10/6/2016
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`C hem otherapy for prostate cancer :: Print Preview
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`Prostate Cancer
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`TREATING PROSTATE CANCER TOPICS
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`Chemotherapy for prostate cancer
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`Hormone therapy for prostate
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`Vaccine treatment for prostate
`cancer
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`Chemotherapy for prostate cancer
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`Chemotherapy (chemo) uses anti-cancer drugs injected into a vein or given by mouth. These drugs enter the bloodstream
`and go throughout the body, making this treatment potentially useful for cancers that have spread (metastasized) to distant
`organs.
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`When is chemotherapy used?
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`Chemo is sometimes used if prostate cancer has spread outside the prostate gland and hormone therapy isn’t working.
`Recent research has also shown that chemo might be helpful if given along with hormone therapy.
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`Chemo is not a standard treatment for early prostate cancer, but some studies are looking to see if it could be helpful if
`given for a short time after surgery.
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`Chemo drugs used to treat prostate cancer
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`For prostate cancer, chemo drugs are typically used one at a time. Some of the chemo drugs used to treat prostate cancer
`include:
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`- Docetaxel (Taxotere)
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`- Cabazitaxe|(Jevtana)
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`- Mitoxantrone (Novantrone)
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`- Estramustine(Emcyt)
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`In most cases, the first chemo drug given is docetaxel, combined with the steroid drug prednisone. If this drug does not work
`(or stops working), cabazitaxel is often the next chemo drug tried (although there may be other treatment options as well).
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`Both of these drugs have been shown to help men live longer, on average, than older chemo drugs. They may slow the
`cancer’s growth and also reduce symptoms, resulting in a better quality of life. Still, chemo is very unlikely to cure prostate
`cancer
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`AVENTIS EXHIBIT 2169
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`Mylan v. Aventis, IPRZO16-00712
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`AVENTIS EXHIBIT 2169
`Mylan v. Aventis, IPR2016-00712
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`10/6/2016
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`Chemotherapy for prostate cancer :: Print Preview
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`Doctors give chemo in cycles, with each period of treatment followed by a rest period to allow the body time to recover.
`Each cycle typically lasts for a few weeks.
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`Possible side effects of chemotherapy
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`Chemo drugs attack cells that are dividing quickly, which is why they work against cancer cells. But other cells in the body,
`such as those in the bone marrow (where new blood cells are made), the lining of the mouth and intestines, and the hair
`follicles, also divide quickly. These cells can also be affected by chemo, which can lead to side effects.
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`The side effects of chemo depend on the type and dose of drugs given and how long they are taken. Some common side
`effects can include:
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`Hair loss
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`Mouth sores
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`Loss of appetite
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`Nausea and vomiting
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`Diarrhea
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`Increased chance of infections (from having too few white blood cells)
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`Easy bruising or bleeding (from having too few blood platelets)
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`Fatigue (from having too few red blood cells)
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`These side effects usually go away once treatment is finished. There is help for many of these side effects. For example,
`drugs can be given to help prevent or reduce nausea and vomiting.
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`Along with the risks above, some side effects are seen more often with certain chemo drugs. For example:
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`Docetaxel and cabazitaxel sometimes cause severe allergic reactions. Medicines are given before each treatment
`to help prevent this. These drugs can also damage nerves (known as peripheral neuropathy), which can cause
`numbness, tingling, or burning sensations in the hands or feet.
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`Mitoxantrone can, very rarely, cause leukemia several years later.
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`Estramustine carries an increased risk of blood clots.
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`If you notice any side effects while getting chemo report them to your medical team so that they can be treated promptly. In
`some cases, the doses of the chemo drugs may need to be reduced or treatment may need to be delayed or stopped to
`prevent the effects from getting worse.
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`To learn more about chemo, see the Chemotherapy section on our website.
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`Last Medical Review: 02/16/2016
`Last Revised: 03/11/2016
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