`
`33
`
`IN ‘rm: UNITED STATES PATENT AND TRADEMARK OFFICE
`BEFORE THE BOARD OF PATENT APPEALS AND IMERFERENCES
`
`) )
`
`Intcrfcrcncc No. 102.572
`
`')
`Examiner-in-Chick‘
`)
`) May 1?. Downey
`
`Cabifly at
`
`11
`
`v.
`
`Boss cl
`
`:1
`
`
`
`1.
`
`I. Mickie! Rey. dcciarc and am: that I Mn 3 citixcn 0! the United Staucs
`
`remain;
`No. 14.
`
`in San Mateo, California. My Chxrrlcuwm Vitle is nuchod Is Clbiliy Exhibit
`
`'
`
`2.
`at Gcacnwch.
`
`From Dcccrnbcr 15. 1980133111 April. 20. 1983:. 1 war I Research Assistlnt
`Inc.
`(Gcncmcch) located an 460 Point San Bruno Blvd“ Scum Sm
`
`Prancisco. Califbrnia. During that time I repcncd
`
`to Dr. Hcrb Hcyncket.
`
`1 un
`
`prcscndy omploycd by Gcncncor.
`Francisco. California.
`
`Inc. as a Senior Research Associate.
`
`in South San
`
`It wns my general practice to due my notebook! 0::
`I11: data the work
`3.
`I bcgan my involvcmcm in the pi-05cc: my exp:-an tgtibodiu directed
`was donc.
`agtinst human carcinocmbryonic antigen in bacteria in Ju1y’1982.
`I had received
`minmrircr dishes with culture:
`thu conuinad cDNA from the hyhrldonn cell
`Ilnc
`
`CEA-66-E3.
`
`1
`
`tnnsfcrrcd these u-nyaa cunurcs to up: plans Ind nliowd than to
`
`to nizroccuuionc filton;
`X Inc: tmnaferrcd the colonies in aupucuc.
`zrcw.
`them onto Ignr pines and incubated mm 1: 37'C. Once those coicnies had
`
`iaycrcd
`
`surficicmiy gxvwn.
`
`I
`
`Iyaud thc colaniu on mass film‘:
`
`Ind treated than for
`
`subsequent probing (Cabmy Exhibit No. 15. Batu Not. 00502 and 00504).
`
`-
`
`4.
`
`1 usisccd in the sequencing of the heavy chain cDNA by subclonin;
`
`DNA into M13 vcctorx. preparing single-stranded template and carrying out
`
`thc
`
`I also uzistcd in th: sequencing of the heavy and light chain
`sequencing reaction.
`cDNA'u (Czbmy Exhibit No. 15. Bates No. 00509-00516. D0521. 0052.2. 00528. and 00531).
`
`GNE-MED-02031
`
`GNE—“G0SAK0000'3434
`Mylan v. Genentech
`Mylan V. Genentech
`IPR2016-00710
`Genentech Exhibit 2030
`Genentech Exhibit 2030 GNE"'""'Y'BMs °°°8°m
`
`IPR2016-00710
`
`GNE-HGS 00082045
`
`GNE-REG00080778
`
`
`
`DECLARATION OF MICHAEL REY
`
`S.
`
`I scquenead a Paul
`
`to Ava}! DNA fnpnanz of the liflll Ghlin following i
`
`primcr
`
`rcpnir
`
`rcaction that
`
`introduced an inlunion codes into this sequence
`
`(Cabin): Exhibit No. 15. Bates No. 00530).
`
`5.
`
`I prupared ms pusmms pKCEAu'p207-1" by dizostin: pKCEAIn‘-2 with
`
`Aval.
`
`filling in. digesting with Pct‘! and isolating the fragmcm by PAGE.
`
`The vector
`
`trazznenx was prepared by cuguting pnmzzcxm with Ecaill.
`
`filling in. and
`
`This fragment was also
`isoiatian by PAGE.
`z-edigcstiag with Pat! {allowed by fragment
`used in thc. construction cf pGmmncEAtrp207-1‘.
`‘ma purified frazmantl wen
`
`iigned.
`
`transformed into E.coii and anaiyzcd by rsnriction digest:
`
`to identify Pusizive
`
`colonies (Cnhiiiy Exhibit No. 15. Bxtcs Not. 00533-00537).
`
`7.
`
`wsmm I-Iolmu and I anaiyzcd mroral
`
`tetracycline retiatant
`
`transfcrznamx frum zhc pCiammaCE.AFABzrp20?-1‘
`
`ligation by rutriacion analysis
`
`and tuqucncing (Cabiny Exhibit No. 13. Bntcsl Nos. 00885-D0887. 00889‘. Cabiiiy Exhibit
`
`15. Bate: Nos. 00551. 00543. and 00544).
`
`statazncnts nude cf my own knowledge no mac
`:1!
`funher dcclarc that
`1
`8.
`and that an smamenu nude: on info:-nucion and bciicf are believed to be true: and
`
`further that
`
`these sum-4-nenu wef¢ hand: with the iznawiedge 111111 $1170‘ 91“
`
`stcternents and the like so‘ made are punishable by {me or imprisonment. or both.
`under Section 1001 of ‘Hue 13 of the Unltcd States 006:.
`
`GNE-MED-02032
`
`GNE—"GsKoooo'3435
`
`GNE-HGS 00082046
`
`GNE-LILLY-BMS 00080779
`
`GNE-REG00080779
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