`
`I PubMed
`
`Tolerability of intramuscular injections of testosterone ester in oil vehicle. - PubMed- NCBI
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`~----------------------------------------------~
`
`Format: Abstract
`
`Hum Reprod. 1995 Apr;10(4):862-5.
`Tolerability of intramuscular injections of testosterone ester in oil
`vehicle.
`Mackey MA 1, Conway AJ, Handelsman DJ.
`Author information
`
`Abstract
`We undertook a prospective survey of the tolerability of deep i.m. injections of testosterone
`enanthate in a castor oil vehicle, the most widely used form of androgen replacement therapy. Over
`a period of 8 months, 26 men received 551 weekly injections into the gluteal, deltoid or thigh muscle
`and side-effects were recorded immediately and 1 week after each injection by the same nurse using
`a standardized questionnaire. Most injections caused no complaints [389/551, 70.6%> (95%>
`confidence interval66.6-74.4%>)] but minor local side-effects, mostly pain and bleeding, were
`common [162/551, 29.4%> (25.6-33.4%)]; no serious side-effects were observed. Considering all
`side-effects, the gluteal site had fewer complaints and was less prone to bleeding but was painful
`more often than deltoid or thigh injection sites. The laterality of injection at any site had no significant
`effect on side-effects. The only systemic side-effect was episodes of sudden-onset, non-productive
`cough associated with faintness following eight injections [1.5% (0.6-2.9%)] which we speculate may
`have been due to pulmonary oil microembolism. We conclude that, when administered by an
`experienced nurse, deep i.m. injection of testosterone enanthate in a castor oil vehicle is generally
`safe and well tolerated but causes relatively frequent minor side-effects, including pain and bleeding.
`An improved depot form of testosterone would be highly desirable for androgen replacement therapy
`and hormonal male contraception.
`
`PMID: 7650133
`
`[Indexed for MEDLINE]
`
`Publication types, MeSH terms, Substances
`
`LinkOut - more resources
`
`https://www.ncbi.nlm.nih.gov/pubmed/7650133
`
`1/2
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`LUYE1032
`Luye Pharma Group Ltd., et al. v. Alkermes Pharma Ireland Ltd.
`IPR2016-01096
`
`
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