CURRICULUM VITAE: KATHRYN L. CALAME
`
`PERSONAL DATA
`
`Business:
`
`Department of Microbiology and Immunology
`Columbia College of Physicians and Surgeons
`701 West 168th St.
`
`New York, N.Y. 10032
`FAX 212-305-1468; email: klc1@columbia.edu
`
`Born: April 23, 1940, Leavenworth, Kansas
`Married, two children
`
`EDUCATION
`
`B.S.(honors) Chemistry, University of Missouri
`1962
`1965 M.S. Biochemistry, The George Washington University
`1975
`Ph.D. Biochemistry, The George Washington University
`
`PROFESSIONAL EXPERIENCE
`
`2008-
`
`1988- 2008
`
`1990-96
`
`1985-87
`1980-85
`1978-80
`197 5 78
`
`Professor Emerita of Microbiology & Immunology and Biochemistry &
`Molecular Biophysics
`Columbia University College of Physicians and Surgeons
`Professor of Microbiology
`Professor of Biochemistry and Molecular Biophysics
`Columbia University College of Physicians and Surgeons
`Director, Integrated Program in Cellular, Molecular and Biophysical Studies,
`Columbia University College of Physicians and Surgeons
`Associate Professor of Biological Chemistry, UCLA School of Medicine
`Assistant Professor of Biological Chemistry, UCLA School of Medicine
`Research Fellow, Div. of Biology, California Institute of Technology
`Postdoctoral Fellow, Dept. of Biochemistry, University of Pittsburgh
`
`OUTSIDE PROFESSIONAL ACTIVITY
`
`1984-87
`1998-00
`1986-88
`
`1986-89
`
`1990
`1990-91
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`1990-96
`
`1990-93
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`1991-01
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`Council member, Midwinter Conference of Immunologists;
`Co-organizer, 1987 and 1998 conferences
`American Cancer Society, California Division, Fellowship Screening
`Committee
`
`N.I.G.M.S. Cellular and Molecular Basis of Disease Committee;
`Committee Chair 1989-90
`
`Co-organizer Keystone Symposium on Transcriptional Regulation
`Co-organizer and Organizer of FASEB "Cellular and Molecular
`Genetics" Summer Conferences, 1990 and 1991
`Leukemia Society of America Grant Review Committee;
`Committee, Chair 1992-96
`Member Publications Committee, American Society for
`Biochemistry and Molecular Biology, Committee Chair 1992-93
`Board of Trustees, Leukemia Society of America; Executive
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`Council Member
`
`1992-2010
`1995-99
`1996-00
`
`Scientific Advisory Council, March of Dimes
`Member, AAI Committee on the Status of Women
`Member, Allergy and Immunology Study Section, NIH, Study section Chair
`1999-2000
`
`2000-04
`
`2001
`2002-08
`
`Member, Board of Scientific Counselors, National Institute of Child Health and
`Development
`Co-organizer Keystone meeting on B Cells
`Member, Scientific Review Board, Howard Hughes Medical Institute
`
`EDITORIAL ACTIVITIES
`
`Gene, editor
`Nucleic Acids Research, editorial board
`Mol. Cell. Biol., editorial board
`Science, reviewing editor
`J. Experimental Medicine, advisory board
`Nucleic Acids Research, Executive Editor
`J. Clin. Invest., Assoc. Editor
`Immunity, Assoc. Editor
`
`1986-89
`1989-92
`1989-94
`1989-2000
`1991-97
`1992-99
`2002-05
`2005-2009
`
`SOCIETY MEMBERSHIP
`
`Sigma Xi, American Society for Microbiology, American Association for the Advancement of
`Science, American Society of Biochemistry and Molecular Biology, New York Academy of Science,
`American Association of Immunologists
`
`HONORS
`
`1962
`
`1975
`1984-89
`1985
`1989
`1991
`1992
`
`1994
`1996
`1998
`
`2002
`2003
`2005
`
`2006
`2007
`2008
`2009
`
`Phi Beta Kappa, American Institute of Chemists Student Award, Merck Award for
`Achievement in Chemistry
`Public Health Service Research Postdoctoral Fellowship
`Leukemia Society Scholar Award
`UCLA Dwyer Award for Outstanding Cancer Research
`Stohlman Memorial Award, Leukemia Society
`William Pyle Philips Distinguished Visitor, Haverford College
`Fellow of the American Association for the Advancement of Science
`
`Kenny Award for Public Service, Leukemia Society of America
`Faculty/ Alumni Award, University of Missouri
`Dean’s Distinguished Lecturer in Basic Science, Columbia College of Physician’s
`and Surgeons
`Marion Koshland Memorial Distinguished Lecturer, University of Chicago
`Fellow, American Academy of Arts and Science
`Fong/Clontech Lecturer, Univ. Indiana
`Dean’s Distinguished Seminar, University Colorado
`Member, Faculty of 1000
`Member, Institute of Medicine of the National Academy
`Distinguished Lecture, AAI National Meeting, San Diego
`Kathryn Calame Honorary Lectureship in Microbiology and Immunology, Columbia
`University, 2009
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`Mylan Ex. 1060, pg 1298
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`2010
`
`2011
`
`Distinguished Service Award, Columbia Presbyterian College of Physicians and
`Surgeons
`Honorary D. Sci. from the University of Missouri
`
`PUBLICATIONS
`
`Refereed Journals
`
`1. Calame, K., Gallo, L., Cheriathundim, E., Vahouny, G. and Treadwell, C. (1975)
`"Purification and Properties of Subunits of Sterol Ester Hydrolase from Rat Pancreas"
`Arch. Biochem.Phys. 168: 57-65.
