approx. 95% (HPLC)
`82)
`Ref.: Goodall, H., et al., Nature, 295, 524 (19

`fW 460.4
`13348-()3~] c25H160 9
`R: 23124; 25-36/37 /38 S: 45-26-36/37/39
`32.45
`25mg
`5(6)-CARBOXYFLUORESCEIN
`90.05
`100 mg
`- c 8166 DIACETATE
`250 mg 198.10
`) [:@
`Mixed isomers
`Minimum 90% (HPLC)
`C25H1609 FW 460.4
`-
`33.05
`1 mg
`0
`D·')'·CARBOXYGLUTAMIC ACID
`5 mg 127.80
`5 c 4272
`0
`[64153-47 -5] C,H,NO,
`10mg 229.55
`fW 191.1
`15.75
`1 mg
`DL"')'·CARBOXYGLUTAMIC ACID
`52.50
`5 mg
`c 3767
`[56271-99-9] C,H,NO,
`25 mg 207.90
`FW 191.1
`[ z-o-e I
`-
`)5
`15.10
`500 flg
`;o C 4147
`L·')'·CARBOXVGLUTAMIC ACID
`25.15
`1 mg
`[53861-57-7] C,H,NO,
`79.70
`5mg
`FW 191.1
`32.60
`1 mg
`4-CARBOXY-3-HYDROXY·
`-
`5mg 130.45
`85 c 3586 L·PHENYLGLYCINE
`90 1!!1
`· t
`([S]-4C3H-PG)
`Metabotropic G\uR, agonist and GluR1 antagoms
`Ref.: 1. Birse, E.F., et al., Neuroscience, 52, 481
`~.96rT~~do, L.R., et al., Neurosci. Lett., 202, 109
`(1995).
`185148.82-9] C9H9NO, FW211.2
`R: 36/37/38 S: 26-36
`250 mg 19.15
`N-[4-CARBOXY ·3-HYDROXY •
`C 5511 PHENYL)MALEIMIDE
`_
`Irreversible InhibitOr of LDH ISoenzyme M-, n t
`[:@
`Ref.: Carvajal, G., et al., Nat1onal Cancer ns 1 u e
`Monograph No. 27, 111 (1967).
`[ 19232-43-()] CnH,NO, fW 233.2
`s-CARBOXY-4-HYDROXY ·2· THIOPYRIMIDINE
`See 5-Carboxy-2-thiouraci\ Page 223
`2-CARBOXYL-3-CARBOXYMETHYL·
`4-ISOPROPENYLPYRROLIDINE
`See: Kainic Acid Page 610
`CARBOXYLESTERASE
`See. Esterase Page 4 19
`--
`SA.
`13.30
`20-CARBOXY·LEUKOTRIENE B4
`c 6046 Minimum 90% (HPLC)
`-- ~ Approx. 1 mg per mlm ethanol
`33.30 +
`[80434 -82-8] CzoH,oO, fW 366.5
`R: 11-36/37/38 S: 16-26-36
`- -
`7-CARBOXYMETHOXY-4-METHYL·
`33.30 c 8783 COUMARIN
`31.80 ~ 1647oo- 1581 C12H100 5 FW 234.2
`R: 36/37/38 S: 26-36
`N,N-bls(2-[bis(CARBOXYMETHYL)AMINO]ETHYL)·
`GLYCINE
`-
`-
`60
`See: Diethylenetriaminepentaacebc Ac1d Page 3 _
`~5_5832 • www.s1gma-aldnch.com/techmfo
`
`'
`
`[:@
`
`!::@
`
`-
`.50
`.65
`
`-
`).80
`
`649,
`
`-
`
`142.70
`25 flg
`Shipped in dry ke
`
`1 g
`
`41.10
`
`-
`-
`
`C9762
`1 2- I'C I
`
`C6393
`I 2-a·c I
`
`N-CARBOXYMETHYL-
`C 6206 6-(2,2-DICYANOVINYL)-
`II!'D
`1,2,3,4-TETRAHYDROQUINOLINE
`(CDCQ)
`Minimum 98% (HPLC)
`Fluorescent molecular rotor
`Ref.: 1. lio, T., et ai., J. Biochem., 113, 196 (1993).
`2. lwaki, T., et al., Biochemistry, 32, 7589 (1993).
