US008293284B2
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`(12) United States Patent
`Baldassarre et al.
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`(10) Patent N0.:
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`(45) Date of Patent:
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`US 8,293,284 B2
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`*Oct. 23, 2012
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`Barst et al., “Nitric Oxide in Combination with Oxygen versus Either
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`Children with Pulmonary Hypertemsion: A Multicenter, Random-
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`ized Study”, INO Therapeutic s/Ikaria, Baltimore Convention Center,
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`May 3, 2009, 2 pages, Abstract, downloaded Jul. 2, 2009 from http://
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`127.0.0.129080/PAS09A1/view.y?nu:PAS09L1_1507.
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`(Continued)
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`Primary Examiner — Ernst Arnold
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`(74) Attorney, Agent, or Firm — Fish & Richardson P.C.
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`(57)
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`ABSTRACT
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`The invention relates methods ofreducing the risk or prevent-
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`ing the occurrence of an adverse event (AE) or a serious
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`adverse event (SAE) associated with a medical treatment
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`comprising inhalation of nitric oxide.
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`30 Claims, No Drawings
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`001
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`PRAXAIR ET AL. 1001
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`(54) METHODS OF REDUCING THE RISK OF
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`OCCURRENCE OF PULMONARY EDEMA IN
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`TERM OR NEAR-TERM NEONATES IN NEED
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`OF TREATMENT WITH INHALED NITRIC
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`OXIDE
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`(75)
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`Inventors: James S. Baldassarre, Doylestown, PA
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`(US); Ralf Rosskamp, Chester, NJ (US)
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`(73) Assignee:
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`INO Therapeutics LLC, Hampton, NJ
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`(US)
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`( * ) Notice:
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`Subject to any disclaimer, the term of this
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`patent is extended or adjusted under 35
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`U.S.C. 154(b) by 0 days.
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`This patent is subject to a terminal dis-
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`claimer.
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`(21) Appl.No.: 12/821,041
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`(22)
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`Filed:
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`Jun. 22, 2010
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`(65)
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`Prior Publication Data
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`US 2010/0331405 A1
`Dec. 30, 2010
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`Related U.S. Application Data
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`(63) Continuation of application No. 12/494,598, filed on
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`Jun. 30, 2009, now abandoned.
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`(51)
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`Int. Cl.
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`(2006.01)
`A01N 59/00
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`(2006.01)
`A61K 33/00
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`(2006.01)
`C01B 21/24
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`(2006.01)
`A6]M 16/00
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`(52) U.S. Cl.
`.................. .. 424/718; 128/200.24; 423/405
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`(58) Field of Classification Search ...................... .. None
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`See application file for complete search history.
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`(56)
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