`2. Calame, K. and lhler, G. (1977) "Visualization of Ribosome-Single Stranded DNA Complexes
`in the Electron Microscope" Biochem. 16: 965-971.
`3. Calame, K. and Ihler, G. (1977) "Mapping Ribosome Binding Sites on Lambda DNA" J . Mol.
`Biol. 116:841-853.
`
`4. Calame, K., Nakada, D. and lhler, G. (1978) "Location of Ribosome Binding Sites on the
`Tetracycline Resistance Transposon Tn10" J . Bacteriol. 135:668-674.
`5. Sussman, R., Resnick, J ., Calame, K. and Baluch, J . (1978) "Interaction of Bacteriophage
`Lambda Repressor with Non-Operator DNA Containing Single-strand Gaps" Proc. Natl.
`Acad. Sci. 7515817-21.
`
`6. Calame, K., Shanblatt, S. and Nakada, D. (1979) "Location of Promoter Sites on Plasmid
`NTP1 which Contains the Ampicillin Resistance Transposon Tn1701" J. Mol. Biol.
`127:397-409
`
`7. Yamada, Y., Calame, K. and Nakada, D. (1979) "Location of Ampicillin Resistance
`Transposon 1701 in a Group of Non-Transferring Plasmids" J. Bacteriol. 137 :990-999.
`8. Davis, M., Calame, K., Early, P., Livant, D. , Joho, R., Weissman, I. and Hood, L. (1980)
`"An Immunoglobulin Heavy Chain Gene is Formed by at Least Two Recombinational
`Events" Nature 283:733-38.
`
`9. Calame, K., Rogers, J., Early, P., Davis, M., Livant, D., Wall, R. and Hood, L. (1980) "The
`Mouse Cu Immunoglobulin Heavy Chain Gene Contains Three Intervening Sequences
`which Appear to Separate Domains" Nature 284:452-455.
`10. Early, P., Huang, H., Davis, M., Calame, K. and Hood, L. (1980) "An Immunoglobulin
`Heavy Chain Variable Region Gene is Generated from Three Segments of DNA: VH, D
`and JH" Cell 19:981-92
`
`11. Rogers, J., Early, P., Carter, C., Calame, K., Bond, M., Davis, M. and Hood, L. (1980)
`"The Immunoglobulin Mu Gene: Two mRNAs with Alternative 3' Ends Encode Membrane
`and Secreted Forms of Mu Chains" Cell 20: 303-12.
`
`12. Early, P., Rogers, J., Davis, M., Calame, K., Bond, M., Wall, R. and Hood, L. (1980)
`"Developmentally Regulated RNA Processing Pathways Generate Separate Messenger
`RNAs for Secreted and Membrane-Bound Forms of an Immunoglobulin Heavy Chain"
`Cell 201313-19.
`
`13. Crews, S., Griffin, J., Huang, H., Calame, K. and Hood, L. (1981) "A Single VH Gene
`Sequence Encodes the Immune Response to Phosphorylcholine: Somatic Mutation is
`Correlated with Class Switching" Cell 25:59-66.
`14. Calame, K., Kim, S., Lalley, P., Hill, R., Davis, M. and Hood, L. (1982) "Molecular
`Cloning of Translocations Involving Chromosome 15 and the Immunoglobulin COL Gene
`from Chromosome 12 in Two Murine Plasmacytomas" Proc. Natl. Acad. Sci. 79:6994-98.
`15. Clarke, C., Berenson, J ., Goverman, J ., Boyer, P., Crews, S., Siu, G. and Calame, K.
`(1982) "An Immunoglobulin Promoter Region is Unaltered by DNA Rearrangement and
`Somatic Mutation During B-Cell Development" Nuc. Acids Res. 10:7731-49.
`16. Crews, S., Barth, R., Hood, L., Prehn, J . and Calame, K. (1982) "The Mouse c-Myc
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`Oncogene is Located on Chromosome 15 and Translocated to Chromosome 12 in
`Plasmacytomas" Sci. 218:1319-21.
`17. Mercola, M., Olsen, J., Wang, X. and Calame, K. (1983) "Transcriptional Enhancer Activity
`in the Immunoglobulin Heavy Chain Locus" Sci. 221 :663-65.
`18. Prehn, J., Mercola, M., Calame, K. (1984) "Translocation Affects Normal c-Myc Promoter
`Usage and Activates Fifteen Cryptic c-Myc Transcription Starts in Plasmacytoma M603"
`Nuc. Acids Res. 12:8987-9007.
`
`19. Brown, N., Liu, C., Berenson, J., Garcia, C., Wang, R., and Calame, K. (1985)
`"Immunoglobulin JH, Cu and Cg Gene Rearrangements in Human B Lymphocytes
`Clonally Transformed by Epstein-Barr Virus" Proc. Natl. Acad. Sci. 82:556-60.
`20. Mercola, M., Goverman, J., Mirell, C. and Calame, K. (1985) "Immunoglobulin Heavy
`Chain Enhancer Requires One or More Tissue Specific Factors" Sci. 227:266-70.
`21. Wang, X. and Calame, K. (1985) "The Endogenous Immunoglobulin Heavy Chain Enhancer
`Can Activate Tandem VH Promoters Separated by a Large Distance" Cell 43 :659-65.