`[47072-52~] C15H13N302 FW 267.3
`R: 36/37/38 S: 26-36
`tris(CARBOXYMETHYL)ETHYLENEDIAMINE-
`AGAROSE
`See under: Affinity Chromatography Media Page 1992
`Na,Na-bls(CARBOXYMETHYL)·
`39.00 C 0386
`50 mg
`c 3205 L-LYSINE
`250 mg 130.00 1 2.a·c 1
`Cllil
`(N-15-Amino-1-carboxypentyl]·
`iminodiacetic acid)
`Trifluoroacetate Salt
`Approx. 95% (TLC)
`Ref.: Hochuli, E., et al., J Chrom., 411, 177 (1987)_
`I 160369-83·5] C10H1sN,O, • C,F,O,H fW 376.3
`CARBOXYMETHYLSEPHADEX
`See.- ion Exchangers and Gel Filtration Media
`Page 1931
`N-CARBOXYMETHYl-L-PHENYLALANYL-L·lEUCINE
`See: Bioactive Peptides Page 1099
`To place an order call 800-325-3010
`
`ALPHABETICAL LIST OF COMPOUNDS
`us s I NUMBER
`
`US$
`25 g 15.35
`
`100 g 28.85
`
`C0261
`I 2· 8'C)
`
`30.85
`1,000 units
`5,000 units 127.10
`
`1·(CARBOXYMETHYL)PYRIDINIUM
`C 6513 CHLORIDE HYDRAZIDE
`(Girard's Reagent P)
`I 2-a-c I
`Crystalline
`[ 1126-58-5] C1H10CIN30 FW 187.6
`(CARBOXYMETHYL)TRIMETHYL-
`C 1757 AMMONIUM CHLORIDE
`HYDRAZIDE
`f!!J
`(Girard's Reagent n
`Crystalline
`[123-46-6] C,H .. N,OCI FW 167.6
`6-CARBOXYMETHYLURACIL
`See. Uracil-4-acetic Acid Page I 054
`6-CARBOXY -5-NITR0-2,4-DIOXYPYRIMIDINE
`See 5-Nitroorotic Acid Page 753
`3-CARBOXY-4-NITROPHENYL DISULFIDE
`See: 5,5'-Dithiobis(2-nitrobenzoic acid) Page 395
`CARBOXYPEPTIDASE A
`(Carboxypolypeptidase; Peptidyh-amino-acid
`hydrolase; EC 3.4.17.1)
`Unit Definition: One unit will hydrolyze 1.0 flmole of
`hippuryi-L·phenylalanine per min at pH 7.5 at 25•c,
`unless otherwise indicated.
`Protein determined by (El~sl-
`M.W. approx. 35,250
`Ref.: Bradshaw, R.A., et ai., Proc. Nati. Acad. Sci.
`U~A, _ 63, _1389_ (1969).
`Type I
`From Bovine Pancreas
`Aqueous suspension with
`toluene added.
`Activity: Approx. 50 units per mg protein.
`Prepared chromatographically by the method of Cox,
`D.J., et al., Biochemistry, 3, 44 (1964).
`The enzyme obtained by this method is carboxypep-
`tidase A.- It contains an additional N-terminal hepta-
`peptide compared to the enzyme prepared by Allan's
`procedure (C 0386 below)_
`[11075-17·5)
`R: 23/24/25:36/37 (38 . S:_ 45:26:36/37 !39
`Type 1-DFP
`30.40
`500 units
`From Bovine Pancreas
`2,500 units 107.95
`C 0261 treated with
`diisopropyl fluorophosphate to eliminate trypsin and
`chymotrypsin activity. Dialyzed and recrystallized:
`aqueous suspension with toluene added.
`Activity: Approx. 50 units per mg protein.
`R: 23/24/25:36/37(38 _ S:_ 45:26:36/37/39 _
`Typei-PMSF
`500 units
`30.40
`From Bovine Pancreas
`C 0261 treated with phenylmethylsulfonyl fluoride to
`eliminate trypsin and chymotrypsin activity. Dialyzed
`and recrystallized: aqueous suspensi9n with toluene
`added.
`Activity: Approx. 50 units per mg protein.
`R: 23/24/25-36/37 (38 _ S:_ 45:26:36/37 /3~ _
`Type II: 2 x Crystallized
`1,000 units
`17.00
`From Bovine Pancreas
`5,000 units
`57.65
`Aqueous suspension with
`toluene added.
`Activity: Approx. 50 units per mg protein.
`Reported to possess approx. 8 times the solubility of
`the enzyme prepared by Anson's procedure. Deac-
`tivation to the apoenzyme occurs with the removal of
`zinc. Activity is reported to be fully restored by
`addition of zinc to the metal free Carboxypeptidase A.
