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Advanced Prostate Cancer Immunotherapy | PROVENGE (sipuleucel-T)
`
`http://www.provenge.com/advanced-prostate-cancer-immunotherapy.aspx
`
`Health Care Professional Site
`
`Important Safety Information Full Prescribing Information | A | A | A
`
`What Is PROVENGE?
`
`Is PROVENGE Right For Me?
`
`How Does PROVENGE Work?
`
`PROVENGE Benefits
`
`PROVENGE and PSA Levels
`
`Starting PROVENGE Treatment
`What Are the Side Effects
`of PROVENGE?
`
`Who Is PROVENGE
`For?
`
`PROVENGE® (sipuleucel-T) is a prescription
`medicine that is used to treat certain patients with
`advanced prostate cancer. PROVENGE is made
`from your own immune cells.
`Find out if PROVENGE could be right for you ›
`
`What Is PROVENGE Immunotherapy?
`
`Share this page
`
`PROVENGE is the first and only FDA-approved immunotherapy
`for advanced prostate cancer
`
`PROVENGE is the only personalized immunotherapy treatment that is clinically proven to help
`extend life in certain men with advanced prostate cancer.
`
`PROVENGE is an immunotherapy that takes your own immune cells and reprograms them to attack
`your advanced prostate cancer. This process delivers a treatment designed just for you.
`
`PROVENGE has proven results as an advanced prostate cancer
`immunotherapy
`
`In the clinical trial, which was known as IMPACT, that supported FDA approval, more men treated
`with PROVENGE lived longer than men not treated with PROVENGE.
`
`Median survival was 4.1 months longer for men who received PROVENGE (25.8 months)
`than for men who did not (21.7 months)*
`PROVENGE reduced the risk of death by 22.5% for patients in the PROVENGE group*
`More men in the PROVENGE group (nearly 38% more) were alive 3 years after the start of
`the study than men not treated with PROVENGE*
`1.5% of men discontinued treatment with PROVENGE due to side effects
`
`*Individual results may vary.
`
`See More
`
`INDICATION
`PROVENGE® (sipuleucel-T) is a prescription medicine that is used to treat certain patients with advanced prostate cancer. PROVENGE is made
`from your own immune cells.
`
`IMPORTANT SAFETY INFORMATION
`Before getting PROVENGE, tell your doctor about all your medical problems, including problems with your heart or lungs, or if you have
`had a stroke
`
`1 of 3
`
`10/5/2016 5:11 PM
`
`AVENTIS EXHIBIT 2157
`Mylan v. Aventis, IPR2016-00712
`
`

`
`Advanced Prostate Cancer Immunotherapy | PROVENGE (sipuleucel-T)
`
`http://www.provenge.com/advanced-prostate-cancer-immunotherapy.aspx
`
`Share this page
`
`How Does PROVENGE Work?
`
`INDICATION
`PROVENGE® (sipuleucel-T) is a prescription medicine that is used to treat certain patients with advanced prostate cancer. PROVENGE is made
`from your own immune cells.
`
`IMPORTANT SAFETY INFORMATION
`Before getting PROVENGE, tell your doctor about all your medical problems, including problems with your heart or lungs, or if you have
`had a stroke
`Tell your doctor about all the medicines you take, including prescription and nonprescription drugs, vitamins, and dietary supplements
`PROVENGE is made from your own immune cells, collected approximately 3 days before each scheduled infusion of PROVENGE. The
`collection is called “leukapheresis” (pronounced loo-kuh-fuh-REE-sis). You will get PROVENGE in 3 intravenous infusions (put into your
`veins), about 2 weeks apart. Each infusion takes about 60 minutes. You will then be monitored for at least 30 minutes. Your doctor will give
`you a schedule for your cell collection and infusion appointments. It is very important that you arrive on time for your appointments
`The most common side effects of PROVENGE include chills, fatigue, fever, back pain, nausea, joint ache, and headache. These are not all
`the possible side effects of PROVENGE treatment
`PROVENGE infusion can cause serious reactions. Tell your doctor right away if you:
`Have breathing problems, chest pains, racing heart or irregular heartbeats, high or low blood pressure, dizziness, fainting, nausea, or
`vomiting after getting PROVENGE. Any of these may be signs of heart or lung problems
`See More
`
`INDICATION
`PROVENGE® (sipuleucel-T) is a prescription medicine that is used to treat certain patients with advanced prostate cancer. PROVENGE is made
`from your own immune cells.
`
`IMPORTANT SAFETY INFORMATION
`Before getting PROVENGE, tell your doctor about all your medical problems, including problems with your heart or lungs, or if you have
`had a stroke
`
`2 of 3
`
`10/5/2016 5:11 PM
`
`

`
`Advanced Prostate Cancer Immunotherapy | PROVENGE (sipuleucel-T)
`
`http://www.provenge.com/advanced-prostate-cancer-immunotherapy.aspx
`
`Find a PROVENGE Treatment Center
`
`How Does PROVENGE Work? | Treating Advanced Prostate Cancer | PROVENGE Financial Coverage
`PROVENGE Treatment Process | Support for Advanced Prostate Cancer Caregivers
`
`Privacy Policy | Legal Notice | Important Safety Information | Prescribing Information | Contact Us
`Site Map | Glossary
`Dendreon, PROVENGE and the Dendreon logo are trademarks of Valeant
`Pharmaceuticals International, Inc. or its affiliates. All other product/brand
`names are trademarks of their respective owners.
`© 2016 Valeant Pharmaceuticals
`PXA.0014.USA.16
`
`See More
`
`INDICATION
`PROVENGE® (sipuleucel-T) is a prescription medicine that is used to treat certain patients with advanced prostate cancer. PROVENGE is made
`from your own immune cells.
`
`IMPORTANT SAFETY INFORMATION
`Before getting PROVENGE, tell your doctor about all your medical problems, including problems with your heart or lungs, or if you have
`had a stroke
`
`3 of 3
`
`10/5/2016 5:11 PM

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