`22. Kakkis, E., Prehn, J. and Calame, K. (1986) "An Active Chromatin Structure Acquired by
`Translocated c-Myc Genes" Mol. Cell. Biol. 6:1357-61.
`23. Brown, N., Liu, C., Garcia, C., Wang, Y-F., Griffith, A., Sparkes, R. and Calame, K.
`(1986) "Clonal Origins of Lymphoproliferative Disease Induced by Epstein Barr Virus" J.
`Virol. 58:975-78.
`
`24. Taplitz, S., Calame, K. and Herschman, H. (1986) "Altemative Inducers of the Rat
`Metallothionein I Gene Cause Distinct Changes in Chromatin Structure in the 5' Region of
`the Gene" Mol. Cell. Biol. 6:2576-81.
`
`25. Peterson, C., Orth, K., and Calame, K. (1986) "Binding In Vitro of Multiple Cellular Proteins
`to Immunoglobulin Heavy Chain Enhancer DNA" Mol. Cell. Biol. 6:4168-78.
`26. Wang, X. and Calame, K. (1986) "SV40 Enhancer Binding Factors Are Required at the
`Establishment but not the Maintenance Step of Enhancer-Dependent Transcriptional
`Activation" Cell 47 :241-47 .
`
`27. Eaton, S. and Calame, K. (1987) "Multiple Elements Are Necessary for the Function of an
`Immunoglobulin Heavy Chain Promoter" Proc. Natl. Acad. Sci. 84:7634-38.
`28. Kakkis, E. and Calame, K. (1987) "A Plasmacytoma Specific Protein Binds to the c-Myc
`Promoter Region" Proc. Natl. Acad. Sci. 84:7031-35.
`29. Peterson, C. and Calame, K. (1987) "Complex Protein-DNA Interactions on the Mouse
`Immunoglobulin Heavy Chain Enhancer" Mol. Cell. Biol. 714194-4203.
`30. Kakkis, E., Mercola, M. and Calame, K. (1988) "Strong Activation of Translocated c-Myc
`Genes Occurs Without a Strong Nearby Enhancer or Promoter" Nuc. Acids Res. 16:77-96.
`31. Tsao, B. Wang, X., Peterson, C., Calame, K. (1988) In vivo Functional Analysis of In Vitro
`Protein Binding Sites in the Immunoglobulin Heavy Chain Enhancer" Nuc. Acids Res.
`1613239-3253
`
`32. Pei, R. and Calame, K. (1988) "Differential Stability of c-myc mRNAs in a Cell-Free System"
`Mol. Cell. Biol. 812860-2868
`
`33. McDougall, S., Peterson, C. and Calame, K. (1988) "A Transcriptional Enhancer 3' of CB2
`in the T Cell Receptor B Locus" Sci. 241: 205-208
`34. Peterson, C., Eaton, S. and Calame, K. (1988) "Purified mEBP-E Binds to Immunoglobulin
`Enhancers and Promoters" Mol. Cell. Biol. 8:4972-4980.
`
`35. Peterson, C. and Calame, K. (1989) "Proteins Binding to Site C2 (uE3) in the
`Immunoglobulin Heavy Chain Enhancer Exist in Multiple Oligomeric Forms" Mol. Cell.
`Biol. 9:776-786.
`
`36. Kakkis, E., Riggs, K., Gillespie, W. and Calame, K. (1989) "A transcriptional Repressor of
`c-Myc" Nature 339: 718-21.
`37. Calame, K. (1989) "Immunoglobulin Gene Transcription: Molecular Mechanisms" Trends in
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`Genetics 5:395-399.
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`Tsao, B., Ebling, F., Calame, K. and Hahn, B. (1990) "Molecular Analysis of Pathogenic
`Antibodies in Autoimmune Mice" J. Clin. Invest. 85:530-540.
`
`Wu, H., Holcenberg, J., Tomich, J., Chen, J., Jones, P., Huang, S-H. and Calame, K.
`(1990) "Inhibition of in vitro transcription by specific double-stranded
`oligodeoxynucleotides" Gene 89: 203-209.
`Roman, C., Platero, J ., Shuman, J. and Calame, K. (1990) "Ig/EBP, a Ubiquitiously
`Expressed Irnmunoglobulin Enhancer Binding Protein That Is Similar to C/EBP and
`Heterodimerizes with C/EBP" Genes and Dev. 4: 1404-1416.
`
`Taplitz, S., Andersen, R., Oberbauer, A., Calame, K. and Herschman, H. (1990)
`"Constitutive and Metal-Dependent Binding of Nuclear Factors to the Rat Metallothionein-I
`Promoter" Nuc. Acids Res. 18:6049-55.
`
`Artandi, S., Canfield, S., Tao, M.-H., Calame, K., Morrison, S. and Bonagura, V. (1991)
`"Molecular Analysis of IgM Rheumatoid Factor Binding to Chimeric IgG" J .Irnmunol.
`1461603-610.
`
`Riggs, K., Merrell, K., Wilson, G. and Calame, K. (1991) "Common Factor 1 Is a
`Transcriptional Activator Which Binds in the c-Myc Promoter, the Skeletal oc-Actin
`Promoter and the Irnmunoglobulin Heavy Chain Enhancer" Mol. Cell. Biol. 11: 1765-69.
`Roman, C., Cohn, L. and Calame, K. (1991) "Creation of a Transdominant Negative Form of
`Transcription Activator mTFE3 by Differential Splicing" Sci. 254194-97.