`Ref.: Allan, B.J, et al., Biochemistry, 3, 40 (1964)_
`[11075-17-5]
`R: .23/24/25:36/37/38 _S: 45:26:36/37/39
`Continued
`221
`
`• www.sigma-aldrich.com/order
`
`LUYE1040
`Luye Pharma Group Ltd., et al. v. Alkermes Pharma Ireland Ltd.
`IPR2016-01096
`
`

`

`. _____ ... - .... Jcopeia XXIII.
`
`h USP test, the allowable range and the lot-specific results are
`;ent directly to your 1nstrtut1on's Compliance Office or it can b cleharly
`•
`e s 1p.
`
`;earch or pilot-plant scale-up. Custom packaging of larger quanti!·
`Is diVISIOn, S1gma-Aidnch F1ne Chemicals.
`les
`
`1 g
`5g
`25 g
`
`38.05
`5g
`25 g 119.50
`
`1 g
`5g
`10 g
`
`97.55
`334.80
`633.30
`
`500ml
`1 liter
`
`40.80
`73.50
`
`100 g
`CETYLPYRIDINIUM CHLORIDE,
`1 kg
`C0732 USP
`5 kg
`(1-Hexadecylpyridinium chloride)
`~
`Monohydrate
`[6004-24-6] C,,H,.CIN • H,O FW 358.0
`S: 26-36
`CHARCOAL, ACTIVATED, USP
`C7606 R: 20-36137138 S: 22-26-36
`~
`
`26.40
`187.70
`595.25
`
`CUPRIC SULFATE, USP
`~ALCIUM LACTATE, USP
`34.30
`250 g
`57.10 C2857 Pentahydrate
`500 g
`cs356 Penta hydrate
`1 kg 102.90 ~ {775899-8] CuSO, • 5H20
`~ 15743-47-5] C6H,0CaO. • 5H20
`FW 249.7
`FW 308.3
`R: 60-63-22-41-37/38-43 S: 45-26-36137139-22
`44.15
`25 g
`-----cALCIUM PANTOTHENATE, USP
`c 8731
`40.25
`500mg
`CYANOCOBALAMIN,USP
`I 137-08-6] c,.H, CaN,OIO
`143.30
`100 g
`232.75
`5g
`::B9
`1 kg 1226.60 C3607 (Vitamin 8,2)
`FW 476.5
`25 g 1081.85
`168-19-9] FW 1355.4
`10.75 I 2- I 'C I
`100 g
`::::-----cALCIUM PHOSPHATE, Dibasic,
`S:36
`500 g
`35.75
`cs606 USP
`17757-93-9] CaHPO, FW 136.1 2.5 kg 135.45
`CYSTEINE, Hydrochloride, USP
`:!11
`[7048-04-6} C,H,NO,S • HCI • H,O FW 175.6
`R: 36/37138 S: 26-36
`R: _36137j38 S: _26-36 .
`...
`. ..
`29.95
`CAPTOPRIL, USP
`-
`99.15 c 3357 Monohydrate
`51.05
`100 g
`css56 ([2$]-1-[3-Mercapto-2-methyl-
`287.10
`1 kg
`329.55
`(MJ
`propiony0-L-proline)
`:!11
`5 kg 1161.25
`162571-86-2} C9H15N03S
`FW 217.3
`22.40
`1 mg
`DAUNORUBICIN, Hydrochloride,
`R: 62-43 S: 36-22
`111.30
`10 mg
`D8809 USP
`50 mg
`440.00
`(Daunomycin)
`CARBAMAZEPINE, USP
`I 2-a·c l
`cs9S1 1298-46-4] C15H12N20 FW 236.3
`Complexes with DNA; inhibits DNA
`R: 22-42143 S: 36137139-22
`and RNA synthesis.
`-
`aEl
`Ref.: Ohnuma, T., et al, Cancer Res. 35, 1767
`CARBENICILLIN, USP
`(1975).