`Webb, C., Das, D., Eaton, S., Calame, K. and Tucker, P. (1991) "Novel Protein-DNA
`Interactions Associated with Increased Irnmunoglobulin Transcription in Response to
`Antigen + Interleukin-5" Mol. Cell. Biol. 1015197-5205.
`Artandi, S., Calame, K., Morrison, S. and Bonagura, V. (1992) "Monoclonal IgM
`Rheumatoid Factors Bind IgG at a Discontinuous Epitope Comprised of Amino Acid
`Loops from Both the CH2 and CH3 Domains" Proc.Natl.Acad.Sci. 89:94-98.
`Roman, C., Matera, G., Cooper, C., Artandi, S., Blain, S., Ward, D. and Calame, K. (1992)
`"mTFE3, An X-Linked Transcription Activator Containing Basic Helix-Loop-Helix and
`Zipper Domains, Utilizes the Zipper to Stabilize Both DNA Binding and Multimerization"
`Mol. Cell. Biol. 12: 817-827.
`
`Cooper, C., Johnson, D., Roman, C., Avitahl, N., Tucker, P. and Calame, K. (1992) "The
`C/EBP Family of Transcriptional Activators Is Functionally Important for Irnmunoglobulin
`VH Promoter Activity In Jfivo and In Jfitro J. Irnrnunol. E 3225-3231.
`
`Numoto, M., Niwa, 0., Kaplan, J., Wong, K., Merrell, K., Kamiya, K., Yanagihara, K.
`and Calame, K. (1993) "Transcriptional Repressor ZF5 Identifies a New Conserved
`Domain in Zinc Finger Proteins" Nuc. Acids Res. 21 :3767-75.
`Riggs, K., Saleque, S., Wong, K., Merrell, K., Shi, Y. and Calame, K. (1993) "Yin-Yang-1
`Activates the c-Myc Promoter" Mol. Cell. Biol. 13: 7487-95.
`Shrivastava, A., Saleque, S., Kalpana, G., Artandi, S., Goff, S. and Calame, K. (1993) "c-
`Myc Association Inhibits Transcriptional Regulator Yin-Yang-1" Sci. 262: 1889-92.
`Henderson, A., McDougall, S., Leiden, J. and Calame, K. (1994) "GATA Elements Are
`Necessary for the Activity and Tissue Specificity of the T-Cell Beta Chain Transcriptional
`Enhancer" Mol. Cell. Biol. 1414286-94.
`
`Avitahl, N. and Calame, K. (1994) "C/EBP Proteins Distort DNA Upon Binding but Do Not
`Introduce a Large Directed Bend" J. Biol. Chem. 269: 23553-23562
`Artandi, S., Cooper, C. and Calame, K. (1994) "Enhancer-Promoter Interaction Mediated by
`TFE3 Requires the Basic Helix-Loop-Helix Zipper Domain" Mol. Cell. Biol. 1417704-16.
`Cooper, C., Berrier, A., Roman, C. and Calame, K. (1994) "Limited Expression of C/EBP
`Family Proteins During B-Lymphocyte Development: Negative Regulator Ig/EBP
`Predominates Early and Activator NF-I16 Is Induced Later" J. Irnrnunol. 153: 5049-58.
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`56. Shrivastava, A. and Calame, K. (1994) "An Analysis of Genes Regulated by the
`Multifunctional Transcriptional Regulator Yin Yang-1" Nuc. Acids Res. 22: 5152-5155.
`57. Wong. K., Hardin, J., Boast, S., Cooper, C., Merrell, K., Doyle, T., Goff, S. and Calame,
`K. "A Role for c-Abl in c-Myc Regulation" (1995) Oncogene 101705-711
`58. Merrell, K., Gonzales, J., Baer, S., Wells, S., Calame, K. and Herman, G. “Genetic and
`Histologic Analyses of Tattered, an X-Linked Dominant, Developmental Mouse Mutation”
`(1995) Mammalian Genome 61291-94.
`59. Panagiotidis, C., Artandi, S., Calame, K. and Silverstein, S. (1995) "Polyamines Alter
`Specific DNA-Protein Interactions" Nucleic Acids Res. 2311800-1809
`60. Henderson, A., Zou, X. and Calame, K. (1995) “C/EBP Transcription Factors Regulate HIV-
`1 Long Terminal Repeat Mediated Transcription in Monocyte/Macrophages” J. Virol. 69:
`5337-5344.
`
`61. Wong, K., Zou, X., Merrell, K., Stupakoff, A., Marcu, K., Chellappan, S. and Calame, K.
`(1995) "v-Abl Activates c-Myc Transcription Through the E2F Site" Mol. Cell. Biol.
`151653 5-44.
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`62. Artandi, S., Merrell, K., Avitahl, N., Wong, K. and Calame, K. (1995) “TFE3 contains two
`activation domains, one acidic and the other prlone-rich, that synergistically activate
`transcription” Nuc. Acids Res. 2313865-71.
`63. Cooper, C., Henderson, A., Artandi, S., Avitahl, N. and Calame, K. (1995) "Ig/EBP
`(C/EBPy) Is a Transdominant Negative Inhibitor of C/EBP Family Transcriptional
`Activators" Nuc. Acids Res. 2314371-77.
`
`64. Avitahl, N. and Calame, K. (1996) “A 125 bp Region of the Irnmumoglobulin VH1 Promoter
`is Sufficient to Confer Lymphocyte-Specific Expression in Transgenic Mice” Int.
`Irnrnunol. 811359-66.