`C9231 Disodium Salt
`12354 1-50-6] C, H,.NOIO • HCI FW 564.0
`14800-94-6] C" H,.N,Na206S
`[Iff]
`R: 45-46-61-22-36137138-42143 S: 53-45-
`FW 422.4
`36137/39-22
`R:42143 S:36
`DEXAMETHASONE,USP
`52.25
`500 g
`CARBOXYMETHYLCELLULOSE,
`(9a-Fiuoro-16a-methyl-
`70.75 D 9184
`1 kg
`C9481 USP
`2.5 kg 157.00 I 2-I ' C I
`prednisolone; 9a-Fiuoro-
`Sodium Salt
`@
`16a-methyl-ll[3,17<>,21-
`Medium Viscosity
`trihydroxy-1 ,4-pregnadiene-3, 20-dione; Prednisolone
`Viscosity of 2% aqueous solution at 25'C: 400-
`F)
`800 cps
`[50-02-2] C22H29F05 FW 392.5
`19004-32-4]
`R: 63-36137138-43 S: 26-36-22
`CASTOR OIL, USP
`DEXTROMETHORPHAN,USP
`C9606 R: 36138 S: 26-36
`D9684 Hydrobromide: Monohydrate
`~
`16700-34-1] C18H25NO • HBr
`(MJ
`• H20 FW 370.3
`R: 22 S:36
`DEXTROSE,USP
`(Glucose)
`.. .
`...
`D9434 Anhydrous
`27.75 ~ r 50-99-71 c,H,,o. FW 180.2
`125 g
`500 g
`78.80
`.... .
`2.5 kg 178.30
`D9559 Monohydrate
`51.05 ~ {5996- I Q-1] c.H"O' • H,O
`25 g
`CHLORAMPHENICOL, USP
`FW 198.2
`100 g
`164.75
`(Chloromycetin; o-[ -]-three-
`C0857
`500 g
`640.05
`~ 2-Dichloroacetamido-1-[p-nitro-
`DIATRIZOIC ACID, USP
`phenyl]-! ,3-propanedioll
`D9809 Dihydrate
`156-75-7] C,,H,,CI,N,O, FW 323.1
`~ 150978-11-5] C11H913N20,
`R: 45-46-63-42/43 S: 45-36137139
`• 2H20 FW 650.0
`19.30
`5g
`CHLORPROMAZINE, USP
`DIBUCAI_NE~ USP __ .
`49.25
`25 g
`C0982 Hydrochloride
`100 g 131.55 D0185 Free Base
`1M!
`•
`169-09-Q] C" H,.CIN,S • HCI
`~ {85-79-0] C20H,.N,O, FW 343.5
`FW 355.3
`R: 41-37 S: 26-36 . ..
`R: 26-25-36137138 S: 45-26-36137139-22
`17.65 D0310 Hydrochloride
`250 mg
`CHOLECALCIFEROL, USP
`c 1357 (Activated 7-dehydrocholesterol;
`29.05 ~ I 6 1-12-1] C20H,.N,O, • HCI
`1 g
`FW 379.9
`371.25
`25 g
`•
`[ffiJ
`Vitamin D3)
`R: 41-37 S: 26-36
`16797-Q] C, H .. o FW 384.7
`R: 60-64-63-25 S: 45-36137139
`DIMETHYL SULFOXIDE, USP
`D 1435 {67-68-5] C,H.SO FW 78.14
`CITRIC ACID, _USP. _.
`13.55 ~ R: 36137 !38 S: 26-36-23
`c 1857 Anhydrous
`100 g
`96.60
`1 kg
`1M!
`[77-92-91 c.H.o, FW 192.1
`DOCUSATE, USP
`25 kg . 1820.00 D 1685 (Sulfobutanedioic acid bis[2-ethyl-
`R: 41-_37138 _S:_ 26_-36 .
`c 1732 Monohydrate
`16.30 ~ hexyl ester]; Dioctyl sulfosuccinate)
`100 g
`Sodium Salt
`116.30
`1!!1
`1 kg
`[5949-29-1] C•HsO, • H,O
`[ 577-1 1-7] C20H37Na07S FW 444.6
`25 kg 2080.00
`FW 210.1
`R: 22-36 37 38-41 S: 26-36
`I
`I
`R: 41-37 38 S: 26-36
`I
`To place an order call800-325-3010
`• www.sigma-aldrich.com/order
`
`US$
`40.15
`250 g
`66.90
`500 g
`2.5 kg 264.75
`
`c (/) .,
`"'CC c;
`c. c a
`
`100 mg
`1 g
`5g
`
`36.95
`161.30
`575.95
`
`34.35
`5g
`61.15
`10 g
`50 g 240.70
`
`24.40
`250 g
`40.60
`500 g
`2.5_kg 114.40
`11.55
`100 g
`64.30
`1 kg
`25 kg 1040.00
`16.30
`10 g
`100 g 114.60
`
`5g
`25 g
`
`29.70
`94.05
`
`51.90
`5g
`25 g 168.30
`
`38.95
`500ml
`65.00
`1 liter
`41iter 165.50
`100 g
`26.60
`500 g 104.10
`
`2209
`
`...
`
`22.85
`100 g
`76.1o
`500 g
`1 kg 137.15
`
`250 ml
`500 ml
`1 liter
`
`20.55
`34.20
`46.85
`
`45.15
`25 mg
`100 mg 121.50
`
`500 mg
`36.50
`5g
`240.15
`25 g 1015.85
`100 g
`85.35
`500 g 170.80
`
`38.60
`250 g
`1 kg 104.25
`
`100 g
`500 g
`
`18.60
`63.20
`
`44.10
`100 g
`500 g 146.95
`
`500 g
`1 kg
`5 kg
`
`61.55
`105.00
`416.20
`
`17.75
`100 g
`59.05
`500 g
`1 kg 106.35
`
`I PROOUCT
`IS$ NUMBER
`uss
`100 mg "14"90
`AZATHIOPRINE, USP
`.00
`.60 A 2593
`(6-[1-Methyl-4-nitroimidazol-5-yl]-

`1
`thiopurine)
`72.40
`5 g
`@£J
`28
`f44&8ooJ s"mo,s FW 277.3
`1.7o
`g
`R: 45-46-63-22-36137/38 S: 45-26-36/37/39-22
`BACITRACIN, USP
`.50
`50,000 units
`17_50
`.80 B 8800 Zinc Salt
`1,250,000 units 149_15
`I 2-rc I
`{1405-89-6]
`-19.05
`BARIUM SULFATE, USP
`-
`100 g
`[7727-43-7] BaSO, FW 233.4
`85 B 8675
`500 g
`63.45
`.50 ~
`~------------------------
`1 g
`BENOXINATE, USP
`26.60
`50 B 9050
`(4-Ammo-3-butoxybenzoic acid diethyl- 5 g
`93.40
`.45 ~ aminoethyl ester)
`Hydrochloride
`[5987-82-6] C"H,.N,O, • HCI FW 344.9
`R: 36137/38 S: 26-36-22
`BENZOIC ACID, USP
`{65-85-Q] C,H.o, FW 122.1
`B 9300
`~ R: 22-41-37138-42143 S: 26-36-
`22
`60
`BENZVL BENZOATE, USP
`{120-51 -4] C14H120 2
`75 B 9550
`65 ~ FW 212.3
`R: 22 S: 25
`50
`BETAMETHASONE, USP
`80 B 9675
`(9a-Fiuoro-16[3-methyi-
`OO
`prednisolone; 9a-Fiuoro-
`(MJ
`16[3-methyl-11[3, 1 7 a,21-trihydroxy-1 ,4-pregnadiene-
`3, 20-diOne)
`1378-44-9] C,,H,.FOs FW 392.5
`R: 63 S: 22-36
`BIOTIN, USP
`B0301 158-85-51 c" H,.N,o,s
`FW 244.3
`I 2-B"C I
`BISMUTH SUBNITRATE, USP
`B0426 11304-85-4} FW 1462.0
`(MJ
`R: 8-3613 7/38 S: 1 7-26-36
`
`40
`80
`
`25
`50
`
`4 0
`9 0
`
`6 5
`9 0
`0 0
`
`8 5
`8 0
`8 5
`8 5
`8 0
`5 0
`9 0
`
`CALCIUM CARBONATE, USP
`c 7981
`{471 -34-IJ caco, FW 100.1
`~ R: 41-37138 S: 26-36
`CALCIUM CHLORIDE, USP
`C8106 Dihydrate
`~ {I 0035-04-8] CaCI2 • 2H20
`FW 147.0
`R: 22-36137138 S: 26-36
`CALCIUM GLUCONATE, USP
`C8231 Anhydrous
`~ {299-285] C12H,Ca0,.
`FW 430.4
`)832 • www.sigma-aldrich.com/techinfo
`
`7 0
`1 5
`
`2
`9 0
`6 0
`
`•
`•
`
`CAFFEINE, USP
`C7731 Anhydrous
`158-08-2] CsH10N,O, FW 194.2
`(MJ
`R: 22
`CALCIUM ACETATE, USP
`C7856 {62-54-4] Ca(C2H302), FW 158.2
`~
`
`LUYE1040
`Luye Pharma Group Ltd., et al. v. Alkermes Pharma Ireland Ltd.
`IPR2016-01096
`
`

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