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`65. Henderson, A.J., Connor, R. and Calame, K. L. (1996) “C/EBP Activators Are Required for
`HIV-1 Replication and Provirus Induction in Monocytic Cell Lines” Immunity 5191-101.
`66. Shrivastava, A., Yu, J., Artandi, S. and Calame, K. (1996) “YY1 and c-Myc Associate In
`Vivo in a Manner Which Depends on c-Myc Levels” Proc. Natl. Acad. Sci. 9311063 8-41.
`67. Zou, X., Rudchentko, S., Wong, K. and Calame, K. (1997) “v-Abl-dependent Induction of
`c-Myc Transcription Requires Ras, Raf and Cyclin-Dependent Kinases” Genes & Dev. 11:
`654-662
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`68. Kaplan, J. and Calame, K. (1997) “The Zin/POZ Domain of ZF5 Is Required for Both
`Transcriptional Activation and Repression” Nuc. Acids Res. 2511108-1116.
`69. Lin, Y., Wong, K. and Calame, K. (1997) “Blimp-1, an Inducer of Terminal B-cell
`Differentiation, Represses c-Myc Transcription” Sci. 2761 596-99
`70. Merrell, K., Wells, S., Henderson, A., Gorman, 1., Alt, F., Stall, A. and Calame, K.(1997)
`“Absence of Transcription Activator TFE3 Irnpairs B-Cell Activation In Wvo" Mol. Cell.
`Biol. 1713335-3344.
`
`71. Henderson, A. and Calame, K. (1997) “C/EBP Sites Are Required for HIV-1 Replication in
`Monocyte/Macrophages but Not T-Cells” Proc. Natl. Acad. Sci.841 8714-19
`72. Berrier, A., Siu, G. and Calame, K. (1998) “Transcription of a Minimal Promoter from the
`NF-IL6 Gene Is Regulated by CREB/ATF and Sp1 Proteins in U937 Promonocytic Cells”
`J. Irnrnunol. 16112267-75.
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`73. Angelin-Duclos, C. and Calame, K. (1998) "V-DJ Recombination of an Irnmunoglobulin VH
`Gene Occurs in the Absence of Its Germline Transcription" Mol. Cell. Biol 1816253-6264.
`74. Zou, X. and Calame, K. (1999) “Signal Transduction by Oncogenic Forms of the Abelson
`Tyrosine Kinase” J. Biol. Chem. 274118141-44.
`75. Cong, F., Zou, X. Hinrichs, K., Calame, K. and Goff, S.P. (1999) “Inhibition of v-Abl
`Transformation by p53 and p19ARF” Oncogene 1817731-9.
`76. Zou, X., Cong, F., Cattoretti, G., Coutts, M., Goff, S.P. and Calame, K. (2000) “p53
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`Deficiency Increases Transformation by v-Abl and Restores the Ability of a C-Terminally
`Truncated v-Abl Mutant to Induce PreB Lymphoma In Vivo” Mol. Cell. Biol. 20: 628-33.
`Coutts, M., Zou, X. and Calame, K. (2000) “v-Abl Utilizes Multiple Mechanisms to Drive
`G1/S Progression in Fibroblasts” Oncogene, 19:801-9.
`Yu, J., Angelin-Duclos, C., Greenwood, J., Liao, J. and Calame, K. (2000) “Transcriptional
`Repression by Blimp-1 (PRDI-BF 1) Involves Recruitment of Histone Deacetylase" Mol.
`Cell. Biol. 20:2592-603
`
`Chang, D., Angelin-Duclos, C. and Calame, K (2000) "Blimp-1: trigger for differentiation of
`myeloid lineage." Nature Immunol. 1:169-76.
`Angelin-Duclos, C., Cattoretti, G. and Calame, K. (2000) "Commitment to a Plasma Cell Fate
`Is Associated with Blimp-1 Expression In Vivo" J. Irnrnunol. 165: 5462-71 and cover 4/01-
`6/01.
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`Lin, K. Lin, Y. and Calame, K. (2000) "Repression of c-Myc Is Necessary but Not Sufficient
`for Terminal Differentiation of B Lymphocytes In Vitro" Mol. Cell. Biol. 20:8684-95.
`Tunyaplin, C., Shapiro, M. and Calame, K.(2000) "Characterization of the B Lymphocyte
`Induced Maturation Protein-1 (Blimp-1) Gene, mRNA Isoforrns and Basal Promoter"
`Nuc. Acids Res. 28:4846-55.
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`Piskurich, J., Lin, K., Wang, Y., Lin, Y., Ting, J. and Calame, K. (2000) “Blimp-1/PRDI-
`BF1 Mediates Extinction of Major Histocompatibility Class II Transactivator (CIITA) in
`Plasmacytes” Nature Irnmunol.1:526-32.
`Calame, K. (2001) “News and Views: End game for B cells” Nature 412:289-91.
`Calame, K. (2001) “Plasma Cells: New Light at the End of B Cell Development” Nature
`Irnrnunol, 2: 1 103 -8
`Lin, K-I, Angelin-Duclos, C., Kuo, T. and Calame, K. (2002) "Blimp-1-Dependent
`Repression of Pax5 Is Required for Differentiation of B Cells to IgM-Secreting Plasma
`Cells” Mol. Cell. Biol.22:4771-4780.
`
`Chang, D., Cattoretti, G. and Calame, K. (2002) “The Dynamic Expression Pattern of B
`Lymphocyte Maturation Induced Protein-1 (Blimp-1) During Mouse Embryonic
`Development” Mech. of Dev., 117 :304-09.
`*Shaffer, A.,* Lin, K., Kuo, T., Yu, X., Hurt, E., Rosenwald, A., Giltnane, J., Zhao, H., *Calame,
`K. and *Staudt, L. (*f1rst authors contributed equally and senior authors contributed
`equally) (2002) “Blimp-1 orchestrates plasma cell differentiation by extingushing the
`mature B cell gene expression program” Immunity, 17:51-62
`Angelin-Duclos, C., Johnson, K., Liao, J. and Calame, K. (2002) “An Interfering Form of
`Blimp-1 increases IgM secreting plasma cells and blocks maturation of peripheral B cells”
`Eur. J. Irnrnunol. 3213765-75.
`
`Johnson, K., Angelin-Duclos, C., Park, S. and Calame, K. (2003) “Changes in Histone
`Acetylation Are Associated with Differences in Accessibility of VH Gene Segments to V-DJ
`Recombination During B-Cell Ontogeny and Development” Mol. Cell. Biol. 23: 2458-50.
`Giangrande, P., Hallstrom, T., Tunyaplin, C., Calame, K. and Nevins, J. (2003)
`“Identification of E-Box Factor TFE3 as a Functional Partner for the E2F3 Transcription
`Factor” Mol. Cell. Biol. 23: 3707-20.
`
`Shapiro-Shelef, M., Lin, K., Mc-Heyzer-Williams, L., Liao, J., Mc-Heyzer-Williams, M.
`and Calame, K. (2003) “Blimp-1 is required for the formation of immunoglobulin-secreting
`plasma cells and pre-plasma memory cells” Immunity. 19:607-620 and the cover of the
`October 15, 2003 issue. Previewed in Iwakoshi, N., Lee, A.-H. and Glimcher, L. “A Good
`Year for Plasma Cells (and Blimp-1),” Immunity 19:466-68.
`Tamura, T., Kong, H.J., Tunyaplin, D., Calame, K. and Ozato, K. (2003) “ICSBP/IRF-8
`Overrides Mitogenic Activity of p210 Bcr/Abl in Myeloid Progenitor Cells” Blood102:4547-
`54.
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`94. Noronha, J ., Hinrichs-Sterling, K. and Calame, K. (2003) “Increased expression of Bcl-xL
`and c-Myc mRNA is associated with transformation by Abelson Murine Leukemia
`Virus” J. Biol. Chem. 278: 50915-22.
`
`95. Johnson, K., Shapiro-Shelef, M., Tunyaplin, C. and Calame, K. (2004) “Regulatory Events in
`Early and Late B-Cell Development” Mol. Immunol. 42:749-61.
`96. Tunyaplin, C., Shaffer, A., Staudt, L.M. and Calame, K.(2004) “Direct Repression of
`Blimp-1 by Bcl-6 Inhibits Plasmacytic Differentiation” J . Immunol. 173: 1 158-65.
`97. Shaffer, A.L. Shapiro-Shelef, M., Iwakoshi, N., Lee’A.-H., Qian, S.-B., Zhao, H. Yu, X., Yang,
`L., Tan, B., Rosenwald, A., Hurt, E. Petroulakis, E., Sonenberg, Yewdell, J . Calame, K.,
`Glimcher, L.H. and Staudt, L. M. (2004) “XBP1 acts downstream of Blimp-1 to expand the
`secretory apparatus, promote organelle biogenesis, and increase protein synthesis during
`plasma cell differentiation” Immunity 21: 81-93.
`98. Johnson, K, Pflugh’ D., Yu’ D., Hesslein, D., Lin, K.-I, Bothwell, A.M., Thomas-Tikhonenko’
`A., Schatz, D.G. and Calame, K. (2004) “B-Cell Specific Loss of Histone 3 Lysine 9
`Methylation in the VH Locus Depends on Pax5” Nature Immunology 5:853-61.
`99. Kuo, T. and Calame, K. (2004) “Blimp-1, IRF-1 and IRF-2 can bind to the same regulatory
`sites” J. Immunol. 173:5556-63.
`
`100. Vincent, S., Dunn, N., Sciammas, R., Shapiro-Shelef, M, Davis, M., Calame, K., Bikoff, E.
`and Robertson, E (2005) “The Zinc-finger Transcriptional Repressor Blimp-1/PRDM Is
`Required for Primordial Germ Cell Specification in the Mouse” Dev. 132: 13 15-25.
`101. Shapiro-Shelef, M,. Lin, K.-L., Savitsky, D., Liao, J. and Calame, K. (2005) Blimp-1 Is Required
`for Maintenance of Long-Lived Plasma Cells in the Bone Marrow” J. Expt. Med. 202: 1471-6
`102. *Martins, G., *Cimmino, L., *Shelef, M., Szabolcs, M., Herron, A., Magnusdottir, E. and
`Calame, K. (*Equal contribution of 3 first authors.) (2006) “Transcriptional Repressor Blimp-1
`Regulates T Cell Homeostasis and Function” Nat. Immunol.. 7:457-65 (News&Views: Fink,
`P. “T cellsjoin the Blimp-1 brigade, (2006) Nat. Immunol. 7:445-46)
`103. Savitsky, D. and K. Calame (2006) “B-1 lymphocytes require Blimp-1 for immunoglobulin
`secretion” J. Exp. Med. 203:2305-14
`104. Omori, S, Cato, M., Anzelon-Mills, A., Puri, K. , Shapiro-Shelef, M., Calame, K., Rickert, R.
`(2006) “Regulation of Class Switch Recombination and Plasma Cell Differentiation by the
`PI3K/Akt/Foxo Signaling Axis” Immunity 25:545-57.
`105. Kuo, T., Shaffer, A., Hadad, J ., Choi, Y., Staudt, L,, Calame, K. (2007) “Repression of Bcl-6 Is
`Required for Formation of Human Memory B Cells In Vitro” J. Exp. Med. 204: 819-30.
`106. Calame, K. and Atchison, M. (2007) “YY1 Helps Bring Loose Ends Together, perspective”
`Genes and Dev. 21:1145-52.
`
`107. Han, J-H, Akira, S., Calame, K., Beutler, B. Selsing, E., Imanishi-Kari, T. (2007) “Class switch
`recombination and somatic hyperrnutation in early mouse B cells are mediated by B cell- and
`Toll-like receptors” Immunity 27: 64-75.
`108. Magnusdottir, E., Savitsky, D. Kalachikov, S.,Mizukoshi, K., Ishida-Yamamoto, A., Panteleyev,
`A., and Calame, K. (2007) “The transcriptional repressor Blimp-1 regulates late epidermal
`development” Proc. Natl. Acad. Sci. USA 104: 14988-93.
`109. Calame, K. (2007) “MiR-155 in B Cells, a preview” Immunity, 27:825-27.
`110. Cimmino, L. Martins, G. A. Liao, J . Magnusdottir, E. Grunig, G. Perez, R. K. Calame, K. (2008)
`"Blimp-1 attenuates Th1 differentiation by repression of ifng, tbx21, and bcl6 gene expression."
`J Immunol 181(4): 2338-47.
`111. Martins, G. A., L. Cimmino, et al. (2008). "Blimp-1 directly represses 112 and the 112 activator
`Fos, attenuating T cell proliferation and survival." J Exp Med 205(9): 1959-65.
`112. Rutishauser, R., Martins, G., Kalachikov, S., Chandele, A., Parish, I. A., Meffre, E., Jacob, J .
`Calame, K., Kaech, S. (2009) “Transcriptional repressor Blimp-1 promotes CD8(+) T cell
`terminal differentiation and represses the acquisition of central memory T cell properties.”
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`Immunity 311296-308
`113. Morgan, M. A., Magnusdottir, E., Kuo, T. C., Tunyaplin, C., Harper, J ., Arnold, S. J ., Calame, K.,
`Robertson, E. J ., Bikoff, E. K. (2009) “Blimp-1/Prdml alternative promoter usage during mouse
`development and plasma cell differentiation” Mol. Cell. Biol. 29:5821-27 .
`114. Lord, C. A., Savitsky, D., Sitcheran, R., Calame, K., Wright, J. R., Ting, J. P., Williams, K. L.
`(2009). "Blimp-1/PRDM1 mediates transcriptional suppression of the NLR gene
`NLRP12/Monarch-1." J Immunol 182(5): 2948-58.
`115. Kwon, H., Thierry-Mieg, D., Thierry-Mieg, J ., Kim, H. P., Oh, J .Tunyaplin, C., Carotta, S.,
`Donovan, C. E., Goldman, M. L., Tailor, P., Ozato, K., Levy, D. E., Nutt, S. L., Calame, K.,
`Leonard, W. J. (2009) “Interleukin-2 Regulates Prdml Gene Expression through
`a STAT3 and IRF4-dependent Bipartite Element” Immunity 31: 941-52.
`116. Muto, A., Ochiai, Kimura, Y., Itoh-Nakadai, A., Calame, K. L., Ikebe, D., Tashiro, S., Igarashi,
`K., (2010) Bach2 represses plasma cell gene regulatory network in B cells to promote antibody
`class switch, EMBO J. 29:4048-61.
`117. Nishikawa, K., Nakashima, T., Hayashi, M., Fukunaga, T., Kato, S., Kodama, T., Takahashi, S.,
`Calame, K., Takayanagi, H. (2010) Blimp-1-mediated repression of negative regulators is
`required for osteoclast differentiation. Proc. Natl. Acad. Sci. USA 107 :3 1 17-22.
`118. Calame, K. (2010) Blimp-1’s Maiden Flight J. Immunol. 185: 3-4.
`
`Book Chapters.‘
`
`1. Calame, K. and Ihler, G. (1978) "Electron Microscopy of Ribosomes Bound to DNA" in
`Microbiology 1978 (D. Schlessinger, ed.) American Society for Microbiology, pp.
`184-87.
`
`2. Ihler, G., Calame, K. and Nakada, D. (1979) "Electron Microscopic Mapping of Ribosome
`Binding Sites on Single Stranded DNA" in Methods in Enzymol., Nucleic Acid and Protein
`Synthesis Part G (L. Grossman and K. Moldave, eds.) pp837-851.
`3. Davis, M., Early, P., Calame, K. and Hood, L. (1979) "The Organization and Rearrangement
`of Mouse Immunoglobulin Heavy Chain Genes" in ICN-UCLA Symposia on Molecular
`and Cellular Biology, Vol. VIII, pp. 393-406.
`4. Hood, L., Early, P., Davis, M., Calame, K., Huang, H. and Crews, S. (1981) "Organization,
`Rearrangement and Diversity of Mouse Immunoglobulin Heavy Chain Genes" in Cold
`Spring Harbor Symposia on Quantitative Biology Vol. XLV, pp. 887-98.
`5. Mercola, M., Olsen, J., Wang, X. and Calame, K. (1983) "The Immunoglobulin Heavy Chain
`JH Cu Intervening Sequence Region Enhances Transcription from the SV40 Early
`Promoter" in Enhancers and Controlling Elements (Cold Spring Harbor) pp. 129-35.
`6. Mercola, M., Kakkis, E., Prehn, J ., Wang, X. and Calame, K. (1984) "Cis-Acting Effects on
`Transcription of c-Myc and Vh Genes within the Immunoglobulin Heavy Chain Locus" in
`Regulation of the Immune System (E. Sercarz, H. Cantor and L. Chess eds) Alan Liss
`Inc.,pp479-89.
`7. Calame, K. (1985) "Mechanisms Which Regulate Immunoglobulin Gene Expression" Ann.
`Rev. Immunol. 3:159-95.
`
`8. Calame, K. (1986) “A Super-Gene Family in the Immune System” Mead Johnson Symp
`Perinat Dev Med., 24: 16-29.
`9. Calame, K. and Eaton, S. (1988) "Control Sequences of Immunoglobulin and T-cell Receptor
`Genes" Adv. Immunol. 43:235-275.
`
`10. Peterson, C., Tsao, B., Kakkis, E. and Calame, K. (1988) "Transcription Factors Which
`Bind to IgH and c-Myc Genes" in Current Topics in Microbiology and Immunology (M.
`Potter ed.) 137:100-106
`11. McDougall, S., Eaton, S., Peterson, C. and Calame, K. (1988) "Transcription of
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`12.
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`Immunoglobulin Heavy Chain and T-Cell Receptor Beta Chain Genes" in Lymphocyge
`Activation and Immune Regulation Vol 12.
`Kakkis, E., Riggs, K., Calame, K. (1988) "A Repressor of c-Myc Transcription is Found
`Specifically in Plasmacytomas" in Curr. Topics Micro. and Immunol. (M. Potter, ed.).
`141: 231-37.
`
`14.
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`15.
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`16.
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`17.
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`18.
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`. Roman, C., Riggs, K., Merrell, K. and Calame, K. (1989) "Immunoglobulin Heavy Chain
`Transcription Factors Belong to Different Families of DNA Binding Proteins" in
`Mechanisms of Hematopoiesis (N. Dainaik, ed.) Alan Liss.
`Artandi, S. and Calame, K. (1993) "Association of DNA-Binding Transcription Activators in
`
`Solution" in Methods in Molecular Genetics Vol.1 (K. Adolph, ed.) pp. 267-279.
`Shrivastava, A. and Calame, K. (1994) "YY1 Association with c-MYC: An Alternative
`Mechanism for c-MYC Function" in Current Topics in Microiology and Immunology (M.
`Potter and F. Melchers, eds) pp 273-281.
`Calame, K. and Ghosh, S. (1995) "Regulation of Immunoglobulin Gene Transcription" in
`Immunoglobulin Genes, 2nd edition (F. Alt and T. Honj o, eds.) pp. 397-422.
`Henderson, A. and Calame, K. (1995) “Lessons in Transcriptional Regulation Learned from
`Studies on Immunoglobulin Genes” in Critical Reviews in Eukaryotic Genes Regulation
`(G. Stein, J. Stein, J. Lian, eds) 5: 255-280
`Zou, X., Lin, Y., Rudchentko, S. and Calame, K (1997) “Positive and Negative
`Transcriptional Regulation of c-Myc ” in Current Topics in Microiology and Immunology
`(M. Potter and F. Melchers, eds) in press.
`Henderson, A. and Calame, K. (1998) “Transcriptional Regulation During B-Cell
`Development” Ann. Rev. Immunol. 16: 163-200.
`Angelin-Duclos, C., Cattoretti, G., Chang, D., Lin, K., Lin, Y., Yu, J. and Calame, K.
`(1999) "The Role of B Lymphocyte Induced Maturation Protein-1 (BL]1\/[P-1) in Terminal
`Differentiation of B Cells and Other Cell Lineages," Cold Spring Harbor Symposium
`on Quantitative Biology, Vol. LXIV pp. 61-70.
`Lin, K.-I., Tunyaplin, C. and Calame, K. (2003) “Transcriptional Cascades Controlling
`Plasma Cell Differentiation” Irnrn. Rev. 194: 19-28.
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`19.
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`20.
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`21.
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`22.
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`23.
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`24.
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`25.
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`26.
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`27.
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`28.
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`29.
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`30.
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`31.
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`Calame, K. (2002) “Regulation of Gene Expression in Plasma Cells” in Biology of Multiple
`Myeloma, (M. Kuehl, ed.)
`Calame, K., Lin, K. and Tunyaplin, C. (2003) “Regulatory Mechanisms in Plasma Cells”
`Annual Reviews of Irnmunology.21 :205-30.
`Calame, K. and Sen, R. (2004) “Transcription of Immunolgoblin Genes” in Molecular
`Biology ofB Cells (F. Alt, T. Honjo and M. Neuberger eds.) pp. 83-100.
`Johnson, K. and Calame, K. (2003) “Transcription Factors at the Beginning and End of B
`Cell Development” Curr. Opin. Genetics and Dev.13:522-28
`Lin, K.-I. And Calame, K. (2004) “Introduction of Genes into Primary Murine Splenic B
`Cells Using Retroviral Vectors” in Methods in Molecular Biology, Humama Press (K.
`Raj ewsky